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Our top choices for South Main hotels

1. Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG Stadium
2. Wyndham Houston at Reliant Park & Medical Center
Wyndham Houston at Reliant Park & Medical Center
3. Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical Center
4. Wingate Houston near Reliant Park/Medical Center
Wingate Houston near Reliant Park/Medical Center
5. Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHG
6. 3 BR Condo near Reliant/NRG Stadium
3 BR Condo near Reliant/NRG Stadium
7. Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG
Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG
8. Hotel Ylem
Hotel Ylem
9. Hyatt House Houston Medical Center
Hyatt House Houston Medical Center
10. Hilton Houston Plaza/Medical Center
Hilton Houston Plaza/Medical Center
11. Hyatt Place Houston Medical Center
Hyatt Place Houston Medical Center
12. InterContinental Houston by IHG
InterContinental Houston by IHG
13. Blossom Hotel Houston, Curio Collection by Hilton
Blossom Hotel Houston, Curio Collection by Hilton
14. The Westin Houston Medical Center/Museum District
The Westin Houston Medical Center/Museum District
15. Hilton Garden Inn Houston Medical Center, TX
Hilton Garden Inn Houston Medical Center, TX
16. DoubleTree by Hilton Hotel Houston - Greenway Plaza
DoubleTree by Hilton Hotel Houston - Greenway Plaza
17. Crowne Plaza Houston Med Ctr-Galleria Area by IHG
Crowne Plaza Houston Med Ctr-Galleria Area by IHG
18. Home2 Suites by Hilton Houston Medical Center, TX
Home2 Suites by Hilton Houston Medical Center, TX
19. Downtowner Inns - Houston Downtown
Downtowner Inns - Houston Downtown
20. Best Western Plus Pearland/Houston Medical Center Hotel
Best Western Plus Pearland/Houston Medical Center HotelCompare popular hotels in South Main
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
![]() Comfort Suites Houston near Medical Center- NRG Stadium | 8.8 Excellent 1,006 reviews | View | ||||||
![]() Candlewood Suites Houston Medical Center by IHG | 7.4 Good 903 reviews | View | ||||||
![]() Wyndham Houston at Reliant Park & Medical Center | 7.2 Good 1,507 reviews | View | ||||||
![]() Wingate Houston near Reliant Park/Medical Center | 6.6 1,006 reviews | View | ||||||
![]() Quality Inn & Suites NRG Park - Medical Center | 6.6 1,002 reviews | View |
Where to stay in South Main

Downtown Houston
Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.
Top South Main Hotel Reviews




































































































