South Main Holidays from £889

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Your South Main Holiday

Immerse yourself in all this neighbourhood has to offer with a tailor-made South Main holiday package. However you picture yourself spending your days here, you'll find endless opportunities for fun, adventure and relaxation. When it's time to explore the sights, you'll find loads of popular attractions nearby including NRG Stadium, NRG Park and Main Street Theatre - Rice Village. Visit one, two or all during your trip to South Main. No matter what your dream South Main holiday looks like, you can make it a reality with Expedia.

Price found within the past 48 hours. Click for updated prices.
Studio 6 Houston, TX – Pearland/Medical Center

Studio 6 Houston, TX – Pearland/Medical Center

2 out of 5
Southeast Houston
Price was £1,038, price is now £889 per person
£889
per person
6 Jun - 11 Jun
found 21 hours ago
Return direct flight included
London (LON) to Houston (IAH)
9.6/10 Exceptional! (24 reviews)
The lady at the front desk was very attentive and professional. I could tell English wasn’t probably her first language but she spoke so well and was very polite.

Reviewed on 9 Apr 2026

WoodSpring Suites Houston 288 South Medical Center

WoodSpring Suites Houston 288 South Medical Center

2.5 out of 5
Southeast Houston
Price was £1,379, price is now £1,192 per person
£1,192
per person
6 Jun - 11 Jun
found 21 hours ago
Return direct flight included
London (LON) to Houston (IAH)
7.4/10 Good! (487 reviews)
Parking was safe . Bed

Reviewed on 14 Mar 2026

Hyatt House Houston Medical Center

Hyatt House Houston Medical Center

3 out of 5
Texas Medical Center
Price was £1,291, price is now £1,117 per person
£1,117
per person
6 Jun - 11 Jun
found 21 hours ago
Return direct flight included
London (LON) to Houston (IAH)
9.2/10 Wonderful! (1,253 reviews)
Clean room, doesn't provide lotion in the bathroom

Reviewed on 28 Mar 2026

Landing Houston Space Center

Landing Houston Space Center

4 out of 5
Nassau Bay
Price was £1,198, price is now £1,038 per person
£1,038
per person
6 Jun - 11 Jun
found 21 hours ago
Return direct flight included
London (LON) to Houston (IAH)
7.8/10 Good! (8 reviews)
There was nothing to not like a amazing place to get away

Reviewed on 5 Jan 2025

Crystal Inn - NorthWest - 290

Crystal Inn - NorthWest - 290

2 out of 5
Price was £1,095, price is now £949 per person
£949
per person
6 Jun - 11 Jun
found 21 hours ago
Return direct flight included
London (LON) to Houston (IAH)
9.8/10 Exceptional! (46 reviews)
The breakfast here was one of the poorest I've seen since Covid's "bag lunch" breakfasts. On the 2nd morning I'd swear the eggs and sausages were the left overs I'd seen the day before. The traffic noises were loud in the room. The parking lot was quite cramped. To the hotel's credit, the rooms were clean and the staff was nice. Usually there is poor lighting in hotel rooms but this room had plenty, requiring This 11 switches to control them all. The TV's were Amazon Fire software driven so if you don't have an Amazon account you'll have to create one if you want to watch anything. There are no cable or antenna connections, only wifi.

Reviewed on 31 Mar 2026

Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most. Learn more about South Main
Downtown Houston

Downtown Houston

3 out of top 10 points of interest in this area
4/5(25 area reviews)

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

Find hotels in Downtown Houston

Top hotels in South Main

Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center

3.5 out of 5
8686 Kirby Drive Houston TX
The price is £78 per night from 26 Apr to 27 Apr
£78
26 Apr - 27 Apr
includes taxes & fees
7/10 Good! (1,288 reviews)
Terrible experience

Reviewed on 10 Apr 2026

Wyndham Houston near NRG Park/Medical Center
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4 out of 5
5353 Westheimer Rd Houston TX
Fully refundableReserve now, pay when you stay
The price is £132 per night from 11 May to 12 May
£132
11 May - 12 May
includes taxes & fees
8.4/10 Very Good! (3,758 reviews)
Great place

Reviewed on 11 Apr 2026

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 out of 5
5701 Main Street Houston TX
Fully refundableReserve now, pay when you stay
The price is £221 per night from 26 Apr to 27 Apr
£221
26 Apr - 27 Apr
includes taxes & fees
9/10 Wonderful! (1,004 reviews)
I recently stayed at Hotel ZaZa Houston Museum District and had an absolutely wonderful experience from start to finish. The hotel perfectly blends luxury with a unique, artistic vibe that immediately sets it apart from more traditional stays. The atmosphere is truly one-of-a-kind—stylish, eclectic, ...

Reviewed on 10 Apr 2026

Hotel Zaza Houston Museum District
See all 6,573 properties in South Main
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Frequently asked questions

How much does a South Main travel package cost?
We make it simple to travel the world, with South Main travel packages starting from as low as £889. You'll have the flexibility to bundle your favourite hotels, airlines and car rental. For the ultimate escape, why not add a few tours and experiences to your travel itinerary?
If I'm not able to travel, can I cancel my South Main travel package?
It's difficult to predict what the future holds, so it's good to know that you can cancel or change your South Main travel package. If your booking was made in the last 24 hours, you may be eligible for a refund. If your booking is older, your hotel, airline or car rental company may charge a fee. Check our Customer Service Portal to find out more.
How do I get a cheap travel package to South Main?
Creating your own South Main travel package with Expedia is a simple way to save. We offer more than 550 airlines and 1,000,000 hotel options across the globe. With such an awesome range to pick from, you'll have no difficulty pulling together your perfect adventure.
Does Expedia offer Book Now, Pay Later South Main holidays?
Expedia has teamed up with online lender Klarna to make booking your next break easier on your wallet. Paying in instalments means you can spread the costs of your next adventure, leaving you with more cash to splash while you're travelling. Klarna has several payment plans to choose from, so you're sure to find something that fits your budget. Browse these flexible payment options:

  • Pay monthly holidays: If paying bite-sized amounts each month works for you, Klarna can help. Paying in convenient monthly instalments will make your holiday dreams possible.
  • Pay in instalments holidays: Into the idea of paying down your holiday in multiple transactions? Then go for this Book Now, Pay Later option with Klarna.
  • Low deposit holidays: Hitting the "book now" button is much easier with this option. Just put down a small deposit on your holiday and then start working on your travel itinerary.

Where should I stay in South Main?
Urban adventurers come from all over the world to experience Johnson Space Centre - NASA and Toyota Centre in South Main. Book a room close to these wonderful attractions to make sightseeing a breeze.
What are the top hotels in South Main?
Reserve a room at Doubletree By Hilton Houston Medical Centre Hotel And Suites. It's one of the neighbourhood's most in-demand hotels. Another top-rated option in South Main is The Whitehall Houston.
How far in advance should I book my South Main holiday?
It's tricky picking the perfect time for airfares, but we normally say the earlier, the better. Many international flights on Expedia become available to compare up to a year in advance. If you're booking late, fear not. Cheap prices occasionally appear just weeks before departure dates.
What does an Expedia South Main travel package include?
It comes down to what you want. If you're travelling solo, you might decide to bundle flights and hotels. Bringing the entire family to South Main? A travel package including hotels, rental cars and flights might suit you better. Expedia gives you the freedom and flexibility to tailor-make your travel package.
What should I know before booking a South Main travel package?
An Expedia travel package can be customized for your circumstances and is a great way to make your budget go further. What you include is up to you. Rental cars, hotels and flights — choose any combination that suits your plans.
Can I choose my airline with a South Main Expedia travel package?
Most definitely. Expedia has over 550 airline partners to select from globally. With such a huge range of choice, finding the ideal carrier to whisk you away to South Main won't be hard.

Popular places to visit

The George R. Brown Convention Center

George R. Brown Convention Center

4/5(3 reviews)

During your trip, find out what's happening in George R. Brown Convention Center, a top convention centre in Houston. Experience the entertainment choices and acclaimed art galleries in this vibrant area.

George R. Brown Convention Center
NRG Stadium

NRG Stadium

5/5(5 reviews)

Catch an event at NRG Stadium during your trip to Houston. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.

NRG Stadium
Houston, Texas Reflections

MD Anderson Cancer Center

4/5(1 review)

If MD Anderson Cancer Center is what brings you to town, hopefully you'll have a chance to explore more of Houston.

MD Anderson Cancer Center

Things to do

Astroville Tunnel Tour of Downtown Houston

Astroville Tunnel Tour of Downtown Houston (Air-Conditioned)

£19
per adult
100% of travellers recommend
Astroville Tunnel Tour of Downtown Houston (Air-Conditioned)
Houston: Houston Botanic Garden Entry Ticket

Houston: Houston Botanic Garden Entry Ticket

£9
per adult
80% of travellers recommend
Houston: Houston Botanic Garden Entry Ticket
Houston: Sloomoo Institute Entry Ticket

Houston: Sloomoo Institute Entry Ticket

£29
per adult
Houston: Sloomoo Institute Entry Ticket
See all activities in Houston

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.