South Main Holidays from £721

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Your South Main Holiday

Immerse yourself in all this neighbourhood has to offer with a tailor-made South Main holiday package. However you picture yourself spending your days here, you'll find endless opportunities for fun, adventure and relaxation. When it's time to explore the sights, you'll find loads of popular attractions nearby including NRG Stadium, NRG Park and Main Street Theatre - Rice Village. Visit one, two or all during your trip to South Main. No matter what your dream South Main holiday looks like, you can make it a reality with Expedia.

Price found within the past 48 hours. Click for updated prices.
Hyatt Place Houston-North

Hyatt Place Houston-North

3.5 out of 5
Northside
Price was £990, price is now £721 per person
£721
per person
6 Oct - 10 Oct
found 10 hours ago
Return direct flight included
London (LHR) to Houston (IAH)
6.8/10 (1,175 reviews)
Easy check in and proximity.

Reviewed on 19 Aug 2025

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4 out of 5
Uptown
Price was £1,161, price is now £836 per person
£836
per person
6 Oct - 10 Oct
found 10 hours ago
Return direct flight included
London (LHR) to Houston (IAH)
8.2/10 Very Good! (2,399 reviews)
Service is good, personnel very good, everything is good 👌

Reviewed on 21 Aug 2025

Blossom Hotel Houston

Blossom Hotel Houston

4 out of 5
Texas Medical Center
Price was £1,201, price is now £869 per person
£869
per person
6 Oct - 10 Oct
found 10 hours ago
Return direct flight included
London (LHR) to Houston (IAH)
9/10 Wonderful! (3,472 reviews)
The hotel is wonderful and I loved it

Reviewed on 21 Aug 2025

Heritage Place Houston Brookhollow

Heritage Place Houston Brookhollow

3 out of 5
Lazybrook/Timbergrove
Price was £996, price is now £722 per person
£722
per person
6 Oct - 10 Oct
found 10 hours ago
Return direct flight included
London (LHR) to Houston (IAH)
8.4/10 Very Good! (374 reviews)
Good stay. Only issue was there was no microwave in the room. A/C was great.

Reviewed on 22 Aug 2025

Omni Houston Hotel

Omni Houston Hotel

4 out of 5
Uptown
Price was £1,388, price is now £1,011 per person
£1,011
per person
6 Oct - 10 Oct
found 10 hours ago
Return direct flight included
London (LHR) to Houston (IAH)
9/10 Wonderful! (1,001 reviews)
Lobby had been updated and is very nice but rooms are still old and dated and doesn’t match the vibe in the lobby.

Reviewed on 22 Aug 2025

Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most. Learn more about South Main
Discovery Green showing city views, modern architecture and a high-rise building

Downtown Houston

3 out of top 10 points of interest in this area
4/5(25 area reviews)

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

Find hotels in Downtown Houston

Top hotels in South Main

Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center

3.5 out of 5
8686 Kirby Drive, Houston, TX
Fully refundableReserve now, pay when you stay
The price is £112 per night from 18 Sept to 19 Sept
£112
18 Sept - 19 Sept
includes taxes & fees
7/10 Good! (1,127 reviews)
"It was quiet and close to our event. It was very clean and staff was helpful"

Reviewed on 19 Aug 2025

Wyndham Houston near NRG Park/Medical Center
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4 out of 5
5353 Westheimer Rd, Houston, TX
Fully refundableReserve now, pay when you stay
The price is £91 per night from 21 Sept to 22 Sept
£91
21 Sept - 22 Sept
includes taxes & fees
8/10 Very Good! (2,419 reviews)
"The staff was amazing! They made it worth while. Thank you Double tree staff."

Reviewed on 22 Aug 2025

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

4 out of 5
1085 Rusk Street, Houston, TX
Fully refundableReserve now, pay when you stay
The price is £86 per night from 22 Sept to 23 Sept
£86
22 Sept - 23 Sept
includes taxes & fees
8.4/10 Very Good! (3,616 reviews)
Quick trip to see the Astros.
"Great location. Easy access to events downtown."

Reviewed on 19 Aug 2025

Club Quarters Hotel Downtown, Houston
See all 6,382 properties in South Main
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Frequently asked questions

How much does a South Main travel package cost?
We make it simple to travel the world, with South Main travel packages starting from as low as £721. You'll have the flexibility to bundle your favourite hotels, airlines and car rental. For the ultimate escape, why not add a few tours and experiences to your travel itinerary?
If I'm not able to travel, can I cancel my South Main travel package?
It's difficult to predict what the future holds, so it's good to know that you can cancel or change your South Main travel package. If your booking was made in the last 24 hours, you may be eligible for a refund. If your booking is older, your hotel, airline or car rental company may charge a fee. Check our Customer Service Portal to find out more.
How do I get a cheap travel package to South Main?
Creating your own South Main travel package with Expedia is a simple way to save. We offer more than 550 airlines and 1,000,000 hotel options across the globe. With such an awesome range to pick from, you'll have no difficulty pulling together your perfect adventure.
Does Expedia offer Book Now, Pay Later South Main holidays?
Expedia has teamed up with online lender Klarna to make booking your next break easier on your wallet. Paying in instalments means you can spread the costs of your next adventure, leaving you with more cash to splash while you're travelling. Klarna has several payment plans to choose from, so you're sure to find something that fits your budget. Browse these flexible payment options:

  • Pay monthly holidays: If paying bite-sized amounts each month works for you, Klarna can help. Paying in convenient monthly instalments will make your holiday dreams possible.
  • Pay in instalments holidays: Into the idea of paying down your holiday in multiple transactions? Then go for this Book Now, Pay Later option with Klarna.
  • Low deposit holidays: Hitting the "book now" button is much easier with this option. Just put down a small deposit on your holiday and then start working on your travel itinerary.

Where should I stay in South Main?
Urban adventurers come from all over the world to experience Johnson Space Centre - NASA and Toyota Centre in South Main. Book a room close to these wonderful attractions to make sightseeing a breeze.
What are the top hotels in South Main?
Reserve a room at Doubletree By Hilton Houston Medical Centre Hotel And Suites. It's one of the neighbourhood's most in-demand hotels. Another top-rated option in South Main is The Whitehall Houston.
How far in advance should I book my South Main holiday?
It's tricky picking the perfect time for airfares, but we normally say the earlier, the better. Many international flights on Expedia become available to compare up to a year in advance. If you're booking late, fear not. Cheap prices occasionally appear just weeks before departure dates.
What does an Expedia South Main travel package include?
It comes down to what you want. If you're travelling solo, you might decide to bundle flights and hotels. Bringing the entire family to South Main? A travel package including hotels, rental cars and flights might suit you better. Expedia gives you the freedom and flexibility to tailor-make your travel package.
What should I know before booking a South Main travel package?
An Expedia travel package can be customized for your circumstances and is a great way to make your budget go further. What you include is up to you. Rental cars, hotels and flights — choose any combination that suits your plans.
Can I choose my airline with a South Main Expedia travel package?
Most definitely. Expedia has over 550 airline partners to select from globally. With such a huge range of choice, finding the ideal carrier to whisk you away to South Main won't be hard.

Popular places to visit

George R. Brown Convention Center

George R. Brown Convention Center

During your trip, find out what's happening in George R. Brown Convention Center, a top convention centre in Houston. Experience the great live music and acclaimed art galleries in this vibrant area.

George R. Brown Convention Center
NASA Johnson Space Center

NASA Johnson Space Center

After visiting NASA Johnson Space Center, make a plan to see the other sights and activities in Houston. Amble around the area's lakeside or attend a sporting event.

NASA Johnson Space Center
Toyota Center

Toyota Center

Catch an event at Toyota Center during your trip to Houston. Experience the acclaimed art galleries and lively festivals in this vibrant area.

Toyota Center

Things to do

Houston Museum of Natural Sciences: Planetarium Ticket

Houston Museum of Natural Sciences: Planetarium Ticket

£9
per adult
82% of travellers recommend
Houston Museum of Natural Sciences: Planetarium Ticket
Houston: Downtown Aquarium All Day Pass

Houston: Downtown Aquarium All Day Pass

£20
per adult
Houston: Downtown Aquarium All Day Pass
Houston: Houston Botanic Garden Entry Ticket

Houston: Houston Botanic Garden Entry Ticket

£9
per adult
80% of travellers recommend
Houston: Houston Botanic Garden Entry Ticket
See all activities in Houston

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.