South Main Holidays

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Your South Main Holiday

Immerse yourself in all this neighbourhood has to offer with a tailor-made South Main holiday package. However you picture yourself spending your days here, you'll find endless opportunities for fun, adventure and relaxation. When it's time to explore the sights, you'll find loads of popular attractions nearby including NRG Stadium, NRG Park and Main Street Theatre - Rice Village. Visit one, two or all during your trip to South Main. No matter what your dream South Main holiday looks like, you can make it a reality with Expedia.

Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most. Learn more about South Main
A city square with tall buildings, trees, and green lights.

Downtown Houston

3 out of top 10 points of interest in this area
4/5(25 area reviews)

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

Find hotels in Downtown Houston

Top hotels in South Main

Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center

3.5 out of 5
8686 Kirby Drive Houston TX
Fully refundableReserve now, pay when you stay
The price is £80 per night from 2 Aug to 3 Aug
£80
2 Aug - 3 Aug
includes taxes & fees
7/10 Good! (1,335 reviews)
"I was very disappointed with my stay at this hotel. The property is extremely dated, from the old furniture to the worn-out bathroom, and it feels like it hasn’t been updated in years. Even basic amenities were lacking—there wasn’t a smart TV, and no shampoo or towels were provided until I specifically ..."

Reviewed on 10 Jul 2026

Wyndham Houston near NRG Park/Medical Center
Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

4 out of 5
1085 Rusk Street Houston TX
Fully refundableReserve now, pay when you stay
The price is £88 per night from 2 Aug to 3 Aug
£88
2 Aug - 3 Aug
includes taxes & fees
8.6/10 Excellent! (4,339 reviews)
"Quite an underwhelming experience was here for the World Cup and the rooms were not very clean everything was quite dusty."

Reviewed on 11 Jul 2026

Club Quarters Hotel Downtown, Houston
Grand Tuscany Hotel

Grand Tuscany Hotel

4 out of 5
12801 Northwest Fwy Houston TX
Fully refundableReserve now, pay when you stay
The price is £81 per night from 19 Jul to 20 Jul
£81
19 Jul - 20 Jul
includes taxes & fees
8/10 Very good! (159 reviews)
"Pool was way too small."

Reviewed on 9 Jul 2026

Grand Tuscany Hotel
See all 7,240 properties in South Main
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Frequently asked questions

How much does a South Main travel package cost?
We make it simple to travel the world, with South Main travel packages starting from as low as . You'll have the flexibility to bundle your favourite hotels, airlines and car rental. For the ultimate escape, why not add a few tours and experiences to your travel itinerary?
If I'm not able to travel, can I cancel my South Main travel package?
It's difficult to predict what the future holds, so it's good to know that you can cancel or change your South Main travel package. If your booking was made in the last 24 hours, you may be eligible for a refund. If your booking is older, your hotel, airline or car rental company may charge a fee. Check our Customer Service Portal to find out more.
How do I get a cheap travel package to South Main?
Creating your own South Main travel package with Expedia is a simple way to save. We offer more than 550 airlines and 1,000,000 hotel options across the globe. With such an awesome range to pick from, you'll have no difficulty pulling together your perfect adventure.
Does Expedia offer Book Now, Pay Later South Main holidays?
Expedia has teamed up with online lender Klarna to make booking your next break easier on your wallet. Paying in instalments means you can spread the costs of your next adventure, leaving you with more cash to splash while you're travelling. Klarna has several payment plans to choose from, so you're sure to find something that fits your budget. Browse these flexible payment options:

  • Pay monthly holidays: If paying bite-sized amounts each month works for you, Klarna can help. Paying in convenient monthly instalments will make your holiday dreams possible.
  • Pay in instalments holidays: Into the idea of paying down your holiday in multiple transactions? Then go for this Book Now, Pay Later option with Klarna.
  • Low deposit holidays: Hitting the "book now" button is much easier with this option. Just put down a small deposit on your holiday and then start working on your travel itinerary.

Where should I stay in South Main?
Urban adventurers come from all over the world to experience Johnson Space Centre - NASA and Toyota Centre in South Main. Book a room close to these wonderful attractions to make sightseeing a breeze.
What are the top hotels in South Main?
Reserve a room at Doubletree By Hilton Houston Medical Centre Hotel And Suites. It's one of the neighbourhood's most in-demand hotels. Another top-rated option in South Main is The Whitehall Houston.
How far in advance should I book my South Main holiday?
It's tricky picking the perfect time for airfares, but we normally say the earlier, the better. Many international flights on Expedia become available to compare up to a year in advance. If you're booking late, fear not. Cheap prices occasionally appear just weeks before departure dates.
What does an Expedia South Main travel package include?
It comes down to what you want. If you're travelling solo, you might decide to bundle flights and hotels. Bringing the entire family to South Main? A travel package including hotels, rental cars and flights might suit you better. Expedia gives you the freedom and flexibility to tailor-make your travel package.
What should I know before booking a South Main travel package?
An Expedia travel package can be customized for your circumstances and is a great way to make your budget go further. What you include is up to you. Rental cars, hotels and flights — choose any combination that suits your plans.
Can I choose my airline with a South Main Expedia travel package?
Most definitely. Expedia has over 550 airline partners to select from globally. With such a huge range of choice, finding the ideal carrier to whisk you away to South Main won't be hard.

Things to do

Picture 3 for Activity Houston: Space Center Houston Admission Ticket

Houston: Space Center Houston Admission Ticket

£23
per adult
92% of travellers recommend
Houston: Space Center Houston Admission Ticket
HOP ON- HOP OFF

Houston's Official City & Mural Tour!

£34
per adult
88% of travellers recommend
Houston's Official City & Mural Tour!
Astroville Tunnel Tour of Downtown Houston

Astroville Tunnel Tour of Downtown Houston (Air-Conditioned)

£23
per adult
96% of travellers recommend
Astroville Tunnel Tour of Downtown Houston (Air-Conditioned)
See all activities in Houston

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.