Search Hotels in South Main, Houston

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Save instantly and earn perks with One Key
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Our top choices for South Main hotels

Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center
3.5 star property
South Main
7.0 out of 10, Good, (1,295 reviews)
"Would stay again!"
United States
Austin
The price is £78
includes taxes & fees
10 May - 11 May
Wyndham Houston near NRG Park/Medical Center

Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.6 out of 10, Excellent, (1,002 reviews)
"Had a great stay!"
United States
Hunter
The price is £74
includes taxes & fees
31 May - 1 Jun
Comfort Suites Houston near Medical Center- NRG Stadium

Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center
3.0 star property
South Main
6.6 out of 10, (1,001 reviews)
"Great location"
United States
Jeremy
The price is £61
includes taxes & fees
27 May - 28 May
Wingate Houston near NRG Park/Medical Center

Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
2.5 star property
South Main
7.4 out of 10, Good, (860 reviews)
"My stay was perfect "
United States
Fredrick
The price is £56
includes taxes & fees
31 May - 1 Jun
Candlewood Suites Houston Medical Center by IHG

Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
2.5 star property
South Main
6.6 out of 10, (1,003 reviews)
"Very clean rooms and excellent staff"
United States
Efrain
The price is £61
includes taxes & fees
21 May - 22 May
Quality Inn & Suites NRG Park - Medical Center

Studio 6 Houston, TX – Pearland/Medical Center

Studio 6 Houston, TX – Pearland/Medical Center
2.0 star property
Southeast Houston, 8 mi from South Main
9.6 out of 10, Exceptional, (57 reviews)
"Wonderful stay and well worth the price."
United States
Francis
The price is £57
includes taxes & fees
14 May - 15 May
Studio 6 Houston, TX – Pearland/Medical Center

Palace Inn Blue 290 W 43rd & Bingle Rd

Palace Inn Blue 290 W 43rd & Bingle Rd
2.5 star property
12 mi from South Main
9.2 out of 10, Wonderful, (51 reviews)
"Very nice clean quiet property close to many restaurants."
United States
Hilary and Cynthia
The price is £84
includes taxes & fees
22 May - 23 May
Palace Inn Blue 290 W 43rd & Bingle Rd

Palace Inn Blue Edgebrook

Palace Inn Blue Edgebrook
3.0 star property
10.4 mi from South Main
9.4 out of 10, Exceptional, (168 reviews)
"Nice place to stay"
United States
Bella
The price is £71
includes taxes & fees
13 May - 14 May
Palace Inn Blue Edgebrook

Hotel Royale

Hotel Royale
2.0 star property
13 mi from South Main
9.2 out of 10, Wonderful, (31 reviews)
"Room was very clean and convenient for my short stay. Would recommend for business trips. "
United States
Jerome
The price is £65
includes taxes & fees
13 May - 14 May
Hotel Royale

Best Western Plus Pearland/Houston Medical Center Hotel

Best Western Plus Pearland/Houston Medical Center Hotel
2.5 star property
Southeast Houston, 6.4 mi from South Main
9.4 out of 10, Exceptional, (239 reviews)
"Simply amazing stay "
United States
Jesus
The price is £73
includes taxes & fees
10 May - 11 May
Best Western Plus Pearland/Houston Medical Center Hotel

Courtyard by Marriott Houston Intercontinental Airport

Courtyard by Marriott Houston Intercontinental Airport
3.0 star property
19.8 mi from South Main
9.0 out of 10, Wonderful, (1,212 reviews)
"Wonderful place to stay!"
United States
Lisa
The price is £108
includes taxes & fees
8 May - 9 May
Courtyard by Marriott Houston Intercontinental Airport

Hampton Inn & Suites Houston-Bush Intercontinental Aprt

Hampton Inn & Suites Houston-Bush Intercontinental Aprt
3.0 star property
19.7 mi from South Main
8.8 out of 10, Excellent, (1,866 reviews)
"Clean, comfy beds & friendly staff!"
United States
Andrea
The price is £76
includes taxes & fees
5 Jun - 6 Jun
Hampton Inn & Suites Houston-Bush Intercontinental Aprt

SpringHill Suites by Marriott Houston Intercontinental Arprt

SpringHill Suites by Marriott Houston Intercontinental Arprt
3.0 star property
19.8 mi from South Main
9.0 out of 10, Wonderful, (1,744 reviews)
"wonderful stay "
United States
Stepfan
The price is £95
includes taxes & fees
16 May - 17 May
SpringHill Suites by Marriott Houston Intercontinental Arprt

Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham

Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham
3.0 star property
11.5 mi from South Main
8.8 out of 10, Excellent, (1,156 reviews)
"Clean, helpful staff, absolutely loved the pool and breakfast. Would definitely stay again. "
United States
Desiree
The price is £71
includes taxes & fees
17 May - 18 May
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham

La Quinta Inn & Suites by Wyndham Houston Bush IAH South

La Quinta Inn & Suites by Wyndham Houston Bush IAH South
3.0 star property
19.4 mi from South Main
8.2 out of 10, Very good, (1,924 reviews)
"Breakfast was good, love everything about this place."
United States
John
The price is £76
includes taxes & fees
24 May - 25 May
La Quinta Inn & Suites by Wyndham Houston Bush IAH South

Tru by Hilton Houston Webster NASA

Tru by Hilton Houston Webster NASA
2.5 star property
19.1 mi from South Main
9.0 out of 10, Wonderful, (1,007 reviews)
"Breakfast was great"
United States
Tracy
The price is £70
includes taxes & fees
24 May - 25 May
Tru by Hilton Houston Webster NASA

Best Western Plus Manvel Inn & Suites

Best Western Plus Manvel Inn & Suites
2.5 star property
14.1 mi from South Main
8.8 out of 10, Excellent, (781 reviews)
"Everything about this place was awesome. Will definitely be staying there again on my next trip!!!!!"
United States
Penny
The price is £66
includes taxes & fees
18 May - 19 May
Best Western Plus Manvel Inn & Suites

Holiday Inn Express Hotel & Suites - Houston Space Center by IHG

Holiday Inn Express Hotel & Suites - Houston Space Center by IHG
2.5 star property
19.1 mi from South Main
9.0 out of 10, Wonderful, (1,004 reviews)
"Great short stay!!!"
United States
BriAnna
The price is £77
includes taxes & fees
10 May - 11 May
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG

Home2 Suites by Hilton Houston Pasadena

Home2 Suites by Hilton Houston Pasadena
3.0 star property
15.1 mi from South Main
9.4 out of 10, Exceptional, (871 reviews)
"Wedding trip Perfect short stay"
United States
Pawel
The price is £93
includes taxes & fees
16 May - 17 May
Home2 Suites by Hilton Houston Pasadena

Spark by Hilton Houston Bush Intercontinental Airport

Spark by Hilton Houston Bush Intercontinental Airport
3.0 star property
19.4 mi from South Main
8.6 out of 10, Excellent, (1,003 reviews)
"Great option close to the airport! "
United States
Lisa
The price is £75
includes taxes & fees
23 May - 24 May
Spark by Hilton Houston Bush Intercontinental Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels in South Main

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Individually decorated, individually furnished, desk, laptop workspace
Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
8.6
Excellent
1,002 reviews
View
Exterior
Candlewood Suites Houston Medical Center by IHG
2.5 star property
7.4
Good
860 reviews
View
Premium bedding, pillow-top beds, in-room safe, individually decorated
Wyndham Houston near NRG Park/Medical Center
3.5 star property
7.0
Good
1,295 reviews
View
Lobby
Wingate Houston near NRG Park/Medical Center
3.0 star property
6.6
1,001 reviews
View
Hypo-allergenic bedding, in-room safe, individually decorated
Quality Inn & Suites NRG Park - Medical Center
2.5 star property
6.6
1,003 reviews
View

Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

Top South Main Hotel Reviews

Frequently asked questions

What are the best hotels in South Main that travellers recommend?
For highly recommended hotels in South Main, consider the Wyndham Houston near NRG Park/Medical Center, Wingate Houston near NRG Park/Medical Center, Quality Inn & Suites NRG Park - Medical Center, and Comfort Suites Houston near Medical Centre- NRG Stadium.

The 3.5-star Wyndham Houston near NRG Park/Medical Center, with a 7.2 rating, is often praised by guests for its amazing staff, comfortable beds, and clean, big rooms. It also features an outdoor pool with sun loungers and is conveniently located close to NRG Astrodome (0.9 km), NRG Park (0.7 km), and NRG Arena (0.8 km).

The 3-star Wingate Houston near NRG Park/Medical Center is another great option. Guests frequently highlight the friendly and extremely polite staff, the free continental breakfast, and the comfortable, clean rooms. It is very close to NRG Astrodome (0.7 km), NRG Park (0.5 km), and NRG Arena (0.7 km).

The Quality Inn & Suites NRG Park - Medical Center is top for its excellent customer service and hospitality, along with clean rooms and a convenient location. This hotel offers free to-go breakfast and some rooms feature a balcony. It is situated near NRG Astrodome (1.0 km), NRG Park (0.8 km), and NRG Arena (0.9 km).

Finally, the Comfort Suites Houston near Medical Centre- NRG Stadium, with an excellent 8.6 rating, is known for its friendly and helpful staff, comfortable and clean rooms, and a great complimentary full breakfast. It also provides fitness facilities and is conveniently located near NRG Astrodome (1.0 km), NRG Park (0.8 km), and NRG Arena (1.4 km).
What are the best family hotels in South Main?
For family hotels in South Main, consider the Wingate Houston near NRG Park/Medical Center, the Wyndham Houston near NRG Park/Medical Center, and the Comfort Suites Houston near Medical Centre- NRG Stadium.

The 3-star Wingate Houston near NRG Park/Medical Center is a great option, located just 0.5 km from NRG Park. Guests appreciate the friendly and extremely polite staff, as well as the free and good breakfast. The comfortable and clean rooms with good beds contribute to a pleasant stay, and it also features a pool for family enjoyment.

Another excellent choice is the 3.5-star Wyndham Houston near NRG Park/Medical Center, rated 7.2. Situated only 0.7 km from NRG Park, this hotel offers child-friendly window design and free cribs, making it suitable for families with young children. Guests frequently mention the great and amazing staff, the superb location, and the clean, big rooms with comfortable beds.

The Comfort Suites Houston near Medical Centre- NRG Stadium, with an 8.6 rating, is also highly recommended. This hotel is conveniently located 0.8 km from NRG Park and features child-friendly window design. Guests consistently praise the comfortable and clean rooms, the friendly and helpful staff, and the great breakfast.
What are the top pet-friendly hotels in South Main?
For highly-rated pet-friendly hotels in South Main, consider the Wingate Houston near NRG Park/Medical Center, the Wyndham Houston near NRG Park/Medical Center, Candlewood Suites Houston Medical Center by IHG, and the Quality Inn & Suites NRG Park - Medical Center.

The 3-star Wingate Houston near NRG Park/Medical Center is a great option, allowing dogs and other pets. Guests frequently highlight the friendly and polite staff, the comfortable and clean rooms, and the good complimentary breakfast. It is conveniently located near NRG Park, NRG Astrodome, and NRG Arena.

Another excellent choice is the 3.5-star Wyndham Houston near NRG Park/Medical Center, which permits pets. This hotel, rated 7.2, is praised for its great and amazing staff, superb location, and clean, big rooms with comfortable beds. It offers free WiFi and is also close to NRG Park, NRG Astrodome, and NRG Arena.

The Candlewood Suites Houston Medical Center by IHG also permits pets and has a review rating of 7.4. This hotel provides free WiFi and free self-parking. It is situated near NRG Park, NRG Astrodome, and NRG Arena.

Finally, the Quality Inn & Suites NRG Park - Medical Center welcomes pets. This hotel offers free breakfast, including a to-go option, free self-parking, and a complimentary area shuttle. Guests often compliment the excellent and clean rooms, the convenient location, and the excellent customer service and hospitality. It is also very close to NRG Park, NRG Astrodome, and NRG Arena.
What are the most romantic hotels in South Main for couples?
For a romantic stay in South Main, the Quality Inn & Suites NRG Park - Medical Center is a good choice for couples.

The Quality Inn & Suites NRG Park - Medical Center offers suites that provide extra space and comfort. Guests have consistently praised the excellent and clean rooms, as well as the convenient location of the hotel. It provides complimentary breakfast and free toiletries, adding to the convenience of your stay. The hotel also offers free self-parking and a free area shuttle, making it easy to explore the surroundings. With NRG Astrodome just 1.0 km away and NRG Arena 0.9 km away, there's plenty to see and do nearby.
What are the best hotels in South Main near NRG Park?
When looking for hotels in South Main near NRG Park, the Wyndham Houston near NRG Park/Medical Center and the Wingate Houston near NRG Park/Medical Center are excellent options, particularly for families.

The 3.5-star Wyndham Houston near NRG Park/Medical Center, with a rating of 7.2, boasts a superb location, being just 0.7 km from NRG Park. Guests frequently praise the amazing staff, the clean and spacious rooms, and the comfortable beds. It also offers child-friendly window designs and free cribs, making it a great choice for those travelling with children.

Another highly-rated option is the 3-star Wingate Houston near NRG Park/Medical Center. While its rating is not provided, it is consistently praised for its good location, just 0.5 km from NRG Park. This hotel offers a pool, connecting rooms, and complimentary continental breakfast, which guests often describe as good. The staff are noted for being friendly and extremely polite, and the rooms are comfortable and clean.
When is the best time to go to South Main?
The best time to go to South Main is during the spring (March to May) and autumn (September to November) months.

These seasons offer pleasant weather, with comfortable temperatures that are ideal for exploring the area's outdoor attractions and walking around. Spring brings blooming flowers and a refreshing atmosphere, while autumn provides cooler temperatures and often clear skies, superb for enjoying the local parks and open-air markets.

For those planning a romantic getaway, spring is particularly lovely. The milder weather allows for leisurely strolls along the riverwalk and enjoying al fresco dining without the intense summer heat. The natural beauty of the area is at its peak, creating a beautiful backdrop for couples.

Families travelling with children might find autumn more appealing. The slightly cooler temperatures are more comfortable for kids, especially when visiting attractions like the local nature centres or attending outdoor festivals.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in South Main.
How can I save on a South Main hotel booking with Expedia?
Members always get our best prices. Find our best South Main hotel deals by joining Expedia's free travel rewards program today. As a member, you can unlock instant savings and member perks when you're logged in to your account. Another tip is to book your hotel and flights together on Expedia, where bundling can result in significant savings.
How much is the nightly rate at a South Main hotel?
Hotel prices in South Main often vary, but you can find a great deal on Expedia. Different factors affect nightly hotel rates, such as the time of year or the days of the week you want to book. To find the best deals for your stay, be flexible with your dates, and sort search results by "Price: low to high" for our cheapest rates.

Explore a world of travel with Expedia