Title: The Best Hotels in South Main, Houston - 2026 Updated Prices | Expedia.co.uk [Holiday Rentals in Houston](https://expedia.co.uk/Houston-Holiday-Rentals.d178265.Travel-Guide-HolidayRentals)[Flights to Houston](https://expedia.co.uk/Cheap-Flights-To-Houston.d178265.Travel-Guide-Flights)[Things to do in Houston](https://expedia.co.uk/Things-To-Do-In-Houston.d178265.Travel-Guide-Activities)[South Main Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-South-Main.d553248635976386992.Car-Hire-Guide)[South Main Holidays](https://expedia.co.uk/South-Main.d553248635976386992.Holidays-City-Breaks) ![](https://images.trvl-media.com/place/1503/2eeb9f80-ebf6-42ad-9574-1d77038420db.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Search Hotels in South Main, Houston - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [19 Dec - 20 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=553248635976386992&startDate=2025-12-19&endDate=2025-12-20&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [20 Dec - 21 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=553248635976386992&startDate=2025-12-20&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [19 Dec - 21 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=553248635976386992&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [26 Dec - 28 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=553248635976386992&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Property class ## Our top choices for South Main hotels ![Lobby](https://images.trvl-media.com/lodging/1000000/910000/904200/904192/0afdb877.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/910000/904200/904192/a1271476.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Individually decorated, individually furnished, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/910000/904200/904192/d9a5db5f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast ](https://images.trvl-media.com/lodging/1000000/910000/904200/904192/d9fe05fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Houston near Medical Center- NRG Stadium [](https://www.expedia.co.uk/Houston-Hotels-Comfort-Suites-Near-Texas-Medical-Center-NRG-Stadium.h904192.Hotel-Information) South Main 8.6/10 Excellent (1000) "Clean room, helpful staff and good location to hospital." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) George £77 includes taxes & fees 1 Jan - 2 Jan 2026 [](https://www.expedia.co.uk/Houston-Hotels-Comfort-Suites-Near-Texas-Medical-Center-NRG-Stadium.h904192.Hotel-Information) ![Hypo-allergenic bedding, in-room safe, individually decorated](https://images.trvl-media.com/lodging/1000000/20000/17600/17531/3135be14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/17600/17531/1e7f9dd7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/17600/17531/c101e36a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast ](https://images.trvl-media.com/lodging/1000000/20000/17600/17531/b55cbe72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn & Suites NRG Park - Medical Center [](https://www.expedia.co.uk/Houston-Hotels-Quality-Inn-Suites-NRG-Park-Medical-Center.h17531.Hotel-Information) South Main 6.6/10 (1002) "Clean rooms, quiet property. We will be back again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Javier £46 includes taxes & fees 18 Jan - 19 Jan 2026 [](https://www.expedia.co.uk/Houston-Hotels-Quality-Inn-Suites-NRG-Park-Medical-Center.h17531.Hotel-Information) ![Gazebo](https://images.trvl-media.com/lodging/67000000/66030000/66022900/66022895/ab4b9445.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Non Smoking | Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/67000000/66030000/66022900/66022895/bdf24163.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/67000000/66030000/66022900/66022895/54d3b468.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/67000000/66030000/66022900/66022895/6b2e094a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wingate Houston near NRG Park/Medical Center [](https://www.expedia.co.uk/Houston-Hotels-Wingate-By-Wyndham-Houston-Reliant-Medical-Center.h66022895.Hotel-Information) South Main 6.6/10 (989) "Great staff, excellent service and convenient to the area we were wanting to be. Room was clean and bed was very comfortable." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Roy £60 includes taxes & fees 22 Dec - 23 Dec [](https://www.expedia.co.uk/Houston-Hotels-Wingate-By-Wyndham-Houston-Reliant-Medical-Center.h66022895.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21300/21297/w2558h1440x0y0-44773629.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pet-friendly](https://images.trvl-media.com/lodging/1000000/30000/21300/21297/982edefb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Food and drink](https://images.trvl-media.com/lodging/1000000/30000/21300/21297/83265e97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Ballroom](https://images.trvl-media.com/lodging/1000000/30000/21300/21297/63833027.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wyndham Houston near NRG Park/Medical Center [](https://www.expedia.co.uk/Houston-Hotels-Wyndham-Houston-Near-NRG-ParkMedical-Center.h21297.Hotel-Information) South Main 7.2/10 Good (1204) "Love this place. Been staying here for many years. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Reynaldo £78 includes taxes & fees 22 Dec - 23 Dec [](https://www.expedia.co.uk/Houston-Hotels-Wyndham-Houston-Near-NRG-ParkMedical-Center.h21297.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/3000000/2230000/2227000/2227000/168bdeac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2230000/2227000/2227000/13fb2418.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/3000000/2230000/2227000/2227000/27e929b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Full-sized fridge, microwave, stovetop, dishwasher](https://images.trvl-media.com/lodging/3000000/2230000/2227000/2227000/14da1a00.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Candlewood Suites Houston Medical Center by IHG [](https://www.expedia.co.uk/Houston-Hotels-Candlewood-Suites-Houston-Medical-Center.h2227000.Hotel-Information) South Main 7.4/10 Good (824) "This is a safe, friendly hotel close to MDA Cancer Center" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Myra £61 includes taxes & fees 1 Jan - 2 Jan 2026 [](https://www.expedia.co.uk/Houston-Hotels-Candlewood-Suites-Houston-Medical-Center.h2227000.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/980000/976200/976144/09dd0b59.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed | 1 bedroom, Egyptian cotton sheets, premium bedding, down duvets](https://images.trvl-media.com/lodging/1000000/980000/976200/976144/8cd20a4c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sun deck](https://images.trvl-media.com/lodging/1000000/980000/976200/976144/51d97881.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/980000/976200/976144/79245093.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Americas-Houston [](https://www.expedia.co.uk/Houston-Hotels-Hilton-Americas-Houston.h976144.Hotel-Information) 6.5 mi from South Main 9.4/10 Exceptional (1608) "Great hotel. Lively bar, great breakfast, friendly staff, nice room, close to everything. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Thomas £123 includes taxes & fees 1 Jan - 2 Jan 2026 [](https://www.expedia.co.uk/Houston-Hotels-Hilton-Americas-Houston.h976144.Hotel-Information) ![City view](https://images.trvl-media.com/lodging/1000000/30000/20100/20005/3940b07d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/30000/20100/20005/6b7ff15f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/20100/20005/bc2b564f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/20100/20005/2ce18769.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Regency Houston Downtown [](https://www.expedia.co.uk/Houston-Hotels-Hyatt-Regency-Houston.h20005.Hotel-Information) Houston Central Business District, 6.5 mi from South Main 9.2/10 Wonderful (1095) "Great staff and nice room. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nikiesha £135 includes taxes & fees 20 Dec - 21 Dec [](https://www.expedia.co.uk/Houston-Hotels-Hyatt-Regency-Houston.h20005.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/880000/878700/878652/9874e960.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Staircase](https://images.trvl-media.com/lodging/1000000/880000/878700/878652/5506d9bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, pillow-top beds, in-room safe](https://images.trvl-media.com/lodging/1000000/880000/878700/878652/w3836h2556x4y4-d736e03c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, City View | View from room](https://images.trvl-media.com/lodging/1000000/880000/878700/878652/a6761ef3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Royal Sonesta Houston Galleria [](https://www.expedia.co.uk/Houston-Hotels-Royal-Sonesta-Houston-Galleria.h878652.Hotel-Information) The Galleria, 5.5 mi from South Main 8.4/10 Very good (1470) "Wonderful hotel!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Debbie £82 includes taxes & fees 22 Dec - 23 Dec [](https://www.expedia.co.uk/Houston-Hotels-Royal-Sonesta-Houston-Galleria.h878652.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1160000/1157000/1156923/44a9a3fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1160000/1157000/1156923/aa7fafd4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1160000/1157000/1156923/76e7278c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 Queen Bed | 1 bedroom, hypo-allergenic bedding, in-room safe, desk](https://images.trvl-media.com/lodging/2000000/1160000/1157000/1156923/c91eaea0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Club Quarters Hotel Downtown, Houston [](https://www.expedia.co.uk/Houston-Hotels-Club-Quarters-Hotel-In-Houston.h1156923.Hotel-Information) Houston Central Business District, 6.8 mi from South Main 8.4/10 Very good (3953) "Rooms were great and the staff was absolutely amazing. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Elmer £70 includes taxes & fees 27 Dec - 28 Dec [](https://www.expedia.co.uk/Houston-Hotels-Club-Quarters-Hotel-In-Houston.h1156923.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/45000000/44400000/44399600/44399547/0c065c18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, Multiple Beds (High Floor) | Egyptian cotton sheets, premium bedding, pillow-top beds, desk](https://images.trvl-media.com/lodging/45000000/44400000/44399600/44399547/fdf1a1ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lounge](https://images.trvl-media.com/lodging/45000000/44400000/44399600/44399547/c04e5fd4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/45000000/44400000/44399600/44399547/dd7d46bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Place Houston Downtown [](https://www.expedia.co.uk/Houston-Hotels-Hyatt-Place-Houston-Downtown.h44399547.Hotel-Information) Houston Central Business District, 6.8 mi from South Main 9.0/10 Wonderful (1565) "Great service, room was relaxing. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alice £91 includes taxes & fees 21 Dec - 22 Dec [](https://www.expedia.co.uk/Houston-Hotels-Hyatt-Place-Houston-Downtown.h44399547.Hotel-Information) ![Exclusive Room, Multiple Beds, Non Smoking | Premium bedding, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/2000000/1250000/1240800/1240788/dcc5346d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/2000000/1250000/1240800/1240788/1b778599.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/2000000/1250000/1240800/1240788/557d86e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/2000000/1250000/1240800/1240788/6c2cf751.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Platinum Inn & Suites Webster [](https://www.expedia.co.uk/Houston-Hotels-Platinum-Inn-Suites-Webster.h1240788.Hotel-Information) 19.1 mi from South Main 7.8/10 Good (1003) "It was a great stay just perfect" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) elvin £46 includes taxes & fees 29 Dec - 30 Dec [](https://www.expedia.co.uk/Houston-Hotels-Platinum-Inn-Suites-Webster.h1240788.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/4000000/3880000/3870100/3870088/8821ccc6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/4000000/3880000/3870100/3870088/30d006b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/4000000/3880000/3870100/3870088/2149bc64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/4000000/3880000/3870100/3870088/a8ba126b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Embassy Suites Houston Downtown [](https://www.expedia.co.uk/Houston-Hotels-Embassy-Suites-Houston-Downtown.h3870088.Hotel-Information) 6.5 mi from South Main 9.2/10 Wonderful (1001) "Comfortable beds, clean room" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Abdul Rasheed £107 includes taxes & fees 28 Dec - 29 Dec [](https://www.expedia.co.uk/Houston-Hotels-Embassy-Suites-Houston-Downtown.h3870088.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/28000000/27300000/27293900/27293821/a403ab12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/28000000/27300000/27293900/27293821/88ce8c5a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/28000000/27300000/27293900/27293821/81b3d19c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/28000000/27300000/27293900/27293821/522c66f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru by Hilton Houston Webster NASA [](https://www.expedia.co.uk/Houston-Hotels-Tru-By-Hilton-Houston-Webster-NASA.h27293821.Hotel-Information) 19.1 mi from South Main 9.0/10 Wonderful (1002) "The staff was super nice and the location worked great for us! " ![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg) Valeria £67 includes taxes & fees 8 Jan - 9 Jan 2026 [](https://www.expedia.co.uk/Houston-Hotels-Tru-By-Hilton-Houston-Webster-NASA.h27293821.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/1000000/910000/907500/907459/0b2adb37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/910000/907500/907459/3785f3f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lounge](https://images.trvl-media.com/lodging/1000000/910000/907500/907459/d9c7e5d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; American cuisine ](https://images.trvl-media.com/lodging/1000000/910000/907500/907459/8cd55d48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Magnolia Hotel Houston, A Tribute Portfolio Hotel [](https://www.expedia.co.uk/Houston-Hotels-Magnolia-Hotel-Houston.h907459.Hotel-Information) Downtown Houston, 6.9 mi from South Main 9.2/10 Wonderful (1341) "Best place to stay downtown Houston!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) John £94 includes taxes & fees 21 Dec - 22 Dec [](https://www.expedia.co.uk/Houston-Hotels-Magnolia-Hotel-Houston.h907459.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/1000000/20000/17800/17746/37423ee4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bars/lounges, lobby lounge](https://images.trvl-media.com/lodging/1000000/20000/17800/17746/1b15f0cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/20000/17800/17746/516b3f9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Nightclub](https://images.trvl-media.com/lodging/1000000/20000/17800/17746/w6992h4673x0y8-ea923e10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Omni Houston Hotel [](https://www.expedia.co.uk/Houston-Hotels-Omni-Houston-Hotel.h17746.Hotel-Information) 6.6 mi from South Main 9.0/10 Wonderful (1001) "A great place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Juan £141 includes taxes & fees 21 Dec - 22 Dec [](https://www.expedia.co.uk/Houston-Hotels-Omni-Houston-Hotel.h17746.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/9000000/8170000/8168200/8168134/f5ea3a06.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/9000000/8170000/8168200/8168134/f95e9509.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/9000000/8170000/8168200/8168134/5de16016.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/9000000/8170000/8168200/8168134/52dcd712.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Houston Downtown by IHG [](https://www.expedia.co.uk/Houston-Hotels-Holiday-Inn-Houston-Downtown.h8168134.Hotel-Information) Houston Central Business District, 6.2 mi from South Main 8.6/10 Excellent (1603) "Great hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) MarTesscia £89 includes taxes & fees 22 Dec - 23 Dec [](https://www.expedia.co.uk/Houston-Hotels-Holiday-Inn-Houston-Downtown.h8168134.Hotel-Information) ![Outdoor pool, open 6:00 AM to 10:00 PM, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/11000000/10630000/10620700/10620692/9a708987.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, hypo-allergenic bedding, in-room safe, desk](https://images.trvl-media.com/lodging/11000000/10630000/10620700/10620692/55e246fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/11000000/10630000/10620700/10620692/b1e04b0e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges, poolside bar](https://images.trvl-media.com/lodging/11000000/10630000/10620700/10620692/5138e12a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Regency Houston/Galleria [](https://www.expedia.co.uk/Houston-Hotels-Hyatt-Regency-HoustonGalleria.h10620692.Hotel-Information) The Galleria, 5.4 mi from South Main 9.0/10 Wonderful (1181) "Great property! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lynn £115 includes taxes & fees 8 Jan - 9 Jan 2026 [](https://www.expedia.co.uk/Houston-Hotels-Hyatt-Regency-HoustonGalleria.h10620692.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/13000000/12530000/12526500/12526454/a9738659.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/13000000/12530000/12526500/12526454/97822fd2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/13000000/12530000/12526500/12526454/7e01b59f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/13000000/12530000/12526500/12526454/23505ae1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Houston Downtown [](https://www.expedia.co.uk/Houston-Hotels-Hampton-Inn-Houston-Downtown.h12526454.Hotel-Information) 6.7 mi from South Main 8.8/10 Excellent (1005) "Great fresh breakfast easy access to things around you and great service " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Angel £89 includes taxes & fees 29 Dec - 30 Dec [](https://www.expedia.co.uk/Houston-Hotels-Hampton-Inn-Houston-Downtown.h12526454.Hotel-Information) ![Standard Room, 2 Queen Beds | Premium bedding, Tempur-Pedic beds, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/30000/28100/28060/38218191.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/30000/28100/28060/4aed2271.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/28100/28060/5d436540.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/30000/28100/28060/3f3eaee7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Crowne Plaza Houston Med Ctr-Galleria Area by IHG [](https://www.expedia.co.uk/Houston-Hotels-Crowne-Plaza-Houston-River-Oaks.h28060.Hotel-Information) 4 mi from South Main 7.8/10 Good (1271) "Enjoyed my stay at hotel " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Reginald £59 includes taxes & fees 24 Dec - 25 Dec [](https://www.expedia.co.uk/Houston-Hotels-Crowne-Plaza-Houston-River-Oaks.h28060.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/13000000/12300000/12294900/12294828/36442d5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/13000000/12300000/12294900/12294828/d494aa11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/13000000/12300000/12294900/12294828/50dbd8d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/13000000/12300000/12294900/12294828/d42cd665.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Place Houston/Galleria [](https://www.expedia.co.uk/Houston-Hotels-Hyatt-Place-HoustonGalleria.h12294828.Hotel-Information) 5.4 mi from South Main 8.8/10 Excellent (1280) "Great location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ramon Alejandro Caballero £83 includes taxes & fees 26 Dec - 27 Dec [](https://www.expedia.co.uk/Houston-Hotels-Hyatt-Place-HoustonGalleria.h12294828.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-01-02&endDate=2026-01-03®ionId=553248635976386992&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Where to stay in South Main Find the best South Main areas for the activities you enjoy most. - Downtown Houston - The Galleria - Texas Medical Center - Northside - Houston Heights ![Discovery Green showing city views, modern architecture and a high-rise building](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/23000/23540-Discovery-Green.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Discovery Green featuring a high-rise building, a city and modern architecture](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/34000/34453-Discovery-Green.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/507000/507468-downtown-houston.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/507000/507497-downtown-houston.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Discovery Green showing modern architecture, a statue or sculpture and a high-rise building](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/34000/34451-Discovery-Green.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.co.uk/Hotel-Search?pwaOverlay=map®ionId=800037) ![Downtown Houston map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:s%7CrtDz%7BbeQiQ_%40eEcBgCkDuQ%7D_%40m%5EeQ%7EMi%5DoAePiLi%60%40m%40%7DTlCsl%40pNj%5CxWzUxS%60Bv%7CAhmAcg%40ncAuI%60DmZx%40&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=WgKNf3zxiTWREKGzy8I1t3uy5Hs=) ### Downtown Houston Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers. [See properties](https://www.expedia.co.uk/Hotel-Search?regionId=800037) ![](https://mediaim.expedia.com/destination/1/733d46a93b53c864b5c00945f6416b51.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://mediaim.expedia.com/destination/1/d7dc12b9d267be169566d38db8ea7eac.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://mediaim.expedia.com/destination/7/01538c9f6eb646ea96e3df2059618b27.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://mediaim.expedia.com/destination/7/374a9a687602bd093583e97522a04bc6.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://mediaim.expedia.com/destination/9/aadfd687906d99829a520409ec046d47.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.co.uk/Hotel-Search?pwaOverlay=map®ionId=501263) ![The Galleria map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:%7DxptDn%7DteQ_AcXqKr%40mHsB%7BXT%5DgYeZY%3F%7D%60%40jGi%40rA_HxCyFTuIpzAsBbBt%7D%40fw%40%60NdA%7Ce%40szAdB&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=5e77b0krOIeDwBK5_jkO84swezY=) ### The Galleria Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower. [See properties](https://www.expedia.co.uk/Hotel-Search?regionId=501263) ![](https://mediaim.expedia.com/destination/1/f4655cac96c82fca6c00f4ab3162178c.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://mediaim.expedia.com/destination/7/29187be13ac57fa24b0f672247c7afbc.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://mediaim.expedia.com/destination/7/52a59f2a0bfb2cf153bbc44f917f7275.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://mediaim.expedia.com/destination/9/921ad7f5733a42c9202d8d16c78f3830.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.co.uk/Hotel-Search?pwaOverlay=map®ionId=6143504) ![Texas Medical Center map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:wbftD%7C%60keQyBu%40u%5DkXgZySqC%7EG%7DEnG%7DQrDyAw%60%40aa%40gYrCsKe%5BcW%7CM_UbGi%40%60LmLjQmE%5DmPvB%60%40vEoQhGyJnDgKjKlC%7DDbTqAUq%40lDrYtHbGdd%40nKsDlOe%40bW%60Oj%40d_%40%7BFd%40%3FdRmCpA%3FdAtC%7CDL%60_%40eF%3F%7B%40uFiDf%40AqAwBB%7BC%60Ae%40yCm%40OlBhOjId%60%40hAnC&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=-txg4h32BKxrIPBjQzTWKWRnz0I=) ### Texas Medical Center Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city. [See properties](https://www.expedia.co.uk/Hotel-Search?regionId=6143504) ![](https://mediaim.expedia.com/destination/7/b249298face16fd5795cf74face8ed8d.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://mediaim.expedia.com/destination/7/7f180593ef78263134eb6f20e72fd6c3.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.co.uk/Hotel-Search?pwaOverlay=map®ionId=553248635976387525) ![Northside map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:muquD%60e%7DeQS_uAwHCiF%7B%40eOkIi%40dAf%40oAhOnIfFz%40%7CHB%3Ff%40bqCs%40%3FqP%7CBA%3FgKkUFzCeb%40%60u%40%5BJlx%40tq%40%3FV%7BOrD_GhAsKxG%7BG%40aB%7DS%7CJwIgSn%5Bo%5Bc%60A%5EUanAmEqAsFwCcGr%40yITqExA%7BBMQkXpJAEkNiFDBaS%7EFaJ%7E%5Eq%5EoBszBgmA%5Ci%40myAgFF%3FeAiDFIoIsYFYcEaBmFuoAj%40eaAgCNf%60%40__AZZzv%40hGx%5Ez%40VJvAk%40l%40HnI%7DQD%40pkA%60%40rMqSJ%3FfEoB%40AgEsKB_%40k%7EAaEyFoC%3F_EkEcEuCtCAY_SmKBBbIqHDgDgDu%40mBGcFnPF%60J_%40CwLqy%40ZD%7Ef%40aG%40%40tMw%40bJEvGcq%40RJyg%40aLC%3FsBzBcFjHC%3Fs%5DkFnBwCxBiS%60W_D%3FW%7Bl%40zd%40mG%3FmGlLM%3FbD%7ENoBhi%40i%40bVaArH%7D%40o%40geB%7DXJMif%40fJGUux%40tdCy_%40vB%7ERj%40dRlOEDtK%7BOHC%7EKnBA%40%7CK%60bBi%40x%40dbBpIVltA%7D%40jIn%40nmCg%40i%40mgCOgAiM%7EG%5D%7BqAmFC%3FrCcHA%40nC%7D%5E%40CaQaVT%40%5EsNaMoARg%40wGj%5DwEl%60A%7DOOe%5D%7EHAHzZdScDvJVw%40csCiLcAcDfBcDf%40Iyh%40jVOHwZvZvNMqfBayCg%7D%40Sc%60%40kq%40E%40u%40%7DF%40AqEyP%3FKkWkZNI%7DZee%40Zl%40eF%7CBC%40%60C%60D%3FGiVxpAk%40NpO%60KIPbn%40ve%40O%5Bqz%40jd%40OEya%40vLEAmHts%40W%5Da_B%60lCrjCjZ_CtfB%7CAXsObgDc%40JxYj%5E%5EpaAzrCvuCXjEtQfl%40vZqG%60R%7DN%7EP%7C%40%7CUhHdSmSrCuBzWvDzNeEbf%40uYnGwRwe%40cCd_ArSfu%40s%60%40%7E%60%40u_%40%7EZiKhk%40dQtm%40uAxaB_JDIpSkK%7CJfFfLC%7EHsK%7DBku%40dDj%40fJaLmAApX%7CLxDcItPeIlFuF%7CNkc%40fN%7BOpNoA%7E%5BsLdPiPjb%40ut%40nYq%40ti%40gNr%5EbAlaAsfC%7EwCkDKw%40mJtCcGavBu%40aZuJoEBn%40%7C%7EAyq%40%5CgCp%5C%7B%60B%3F%5DcfAgwCbuA&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=SL4qRZsnUhbIVHkfA1was5maM1w=) ### Northside While you're in Northside, take in top sights like The Heights Theater or Greenspoint Mall, and hop on the metro to see more of the city at Northline Transit Center/HCC Station or Melbourne/North Lindale Station. [See properties](https://www.expedia.co.uk/Hotel-Search?regionId=553248635976387525) [](https://www.expedia.co.uk/Hotel-Search?pwaOverlay=map®ionId=553248633938962798) ![Houston Heights map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:%7B%7DvtD%60jkeQe%5DSwm%40uIujC%7EF%5D%7B%7DBkC_Ne%40sSly%40oTpkCmAnIgCrJr%40%60Br%40vH%7EFm%40rkBN%7C%60%40%7BHdg%40&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=opqAVmz9leLiGgUlmOqGYTLlj10=) ### Houston Heights You'll enjoy the coffee shops and live music in Houston Heights. You might want to make time for a stop at The Heights Theater or Artcar Museum. [See properties](https://www.expedia.co.uk/Hotel-Search?regionId=553248633938962798) ## Top South Main Hotel Reviews ![Crowne Plaza Houston Med Ctr-Galleria Area by IHG](https://images.trvl-media.com/lodging/1000000/30000/28100/28060/38218191_y.jpg) ### Crowne Plaza Houston Med Ctr-Galleria Area by IHG 10/10 Excellent "The room was very clean and spacious. Comfortable bed " [](https://expedia.co.uk/Houston-Hotels-Crowne-Plaza-Houston-River-Oaks.h28060.Hotel-Information) ![Club Quarters Hotel Downtown, Houston](https://images.trvl-media.com/lodging/2000000/1160000/1157000/1156923/44a9a3fd_y.jpg) ### Club Quarters Hotel Downtown, Houston 10/10 Excellent "Wonderful experience great staff" [](https://expedia.co.uk/Houston-Hotels-Club-Quarters-Hotel-In-Houston.h1156923.Hotel-Information) ![Omni Houston Hotel](https://images.trvl-media.com/lodging/1000000/20000/17800/17746/37423ee4_y.jpg) ### Omni Houston Hotel 10/10 Excellent "Great location, clean rooms and friendly staff" [](https://expedia.co.uk/Houston-Hotels-Omni-Houston-Hotel.h17746.Hotel-Information) ![The Whitehall Houston](https://images.trvl-media.com/lodging/1000000/700000/693700/693655/f1d85056_y.jpg) ### The Whitehall Houston 10/10 Excellent "Great hotel and friendly staff" [](https://expedia.co.uk/Houston-Hotels-The-Whitehall-Houston.h693655.Hotel-Information) ![DoubleTree by Hilton Hotel Houston - Greenway Plaza](https://images.trvl-media.com/lodging/1000000/30000/20200/20177/682ca680_y.jpg) ### DoubleTree by Hilton Hotel Houston - Greenway Plaza 10/10 Excellent "Did you eat there" [](https://expedia.co.uk/Houston-Hotels-DoubleTree-By-Hilton-Hotel-Houston-Greenway-Plaza.h20177.Hotel-Information) ![The Royal Sonesta Houston Galleria](https://images.trvl-media.com/lodging/1000000/880000/878700/878652/9874e960_y.jpg) ### The Royal Sonesta Houston Galleria 10/10 Excellent "Great overall stay!!!" [](https://expedia.co.uk/Houston-Hotels-Royal-Sonesta-Houston-Galleria.h878652.Hotel-Information) ![Hilton Americas-Houston](https://images.trvl-media.com/lodging/1000000/980000/976200/976144/09dd0b59_y.jpg) ### Hilton Americas-Houston 10/10 Excellent "Beautiful amenities, excellent service and good staff" [](https://expedia.co.uk/Houston-Hotels-Hilton-Americas-Houston.h976144.Hotel-Information) ![DoubleTree by Hilton Hotel & Suites Houston by the Galleria](https://images.trvl-media.com/lodging/1000000/30000/20200/20116/555244ce_y.jpg) ### DoubleTree by Hilton Hotel & Suites Houston by the Galleria 10/10 Excellent "The staff and facilities were amazing. I will definitely stay here again in the future." [](https://expedia.co.uk/Houston-Hotels-DoubleTree-By-Hilton-Hotel-Suites-Houston-By-The-Galleria.h20116.Hotel-Information) ![Hotel Zaza Houston Museum District](https://images.trvl-media.com/lodging/1000000/10000/3400/3306/47c5ade4_y.jpg) ### Hotel Zaza Houston Museum District 10/10 Excellent "I was not offered a free breakfast" [](https://expedia.co.uk/Houston-Hotels-Hotel-Zaza-Houston-Museum-District.h3306.Hotel-Information) ## Frequently asked questions ### What are the best hotels in South Main that travellers recommend? > For families, Wingate Houston near NRG Park/Medical Center is another great option. With a complimentary continental breakfast to fuel your adventures and a refreshing outdoor pool, it caters superbly to parents and kids alike. The accessible fitness centre allows for some family fun, while the hotel's pet-friendly policies make it a fantastic choice for those traveling with furry companions. With a focus on convenience and value, this hotel provides excellent amenities while keeping everyone comfortable. ### What are the best family hotels in South Main? > Another excellent option is the Candlewood Suites Houston Medical Center by IHG, which boasts a family-friendly atmosphere with its free cribs, connecting rooms, and a sofa bed, making it great for families needing extra space. Guests appreciate the convenience of in-room kitchen amenities like a microwave and dishwasher, allowing for easy meal prep during your stay. It has a review score of 7.6, reflecting its appeal to families on the go. > > > For those seeking a place with a pool, the Quality Inn & Suites NRG Park - Medical Center is a great choice. With its inviting pool area, free meals for children, and options for rollaway beds at no extra charge, families can enjoy a splash-filled vacation while also benefiting from daily housekeeping and snack options. > > > Lastly, the Wyndham Houston near NRG Park/Medical Center features child-friendly window designs and connecting rooms, catering specifically to families' needs. The presence of kitchenettes adds to the convenience, allowing families to prepare snacks or meals together. This property has a traveller rating of 7.2, making it a reliable choice for family stays. > > > These hotels exemplify quality and convenience, ensuring that your family's adventure in South Main is both enjoyable and comfortable. ### What hotels in South Main offer free breakfast? > Another great choice is Quality Inn & Suites NRG Park - Medical Center, which also provides a free breakfast, including options for those on the go. This family-friendly hotel offers spacious suites with balconies and patios, allowing families to unwind outdoors. The outdoor pool invites guests to relax and enjoy the Texas sunshine, while the complimentary area shuttle makes it simple to explore the attractions nearby. > > > For those traveling without children, the Wingate Houston near NRG Park/Medical Center presents a delightful blend of comfort and accessibility. With an outdoor pool and fitness centre, it caters to adults looking for a rejuvenating getaway. The hotel's continental breakfast is another perk that guarantees a satisfying start to your morning adventures. ### What are the best budget hotels in South Main? > For another appealing choice, Candlewood Suites Houston Medical Center by IHG stands out with a review score of 7.6\. This property is superb for families, as it features kitchenettes in the rooms, allowing for meal preparation and snacks on the go. Kids can also enjoy the complimentary cribs and sofa beds, making it a comfortable stay for everyone. Additionally, the hotel offers a free area shuttle, which is great for exploring local attractions without the hassle of driving. > > > If you're traveling with your partner or friends, the Wyndham Houston near NRG Park/Medical Center offers a more relaxed atmosphere with a lower review score of 7.2\. This hotel features outdoor pool access and convenient amenities, including a kitchenette in some rooms, which can appeal to those looking for a home-like experience while away. > > > No matter your travel group, these options in South Main cater to various needs while ensuring a comfortable and enjoyable stay. ### Can I cancel my hotel reservation on Expedia? ### How can I save on a South Main hotel booking with Expedia? ### How much is the nightly rate at a South Main hotel? ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - Other - More ways to book - [4 Star Hotels in Southwest Houston ](https://www.expedia.co.uk/4Star-Southwest-Houston-Hotels.s40-0-d6189441.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Southwest Houston ](https://www.expedia.co.uk/5Star-Southwest-Houston-Hotels.s50-0-d6189441.Travel-Guide-Filter-Hotels) - [5 Star Hotels in The Galleria ](https://www.expedia.co.uk/5Star-The-Galleria-Houston-Hotels.s50-n501263-0.Travel-Guide-Filter-Hotels) - 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