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Our top choices for South Main hotels

Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
2.5 star property
South Main
6.6 out of 10, (1,006 reviews)
"Very clean rooms and excellent staff"
United States
Efrain
The price is £52
includes taxes & fees
19 Jul - 20 Jul
Quality Inn & Suites NRG Park - Medical Center

Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center
3.0 star property
South Main
6.6 out of 10, (1,003 reviews)
"Good parking"
United States
joseph
The price is £63
includes taxes & fees
5 Jul - 6 Jul
Wingate Houston near NRG Park/Medical Center

Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
2.5 star property
South Main
7.4 out of 10, Good, (872 reviews)
"My stay was perfect "
United States
Fredrick
The price is £66
includes taxes & fees
12 Jul - 13 Jul
Candlewood Suites Houston Medical Center by IHG

Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center
3.5 star property
South Main
7.0 out of 10, Good, (1,296 reviews)
"Would stay again!"
United States
Austin
The price is £88
includes taxes & fees
12 Jul - 13 Jul
Wyndham Houston near NRG Park/Medical Center

Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.6 out of 10, Excellent, (1,001 reviews)
"Clean & comfortable, super nice staff, good breakfast options, convenient to MDA."
United States
Cleota
The price is £96
includes taxes & fees
21 Jun - 22 Jun
Comfort Suites Houston near Medical Center- NRG Stadium

Studio 6 Houston, TX – Pearland/Medical Center

Studio 6 Houston, TX – Pearland/Medical Center
2.0 star property
Southeast Houston, 8 mi from South Main
9.4 out of 10, Exceptional, (120 reviews)
"Awesome staff, clean rooms and love the free parking! Thanks a lot for a great stay!"
United States
Rorie
The price is £55
includes taxes & fees
30 Jun - 1 Jul
Studio 6 Houston, TX – Pearland/Medical Center

GreenTree Inn Houston IAH Airport

GreenTree Inn Houston IAH Airport
2.0 star property
19.5 mi from South Main
6.8 out of 10, (1,203 reviews)
"Great, great , great"
United States
Joshua
The price is £43
includes taxes & fees
10 Jul - 11 Jul
GreenTree Inn Houston IAH Airport

GreenTree Hotel & Extended Stay I-10 FWY Houston, Channelview, Baytown

GreenTree Hotel & Extended Stay I-10 FWY Houston, Channelview, Baytown
3.0 star property
17.9 mi from South Main
8.6 out of 10, Excellent, (728 reviews)
"It was clean and the staff was helpful."
United States
Yuan Chao
The price is £42
includes taxes & fees
25 Jun - 26 Jun
GreenTree Hotel & Extended Stay I-10 FWY Houston, Channelview, Baytown

Hotel Royale

Hotel Royale
2.0 star property
13 mi from South Main
9.0 out of 10, Wonderful, (42 reviews)
"Room was very clean and convenient for my short stay. Would recommend for business trips. "
United States
Jerome
The price is £62
includes taxes & fees
22 Jun - 23 Jun
Hotel Royale

Best Western Plus Pearland/Houston Medical Center Hotel

Best Western Plus Pearland/Houston Medical Center Hotel
2.5 star property
Southeast Houston, 6.4 mi from South Main
9.2 out of 10, Wonderful, (292 reviews)
"Great experience with friendly staff."
United States
Maria
The price is £70
includes taxes & fees
19 Jul - 20 Jul
Best Western Plus Pearland/Houston Medical Center Hotel

Tru by Hilton Houston Webster NASA

Tru by Hilton Houston Webster NASA
2.5 star property
19.1 mi from South Main
9.0 out of 10, Wonderful, (1,003 reviews)
"Definitely will stay here again. Great location near Great Wolf Lodge."
United States
Deanndra
The price is £77
includes taxes & fees
6 Jul - 7 Jul
Tru by Hilton Houston Webster NASA

Crystal Inn Northeast Houston Downtown I-610

Crystal Inn Northeast Houston Downtown I-610
2.5 star property
Northside, 11.7 mi from South Main
8.4 out of 10, Very good, (225 reviews)
"The room was clean parked right in front of the door of the room and staff was very happy and helpful"
United States
Sonji Machelle
The price is £61
includes taxes & fees
4 Jul - 5 Jul
Crystal Inn Northeast Houston Downtown I-610

La Quinta Inn & Suites by Wyndham Houston Bush IAH South

La Quinta Inn & Suites by Wyndham Houston Bush IAH South
3.0 star property
19.4 mi from South Main
8.0 out of 10, Very good, (2,148 reviews)
"Great Hotel!"
United States
Alexa
The price is £75
includes taxes & fees
7 Jul - 8 Jul
La Quinta Inn & Suites by Wyndham Houston Bush IAH South

Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown
2.0 star property
Midtown, 5.7 mi from South Main
9.2 out of 10, Wonderful, (169 reviews)
"Great place. The staff is very friendly and the place is clean."
United States
Fernando
The price is £74
includes taxes & fees
8 Jul - 9 Jul
Downtowner Inns - Houston Downtown

Holiday Inn Express Hotel & Suites - Houston Space Center by IHG

Holiday Inn Express Hotel & Suites - Houston Space Center by IHG
2.5 star property
19.1 mi from South Main
9.0 out of 10, Wonderful, (1,004 reviews)
"Wonderful enjoyed the stay and breakfast clean rooms"
United States
Albert
The price is £77
includes taxes & fees
7 Jul - 8 Jul
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG

Crowne Plaza Houston Med Ctr-Galleria Area by IHG

Crowne Plaza Houston Med Ctr-Galleria Area by IHG
3.5 star property
Greenway Plaza-Upper Kirby, 4 mi from South Main
7.8 out of 10, Good, (1,488 reviews)
"The kitchen staff was wonderful and one of the nicest breakfast I've had at any hotel!"
United States
Christy
The price is £62
includes taxes & fees
6 Jul - 7 Jul
Crowne Plaza Houston Med Ctr-Galleria Area by IHG

Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham

Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham
3.0 star property
11.5 mi from South Main
8.8 out of 10, Excellent, (1,228 reviews)
"Great location"
United States
Maxwell
The price is £73
includes taxes & fees
6 Jul - 7 Jul
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham

Hampton Inn & Suites Houston-Bush Intercontinental Aprt

Hampton Inn & Suites Houston-Bush Intercontinental Aprt
3.0 star property
19.7 mi from South Main
8.8 out of 10, Excellent, (1,916 reviews)
"Close to the airport and near many restaurants."
United States
Lori
The price is £80
includes taxes & fees
6 Jul - 7 Jul
Hampton Inn & Suites Houston-Bush Intercontinental Aprt

Haven Inn & Suites Downtown Houston

Haven Inn & Suites Downtown Houston
2.5 star property
11.6 mi from South Main
9.4 out of 10, Exceptional, (1,058 reviews)
"Great stay!"
United States
Dalisia
The price is £63
includes taxes & fees
14 Jul - 15 Jul
Haven Inn & Suites Downtown Houston

Sonesta Simply Suites Houston – NASA Clear Lake

Sonesta Simply Suites Houston – NASA Clear Lake
2.5 star property
Nassau Bay, 19.7 mi from South Main
8.2 out of 10, Very good, (1,003 reviews)
"This is the third time I stayed here and I always love my stay!"
United States
Deena
The price is £57
includes taxes & fees
22 Jun - 23 Jun
Sonesta Simply Suites Houston – NASA Clear Lake
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels in South Main

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Individually decorated, individually furnished, desk, laptop workspace
Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
8.6
Excellent
1,001 reviews
View
Exterior
Candlewood Suites Houston Medical Center by IHG
2.5 star property
7.4
Good
872 reviews
View
Premium bedding, pillow-top beds, in-room safe, individually decorated
Wyndham Houston near NRG Park/Medical Center
3.5 star property
7.0
Good
1,296 reviews
View
Hypo-allergenic bedding, in-room safe, individually decorated
Quality Inn & Suites NRG Park - Medical Center
2.5 star property
6.6
1,006 reviews
View
Lobby
Wingate Houston near NRG Park/Medical Center
3.0 star property
6.6
1,003 reviews
View

Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

Top South Main Hotel Reviews

Frequently asked questions

What are the best hotels in South Main that travellers recommend?
For highly recommended hotels in South Main, consider the Wyndham Houston near NRG Park/Medical Center, Wingate Houston near NRG Park/Medical Center, Quality Inn & Suites NRG Park - Medical Center, and Comfort Suites Houston near Medical Centre- NRG Stadium.

The 3.5-star Wyndham Houston near NRG Park/Medical Center, with a 7.2 rating, is often praised by guests for its amazing staff, comfortable beds, and clean, big rooms. It also features an outdoor pool with sun loungers and is conveniently located close to NRG Astrodome (0.9 km), NRG Park (0.7 km), and NRG Arena (0.8 km).

The 3-star Wingate Houston near NRG Park/Medical Center is another great option. Guests frequently highlight the friendly and extremely polite staff, the free continental breakfast, and the comfortable, clean rooms. It is very close to NRG Astrodome (0.7 km), NRG Park (0.5 km), and NRG Arena (0.7 km).

The Quality Inn & Suites NRG Park - Medical Center is top for its excellent customer service and hospitality, along with clean rooms and a convenient location. This hotel offers free to-go breakfast and some rooms feature a balcony. It is situated near NRG Astrodome (1.0 km), NRG Park (0.8 km), and NRG Arena (0.9 km).

Finally, the Comfort Suites Houston near Medical Centre- NRG Stadium, with an excellent 8.6 rating, is known for its friendly and helpful staff, comfortable and clean rooms, and a great complimentary full breakfast. It also provides fitness facilities and is conveniently located near NRG Astrodome (1.0 km), NRG Park (0.8 km), and NRG Arena (1.4 km).
What are the best family hotels in South Main?
For family hotels in South Main, consider the Wingate Houston near NRG Park/Medical Center, the Wyndham Houston near NRG Park/Medical Center, and the Comfort Suites Houston near Medical Centre- NRG Stadium.

The 3-star Wingate Houston near NRG Park/Medical Center is a great option, located just 0.5 km from NRG Park. Guests appreciate the friendly and extremely polite staff, as well as the free and good breakfast. The comfortable and clean rooms with good beds contribute to a pleasant stay, and it also features a pool for family enjoyment.

Another excellent choice is the 3.5-star Wyndham Houston near NRG Park/Medical Center, rated 7.2. Situated only 0.7 km from NRG Park, this hotel offers child-friendly window design and free cribs, making it suitable for families with young children. Guests frequently mention the great and amazing staff, the superb location, and the clean, big rooms with comfortable beds.

The Comfort Suites Houston near Medical Centre- NRG Stadium, with an 8.6 rating, is also highly recommended. This hotel is conveniently located 0.8 km from NRG Park and features child-friendly window design. Guests consistently praise the comfortable and clean rooms, the friendly and helpful staff, and the great breakfast.
What are the top pet-friendly hotels in South Main?
For highly-rated pet-friendly hotels in South Main, consider the Wingate Houston near NRG Park/Medical Center, the Wyndham Houston near NRG Park/Medical Center, Candlewood Suites Houston Medical Center by IHG, and the Quality Inn & Suites NRG Park - Medical Center.

The 3-star Wingate Houston near NRG Park/Medical Center is a great option, allowing dogs and other pets. Guests frequently highlight the friendly and polite staff, the comfortable and clean rooms, and the good complimentary breakfast. It is conveniently located near NRG Park, NRG Astrodome, and NRG Arena.

Another excellent choice is the 3.5-star Wyndham Houston near NRG Park/Medical Center, which permits pets. This hotel, rated 7.2, is praised for its great and amazing staff, superb location, and clean, big rooms with comfortable beds. It offers free WiFi and is also close to NRG Park, NRG Astrodome, and NRG Arena.

The Candlewood Suites Houston Medical Center by IHG also permits pets and has a review rating of 7.4. This hotel provides free WiFi and free self-parking. It is situated near NRG Park, NRG Astrodome, and NRG Arena.

Finally, the Quality Inn & Suites NRG Park - Medical Center welcomes pets. This hotel offers free breakfast, including a to-go option, free self-parking, and a complimentary area shuttle. Guests often compliment the excellent and clean rooms, the convenient location, and the excellent customer service and hospitality. It is also very close to NRG Park, NRG Astrodome, and NRG Arena.
What are the most romantic hotels in South Main for couples?
For a romantic stay in South Main, the Quality Inn & Suites NRG Park - Medical Center is a good choice for couples.

The Quality Inn & Suites NRG Park - Medical Center offers suites that provide extra space and comfort. Guests have consistently praised the excellent and clean rooms, as well as the convenient location of the hotel. It provides complimentary breakfast and free toiletries, adding to the convenience of your stay. The hotel also offers free self-parking and a free area shuttle, making it easy to explore the surroundings. With NRG Astrodome just 1.0 km away and NRG Arena 0.9 km away, there's plenty to see and do nearby.
What are the best hotels in South Main near NRG Park?
When looking for hotels in South Main near NRG Park, the Wyndham Houston near NRG Park/Medical Center and the Wingate Houston near NRG Park/Medical Center are excellent options, particularly for families.

The 3.5-star Wyndham Houston near NRG Park/Medical Center, with a rating of 7.2, boasts a superb location, being just 0.7 km from NRG Park. Guests frequently praise the amazing staff, the clean and spacious rooms, and the comfortable beds. It also offers child-friendly window designs and free cribs, making it a great choice for those travelling with children.

Another highly-rated option is the 3-star Wingate Houston near NRG Park/Medical Center. While its rating is not provided, it is consistently praised for its good location, just 0.5 km from NRG Park. This hotel offers a pool, connecting rooms, and complimentary continental breakfast, which guests often describe as good. The staff are noted for being friendly and extremely polite, and the rooms are comfortable and clean.
When is the best time to go to South Main?
The best time to go to South Main is during the spring (March to May) and autumn (September to November) months.

These seasons offer pleasant weather, with comfortable temperatures that are ideal for exploring the area's outdoor attractions and walking around. Spring brings blooming flowers and a refreshing atmosphere, while autumn provides cooler temperatures and often clear skies, superb for enjoying the local parks and open-air markets.

For those planning a romantic getaway, spring is particularly lovely. The milder weather allows for leisurely strolls along the riverwalk and enjoying al fresco dining without the intense summer heat. The natural beauty of the area is at its peak, creating a beautiful backdrop for couples.

Families travelling with children might find autumn more appealing. The slightly cooler temperatures are more comfortable for kids, especially when visiting attractions like the local nature centres or attending outdoor festivals.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in South Main.
How can I save on a South Main hotel booking with Expedia?
Members always get our best prices. Find our best South Main hotel deals by joining Expedia's free travel rewards program today. As a member, you can unlock instant savings and member perks when you're logged in to your account. Another tip is to book your hotel and flights together on Expedia, where bundling can result in significant savings.
How much is the nightly rate at a South Main hotel?
Hotel prices in South Main often vary, but you can find a great deal on Expedia. Different factors affect nightly hotel rates, such as the time of year or the days of the week you want to book. To find the best deals for your stay, be flexible with your dates, and sort search results by "Price: low to high" for our cheapest rates.

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