Photo by Hazem Abdul

Search Hotels in South Main, Houston

    price find illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Save instantly and earn perks with One Key
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Property class

Top Trending Hotels Near South Main, Houston

Hyatt Regency Houston/Galleria

4.0 star property
8.8 out of 10, Excellent, (1001)
"Great accommodation and service highly recommend"
The price is £119
includes taxes & fees
1 Aug - 2 Aug
Hyatt Regency Houston/Galleria

Hilton Garden Inn Houston/Bush Intercontinental Airport

3.0 star property
8.2 out of 10, Very good, (1012)
"priced right, well located, staff was wonderful and the bar was great!"
The price is £83
includes taxes & fees
18 Jul - 19 Jul
Hilton Garden Inn Houston/Bush Intercontinental Airport

Blossom Hotel Houston

4.0 star property
9.0 out of 10, Wonderful, (3410)
"Amazing stay"
The price is £109
includes taxes & fees
29 Jul - 30 Jul
Blossom Hotel Houston

Comfort Suites near Texas Medical Center - NRG Stadium

2.5 star property
8.6 out of 10, Excellent, (946)
"Everything is good,will definitely stay next time. "
The price is £70
includes taxes & fees
2 Aug - 3 Aug
Comfort Suites near Texas Medical Center - NRG Stadium

Wyndham Houston near NRG Park/Medical Center

3.5 star property
7.2 out of 10, Good, (1118)
"Very conveniently located for concerts."
The price is £82
includes taxes & fees
22 Jul - 23 Jul
Wyndham Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center

3.0 star property
6.6 out of 10, (924)
"This property is only good for convenience, breakfast is just store bought muffins and box cereal. Rooms are dirty with a sketchy connecting door, has an odd odor too."
The price is £69
includes taxes & fees
17 Jul - 18 Jul
Wingate Houston near NRG Park/Medical Center

Quality Inn & Suites NRG Park - Medical Center

2.5 star property
6.4 out of 10, (1000)
"Vanessa and everyone at front desk was extremely accommodating & gracious. The BEST out of the whole stay. Thank yall so much "
The price is £51
includes taxes & fees
13 Aug - 14 Aug
Quality Inn & Suites NRG Park - Medical Center

Candlewood Suites Houston Medical Center by IHG

2.5 star property
7.4 out of 10, Good, (785)
"Convenient to where I wanted to be staff was nice too"
The price is £59
includes taxes & fees
20 Jul - 21 Jul
Candlewood Suites Houston Medical Center by IHG

La Quinta Inn & Suites by Wyndham Houston Bush IAH South

3.0 star property
8.2 out of 10, Very good, (610)
"We enjoyed our stay."
The price is £67
includes taxes & fees
20 Jul - 21 Jul
La Quinta Inn & Suites by Wyndham Houston Bush IAH South

Palace Inn Blue Edgebrook

2.5 star property
9.4 out of 10, Exceptional, (123)
"Really great hospitality"
The price is £77
includes taxes & fees
17 Jul - 18 Jul
Palace Inn Blue Edgebrook

Moxy Houston Downtown

3.0 star property
9.0 out of 10, Wonderful, (509)
"Cool place!!"
The price is £107
includes taxes & fees
18 Jul - 19 Jul
Moxy Houston Downtown

Sheraton North Houston at George Bush Intercontinental

3.5 star property
8.0 out of 10, Very good, (1000)
"Very clean and the staff was awesome "
The price is £88
includes taxes & fees
8 Aug - 9 Aug
Sheraton North Houston at George Bush Intercontinental

Hyatt Place Houston Medical Center

3.0 star property
9.2 out of 10, Wonderful, (1802)
"The staff is exceptional and the location of the hotel was exactly what we were looking for. "
The price is £102
includes taxes & fees
18 Jul - 19 Jul
Hyatt Place Houston Medical Center

Hampton Inn & Suites Houston-Bush Intercontinental Aprt

3.0 star property
8.8 out of 10, Excellent, (1447)
"Thank you, great hotel and enjoyable stayed😍"
The price is £75
includes taxes & fees
9 Aug - 10 Aug
Hampton Inn & Suites Houston-Bush Intercontinental Aprt

Bluestar Inn

2.5 star property
9.0 out of 10, Wonderful, (252)
"Nice place at a good rate "
The price is £52
includes taxes & fees
17 Jul - 18 Jul
Bluestar Inn

Americas Best Value Inn & Suites NE Houston Downtown I-610

2.0 star property
8.6 out of 10, Excellent, (594)
"Always clean and close to downtown. "
The price is £64
includes taxes & fees
17 Jul - 18 Jul
Americas Best Value Inn & Suites NE Houston Downtown I-610

Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham

3.0 star property
8.8 out of 10, Excellent, (1023)
"Great place to stay "
The price is £72
includes taxes & fees
17 Jul - 18 Jul
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham

Haven Inn & Suites Downtown Houston

2.5 star property
9.4 out of 10, Exceptional, (1000)
"Nice place to stay"
Haven Inn & Suites Downtown Houston

Best Western Plus Hobby Airport Inn & Suites

2.5 star property
8.8 out of 10, Excellent, (1189)
"I will definitely stay here again"
The price is £67
includes taxes & fees
22 Jul - 23 Jul
Best Western Plus Hobby Airport Inn & Suites

Days Inn & Suites by Wyndham Downtown/University of Houston

2.0 star property
8.0 out of 10, Very good, (673)
"Better breakfast, needs more towels, needs assigned parking "
The price is £51
includes taxes & fees
20 Jul - 21 Jul
Days Inn & Suites by Wyndham Downtown/University of Houston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.
Downtown Houston map

Downtown Houston

3 out of top 10 points of interest in this area

Gourmet restaurants acclaimed theatres and top sights from Toyota Center to Daikin Park – discover Downtown Houston, a destination also famous for its sports teams.

The Galleria map

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Texas Medical Center map

Texas Medical Center

1 out of top 10 points of interest in this area

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Montrose map

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Menil Collection or Westheimer Rd while you're exploring the area.

Houston Central Business District map

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Main Street Square Station.

Frequently asked questions

What are the best hotels in South Main that travellers recommend?
Wyndham Houston near NRG Park/Medical Center is a solid choice for travellers seeking comfort and convenience, earning a customer review rating of 7.2. This hotel features an inviting outdoor pool, superb for unwinding after a day of exploration, along with kitchenettes in the rooms---ideal for families wanting to prepare snacks or meals. The combination of free WiFi and a 24-hour business centre makes it suitable for both leisure and business travellers, ensuring a straightforward stay.

For families, Wingate Houston near NRG Park/Medical Center is another great option. With a complimentary continental breakfast to fuel your adventures and a refreshing outdoor pool, it caters superbly to parents and kids alike. The accessible fitness centre allows for some family fun, while the hotel's pet-friendly policies make it a fantastic choice for those traveling with furry companions. With a focus on convenience and value, this hotel provides excellent amenities while keeping everyone comfortable.
What are the best family hotels in South Main?
When it comes to family-friendly hotels in South Main, the Comfort Suites near Texas Medical Center - NRG Stadium shines brightly with a solid traveller review rating of 8.6. This hotel offers daily housekeeping to ensure your family's stay is comfortable and straightforward.

Another excellent option is the Candlewood Suites Houston Medical Center by IHG, which boasts a family-friendly atmosphere with its free cribs, connecting rooms, and a sofa bed, making it great for families needing extra space. Guests appreciate the convenience of in-room kitchen amenities like a microwave and dishwasher, allowing for easy meal prep during your stay. It has a review score of 7.6, reflecting its appeal to families on the go.

For those seeking a place with a pool, the Quality Inn & Suites NRG Park - Medical Center is a great choice. With its inviting pool area, free meals for children, and options for rollaway beds at no extra charge, families can enjoy a splash-filled vacation while also benefiting from daily housekeeping and snack options.

Lastly, the Wyndham Houston near NRG Park/Medical Center features child-friendly window designs and connecting rooms, catering specifically to families' needs. The presence of kitchenettes adds to the convenience, allowing families to prepare snacks or meals together. This property has a traveller rating of 7.2, making it a reliable choice for family stays.

These hotels exemplify quality and convenience, ensuring that your family's adventure in South Main is both enjoyable and comfortable.
What hotels in South Main offer free breakfast?
Comfort Suites near Texas Medical Center - NRG Stadium is a fantastic option for travellers seeking comfort and convenience in South Main. With a traveller review rating of 8.6, this hotel offers a delightful free full breakfast to start your day right. Families will appreciate the seasonal outdoor pool, superb for a refreshing dip after a day of exploring. Additionally, the property features complimentary WiFi and self-parking, making it easy to stay connected and save on travel expenses.

Another great choice is Quality Inn & Suites NRG Park - Medical Center, which also provides a free breakfast, including options for those on the go. This family-friendly hotel offers spacious suites with balconies and patios, allowing families to unwind outdoors. The outdoor pool invites guests to relax and enjoy the Texas sunshine, while the complimentary area shuttle makes it simple to explore the attractions nearby.

For those traveling without children, the Wingate Houston near NRG Park/Medical Center presents a delightful blend of comfort and accessibility. With an outdoor pool and fitness centre, it caters to adults looking for a rejuvenating getaway. The hotel's continental breakfast is another perk that guarantees a satisfying start to your morning adventures.
What are the best budget hotels in South Main?
Comfort Suites near Texas Medical Center - NRG Stadium is a fantastic budget-friendly option for travellers seeking convenience and quality in South Main. With an excellent review score of 8.6, this hotel offers a range of family-friendly amenities, including a seasonal outdoor pool, free breakfast, and complimentary WiFi. Families will appreciate the spacious rooms and the convenience of free self-parking, making it easy to explore the area together.

For another appealing choice, Candlewood Suites Houston Medical Center by IHG stands out with a review score of 7.6. This property is superb for families, as it features kitchenettes in the rooms, allowing for meal preparation and snacks on the go. Kids can also enjoy the complimentary cribs and sofa beds, making it a comfortable stay for everyone. Additionally, the hotel offers a free area shuttle, which is great for exploring local attractions without the hassle of driving.

If you're traveling with your partner or friends, the Wyndham Houston near NRG Park/Medical Center offers a more relaxed atmosphere with a lower review score of 7.2. This hotel features outdoor pool access and convenient amenities, including a kitchenette in some rooms, which can appeal to those looking for a home-like experience while away.

No matter your travel group, these options in South Main cater to various needs while ensuring a comfortable and enjoyable stay.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in South Main.
How can I save on a South Main hotel booking with Expedia?
Before booking your South Main hotel, remember to join Expedia's free travel rewards program. Just sign up and sign in to access our lowest Member Prices as well as members-only perks. You could also enjoy savings by bundling together your hotel and flights on Expedia.
How much is the nightly rate at a South Main hotel?
Hotel prices in South Main often vary, but you can find a great deal from £51 on Expedia. Different factors affect nightly hotel rates, such as the time of year or the days of the week you want to book. To find the best deals for your stay, be flexible with your dates, and sort search results by "Price: low to high" for our cheapest rates.