A bench, a bicycle, and a lake surrounded by trees.

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Check availability on Upstate South Carolina Luxury Hotels

Tonight
12 Oct - 13 Oct
Tomorrow
13 Oct - 14 Oct
This weekend
16 Oct - 18 Oct
Next weekend
23 Oct - 25 Oct

Our top choices for Upstate South Carolina luxury hotels

A multi-level interior with a spiral staircase, wooden railings, and a seating area with tables and chairs.
An outdoor patio with wicker furniture, a round table, and a fountain.
A modern bar area with a wooden ceiling, green bar stools, and a bar counter.
A spacious restaurant with high ceilings, wooden flooring, and a mix of modern and classic furniture.

1. The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
Clemson
£154
includes taxes & fees
28 Oct - 29 Oct
The Shepherd Hotel Downtown Clemson
A white, two-story house with a front porch, surrounded by trees and shrubs.
A hallway with a wooden bench, a chair, a cabinet, and a painting on the wall.
A dining area with round tables, black chairs, and white tablecloths.
A bedroom with two beds, a TV, and a fireplace.

2. Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast
Pendleton
£95
includes taxes & fees
14 Oct - 15 Oct
Liberty Hall Bed and Breakfast
A modern lounge area with a brick accent wall, a fireplace, and comfortable seating.
A hotel room with a bed, a sofa, a dining table with chairs, a coffee machine, and a TV mounted on the wall.
A modern living room with a sofa, two armchairs, a coffee table, and a potted plant.
A multi-story hotel with a prominent entrance, a parking lot, and a landscaped area with a small tree.

3. The Abernathy of Clemson

The Abernathy of Clemson
Clemson
£124
includes taxes & fees
19 Oct - 20 Oct
The Abernathy of Clemson
A two-story house with a tiled roof, a stone fire pit, and outdoor seating.
A bar with a large window view of mountains and a chandelier.
A spacious room with wooden beams, a large chandelier, and a cozy seating area with orange chairs and a white sofa.
A restaurant with a stone fireplace, hanging crystal chandelier, and multiple dining tables set with white tablecloths and wine glasses.

4. Hotel Domestique

Hotel Domestique
Travelers Rest
£348
includes taxes & fees
25 Oct - 26 Oct
Hotel Domestique
A swimming pool with lounge chairs and umbrellas, surrounded by brick buildings with large windows.
A spacious living room with a large window, a dining area with a wooden table and chairs, a sofa, and a small side table.
A modern living room with a grey sofa, a round coffee table, and a wooden cabinet.
A modern kitchen with white cabinets, stainless steel appliances, and a wooden ceiling.

5. Spacious Sanctuary | Near DT Action

Spacious Sanctuary | Near DT Action
Greenville
£173
includes taxes & fees
13 Oct - 14 Oct
Spacious Sanctuary | Near DT Action
Exterior
Dining
Terrace/patio
Interior

6. Bed & Breakfast on Tiffany Hill

Bed & Breakfast on Tiffany Hill
Mills River
£230
includes taxes & fees
8 Nov - 9 Nov
Bed & Breakfast on Tiffany Hill
A hotel room with a bed, a desk, a television, and a ceiling fan.
A large, multi-story building with a stone facade, situated in a valley surrounded by autumn-colored trees.
A waterfall cascading over rocks surrounded by dense green foliage.
A modern bathroom with a granite countertop, a large mirror, and a walk-in shower.

7. Bright's Creek Lodge - King Room- Near Tryon and TIEC & Hendersonville

Bright's Creek Lodge - King Room- Near Tryon and TIEC & Hendersonville
Mill Spring
£201
includes taxes & fees
18 Oct - 19 Oct
Bright's Creek Lodge - King Room- Near Tryon and TIEC & Hendersonville
A bedroom with a bed, a sofa, a dresser, and a ceiling fan.
A two-story house with a front porch, a driveway, and a well-maintained lawn.
A porch with two wicker chairs and a small table, a green door, and a window with a view of the backyard.
A dining room with a wooden table and chairs, a sofa, and a view of the outdoors.

8. Opal and West House

Opal and West House
Shelby
£158
includes taxes & fees
21 Oct - 22 Oct
Opal and West House
Interior
Interior
Private kitchen
Room

9. ~Cree’s Retreat in the Heart of Brevard~

~Cree’s Retreat in the Heart of Brevard~
Brevard
£161
includes taxes & fees
9 Nov - 10 Nov
~Cree’s Retreat in the Heart of Brevard~
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Top Upstate South Carolina Hotel Reviews

Best Western Plus Greenville I-385 Inn & Suites

Best Western Plus Greenville I-385 Inn & Suites

10/10 Excellent
"The location is located close to everything that you will need, food, entertainment. All of the staff was very friendly. The rooms were very spacious and the bathroom was very nice as well."
Tanya 3-night trip
Posted 3 hours ago
Best Western Plus Greenville I-385 Inn & Suites
Hyatt Place Greenville/Haywood

Hyatt Place Greenville/Haywood

8/10 Good
"Room was good size and clean. Staff were helpful and welcoming. Construction was ongoing and they did their best to accommodate in spite of all the activity. It was a busy weekend and their elevators couldn't keep up. Overall not bad."
Thomas 4-night trip
Posted 7 hours ago
Hyatt Place Greenville/Haywood

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