A bench, a bicycle, and a lake surrounded by trees.

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Check availability on Upstate South Carolina Luxury Hotels

Tonight
9 Oct - 10 Oct
Tomorrow
10 Oct - 11 Oct
This weekend
9 Oct - 11 Oct
Next weekend
16 Oct - 18 Oct

Our top choices for Upstate South Carolina luxury hotels

A multi-level interior with a spiral staircase, wooden railings, and a seating area with tables and chairs.
A modern bar area with a wooden ceiling, green bar stools, and a bar counter.
A spacious restaurant with high ceilings, wooden flooring, and a mix of modern and classic furniture.
An outdoor patio with wicker furniture, a round table, and a fountain.

1. The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
Clemson
£160
includes taxes & fees
31 Oct - 1 Nov
The Shepherd Hotel Downtown Clemson
A white, two-story house with a front porch, surrounded by trees and shrubs.
A two-story building with a white exterior, a front door, and a balcony.
A hallway with a wooden bench, a chair, a cabinet, and a painting on the wall.
A bedroom with two beds, a TV, and a fireplace.

2. Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast
Pendleton
£95
includes taxes & fees
14 Oct - 15 Oct
Liberty Hall Bed and Breakfast
A modern lounge area with a brick accent wall, a fireplace, and comfortable seating.
A bar area with a counter, multiple chairs, and a display of bottles and glasses.
A multi-story hotel with a prominent entrance, a parking lot, and a landscaped area with a small tree.
A hotel room with a bed, a sofa, a dining table with chairs, a coffee machine, and a TV mounted on the wall.

3. The Abernathy of Clemson

The Abernathy of Clemson
Clemson
£124
includes taxes & fees
18 Oct - 19 Oct
The Abernathy of Clemson
A two-story house with a tiled roof, a stone fire pit, and outdoor seating.
A restaurant with a stone fireplace, hanging crystal chandelier, and multiple dining tables set with white tablecloths and wine glasses.
A bar with a large window view of mountains and a chandelier.
A spacious room with wooden beams, a large chandelier, and a cozy seating area with orange chairs and a white sofa.

4. Hotel Domestique

Hotel Domestique
Travelers Rest
£348
includes taxes & fees
25 Oct - 26 Oct
Hotel Domestique
A swimming pool with lounge chairs and umbrellas, surrounded by brick buildings with large windows.
A modern kitchen with white cabinets, stainless steel appliances, and a wooden ceiling.
A modern living room with a grey sofa, a round coffee table, and a wooden cabinet.
A spacious living room with a large window, a dining area with a wooden table and chairs, a sofa, and a small side table.

5. Spacious Sanctuary | Near DT Action

Spacious Sanctuary | Near DT Action
Greenville
£173
includes taxes & fees
12 Oct - 13 Oct
Spacious Sanctuary | Near DT Action
Exterior
Interior
Interior
Terrace/patio

6. Bed & Breakfast on Tiffany Hill

Bed & Breakfast on Tiffany Hill
Mills River
£230
includes taxes & fees
8 Nov - 9 Nov
Bed & Breakfast on Tiffany Hill
A bedroom with a bed, a sofa, a dresser, and a ceiling fan.
A spacious room with hardwood flooring, a fireplace, a dining table, and a large window with a view.
A two-story house with a front porch, a driveway, and a well-maintained lawn.
A dining room with a wooden table and chairs, a sofa, and a view of the outdoors.

7. Opal and West House

Opal and West House
Shelby
£158
includes taxes & fees
21 Oct - 22 Oct
Opal and West House
View all properties

Top Upstate South Carolina Hotel Reviews

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

10/10 Excellent
"Great place i loved the environment"
Cedric 1-night trip
Posted 15 hours ago
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
Hyatt Place Greenville/Haywood

Hyatt Place Greenville/Haywood

10/10 Excellent
"This is the only place I stay when in Greenville!"
Fredericka 2-night trip
Posted 18 hours ago
Hyatt Place Greenville/Haywood
Hampton Inn & Suites Greenville-Downtown-RiverPlace

Hampton Inn & Suites Greenville-Downtown-RiverPlace

10/10 Excellent
"Clean well maintained and convenient location good value"
Vincent 2-night trip
Posted 3 days ago
Hampton Inn & Suites Greenville-Downtown-RiverPlace

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