Title: TOP Hotels with Air Conditioning in Upstate South Carolina, SC for 2026 | Expedia.co.uk [Upstate South Carolina Travel Guide](https://expedia.co.uk/Upstate-South-Carolina.dx6057939)[Hotels in Upstate South Carolina](https://expedia.co.uk/Upstate-South-Carolina-Hotels.d6057939.Travel-Guide-Hotels)[Holiday Rentals in Upstate South Carolina](https://expedia.co.uk/Upstate-South-Carolina-Holiday-Rentals.d6057939.Travel-Guide-HolidayRentals)[Flights to Upstate South Carolina](https://expedia.co.uk/Cheap-Flights-To-Upstate-South-Carolina.d6057939.Travel-Guide-Flights)[Things to do in Upstate South Carolina](https://expedia.co.uk/Things-To-Do-In-Upstate-South-Carolina.d6057939.Travel-Guide-Activities)[Upstate South Carolina Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Upstate-South-Carolina.d6057939.Car-Hire-Guide)[Upstate South Carolina Holidays](https://expedia.co.uk/Upstate-South-Carolina.d6057939.Holidays-City-Breaks) ![Greenville - Spartanburg](https://images.trvl-media.com/place/6035267/cb556cb0-09f4-48a1-92a0-474aceebaeea.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Visit Greenville, South Carolina ![](https://images.trvl-media.com/place/6035267/cb556cb0-09f4-48a1-92a0-474aceebaeea.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Upstate South Carolina Hotels with Air Conditioning Tonight [28 Jan - 29 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6057939&startDate=2026-01-28&endDate=2026-01-29&adults=2&amenities=AIR_CONDITIONING&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [29 Jan - 30 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6057939&startDate=2026-01-29&endDate=2026-01-30&adults=2&amenities=AIR_CONDITIONING&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [30 Jan - 1 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6057939&startDate=2026-01-30&endDate=2026-02-01&adults=2&amenities=AIR_CONDITIONING&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [6 Feb - 8 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6057939&startDate=2026-02-06&endDate=2026-02-08&adults=2&amenities=AIR_CONDITIONING&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Upstate South Carolina hotels with air conditioning ![Free daily full breakfast ](https://images.trvl-media.com/lodging/72000000/71520000/71515100/71515054/589dc000.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down duvets, desk, blackout curtains](https://images.trvl-media.com/lodging/72000000/71520000/71515100/71515054/39d93722.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/72000000/71520000/71515100/71515054/a5e4dea1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/72000000/71520000/71515100/71515054/a9c6228a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Gaffney by IHG [](https://www.expedia.co.uk/Gaffney-Hotels-Holiday-Inn-Express-Gaffney.h71515054.Hotel-Information) Gaffney 8.8/10 Excellent (440 reviews) "Great people n place" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Janice £62 includes taxes & fees 8 Feb - 9 Feb [](https://www.expedia.co.uk/Gaffney-Hotels-Holiday-Inn-Express-Gaffney.h71515054.Hotel-Information) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/f09ffe86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillow-top beds, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/b54ae3f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/e91d409a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillow-top beds, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/fea97b11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Greenville I-385 Inn & Suites [](https://www.expedia.co.uk/Greenville-Hotels-Best-Western-Plus-Greenville-I-385-Inn-Suites.h23003.Hotel-Information) Greenville 9.0/10 Wonderful (1,429 reviews) "Excellent hotel nice and clean. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Irasema £62 includes taxes & fees 8 Feb - 9 Feb [](https://www.expedia.co.uk/Greenville-Hotels-Best-Western-Plus-Greenville-I-385-Inn-Suites.h23003.Hotel-Information) ![Aerial view](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/db449d90.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Aerial view](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/ad742419.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/6abd26aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/91e6d418.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lakeside Lodge Clemson [](https://www.expedia.co.uk/Anderson-Hotels-Lakeside-Lodge-Clemson.h40217319.Hotel-Information) Seneca 9.0/10 Wonderful (1,008 reviews) "Great place to stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gene £98 includes taxes & fees 29 Jan - 30 Jan [](https://www.expedia.co.uk/Anderson-Hotels-Lakeside-Lodge-Clemson.h40217319.Hotel-Information) ![Hallway](https://images.trvl-media.com/lodging/20000000/19520000/19511400/19511329/4d00561c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Café](https://images.trvl-media.com/lodging/20000000/19520000/19511400/19511329/893b2bfc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/20000000/19520000/19511400/19511329/d217b18b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property – evening/night](https://images.trvl-media.com/lodging/20000000/19520000/19511400/19511329/cb83efe8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Inn at Patrick Square [](https://www.expedia.co.uk/Anderson-Hotels-The-Inn-At-Patrick-Square.h19511329.Hotel-Information) Clemson 9.8/10 Exceptional (794 reviews) "Clean room, great location, wonderful staff!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joyce £120 includes taxes & fees 29 Jan - 30 Jan [](https://www.expedia.co.uk/Anderson-Hotels-The-Inn-At-Patrick-Square.h19511329.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1350000/1340700/1340606/5902a5ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1350000/1340700/1340606/78e2a715.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1350000/1340700/1340606/bb1bfaf9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast served](https://images.trvl-media.com/lodging/2000000/1350000/1340700/1340606/27046188.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Garden Inn Anderson [](https://www.expedia.co.uk/Anderson-Hotels-Hilton-Garden-Inn-Anderson.h1340606.Hotel-Information) Anderson 9.0/10 Wonderful (697 reviews) "Rooms were clean, staff were friendly, and we had 2 good night’s sleep." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sadie £85 includes taxes & fees 5 Feb - 6 Feb [](https://www.expedia.co.uk/Anderson-Hotels-Hilton-Garden-Inn-Anderson.h1340606.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/59000000/58950000/58945900/58945857/3ff858d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/59000000/58950000/58945900/58945857/5af30e15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/59000000/58950000/58945900/58945857/015cc42b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/59000000/58950000/58945900/58945857/561d946e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott Greenville Mauldin [](https://www.expedia.co.uk/Greenville-Hotels-Courtyard-By-Marriott-Greenville-Mauldin.h58945857.Hotel-Information) Greenville 9.0/10 Wonderful (311 reviews) "Courteous and friendly front desk" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Bernard £87 includes taxes & fees 1 Feb - 2 Feb [](https://www.expedia.co.uk/Greenville-Hotels-Courtyard-By-Marriott-Greenville-Mauldin.h58945857.Hotel-Information) ![Free breakfast ](https://images.trvl-media.com/lodging/4000000/3630000/3629900/3629858/e417f297.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/4000000/3630000/3629900/3629858/60389240.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/4000000/3630000/3629900/3629858/70604dbb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Two queens | In-room safe, blackout curtains, iron/ironing board, rollaway beds](https://images.trvl-media.com/lodging/4000000/3630000/3629900/3629858/91fb1400.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Anderson/ Alliance Business Park [](https://www.expedia.co.uk/Anderson-Hotels-Hampton-Inn-Anderson-North.h3629858.Hotel-Information) Anderson 9.2/10 Wonderful (820 reviews) "Staff, Just a Nice Hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Christopher £91 includes taxes & fees 7 Feb - 8 Feb [](https://www.expedia.co.uk/Anderson-Hotels-Hampton-Inn-Anderson-North.h3629858.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/51000000/50830000/50828700/50828647/0007de95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/51000000/50830000/50828700/50828647/f59bfe6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/51000000/50830000/50828700/50828647/w1021h678x3y4-70d9704c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/51000000/50830000/50828700/50828647/074f4a70.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### DoubleTree by Hilton Greenville Woodruff Road [](https://www.expedia.co.uk/Greenville-Hotels-DoubleTree-By-Hilton-Greenville-Woodruff-Road.h50828647.Hotel-Information) Greenville 9.4/10 Exceptional (1,011 reviews) "Room for was super clean! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kristina £94 includes taxes & fees 7 Feb - 8 Feb [](https://www.expedia.co.uk/Greenville-Hotels-DoubleTree-By-Hilton-Greenville-Woodruff-Road.h50828647.Hotel-Information) ![Free daily on-the-go breakfast ](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/375f69b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/16b3def6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillow-top beds, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/81c4f249.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/eab53b27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Seneca Clemson Area US-123 [](https://www.expedia.co.uk/Anderson-Hotels-Quality-Inn-Seneca-US-123.h76800.Hotel-Information) Downtown 8.0/10 Very good (673 reviews) "Our stay was very nice. Clean room. The outside was clean. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gayle £66 includes taxes & fees 4 Feb - 5 Feb [](https://www.expedia.co.uk/Anderson-Hotels-Quality-Inn-Seneca-US-123.h76800.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/3300/3223/b0e15e12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/3300/3223/31b0d05e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/10000/3300/3223/b840578e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/3300/3223/8238721d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Embassy Suites Greenville Golf Resort & Conference Center [](https://www.expedia.co.uk/Greenville-Hotels-Embassy-Suites-Greenville-Golf-Resort-Conference-Center.h3223.Hotel-Information) Greenville 9.0/10 Wonderful (1,043 reviews) "Great stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) kurt £84 includes taxes & fees 15 Feb - 16 Feb [](https://www.expedia.co.uk/Greenville-Hotels-Embassy-Suites-Greenville-Golf-Resort-Conference-Center.h3223.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-02-11&endDate=2026-02-12®ionId=6057939&adults=2&amenities=AIR_CONDITIONING&sort=RECOMMENDED&openPlayBack=true) ## Top Upstate South Carolina Hotel Reviews ![Hyatt Regency Greenville](https://images.trvl-media.com/lodging/1000000/30000/22300/22252/fa37e256_y.jpg) ### Hyatt Regency Greenville 10/10 Excellent "We love the Hyatt. Great location and a beautiful and clean hotel. We stay here very often especially around Christmas time. " [](https://expedia.co.uk/Greenville-Hotels-Hyatt-Regency-Greenville.h22252.Hotel-Information) ![Hampton Inn & Suites Greenville-Downtown-RiverPlace](https://images.trvl-media.com/lodging/2000000/1470000/1460400/1460359/d9184989_y.jpg) ### Hampton Inn & Suites Greenville-Downtown-RiverPlace 10/10 Excellent "Wonderful staff and perfect location " [](https://expedia.co.uk/Greenville-Hotels-Hampton-Inn-Suites-Greenville-Downtown-RiverPlace.h1460359.Hotel-Information) ![Embassy Suites by Hilton Greenville Downtown Riverplace](https://images.trvl-media.com/lodging/16000000/15060000/15052000/15051911/b5c8aa89_y.jpg) ### Embassy Suites by Hilton Greenville Downtown Riverplace 10/10 Excellent "The room was neat and clean. The cleaning and kitchen staff were very kind and courteous. It was a great stay." [](https://expedia.co.uk/Greenville-Hotels-Embassy-Suites-By-Hilton-Greenville-Downtown-Riverplace.h15051911.Hotel-Information) ![Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG](https://images.trvl-media.com/lodging/1000000/10000/1400/1379/91409d5a_y.jpg) ### Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG 10/10 Excellent "Everything was up to par " [](https://expedia.co.uk/Greenville-Hotels-Crowne-Plaza-Hotel-Greenville-I-385-Roper-Mtn-Rd.h1379.Hotel-Information) ![Embassy Suites Greenville Golf Resort & Conference Center](https://images.trvl-media.com/lodging/1000000/10000/3300/3223/31b0d05e_y.jpg) ### Embassy Suites Greenville Golf Resort & Conference Center 10/10 Excellent "Breakfast is always great. Quiet room and location" [](https://expedia.co.uk/Greenville-Hotels-Embassy-Suites-Greenville-Golf-Resort-Conference-Center.h3223.Hotel-Information) ![Hyatt Place Greenville/Haywood](https://images.trvl-media.com/lodging/1000000/70000/64600/64570/9a71f6a4_y.jpg) ### Hyatt Place Greenville/Haywood 10/10 Excellent "Friendly staff and comfortable room " [](https://expedia.co.uk/Greenville-Hotels-Hyatt-Place-GreenvilleHaywood.h64570.Hotel-Information) ![Hilton Greenville](https://images.trvl-media.com/lodging/1000000/30000/23200/23172/401b294d_y.jpg) ### Hilton Greenville 10/10 Excellent "Place is very" [](https://expedia.co.uk/Greenville-Hotels-Hilton-Greenville.h23172.Hotel-Information) ![Best Western Plus Greenville I-385 Inn & Suites](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/20a0c66a_y.jpg) ### Best Western Plus Greenville I-385 Inn & Suites 10/10 Excellent "Good" [](https://expedia.co.uk/Greenville-Hotels-Best-Western-Plus-Greenville-I-385-Inn-Suites.h23003.Hotel-Information) ![Sleep Inn Spartanburg Southwest](https://images.trvl-media.com/lodging/1000000/50000/42900/42867/5eb71761_y.jpg) ### Sleep Inn Spartanburg Southwest 10/10 Excellent "Beautiful, cheap, clean, incredibly nice…" [](https://expedia.co.uk/Spartanburg-Hotels-Sleep-Inn.h42867.Hotel-Information) ## Frequently asked questions ### How much do hotels with air conditioning in Upstate South Carolina cost? ### What are the best hotels with air conditioning in Upstate South Carolina? ### How many hotels with air conditioning are there in Upstate South Carolina? ### What are the best cheap hotels with air conditioning in Upstate South Carolina? ### What are the top motels with air conditioning in Upstate South Carolina? ### Are there any family-friendly hotels with air conditioning in Upstate South Carolina? ### Are there any 5-star hotels with air conditioning in Upstate South Carolina? ### Why book your hotel with air conditioning in Upstate South Carolina with Expedia? ### How can I find cheap hotels with air conditioning in Upstate South Carolina? ### What is there to do in Upstate South Carolina near my hotel with air conditioning? ## Explore a world of travel with Expedia - 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