TOP Hotels with Air Conditioning in Upstate South Carolina, SC for 2026

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Check availability on Upstate South Carolina Hotels with Air Conditioning

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Our top choices for Upstate South Carolina hotels with air conditioning

Pillow-top beds, in-room safe, desk, laptop workspace

1. Best Western Plus Greenville I-385 Inn & Suites

Greenville

Nancy

£67

includes taxes & fees

30 Aug - 31 Aug

37-inch flat-screen TV with cable channels, TV, pay films

2. Embassy Suites Greenville Golf Resort & Conference Center

Greenville

Robert

£81

includes taxes & fees

30 Aug - 31 Aug

3. La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

Greenville

Cole

£61

includes taxes & fees

26 Aug - 27 Aug

Standard Room, 2 Queen Beds, Non Smoking, Refrigerator & Microwave | Desk, iron/ironing board, free cots/infant beds, rollaway beds

4. Best Western Spartanburg I-26

Spartanburg

Francisco

£68

includes taxes & fees

30 Aug - 31 Aug

Desk, blackout curtains, iron/ironing board, free cots/infant beds

5. Drury Inn & Suites Greenville

Greenville

Gohan

£93

includes taxes & fees

30 Aug - 31 Aug

6. Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd

Greenville

Steven

£62

includes taxes & fees

8 Sept - 9 Sept

7. Hilton Greenville

Greenville

Gildardo

£85

includes taxes & fees

4 Sept - 5 Sept

8. Holiday Inn Express & Suites Greenville SE - Simpsonville by IHG

Simpsonville

Alicia

£105

includes taxes & fees

5 Sept - 6 Sept

View all properties

Top Upstate South Carolina Hotel Reviews

Embassy Suites Greenville Golf Resort & Conference Center

10/10 Excellent

"Room was clean and well stocked."

Best Western Plus Greenville I-385 Inn & Suites

10/10 Excellent

"Staff was very helpful and delightful!"

Best Western Plus Clemson Hotel & Conference Center

8/10 Good

"Fair/Decent accommodations."

Hyatt Regency Greenville

10/10 Excellent

"..."

Comfort Inn & Suites Clemson - University Area

8/10 Good

"Close to campus."

AC Hotel by Marriott Spartanburg

10/10 Excellent

"This is a first class property. Verry clean Verry modern our stay was short but overall impressive I would definitely satay there again"

Hyatt Place Greenville/Haywood

10/10 Excellent

"Comfortable staying"

Comfort Suites At WestGate Mall

10/10 Excellent

"The staff was amazing! And I loved the spacious room - very clean."

Frequently asked questions

How much do hotels with air conditioning in Upstate South Carolina cost?

Prices for hotels with air conditioning in Upstate South Carolina range between £42 and £105 per night. No matter your budget, you'll be sure to discover a terrific place to enjoy a holiday in air-conditioned comfort. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.

What are the best hotels with air conditioning in Upstate South Carolina?

Glide straight into holiday mode and wind down in one of Upstate South Carolina's multiple hotels with air conditioning. With a total average guest review rating of 9.2, there's a place for everyone, no matter your style and budget. Many visitors to Greenville recommend staying at Homewood Suites by Hilton Greenville Downtown, a highly rated 3-stars hotel with designer toiletries, a swimming pool and air conditioning. Another favourite in this popular city is SpringHill Suites by Marriott Greenville Downtown. This 2.5-stars escape features a swimming pool and a terrace.

How many hotels with air conditioning are there in Upstate South Carolina?

Choose from 181 hotels with air conditioning in Upstate South Carolina. Whether you're travelling with your family or your favourite friends, and wherever you're venturing, Expedia makes it easy to find the perfect space to kick back in air-conditioned comfort.

What are the best cheap hotels with air conditioning in Upstate South Carolina?

With hotels with air conditioning starting at just £42 per night, you'll have more cash in your wallet for exploring Upstate South Carolina. If Greenville is on your radar, check out SpringHill Suites by Marriott Greenville Downtown. A barbecue grill, a terrace and in-room air conditioning help make this option a popular choice. Expedia also has low-cost hotels with air conditioning in Spartanburg. Make yourself at home at Tru by Hilton Spartanburg and enjoy the use of handy amenities such as complimentary breakfast and WiFi. Want to go sightseeing in Upstate South Carolina without hurting your hip pocket? Add some fantastic free attractions to your itinerary, like Cleveland Park in Greenville. Spartanburg also has loads of things to do that don't cost anything, including WestGate Mall. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.

What are the top motels with air conditioning in Upstate South Carolina?

Staying in motels with air conditioning is a low-cost way to enjoy a comfortable break while in Upstate South Carolina. Planning a night or two in Greenville? Urban Boutique Hotel, BW Signature Collection comes with complimentary breakfast and free WiFi and is a traveller fave. Located about 2 mi northeast of the downtown area, you won't be far from the action here. Days Inn by Wyndham Greenville, around 5 mi east of central Greenville, is another good pick with air-conditioned comfort as well as conveniences such as a swimming pool and front desk services.There are lots of things to entertain you in Greenville. Frankie's Fun Park and Greenville Zoo are two great places to start.

Are there any family-friendly hotels with air conditioning in Upstate South Carolina?

You'll discover family-friendly hotels with air conditioning in cities across Upstate South Carolina, including Greenville. SpringHill Suites by Marriott Greenville Downtown is one option that'll accommodate your needs in this bustling city. It has a 2.5-stars rating and conveniences such as complimentary breakfast and WiFi. Alternatively, put down your bags at Hampton Inn & Suites Greenville-Downtown-RiverPlace. With complimentary breakfast, WiFi and AC, this 2.5-stars pick in Greenville will make you and your travel buddies feel welcome. You'll discover plenty of fabulous things to do with your family in Greenville. Cleveland Park and Topgolf provide a superb day out.

Are there any 5-star hotels with air conditioning in Upstate South Carolina?

There are no 5-star hotels with air conditioning in Upstate South Carolina. However, you can still find some 4-star hotels that come with what you need. If you're headed to the popular city of Greenville, check out The Westin Poinsett Greenville. Concierge services and room service are two of its many conveniences. Another top pick is Greenville Marriott. Air conditioning, concierge services and pillow top mattresses help make this 4-star stay in Greenville a traveller favourite.

Why book your hotel with air conditioning in Upstate South Carolina with Expedia?

We think that vacays should be simple, so if you're seeking hotels with air conditioning at the perfect price, Expedia has got your back. Keep costs down and select an all-inclusive resort with AC, or splurge and book a ritzy hotel to spoil the ones you love most.

How can I find cheap hotels with air conditioning in Upstate South Carolina?

Expedia can help you search for cheap hotels with air conditioning in Upstate South Carolina. Simply select "air conditioned" under the amenities filter heading to view stays with this feature. Next, choose your hotel star rating (lower-rated stays are generally cheaper) and your budget per night to find the best places with air conditioning at the most affordable price.

What is there to do in Upstate South Carolina near my hotel with air conditioning?

The best travel accessory for your Upstate South Carolina adventure is a fabulous itinerary! Greenville Zoo, The Children's Museum of the Upstate and Shoeless Joe Jackson Museum are some of the leading sights if you're bound for Greenville. Spartanburg also lures visitors with its famous attractions, such as Spartanburg Regional History Museum. Need more ideas for your to-do list? Stop by Wofford College and Converse College too.

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Change your mind

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Check availability on Upstate South Carolina Hotels with Air Conditioning

Our top choices for Upstate South Carolina hotels with air conditioning

1. Best Western Plus Greenville I-385 Inn & Suites

2. Embassy Suites Greenville Golf Resort & Conference Center