Title: Sikeston Holidays 2026 from £849 | Expedia.co.uk [Sikeston Travel Guide](https://expedia.co.uk/Sikeston.dx6058766)[Hotels in Sikeston](https://expedia.co.uk/Sikeston-Hotels.d6058766.Travel-Guide-Hotels)[Holiday Rentals in Sikeston](https://expedia.co.uk/Sikeston-Holiday-Rentals.d6058766.Travel-Guide-HolidayRentals)[Sikeston Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Sikeston.d6058766.Car-Hire-Guide) ![](https://images.trvl-media.com/place/6058766/0353751e-5978-48d0-a913-84533caba2b0.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Sikeston Holidays from £849 ## Book a Hotel + Flight or Car together to unlock savings - ## Plan, book, travel with confidence - ### Better together Save up to £335 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Packages with flights are ATOL protected #### Your Sikeston Holiday There's tons to like about Sikeston, from its rich history to its rural countryside. When you're ready to say hi to this captivating city, our Sikeston holiday packages will be perfect for you. Fill your spare time with visits to [Sikeston Depot Museum](https://www.expedia.co.uk/Sikeston-Depot-Museum-Sikeston.d6305602.Attraction), [The Book Bug](https://www.expedia.co.uk/The-Book-Bug-Sikeston.d553248621532655751.Attraction) and [Central Park](https://www.expedia.co.uk/Central-Park-Sikeston.d6305608.Attraction), some of the top attractions you just have to see during your trip to Sikeston. That dream Sikeston holiday is clicks away. Browse hotels, flights and more on Expedia for a getaway that's tailored to suit your travel style. ## Top Sikeston Flight + Hotel Deals Price found within the past 48 hours. Click for updated prices. ![21C Museum Hotel St Louis ](https://images.trvl-media.com/lodging/90000000/89170000/89164600/89164592/cd6b7758_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### 21C Museum Hotel St Louis Downtown West £849 per person 4 Mar - 10 Mar found 6 hours ago Return direct flight included London (LHR) to St. Louis (STL) 9/10 Wonderful! (1,458 reviews) Great staff, cool amenities, amazing environment. We had a lot of fun with the penguins! ;) Reviewed on 19 Jan 2026 ![The Wildwood Hotel](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/800a6847_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Wildwood Hotel Save 100% on your flight £1,337 per person 19 Apr - 25 Apr found 1 day ago Return direct flight included London (LON) to St. Louis (STL) 9.2/10 Wonderful! (1,600 reviews) Room was very fun layout. Grocery store and restaurants near by. Pool was very small but we didn't use the pool. Staff was great. Reviewed on 25 Jan 2026 ![The Cheshire](https://images.trvl-media.com/lodging/1000000/30000/26100/26061/b6ec06de_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Cheshire £1,049 per person 19 Apr - 26 Apr found 1 day ago Return direct flight included London (LON) to St. Louis (STL) 8.6/10 Excellent! (1,002 reviews) The Cheshire is in a class by itself. The halls and sitting areas are so full of history and there’s an ambiance that we just love. Our suite, Treasure Island, was amazing! Large, clean, luxurious and cozy with a beautiful fireplace and large jacuzzi. We had a delicious dinner at the Basso, relaxed in the very British, cozy Fox & Hound, enjoyed a coffee at the Tudor styled Starbucks and as always, enjoyed breakfast beside the fireplace. We loved our stay! Reviewed on 28 Jan 2026 ![Angad Arts Hotel St. Louis, Tapestry Collection by Hilton](https://images.trvl-media.com/lodging/28000000/27620000/27617000/27616925/25bc97a8_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Angad Arts Hotel St. Louis, Tapestry Collection by Hilton Grand Center £870 per person 4 Mar - 10 Mar found 6 hours ago Return direct flight included London (LHR) to St. Louis (STL) 8.8/10 Excellent! (1,022 reviews) Clean room and great staff Reviewed on 27 Jan 2026 ![Hilton Garden Inn St. Louis/O'Fallon MO](https://images.trvl-media.com/lodging/1000000/930000/921500/921433/e9a336ca_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hilton Garden Inn St. Louis/O'Fallon MO £1,179 per person 19 Apr - 25 Apr found 1 day ago Return direct flight included London (LON) to St. Louis (STL) 8.8/10 Excellent! (705 reviews) Clean!!! Friendly staff. Wish breakfast was included!!! Reviewed on 18 Jan 2026 ## Sikeston Essential Information | Language | English | | --------------- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | | Currency | U.S dollars | | Closest Airport | Cape Girardeau Municipal Airport (CGI) | | Population | 16,400 | | Max Temp Winter | 7ºC | | Max Temp Summer | 29ºC | | Top Sights | [Sikeston Depot Museum](https://www.expedia.co.uk/Sikeston-Depot-Museum-Sikeston.d6305602.Attraction), [Central Park](https://www.expedia.co.uk/Central-Park-Sikeston.d6305608.Attraction) and [The Book Bug](https://www.expedia.co.uk/The-Book-Bug-Sikeston.d553248621532655751.Attraction) | ## Top hotels in Sikeston ![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Drury Inn & Suites Sikeston, MO 2608 East Malone Ave, Miner Sikeston MO Fully refundableReserve now, pay when you stay £75 3 Feb - 4 Feb includes taxes & fees 9.4/10 Exceptional! (1,005 reviews) As always it was a perfect visit Reviewed on 19 Jan 2026 [](https://expedia.co.uk/Hotel-Search?startDate=03%2F02%2F2026&endDate=04%2F02%2F2026&selected=24210&PinnedHotelID=24210&HadPinnedHotel=true®ionId=6058766) ![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hampton Inn Sikeston 1240 Commerce Drive Sikeston MO Fully refundableReserve now, pay when you stay £79 8 Feb - 9 Feb includes taxes & fees 8.8/10 Excellent! (472 reviews) Great place for an overnight stay. I will be back! Reviewed on 26 Jan 2026 [](https://expedia.co.uk/Hotel-Search?startDate=08%2F02%2F2026&endDate=09%2F02%2F2026&selected=25178175&PinnedHotelID=25178175&HadPinnedHotel=true®ionId=6058766) ![Best Western Plus Sikeston](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Best Western Plus Sikeston 120 S Interstate Drive Sikeston MO Fully refundableReserve now, pay when you stay £67 8 Feb - 9 Feb includes taxes & fees 8.2/10 Very Good! (1,003 reviews) Staff was great. Reviewed on 25 Jan 2026 [](https://expedia.co.uk/Hotel-Search?startDate=08%2F02%2F2026&endDate=09%2F02%2F2026&selected=8420572&PinnedHotelID=8420572&HadPinnedHotel=true®ionId=6058766) [See all 284 properties in Sikeston](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=31%2F01%2F2026&endDate=01%2F02%2F2026®ionId=6058766) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Holidays [](https://expedia.co.uk/lp/theme-holidays/all-inclusive-holidays?rfrr=editorial.All_Inclusive%20Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Holidays [](https://expedia.co.uk/lp/theme-holidays/beach-holidays?rfrr=editorial.Beach_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Family Friendly Holidays [](https://expedia.co.uk/lp/theme-holidays/kid-friendly-holidays?rfrr=editorial.Family_Friendly%20Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Holidays [](https://expedia.co.uk/lp/theme-holidays/golf-holidays?rfrr=editorial.Golf_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Holidays [](https://expedia.co.uk/lp/theme-holidays/luxury-holidays?rfrr=editorial.Luxury_Holidays.click) ![gay friendly holidays](https://forever.travel-assets.com/flex/flexmanager/images/2023/06/15/LGBTQIA_Holiday_Package.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) LGBTQ+ Holidays [](https://expedia.co.uk/lp/theme-holidays/gay-friendly-holidays?rfrr=editorial.LGBTQ+_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Holidays [](https://expedia.co.uk/lp/theme-holidays/romantic-holidays?rfrr=editorial.Romantic_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Holidays [](https://expedia.co.uk/lp/theme-holidays/ski-holidays?rfrr=editorial.Ski_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/22/hero-image-pet-friendly_copy.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Pet Friendly Holidays [](https://expedia.co.uk/lp/theme-holidays/pet-friendly-holidays?rfrr=editorial.Pet_Friendly%20Holidays.click) ![Holiday in Month](https://forever.travel-assets.com/flex/flexmanager/images/2023/05/10/mesog-34434-card-venice.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Where to go when [](https://expedia.co.uk/lp/b/where-to-go-when?rfrr=editorial.Where_to%20go%20when.click) ## Explore a world of travel with Expedia - 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