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Our top choices for Sikeston holiday rentals

Little Blue Cottage on Spanish

Little Blue Cottage on Spanish
Cape Girardeau
8.4 out of 10, Very good, (56 reviews)
"Great cute place. "
United States
Jeremy W.
The price is £83
includes taxes & fees
23 May - 24 May
Little Blue Cottage on Spanish

Charming Secluded Getaway Cabin within minutes of amenities

Charming Secluded Getaway Cabin within minutes of amenities
Cape girardeau
10.0 out of 10, Exceptional, (20 reviews)
"Nice little Cabin in a beautiful area. Blair and her family were wonderful!"
United States
Keegan C.
The price is £227
includes taxes & fees
22 May - 23 May
Charming Secluded Getaway Cabin within minutes of amenities

Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy

Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy
Dexter
7.8 out of 10, Good, (31 reviews)
"Stayed many times. Nice and comfortable "
United States
Susan R.
The price is £161
includes taxes & fees
24 May - 25 May
Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy

The Twisted Sassafras Treehouse

The Twisted Sassafras Treehouse
Cape Girardeau
10.0 out of 10, Exceptional, (34 reviews)
"Amazing stay, loved the bed and hot tub. Close to town but also away. "
United States
Maria B.
The price is £260
includes taxes & fees
3 Jun - 4 Jun
The Twisted Sassafras Treehouse

Serenity South -- Gardens, River-Views, and Refreshing Space

Serenity South -- Gardens, River-Views, and Refreshing Space
Cape Girardeau
10.0 out of 10, Exceptional, (155 reviews)
"Nice location to river front and downtown. Very lovely place."
United States
Marcie R.
The price is £184
includes taxes & fees
20 May - 21 May
Serenity South -- Gardens, River-Views, and Refreshing Space

Relax in the country at Countryside Villas! - Villa A

Relax in the country at Countryside Villas! - Villa A
Jackson
10.0 out of 10, Exceptional, (34 reviews)
"Great place to stay, felt like home away from home. "
United States
Brittany
The price is £136
includes taxes & fees
26 May - 27 May
Relax in the country at Countryside Villas! - Villa A

Gorgeous 1856 Log Cabin, Completely Renovated

Gorgeous 1856 Log Cabin, Completely Renovated
Jackson
10.0 out of 10, Exceptional, (3 reviews)
"incredible place. I was there for work, but it was a really nice relaxing area to retreat too, and also get some work done in a serene environment. It would be an incredible place for an entire family. And, a good place for friends to get together."
United States
Chandler G.
The price is £231
includes taxes & fees
27 May - 28 May
Gorgeous 1856 Log Cabin, Completely Renovated

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Cape Girardeau
8.8 out of 10, Excellent, (40 reviews)
"Will definitely book again! Great location, comfortable stay."
United States
Pynktoria !.
The price is £230
includes taxes & fees
26 May - 27 May
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

Villa B offers peace and quiet with beautiful views of the countryside.

Villa B offers peace and quiet with beautiful views of the countryside.
Jackson
10.0 out of 10, Exceptional, (11 reviews)
"It was great. "
United States
Benjamin Q.
The price is £137
includes taxes & fees
20 May - 21 May
Villa B offers peace and quiet with beautiful views of the countryside.

Modern 2BR Apt w Electric Fireplace By KeenStays

Modern 2BR Apt w Electric Fireplace By KeenStays
Cape Girardeau
8.0 out of 10, Very good, (1 review)
The price is £162
includes taxes & fees
18 Jun - 19 Jun
Modern 2BR Apt w Electric Fireplace By KeenStays

Studio Apt | King Bed, Full Kitchen · By KeenStays

Studio Apt | King Bed, Full Kitchen · By KeenStays
Cape Girardeau
The price is £132
includes taxes & fees
14 Jun - 15 Jun
Studio Apt | King Bed, Full Kitchen · By KeenStays

The Cottage, Rusted Route Farms

The Cottage, Rusted Route Farms
Jackson
10.0 out of 10, Exceptional, (2 reviews)
"This Cottage was very nice and clean and well maintained. The meat tray that we ordered and the breakfast tray was beyond Fabulous!!! My husband is still talking about it. . .Rick & Renee Christman"
United States
Renee C.
The price is £150
includes taxes & fees
21 May - 22 May
The Cottage, Rusted Route Farms

Modern Boho Getaway · 1BR Apartment · By KeenStays

Modern Boho Getaway · 1BR Apartment · By KeenStays
Cape Girardeau
The price is £127
includes taxes & fees
31 May - 1 Jun
Modern Boho Getaway · 1BR Apartment · By KeenStays

Enjoy easy access to everything from this centrally located place.

Enjoy easy access to everything from this centrally located place.
Dexter
The price is £120
includes taxes & fees
2 Jun - 3 Jun
Enjoy easy access to everything from this centrally located place.

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Cape Girardeau
9.6 out of 10, Exceptional, (9 reviews)
"Nice place, great times"
United States
Jace W.
The price is £405
includes taxes & fees
26 May - 27 May
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

Luxe 2KBR Apt w/ Electric Fireplace · By KeenStays

Luxe 2KBR Apt w/ Electric Fireplace · By KeenStays
Cape Girardeau
The price is £157
includes taxes & fees
1 Jun - 2 Jun
Luxe 2KBR Apt w/ Electric Fireplace · By KeenStays

Building at Cape Girardeau Regional Airport

Building at Cape Girardeau Regional Airport
Scott City
The price is £465
includes taxes & fees
20 May - 21 May
Building at Cape Girardeau Regional Airport

The Atrium - A Boutique Hotel

The Atrium - A Boutique Hotel
2.0 star property
Perryville
9.4 out of 10, Exceptional, (3 reviews)
"Very nice clean room with comfortable bed and nice shower. Kitchenette was good with microwave and mini fridge, basic dishes. The owner was very easy to communicate with. Good location with Mary Jane’s restaurant bar next door had excellent food and nice atmosphere. My only small suggestion would be to put variable light switches so you could turn down the lighting at night. I would definitely recommend and would stay here again on my next trip to Perryville."
United States
James
The price is £116
includes taxes & fees
21 May - 22 May
The Atrium - A Boutique Hotel

Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!

Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!
Makanda
9.8 out of 10, Exceptional, (48 reviews)
"Cabin was clean. Contact with host was very good and helpful."
United States
Steve K.
The price is £161
includes taxes & fees
20 May - 21 May
Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!

3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!

3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!
Makanda
9.8 out of 10, Exceptional, (64 reviews)
"A nice quiet stay in the Shawnee Forest. Host was easy to communicate with and the cabin had everything we needed for a nice get away. Close to nature or close to shopping and dinner. It was the perfect little spot "
United States
Ruth O.
The price is £138
includes taxes & fees
20 May - 21 May
3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Sikeston Hotel Reviews

Find out more about Sikeston

Everything you need to know about Sikeston holiday rentals

Whether you’re excited for the perfect family holiday, a romantic getaway for two, or the ultimate city break, we’ve got the Sikeston holiday rental for you. At Expedia, you can take your pick from private holiday homes, apartments, cottages, apart-hotels, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Sikeston holiday rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search. 

Sikeston holiday rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Sikeston. If you’re looking for a little peace, consider booking during the quieter months, such as  . For more hustle and bustle, you may prefer to visit in . 

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Sikeston holiday rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a holiday rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Sikeston holiday rentals we have selected for you start as low as £83 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on Sikeston rentals

At Expedia, we put the best Sikeston holiday rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. 

To find some top Sikeston rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Sikeston holiday.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Sikeston. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence. 

Frequently asked questions

Can I find a holiday rental in Sikeston?

Yes, there are holiday rentals close to the most popular sights in Sikeston, or you can select a more secluded option if you're looking for a relaxing stay. Tourists like the array of shops and top-notch restaurants in Sikeston. Make sure you allow time to enjoy the riverfront during your holiday.

What are some of the best holiday rentals that Sikeston has to offer?

Beautiful location in the secluded woods : This holiday home rental outside of Sikeston offers a fireplace, a patio and a BBQ to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. Make the most of games in this rental home to help you unwind.

What’s there to see and do in Sikeston?

Cultural attractions include Sikeston Depot Museum, whereas Central Park is a spot to enjoy nature. In the wider area, you’ll find Front Street Studio & Art Gallery and Stoddard County Civil War Memorial Cemetery.

What’s a holiday rental in Sikeston like?

Holiday rentals are private properties where you can stay for a few weeks, or just a few days, in Sikeston. Holiday rentals offer amenities such as WiFi and washers and dryers so you'll be comfy for your stay. If you're concerned about a clean environment, a holiday rental can offer a sense of security away from public hotel lifts and bustling concierge desks while still allowing you a great travel experience. You'll also find more space in a holiday rental than in a hotel, which is another reason why a holiday rental is a popular option for family gatherings.