The Best Hotels Closest to Sikeston Depot Museum in Sikeston - 2026 Updated Prices

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Our top choices for Sikeston Depot Museum hotels

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.

A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.

1. Fairfield Inn & Suites by Marriott Sikeston

1.5 mi from Sikeston Depot Museum

Allen

£87

includes taxes & fees

18 Oct - 19 Oct

An outdoor bar area with a modern design, featuring a counter, bar stools, and a seating area with chairs.

A modern hotel room with a large window, a gray sofa, a small round table, a white chair, and a bed.

2. TownePlace Suites by Marriott Sikeston

1.4 mi from Sikeston Depot Museum

Rubin

£87

includes taxes & fees

18 Oct - 19 Oct

A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

An indoor swimming pool with lounge chairs, a lifeguard stand, and large windows offering a view of the outside.

A hotel lobby with a bar area, seating arrangements, and a large window providing natural light.

A conference room with a large rectangular table, six chairs with patterned upholstery, two modern ceiling lights, a bowl of fruit on the table, and large windows with curtains.

3. Hampton Inn Sikeston

1.4 mi from Sikeston Depot Museum

Carolyn

£91

includes taxes & fees

18 Oct - 19 Oct

A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.

A Holiday Inn Express & Suites building with a covered entrance, multiple windows, and a parking lot.

A reception area with a reception desk, a large wall-mounted sign, and a potted plant.

A kitchenette with a coffee machine, a kettle, and storage shelves.

4. Holiday Inn Express & Suites Sikeston Southwest by IHG

1.3 mi from Sikeston Depot Museum

Melissa

£83

includes taxes & fees

8 Nov - 9 Nov

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

A hotel room with a patterned sofa, a yellow ottoman, a desk with a TV, and a framed picture on the wall.

An outdoor seating area with sofas and planters, surrounded by a building with large windows and a brick wall.

A spacious lobby with a polished floor, seating areas, and modern lighting fixtures.

5. Drury Inn & Suites Sikeston, MO

3.2 mi from Sikeston Depot Museum

Scott

£82

includes taxes & fees

18 Oct - 19 Oct

A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.

An indoor swimming pool with clear water, surrounded by lounge chairs and tables, and large windows providing natural light.

A reception area with a wooden reception desk, a large painting on the wall, and a potted plant.

6. Best Western Plus Sikeston I-55

3.4 mi from Sikeston Depot Museum

Shelley

£73

includes taxes & fees

1 Nov - 2 Nov

A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.

A reception area with a sign for 'Travel Inn and Suites' and a counter with a computer and a phone.

A Travel Inn and Suites with a brick facade, a flat roof, and a welcoming entrance.

A modern kitchen with stainless steel appliances, wooden cabinets, and a bright yellow accent wall.

7. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

3.1 mi from Sikeston Depot Museum

Craig

£53

includes taxes & fees

20 Oct - 21 Oct

A Comfort Inn & Suites hotel with a clear entrance, a covered parking area, and a sign indicating a 12' clearance.

A hotel lobby with a reception desk, seating area, and large windows offering a view of the outdoors.

A living room with two sofas, a coffee table, a TV, and a cabinet.

A hotel room with a bed, a desk with a TV, a chair, a bathroom with a bathtub, and a window with curtains.

8. Comfort Inn & Suites Sikeston I-55

3.1 mi from Sikeston Depot Museum

Kathryn

£72

includes taxes & fees

1 Nov - 2 Nov

A modern hotel room with a large bed, a smaller bed, a desk, and a chair. There is a window with curtains and a painting on the wall.

A spacious room with a large dining table and chairs, a kitchenette area, and a television mounted on the wall.

A Days Inn hotel with a brick facade, large windows, and a sign above the entrance.

9. Days Inn and Suites by Wyndham Sikeston

3.4 mi from Sikeston Depot Museum

David

£57

includes taxes & fees

13 Oct - 14 Oct

A hotel room with a bed, a desk with a chair, a TV, two bedside lamps, and a large window.

A hotel room with two beds, a sofa, a coffee table, and artwork on the walls.

A motel with a covered entrance, multiple rooms, and a parking lot.

A hotel kitchen with a long counter, various appliances, and a tiled backsplash.

10. Super 8 by Wyndham Sikeston/Miner Area

2.9 mi from Sikeston Depot Museum

Marcia

£49

includes taxes & fees

18 Oct - 19 Oct

A hotel room with two beds, a desk, a chair, a TV, and a mirror.

A reception area with a counter, a coffee machine, and seating.

A motel with a blue awning and a green 7-Eleven. It has a covered parking area and a two-story structure with a balcony.

A bathroom with a bathtub, toilet, and shower curtain.

11. Country Yard Inn and Suite

3.4 mi from Sikeston Depot Museum

William

£48

includes taxes & fees

12 Oct - 13 Oct

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Compare popular hotels close to Sikeston Depot Museum

Property	Property class	Guest rating
Fairfield Inn & Suites by Marriott Sikeston	9.4 Exceptional 117 reviews	View
TownePlace Suites by Marriott Sikeston	9.4 Exceptional 26 reviews	View
Hampton Inn Sikeston	9.0 Wonderful 633 reviews	View
Holiday Inn Express & Suites Sikeston Southwest by IHG	8.8 Excellent 517 reviews	View
Drury Inn & Suites Sikeston, MO	9.6 Exceptional 1,007 reviews	View

Top Sikeston Depot Museum Hotel Reviews

Hampton Inn Sikeston

10/10 Excellent

"The front desk staff were very kind and helpful. Everything was clean and there was a good breakfast!"

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

8/10 Good

"Easy parking, our bathroom sink was leaning forward and we had to place our soap in the sink so it didn't slide on the floor."

Days Inn and Suites by Wyndham Sikeston

8/10 Good

"We were traveling through and wanted a quiet clean place to sleep. This was quiet clean although it is a bit dated. Only issue with maintenance was the outlet in the bathroom did not work which did not bother us but it should be attended to. We actually had a suite so it was very spacious. It was about $30 less than other rooms that were available in the area so it was quite a value in my opinion."

Comfort Inn & Suites Sikeston I-55

8/10 Good

"Our room was very clean and comfy. The bathroom was clean but could use an update. The bathroom tissue and face tissues are on the thin side. Breafast bar was excellent. The staff was very nice and helpful."

Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy

8/10 Good

"Host is great. I've stayed here many times."

TownePlace Suites by Marriott Sikeston

10/10 Excellent

"My overall experience was amazing from the time I checked in until I left. The staff were super pleasant and incredible. My room was clean and spacious. I never been in an extended stay room before. I definitely will be booking a suite like this one again."

Eagle Inn Charleston

10/10 Excellent

"Great"

Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!

10/10 Excellent

"The host was very quick to respond and so great to work with for on our stay. "

Other attractions near Sikeston Depot Museum

Central Park

7.2/10 (56 reviews)

Explore the great outdoors at Central Park, a lovely green space in Sikeston. While in this family-friendly area, you can savour the top-notch restaurants.

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City of Miner Convention Center

Learn about the events happening in City of Miner Convention Center during your trip to Miner. While in this relaxing area, you can savour the top-notch restaurants.

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Front Street Studio & Art Gallery

8.6/10 (15 reviews)

You can spend time browsing the exhibits at Front Street Studio & Art Gallery during your travels in Blodgett. While in this relaxing area, you can savour the top-notch restaurants.

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Hunter-Dawson State Historic Site

7.6/10 (13 reviews)

You can browse the exhibits at Hunter-Dawson State Historic Site, a museum with a story of its own, during your trip to New Madrid. Amble around the area's parks or experience its museums.

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River Ridge Winery

8.4/10 (15 reviews)

You can enjoy a tasting or tour at River Ridge Winery during your travels to New Madrid. Amble around the area's parks or experience its museums.

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New Madrid Historical Museum

8.2/10 (36 reviews)

You can study the exhibits at New Madrid Historical Museum, a museum with a storied past, during your travels to New Madrid. Amble around the area's parks or experience its museums.

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Dexter Welcome Center Depot and Museum

7.6/10 (12 reviews)

You can study the exhibits at Dexter Welcome Center Depot and Museum, a museum with a story of its own, during your holiday in Dexter. While in this family-friendly area, you can enjoy the restaurants.

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The Heritage House

8.4/10 (7 reviews)

Learn about the local history of Dexter with a stop at The Heritage House. While in this family-friendly area, you can enjoy the restaurants.

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Frequently asked questions

What's the area like around Sikeston Depot Museum?

Sikeston Depot Museum is located in a welcoming area of Sikeston known for its array of dining options. If you're looking for a convenient place to stay, take a look at the 5 hotels and other accommodation options you'll find within a mile.

What's the best place to stay near Sikeston Depot Museum?

Drury Inn & Suites Sikeston, MO is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and an outdoor pool. It's located 3.2 mi (5.1 km) from Sikeston Depot Museum. Other good choices within 5 miles include Hampton Inn Sikeston and Days Inn and Suites by Wyndham Sikeston.

How many hotels will I find close to Sikeston Depot Museum?

Expedia has 5 hotels and other accommodation options within a mile from Sikeston Depot Museum.

If I need to cancel the hotel reservation for my stay near Sikeston Depot Museum, will I receive a refund?

Yes! The majority of hotel room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you have a non-refundable reservation, you might be able to still cancel and get a refund within a 24-hour period of booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to view the best options available near Sikeston Depot Museum.

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Our top choices for Sikeston Depot Museum hotels

1. Fairfield Inn & Suites by Marriott Sikeston