Sikeston Holidays

Book a Hotel + Flight or Car together to unlock savings

Your Sikeston Holiday

There's tons to like about Sikeston, from its rich history to its rural countryside. When you're ready to say hi to this captivating city, our Sikeston holiday packages will be perfect for you. Fill your spare time with visits to Sikeston Depot Museum, The Book Bug and Central Park, some of the top attractions you just have to see during your trip to Sikeston. That dream Sikeston holiday is clicks away. Browse hotels, flights and more on Expedia for a getaway that's tailored to suit your travel style.

Sikeston Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Cape Girardeau Municipal Airport (CGI)
Population
16,400
Max Temp Winter
7ºC
Max Temp Summer
29ºC
Top Sights
Sikeston Depot Museum, Central Park and The Book Bug

Top hotels in Sikeston

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
The price is £95 per night from 9 Aug to 10 Aug
£95
9 Aug - 10 Aug
includes taxes & fees
9.6/10 Exceptional! (1,004 reviews)
"Our room looked new and clean and specious ! Breakfast was delicious, variety and better quality compared to some other.. The air conditioner was quite as well.The environments were safe. Overall we loved our stay, thank you for your great service !"

Reviewed on 31 Jul 2026

Drury Inn & Suites Sikeston, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
Fully refundableReserve now, pay when you stay
The price is £58 per night from 26 Aug to 27 Aug
£58
26 Aug - 27 Aug
includes taxes & fees
Days Inn and Suites by Wyndham Sikeston
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

2.5 out of 5
115 Hospitality Dr Sikeston MO
Fully refundable
The price is £78 per night from 30 Aug to 31 Aug
£78
30 Aug - 31 Aug
includes taxes & fees
8.6/10 Excellent! (488 reviews)
"It's a block off the main drag, but wasn't hard to find. Elevator was noisy enough that we preferred the stairs but never had a problem with it. Stairs were carpeted and nice. They had a surprise $50 incidental fee they charged at checkin which surprised us, none of the other ones on our trip did ..."

Reviewed on 28 Jul 2026

Holiday Inn Express & Suites Sikeston Southwest by IHG
See all 318 properties in Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Sikeston attractions

Sikeston Depot Museum

7.6/10 (57 reviews)
Housed in a restored 1916 train depot, this museum showcases Sikeston's cotton-growing heritage and local art. Explore regional history through rotating exhibits while admiring the building's National Register status.
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Frequently asked questions

Why should I book my Sikeston holiday with Expedia?
Choose Expedia to organise your next big escape easily and all in the same place. Our top tip for bagging a great deal on a Sikeston retreat? Bundle your airfares, hotel and/or hire car into a package holiday. Then add a couple of fun tours and activities. Many bookings also include flexible cancellation policies, so there's no need to worry if you have to change plans. Round-the-clock assistance with changing and cancelling your trip is available via our Customer Service Portal link.
When is the best time of year to holiday in Sikeston?
Love sightseeing but don't like crowds? Lock in your Sikeston escape for November, December and January. Typically, it's much quieter than in May, June and July. To get an idea of what type of weather you can experience, the average daytime temperature in January, the coolest month in Sikeston, is 2ºC. The warmest period here is July, when temperatures average 26ºC.
What are the top hotels for my holiday in Sikeston?
Pear Tree Inn Sikeston will be a fantastic base for your Sikeston escape. Located in Miner, it's one of the area's best hotels.
How do I get a cheap holiday to Sikeston?
If you love getting a great deal, combine your bookings into a Sikeston holiday. Whether you need flights, hotels, hire cars or activities, you can book everything in one place. You'll have plenty of choice at your fingertips too. Expedia has over 400 partner airlines and 321,000 hotels around the globe to take your pick of. Fly with who you prefer, check in where you like and save a bundle — now that's the perfect getaway! Learn more about how you can save money on your holiday when you book a flight and hotel together with Expedia.
What should I do on my Sikeston holiday?
Offering top attractions like The Book Bug and Sikeston Depot Museum, a holiday in Sikeston is packed with exciting places to visit. Central Park and Boot Heel Golf Club are two other sights also worth checking out.
What is the best area to stay in when on holiday in Sikeston?
There's loads to do in Sikeston, so stay close to its attractions and spend more time sightseeing. Isle Casino Cape Girardeau is one place to put on your must-see list.
Do I need a visa for my Sikeston holiday?
Check the latest information on official government websites. Your nationality and whether you're visiting for leisure, study or business will determine if you'll need a visa for Sikeston. Get familiar with the application process, including the required documentation, turnaround times and fees. Submit your application well in advance to allow sufficient processing time. Some visas can take weeks or even months to obtain, depending on the country.
What should I wear on my Sikeston holiday?
Although everyone's personal style is different, it can help to have a few guidelines for what kind of clothes to wear on your holiday in Sikeston. We recommend browsing style blogs before you go for inspiration on local fashion trends. Be sure to check the local weather forecast so you can pack appropriately. The warmest time of year in Sikeston is July, with average daytime temperatures of 26ºC. If you're holidaying during the coolest month of January, the mercury hovers around 2ºC during the day.
What does an Expedia Sikeston holiday include?
With Expedia, you can choose any combination of flights, car hires and hotels to create your perfect Sikeston package. Once you've made your booking, simply add on the fun things like sightseeing tours and activities. Don't forget, the more you bundle, the bigger the savings! Hotels and private holiday homes are a couple of highly sought-after property types in Sikeston. Whatever your group size or holiday style, you can rely on Expedia for the flexibility to tailor your next big adventure.
Does Expedia offer Book Now, Pay Later Sikeston holidays?
We do. Expedia has partnered with online lender Klarna to help you easily pay for your holiday in instalments. Simply pick the payment plan that works for you during the checkout process and take away the stress of budgeting for your next trip. Remember to bundle your flights, accommodation and car hire with Expedia to get the biggest bang for your holiday buck. Take a look at our flexible payment options below:

  • Pay monthly holidays: Klarna offers the ability to pay in multiple instalments that fit all budgets, so you can take that well-deserved holiday sooner.
  • No-deposit holidays: When you see an incredible deal but your budget doesn't quite cover it yet, Klarna's no-deposit holiday plan will allow you to Book Now, Pay Later to lock in your escape.

Can I choose my airline with a Sikeston Expedia holiday?
Yes — and it's easy too. Expedia has access to more than 400 partner airlines all over the world. Our holiday packages give you the freedom to pick from available flights, hotels and activities that suit you.

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.