Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Santa Cruz Business Hotels

See all 73 Hotels in Santa Cruz
Camino Real Hotel

Camino Real Hotel

Av. San Martín y 4to. Anillo, Santa Cruz
3.5 out of 5.0
4.0 out of 5 (31 reviews)
Nice Hotel close to Ventura mall. Clean room , professional and great service. Comfortable room
  10 Aug 2016

£105

£105
Senses Boutique Hotel

Senses Boutique Hotel

Calle 24 de Septiembre, Esq. Sucre No 5, Santa Cruz
3.5 out of 5.0
3.8 out of 5 (39 reviews)
good price , quality , service and location. I recommend it.
  4 Dec 2016

£51

£51
Hotel LP Santa Cruz Centro

Hotel LP Santa Cruz Centro

Av.Ejercito Nacional 290, Santa Cruz
3.0 out of 5.0
3.9 out of 5 (45 reviews)
Walkable to the main PlazaPicked us up at the airport at 4am. Terrific! Room and bathroom spacious and clean and staff very helpful, even though we could not speak Spanish. Twenty minute easy walk to the city centre.
  4 Nov 2016

£46

£46
Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz

Calle Las Begonias Nro 30, Santa Cruz
3.5 out of 5.0
4.1 out of 5 (16 reviews)
Walk to great eateriesGlorimar Salteñas, Aviator Wings, Fidalga supermarket, etc.
  16 May 2017

£44

£44
Buganvillas Hotel Suites & Spa

Buganvillas Hotel Suites & Spa

Av. Roca y Coronado No. 901, Santa Cruz
4.0 out of 5.0
3.7 out of 5 (7 reviews)
Beautiful oasis within the cityWonderful place a bit outdated but still the kind of oasis you look for being in a city with great ways to go everywhere else and still come back to the nature and quietness of the pool and just seating outside of your room or balcony.
  10 May 2017

£120

£120
Gran Hotel Santa Cruz

Gran Hotel Santa Cruz

RENE MORENO 289,, SANTA CRUZ DE LA SIERRA
2.5 out of 5.0
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

San Martin Avenue Esq Street E - E, Santa Cruz
3.5 out of 5.0
4.3 out of 5 (10 reviews)
Service was great, just have to watch the inflated taxi charges.
  18 Dec 2016

£82

£82
Hostal & Restaurante Warique

Hostal & Restaurante Warique

Av. Radial 27 #205, Santa Cruz
2.5 out of 5.0
4.0 out of 5 (1 reviews)
Hotel Alaska

Hotel Alaska

Florida Nro. 569, Santa Cruz
2.5 out of 5.0
Hotel Arenal

Hotel Arenal

Calle Beni # 340, Santa Cruz
3.5 out of 5.0
3.1 out of 5 (7 reviews)
nice hotal close to the main square Good place to stay with excllent service and personnel. Electrical installation needs to be improved but overall its an excellent hotel with a good family administration and price.
  27 Nov 2015

£46

£46
Map

Recently booked Santa Cruz hotels

Hotel Continental Park
3.0 out of 5.0
Last booking: 31 hours ago
Apart Hotel Premium Suites Santa Cruz
3.5 out of 5.0
Last booking: 47 hours ago

Pocket Guide: Business Hotels in Santa Cruz

Search for Business Hotels in Santa Cruz on Expedia.co.uk. You can easily find your Business Hotels in Santa Cruz using one of the methods below:

  • View our selection of featured hotels in Santa Cruz
  • Use the map to find budget hotels in the Santa Cruz neighborhood you prefer
  • Use the filters to see hotels in a specific area of Santa Cruz, select a specific theme, brand, or hotel class in Santa Cruz
  • Enter your travel dates to view the best deals on hotels in Santa Cruz - while they last