Santa Cruz Holidays from £1,337

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Your Santa Cruz Holiday

With one of our holiday packages to Santa Cruz, you'll find countless opportunities for adventure and relaxation. There's so much to experience, including its beaches and lively atmosphere. If taking in sights is part of the programme during your trip to Santa Cruz, check out major attractions like Plaza 24 de Septiembre, Guembe Biocenter and Ventura Mall. Whoever you're heading away with and whatever the size of your budget, your dream Santa Cruz holiday is just clicks away with Expedia.

Top Santa Cruz Flight + Hotel Deals

Price found within the past 48 hours. Click for updated prices.
Swissôtel Santa Cruz De La Sierra

Swissôtel Santa Cruz De La Sierra

4.5 out of 5
Price was £1,368, price is now £1,337 per person
£1,337
per person
26 Sept - 27 Sept
found 1 day ago
Return flight included
Manchester (MAN) to Santa Cruz (VVI)
9.2/10 Wonderful! (87 reviews)
Great room, spacious, quiet and the shower was great

Reviewed on 2 Mar 2026

Camino Real Hotel

Camino Real Hotel

4.5 out of 5
Price was £1,427, price is now £1,364 per person
£1,364
per person
26 Sept - 27 Sept
found 1 day ago
Return flight included
Manchester (MAN) to Santa Cruz (VVI)
9/10 Wonderful! (428 reviews)
Wonderful place to stay while visiting Santa Cruz Bolivia.

Reviewed on 7 Jul 2026

Hotel Cortez

Hotel Cortez

3.5 out of 5
Price was £1,374, price is now £1,346 per person
£1,346
per person
26 Sept - 27 Sept
found 1 day ago
Return flight included
Manchester (MAN) to Santa Cruz (VVI)
9.2/10 Wonderful! (144 reviews)

Novotel Santa Cruz De La Sierra

Novotel Santa Cruz De La Sierra

5 out of 5
Price was £1,356, price is now £1,340 per person
£1,340
per person
26 Sept - 27 Sept
found 1 day ago
Return flight included
Manchester (MAN) to Santa Cruz (VVI)
9/10 Wonderful! (118 reviews)

Alfonsina Hotel Boutique by Inboccaluppo

Alfonsina Hotel Boutique by Inboccaluppo

3.5 out of 5
Price was £1,362, price is now £1,348 per person
£1,348
per person
26 Sept - 27 Sept
found 1 day ago
Return flight included
Manchester (MAN) to Santa Cruz (VVI)
9.4/10 Exceptional! (44 reviews)
Good hotel. Very contemporary; buffet breakfast included. We walked to the old part of the city/cathedral - probably about 40 minutes walk but can stop for a coffee along the way! Restaurant and bar in hotel. Hotel also close to many other restaurants/bars

Reviewed on 6 Jul 2026

Santa Cruz Essential Information

Language
Spanish
Currency
Bolivian bolivianos
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Viru Viru Intl. Airport (VVI)
Max Temp Winter
27ºC
Max Temp Summer
32ºC
Top Sights
Santa Cruz Zoo, San Lorenzo Cathedral and Sacred Art Museum

Top hotels in Santa Cruz

Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

3 out of 5
AVENIDA CRISTOBAL DE MENDOZA Santa Cruz
The price is £40 per night from 26 Jul to 27 Jul
£40
26 Jul - 27 Jul
9.4/10 Exceptional! (124 reviews)
"Good location and value for money."

Reviewed on 23 May 2026

Ibis Santa Cruz DE LA Sierra
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455 Santa Cruz
The price is £94 per night from 24 Jul to 25 Jul
£94
24 Jul - 25 Jul
9/10 Wonderful! (385 reviews)
"No hot water for almost the old trip"

Reviewed on 8 Jul 2026

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel

5 out of 5
4to Anillo Entre Radial 23 Santa Cruz Santa Cruz
The price is £91 per night from 24 Jul to 25 Jul
£91
24 Jul - 25 Jul
9/10 Wonderful! (236 reviews)
"The room was too cold and the last day there was no hot water for the shower."

Reviewed on 13 Jun 2026

Marriott Santa Cruz de la Sierra Hotel
See all 298 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Stay near popular Santa Cruz attractions

A historic building with arched windows and a clock. People are sitting and standing on the steps in front of the building.

Plaza 24 de Septiembre

8.8/10 (164 reviews)
Plaza 24 de Septiembre buzzes with local culture beneath swaying palms and colonial architecture. Climb the Cathedral's bell tower for spectacular city views while sampling authentic Bolivian coffee from vendors.
See properties

What to do in Santa Cruz

Private Tour of Santa Cruz: We'll visit the center, Porongo, markets, and the river

Private Tour of Santa Cruz: We visit the city center, Porongo, markets, and the river

£49
per adult
Private Tour of Santa Cruz: We visit the city center, Porongo, markets, and the river
Fuerte de Samaipata, Bolivia

Samaipata Fort Tour: Ancient Ruins in 1 Full Day

£238
per adult
Samaipata Fort Tour: Ancient Ruins in 1 Full Day
The Che Guevara route is the most peculiar tourist destination in Bolivia.

4D/3N Expedition: Che Guevara Route - Disconnect from the World

£603
per adult
4D/3N Expedition: Che Guevara Route - Disconnect from the World
See all activities in Santa Cruz

Frequently asked questions

Why should I book my Santa Cruz holiday with Expedia?
With great-value airfares, car hire and accommodation choices all in the same place, Expedia makes planning your Santa Cruz adventure hassle-free. Plus, we can help you bundle your bookings into a package holiday so you can get even more savings. Select from amazing stays, add flights and/or a hire car (and maybe even some exciting activities!) and score incredible prices. Had a change of plans? Expedia offers a flexible cancellation policy for many reservations. To learn more, head over to our Customer Service Portal link.
When is the best time of year to holiday in Santa Cruz?
Santa Cruz is at its busiest in March, August and September. If you want a more laid-back getaway, go there in January, May and December. To get an idea of the type of weather to expect, the daytime average temperature in June, the coolest month in Santa Cruz, is 19ºC. The warmest month here is October, when temperatures are around 26ºC.
What is the top hotel for my holiday in Santa Cruz?
Offering many of home's creature comforts, Camino Real Hotel will make the ideal base for your Santa Cruz getaway.
How do I get a cheap holiday to Santa Cruz?
Creating your own Santa Cruz holiday with Expedia is a great way to save. We have more than 400 airlines and 321,000 hotel options throughout the world. With such a huge range to select from, you'll have no trouble putting together your ideal holiday. Learn more about how you can save money on your holiday when you bundle your flight and hotel bookings with Expedia.
What should I do on my Santa Cruz holiday?
Make sure your holiday in Santa Cruz is an unforgettable one by visiting its most popular attractions. Plaza 24 de Septiembre, Ventura Mall, Guembe Biocenter and Santa Cruz Zoo are just some of the things we recommend seeing while you're in the city.
What is the best area to stay in when on holiday in Santa Cruz?
There's so much to do in Santa Cruz, so stay near its top attractions and maximise your time sightseeing. Plaza 24 de Septiembre is one place to put on your itinerary.
Do I need a visa for my Santa Cruz holiday?
Visa requirements for Santa Cruz vary depending on your nationality and the reason for your visit. It's wise to check official government websites to determine if you need a visa for your trip. They'll give you the most up-to-date information, including details about application procedures or supporting documentation that may be necessary. Enquire about your visa requirements well in advance to ensure a hassle-free travel experience. Finally, make sure your passport is valid for a further six months from your return date.
What should I wear on my Santa Cruz holiday?
First, think about the types of things you'll be doing during your trip to Santa Cruz and travel with pieces that you can easily mix and match. For fashion inspiration or even information on dress codes, look up a few style blogs or relevant social media accounts. Pack your bags with confidence by checking the weather conditions in Santa Cruz. October brings the warmest temperatures, with daytime averages of 26ºC, while June days average 19ºC, making it the coolest time of year.
What does an Expedia Santa Cruz holiday include?
Expedia has everything you need to organise your Santa Cruz trip, but what your package looks like is up to you. Choose from a combination of hotels, flights and hire cars. Searching for some tours or activities to keep you busy? Once you've made your booking, you can add them too. No matter your budget or style, there's a holiday package to meet your needs. Expedia features all types of properties, with the most popular in Santa Cruz including apartments and hotels. With Expedia, you can expect the freedom and flexibility to tailor-make your holiday your way.
Does Expedia offer Book Now, Pay Later Santa Cruz holidays?
Expedia has joined forces with online lender Klarna to make your next break a little easier on the wallet. Paying in instalments means you can spread the costs of your dream holiday, leaving you with more cash to splash while you're travelling. Klarna has several payment plans to pick from, so you're sure to find one that works with your budget. Browse these flexible payment options:

  • Pay monthly holidays: Klarna offers the ability to pay in multiple transactions that fit all budgets, so you can have that well-deserved holiday now.
  • No-deposit holidays: When you want to jump on an awesome deal but don't have the full amount yet, Klarna's no-deposit holiday plan will allow you to Book Now, Pay Later to secure your getaway.

Can I choose my airline with a Santa Cruz Expedia holiday?
Yes — that's one of the best things about an Expedia holiday package. You get to decide. We have more than 400 airline partners across the globe, so you have lots of choice when creating your Santa Cruz getaway.

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.