Santa Cruz Holidays
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Your Santa Cruz Holiday
With one of our holiday packages to Santa Cruz, you'll find countless opportunities for adventure and relaxation. There's so much to experience, including its beaches and lively atmosphere. If taking in sights is part of the programme during your trip to Santa Cruz, check out major attractions like Plaza 24 de Septiembre, Guembe Biocenter and Ventura Mall. Whoever you're heading away with and whatever the size of your budget, your dream Santa Cruz holiday is just clicks away with Expedia.
Santa Cruz Essential Information
Language | Spanish |
|---|---|
Currency | Bolivian bolivianos |
Local Welcome | ¡Hola! |
Local Goodbye | Adiós |
Closest Airport | Viru Viru Intl. Airport (VVI) |
Max Temp Winter | 27ºC |
Max Temp Summer | 32ºC |
Top Sights | Santa Cruz Zoo, San Lorenzo Cathedral and Sacred Art Museum |
Top hotels in Santa Cruz
Ibis Santa Cruz DE LA Sierra
AVENIDA CRISTOBAL DE MENDOZA Santa Cruz
The price is £37 per night from 3 Mar to 4 Mar
£37
3 Mar - 4 Mar
9.6/10 Exceptional! (90 reviews)
Great value
Reviewed on 21 Feb 2026
Camino Real Hotel
Av. San Martín y 4to. Anillo Santa Cruz
The price is £94 per night from 15 Mar to 16 Mar
£94
15 Mar - 16 Mar
9/10 Wonderful! (420 reviews)
Spotless, large and comfortable room was well maintained. Friendly and helpful staff. Delicious breakfast buffet. Location is near excellent shopping and dining options.
Reviewed on 5 Feb 2026
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Ave. San Martin, #455 Santa Cruz
The price is £101 per night from 14 Mar to 15 Mar
£101
14 Mar - 15 Mar
9/10 Wonderful! (362 reviews)
Lovely staff. Great buffets.
Reviewed on 23 Feb 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Popular places to visit
Ethno-folkloric Museum
You can spend an afternoon exploring the galleries in Ethno-folkloric Museum in Santa Cruz. While in the area, you can find time to visit its shops.
What to do in Santa Cruz
Samaipata Fort Tour: Ancient Ruins in 1 Full Day
£230
per adult
4D/3N Expedition: Che Guevara Route - Disconnect from the World
£583
per adult
3D/2N Getaway on the Che Guevara Route Live the Adventure!
£510
per adult
Explore a world of travel with Expedia
- Flights to El Trompillo
- Flights to Santa Cruz
- Flights from El Trompillo
- Flights from Viru Viru Intl.
- Boliviana De Aviacion Madrid (MAD) to Santa Cruz (VVI) flights
- Flights from Wanigela (AGL) to Santa Cruz (SRZ)
- Flights from Antalaha (ANM) to Santa Cruz (SRZ)
- Flights from Artigas (ATI) to Santa Cruz (SRZ)
- Flights from Altamira (ATM) to Santa Cruz (SRZ)
- Flights from Alexandria (AXN) to Santa Cruz (SRZ)
- Flights from Hartford (BDL) to Santa Cruz (SRZ)
- Flights from Bereina (BEA) to Santa Cruz (SRZ)
- Flights from Beirut (BEY) to Santa Cruz (SRZ)
- Flights from Belfast (BHD) to Santa Cruz (SRZ)
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- Flights from Bata (BSG) to Santa Cruz (SRZ)
- Flights from Buenos Aires (BUE) to Santa Cruz (SRZ)
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- Flights from Cagliari (CAG) to Santa Cruz (SRZ)
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- Flights from Guangzhou (CAN) to Santa Cruz (SRZ)
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- Flights from Paris (CDG) to Santa Cruz (SRZ)
- Flights from Central (CEM) to Santa Cruz (SRZ)
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- Flights from Ciudad Del Carmen (CME) to Santa Cruz (SRZ)
- Flights from Copiapo (CPO) to Santa Cruz (SRZ)
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- Flights from The Dalles (DLS) to Santa Cruz (SRZ)
- Flights from Derby (DRB) to Santa Cruz (SRZ)
- Flights from Dublin (DUB) to Santa Cruz (SRZ)
- Flights from Dubai (DXB) to Santa Cruz (SRZ)
- Flights from Buenos Aires (EZE) to Santa Cruz (VVI)
- Flights from Flores (FRS) to Santa Cruz (SRZ)
- Flights from Gaya (GAY) to Santa Cruz (SRZ)
- Flights from Rio de Janeiro (GIG) to Santa Cruz (SRZ)
- Flights from Isla Baltra (GPS) to Santa Cruz (SRZ)
- Flights from São Paulo (GRU) to Santa Cruz (VVI)
- Flights from Gatokae (GTA) to Santa Cruz (SRZ)
- Flights from Guayaquil (GYE) to Santa Cruz (VVI)
- Flights from Freetown (HGS) to Santa Cruz (SRZ)
- Flights from Frankfurt (HHN) to Santa Cruz (SRZ)
- Flights from Khajuraho (HJR) to Santa Cruz (SRZ)
- Flights from Takaka (KTF) to Santa Cruz (SRZ)
- Flights from Las Vegas (LAS) to Santa Cruz (SRZ)
- Flights from Los Angeles (LAX) to Santa Cruz (VVI)
- Flights from London (LGW) to Santa Cruz (VVI)
- Flights from London (LHR) to Santa Cruz (SRZ)
- Flights from London (LHR) to Santa Cruz (VVI)
- Flights from Lima (LIM) to Santa Cruz (VVI)
- Flights from Ljubljana (LJU) to Santa Cruz (SRZ)
- Flights from London (LON) to Santa Cruz (VVI)
- Flights from La Paz (LPB) to Santa Cruz (VVI)
- Flights from Madrid (MAD) to Santa Cruz (SRZ)
- Flights from Madrid (MAD) to Santa Cruz (VVI)
- Flights from Manchester (MAN) to Santa Cruz (VVI)
- Flights from Orlando (MCO) to Santa Cruz (SRZ)
- Flights from Managua (MGA) to Santa Cruz (SRZ)
- Flights from Nuremberg (NUE) to Santa Cruz (SRZ)
- Flights from Oakland (ODM) to Santa Cruz (SRZ)
- Flights from Orlando (ORL) to Santa Cruz (SRZ)
- Flights from Panama City (PAC) to Santa Cruz (SRZ)
- Flights from Punta Islita (PBP) to Santa Cruz (SRZ)
- Flights from Potosi (POI) to Santa Cruz (SRZ)
- Flights from Panama City (PTY) to Santa Cruz (SRZ)
- Flights from Puerto Vallarta (PVR) to Santa Cruz (SRZ)
- Flights from Dallas (RBD) to Santa Cruz (SRZ)
- Flights from Resende (REZ) to Santa Cruz (SRZ)
- Flights from Riberalta (RIB) to Santa Cruz (SRZ)
- Flights from San Diego (SAN) to Santa Cruz (SRZ)
- Flights from Santa Ana del Yacuma (SBL) to Santa Cruz (SRZ)
- Flights from Stockton (SCK) to Santa Cruz (SRZ)
- Flights from Santiago (SCL) to Santa Cruz (SRZ)
- Flights from San Francisco (SFO) to Santa Cruz (SRZ)
- Flights from San Francisco (SFO) to Santa Cruz (VVI)
- Flights from Springfield (SGF) to Santa Cruz (SRZ)
- Flights from San Juan (SJU) to Santa Cruz (SRZ)
- Flights from Salt Lake City (SLC) to Santa Cruz (SRZ)
- Flights from Santa Maria (SMX) to Santa Cruz (SRZ)
- Flights from Alcantarí Intl. Airport (SRE) to Santa Cruz (SRZ)
- Flights from Sydney (SYD) to Santa Cruz (SRZ)
- Flights from Trinidad (TDD) to Santa Cruz (SRZ)
- Flights from Tarija (TJA) to Santa Cruz (SRZ)
- Flights from Tsushima (TSJ) to Santa Cruz (SRZ)
- Flights from Lake Tahoe (TVL) to Santa Cruz (SRZ)
- Flights from Ulaangom (ULO) to Santa Cruz (SRZ)
- Flights from Upolu Point (UPP) to Santa Cruz (SRZ)
- Flights from Uyuni (UYU) to Santa Cruz (VVI)
- Flights from Veracruz (VER) to Santa Cruz (SRZ)
- Flights from Van Nuys (VNY) to Santa Cruz (SRZ)
- Flights from Mayo (YMA) to Santa Cruz (SRZ)
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.
