Title: Holiday Rentals Santa Cruz from £28: Find Short-Term Rentals & Holiday Accommodations | Expedia.co.uk [Santa Cruz Hotels](https://expedia.co.uk/Destinations-In-Santa-Cruz.d6297178.Hotel-Destinations)[Santa Cruz Flights](https://expedia.co.uk/Destinations-In-Santa-Cruz.d6297178.Flight-Destinations)[Santa Cruz Car Hire](https://expedia.co.uk/Destinations-In-Santa-Cruz.d6297178.Car-Hire-Destinations)[Santa Cruz Holidays](https://expedia.co.uk/Santa-Cruz.d6297178.Holidays-City-Breaks) ![San Lorenzo Cathedral showing a garden](https://images.trvl-media.com/place/6098830/62a42b3d-1dbd-4a81-8566-cea655ebca33.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Search Holiday Rentals in Santa Cruz - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Santa Cruz Accommodation: Most Popular Cities to Stay ![San Lorenzo Cathedral showing a garden](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/115000/115563-Santa-Cruz.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Santa Cruz [](https://expedia.co.uk/Santa-Cruz-Holiday-Rentals.d6053940.Travel-Guide-HolidayRentals) ![](https://mediaim.expedia.com/destination/2/06496d3cec9b6cad4a738ddeb6156d1c.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Samaipata [](https://expedia.co.uk/Samaipata-Holiday-Rentals.d6200976.Travel-Guide-HolidayRentals) ## Our top choices for Santa Cruz holiday rentals ![Business Apartment, Terrace (Plus) | Terrace/patio](https://images.trvl-media.com/lodging/6000000/5930000/5928300/5928237/e5844260.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business Apartment, Terrace (Plus) | 1 bedroom, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/6000000/5930000/5928300/5928237/bb64c9e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Apartment, Terrace | Private kitchen | Fridge, microwave, stovetop, dishwasher](https://images.trvl-media.com/lodging/6000000/5930000/5928300/5928237/cb07702a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/6000000/5930000/5928300/5928237/b0eabde8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Santa Cruz [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Apart-Hotel-Premium-Suites-Santa-Cruz.h5928237.Hotel-Information) 8.6/10 Excellent (93) "Come and go easily, intellectual and kind owners who are working hard to make the property improvements that will bring this hotel up to the next level. A family friendly environment with easy walking distance to everything you need. Bed was not the best, but I know they are upgrading so I appreciate the ongoing process. For a few nights stay, the deals are very fair prices. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Andrew [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Apart-Hotel-Premium-Suites-Santa-Cruz.h5928237.Hotel-Information) ![Outdoor pool, open 9:00 AM to 8:00 PM, pool loungers](https://images.trvl-media.com/lodging/25000000/24410000/24404300/24404225/12ef5e8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast (USD 2.40 per person)](https://images.trvl-media.com/lodging/25000000/24410000/24404300/24404225/cbf735a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/25000000/24410000/24404300/24404225/9c72e6dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Panoramic Apartment, 1 King Bed with Sofa bed, Terrace | Premium bedding, down duvets, Tempur-Pedic beds, in-room safe](https://images.trvl-media.com/lodging/25000000/24410000/24404300/24404225/72a81d70.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Aparthotel in Santa Cruz [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Premium-Suites-Deluxe-Aparthotel-Equipetrol.h24404225.Hotel-Information) 9.0/10 Wonderful (81) "Good price, great hotel!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) James £29 18 Dec - 19 Dec [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Premium-Suites-Deluxe-Aparthotel-Equipetrol.h24404225.Hotel-Information) ![Standard Suite, 2 Single Beds | Hypo-allergenic bedding, down duvets, desk, laptop workspace](https://images.trvl-media.com/lodging/91000000/90600000/90599400/90599395/2b6207d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Suite | Living area | Printers](https://images.trvl-media.com/lodging/91000000/90600000/90599400/90599395/f61407b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/91000000/90600000/90599400/90599395/3e13fa51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Suite, 1 Queen Bed | Private kitchen | Mini-fridge, microwave, dishwasher, toaster](https://images.trvl-media.com/lodging/91000000/90600000/90599400/90599395/6f15dda8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Aparthotel in Santa Cruz [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Equipetrol-Suites-Apart-Hotel.h90599395.Hotel-Information) 8.4/10 Very good (7) "Perfect hotel" ![Turkey](https://a.travel-assets.com/egds/marks/flags/tr.svg) Yener £28 13 Jan - 14 Jan 2026 [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Equipetrol-Suites-Apart-Hotel.h90599395.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/11000000/10960000/10950300/10950250/1f2b7f07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Executive Twin Room | Premium bedding, down duvets, in-room safe, laptop workspace](https://images.trvl-media.com/lodging/11000000/10960000/10950300/10950250/0202a8df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Executive Apartment, 1 Bedroom | Premium bedding, down duvets, in-room safe, laptop workspace](https://images.trvl-media.com/lodging/11000000/10960000/10950300/10950250/4dc82f92.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/11000000/10960000/10950300/10950250/7e27a563.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Aparthotel in Santa Cruz [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Terranova-Suites.h10950250.Hotel-Information) 8.0/10 Very good (90) "Easy to access" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dorothy £35 24 Dec - 25 Dec [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Terranova-Suites.h10950250.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/121000000/120450000/120442100/120442096/e74af5c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Classic Apartment, City View | Desk, blackout curtains, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/121000000/120450000/120442100/120442096/c3714572.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic Area](https://images.trvl-media.com/lodging/121000000/120450000/120442100/120442096/w1125h1500x0y7-eed47d03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Classic Apartment, City View | Desk, blackout curtains, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/121000000/120450000/120442100/120442096/00e02072.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Santa Cruz [](https://www.expedia.co.uk/Santa-Cruz-Hotels-AMERICA-APARTMENTS.h120442096.Hotel-Information) £41 16 Dec - 17 Dec [](https://www.expedia.co.uk/Santa-Cruz-Hotels-AMERICA-APARTMENTS.h120442096.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/11000000/10040000/10032000/10031984/4f23dcbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/11000000/10040000/10032000/10031984/2d334027.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/11000000/10040000/10032000/10031984/0a98f99b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/11000000/10040000/10032000/10031984/c0d4ffcf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Aparthotel in Santa Cruz [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Apart-Hotel-Toborochi.h10031984.Hotel-Information) 8.8/10 Excellent (60) "Property is close to nice dining options and entertainment places in Santa Cruz. The room is confortable and spacious " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stefany [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Apart-Hotel-Toborochi.h10031984.Hotel-Information) ![House | Pool | Outdoor pool, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/16000000/15040000/15030900/15030862/cb1eeefb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Home in Santa Cruz [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Casa-Vida.h15030862.Hotel-Information) 9.0/10 Wonderful (2) "buena recepción, el lugar es muy bueno un poco alejado de la ciudad, falta comodidad en algunos aspectos pero la casa es grande y espaciosa" ![Chile](https://a.travel-assets.com/egds/marks/flags/cl.svg) FERNANDO [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Casa-Vida.h15030862.Hotel-Information) ![Pool](https://images.trvl-media.com/lodging/113000000/112790000/112789900/112789864/47db859c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/113000000/112790000/112789900/112789864/71cea0ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave](https://images.trvl-media.com/lodging/113000000/112790000/112789900/112789864/7576825b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/113000000/112790000/112789900/112789864/76d24755.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Santa Cruz de la Sierra [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Vrbo-Property.h112789864.Hotel-Information) £43 26 Dec - 27 Dec [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Vrbo-Property.h112789864.Hotel-Information) ![Pool](https://images.trvl-media.com/lodging/119000000/118520000/118517600/118517530/6663a26a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave, stovetop](https://images.trvl-media.com/lodging/119000000/118520000/118517600/118517530/cd3d8ec3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/119000000/118520000/118517600/118517530/ad376765.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave, stovetop](https://images.trvl-media.com/lodging/119000000/118520000/118517600/118517530/fa40047b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Santa Cruz de la Sierra [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Cozy-Studio-In-Enchanting-Santa-Cruz-De-La-Sierra-With-WiFi.h118517530.Hotel-Information) £35 16 Dec - 17 Dec [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Cozy-Studio-In-Enchanting-Santa-Cruz-De-La-Sierra-With-WiFi.h118517530.Hotel-Information) ![Pool](https://images.trvl-media.com/lodging/101000000/100290000/100284400/100284354/1c0d3586.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/101000000/100290000/100284400/100284354/6d55bdca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/101000000/100290000/100284400/100284354/43ed5064.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/101000000/100290000/100284400/100284354/9a14a6db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Condo in Santa Cruz de la Sierra [](https://www.expedia.co.uk/Santa-Cruz-Hotels-COMODO-MONOAMBIENTE-EN-EQUIPETROL-CON-PISCINA-EN-CONDOMINIO.h100284354.Hotel-Information) £53 16 Dec - 17 Dec [](https://www.expedia.co.uk/Santa-Cruz-Hotels-COMODO-MONOAMBIENTE-EN-EQUIPETROL-CON-PISCINA-EN-CONDOMINIO.h100284354.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/105000000/104270000/104261800/104261770/286c5800.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/105000000/104270000/104261800/104261770/080d90c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/105000000/104270000/104261800/104261770/w1440h1927x0y24-b8c75958.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool](https://images.trvl-media.com/lodging/105000000/104270000/104261800/104261770/f2651883.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Santa Cruz de la Sierra [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Dppto-Luminoso-Y-Lujoso-En-Equipe-Zona-Empresarial.h104261770.Hotel-Information) £52 16 Dec - 17 Dec [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Dppto-Luminoso-Y-Lujoso-En-Equipe-Zona-Empresarial.h104261770.Hotel-Information) ![Children’s area](https://images.trvl-media.com/lodging/103000000/102560000/102550900/102550831/81a819db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/103000000/102560000/102550900/102550831/6649134a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, hair dryer, towels, soap](https://images.trvl-media.com/lodging/103000000/102560000/102550900/102550831/6191ecc7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/103000000/102560000/102550900/102550831/8ef87fa2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Chalet in Santa Cruz de la Sierra [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Chalet-Indept.h102550831.Hotel-Information) £29 16 Dec - 17 Dec [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Chalet-Indept.h102550831.Hotel-Information) ![Living area](https://images.trvl-media.com/lodging/101000000/100980000/100979600/100979521/99089910.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/101000000/100980000/100979600/100979521/06f19d9a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/101000000/100980000/100979600/100979521/ada57e01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, electric kettle, blender](https://images.trvl-media.com/lodging/101000000/100980000/100979600/100979521/272f7d30.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Santa Cruz de la Sierra [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Travelers-Hideout.h100979521.Hotel-Information) 10/10 Exceptional (1) "The place was cozy, neat, and th host was very attentive and supportive. I recomend this place" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mauricio O. £40 16 Dec - 17 Dec [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Travelers-Hideout.h100979521.Hotel-Information) ![Apartment, 1 Bedroom, Accessible, Smoking | Exterior](https://images.trvl-media.com/lodging/106000000/105900000/105899800/105899783/cf1d467f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment, 1 Bedroom, Accessible, Smoking | Lounge](https://images.trvl-media.com/lodging/106000000/105900000/105899800/105899783/w2046h1360x2y3-cf85833e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment, 1 Bedroom, Accessible, Smoking | 1 bedroom](https://images.trvl-media.com/lodging/106000000/105900000/105899800/105899783/w2045h1360x3y3-9e64d794.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment, 1 Bedroom, Accessible, Smoking | Interior](https://images.trvl-media.com/lodging/106000000/105900000/105899800/105899783/167fc0c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Santa Cruz [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Buena-Vista-Rental-House.h105899783.Hotel-Information) [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Buena-Vista-Rental-House.h105899783.Hotel-Information) ![Pool](https://images.trvl-media.com/lodging/112000000/111740000/111734600/111734526/53688531.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/112000000/111740000/111734600/111734526/7e38476c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/112000000/111740000/111734600/111734526/bda32973.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/112000000/111740000/111734600/111734526/aaae0a59.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Santa Cruz de la Sierra [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Modern-2-Bedroom-Apartment-In-An-Exclusive-Building-In-Santa-Cruz.h111734526.Hotel-Information) [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Modern-2-Bedroom-Apartment-In-An-Exclusive-Building-In-Santa-Cruz.h111734526.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/118000000/117690000/117687800/117687703/643fec6d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/118000000/117690000/117687800/117687703/bdb54fab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Games room](https://images.trvl-media.com/lodging/118000000/117690000/117687800/117687703/5ceba07c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/118000000/117690000/117687800/117687703/6b46e3c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Santa Cruz de la Sierra [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Luxury-Apartment.h117687703.Hotel-Information) £37 16 Dec - 17 Dec [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Luxury-Apartment.h117687703.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/109000000/108060000/108056200/108056147/5af8579d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/109000000/108060000/108056200/108056147/0f570e73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, towels, toilet paper](https://images.trvl-media.com/lodging/109000000/108060000/108056200/108056147/09ebee18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/109000000/108060000/108056200/108056147/f2893bf6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Santa Cruz de la Sierra [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Apartamento-Confortable-Para-2-Personas.h108056147.Hotel-Information) £34 20 Dec - 21 Dec [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Apartamento-Confortable-Para-2-Personas.h108056147.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/113000000/112790000/112789500/112789433/f31789dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/113000000/112790000/112789500/112789433/6fa8d2d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/113000000/112790000/112789500/112789433/e1171f24.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool](https://images.trvl-media.com/lodging/113000000/112790000/112789500/112789433/09d9d05d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Santa Cruz de la Sierra [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Vrbo-Property.h112789433.Hotel-Information) £43 19 Dec - 20 Dec [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Vrbo-Property.h112789433.Hotel-Information) ![Basic Apartment, 3 Bedrooms | Living area | TV](https://images.trvl-media.com/lodging/109000000/108440000/108438700/108438680/a62553a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/109000000/108440000/108438700/108438680/12996667.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Soundproofing](https://images.trvl-media.com/lodging/109000000/108440000/108438700/108438680/5e910633.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment, 2 Bedrooms, Balcony, City View | Soundproofing](https://images.trvl-media.com/lodging/109000000/108440000/108438700/108438680/01e1f934.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Aparthotel in Santa Cruz [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Apartamentos-ARTECI.h108438680.Hotel-Information) [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Apartamentos-ARTECI.h108438680.Hotel-Information) ![TV](https://images.trvl-media.com/lodging/91000000/90330000/90324500/90324441/af1568a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/91000000/90330000/90324500/90324441/1f2fffdb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, WiFi](https://images.trvl-media.com/lodging/91000000/90330000/90324500/90324441/86be4d82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, oven, dishwasher, electric kettle](https://images.trvl-media.com/lodging/91000000/90330000/90324500/90324441/7272b045.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Home in Santa Cruz de la Sierra [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Furnished-Independent-House.h90324441.Hotel-Information) £42 16 Dec - 17 Dec [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Furnished-Independent-House.h90324441.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-12-29&endDate=2025-12-30®ionId=6297178&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Santa-Cruz.d6297178.Holiday-Rental-Destinations)[ Sign up, it's free ](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Santa-Cruz.d6297178.Holiday-Rental-Destinations) ## Top Santa Cruz Hotel Reviews ![Hotel LP Santa Cruz Centro](https://images.trvl-media.com/lodging/3000000/2770000/2761500/2761435/60285ad5_y.jpg) ### Hotel LP Santa Cruz Centro 10/10 Excellent "Clean rooms, well kept facilities and nice staff" [](https://expedia.co.uk/Santa-Cruz-Hotels-Hotel-LP-Santa-Cruz-Centro.h2761435.Hotel-Information) ![Ibis Santa Cruz DE LA Sierra](https://images.trvl-media.com/lodging/88000000/87140000/87138700/87138613/53c67151_y.jpg) ### Ibis Santa Cruz DE LA Sierra 10/10 Excellent "Well kept. Clean, great staff! " [](https://expedia.co.uk/Santa-Cruz-Hotels-Ibis-Santa-Cruz-DE-LA-Sierra.h87138613.Hotel-Information) ![Sun Hotel](https://images.trvl-media.com/lodging/13000000/12840000/12836300/12836211/d021f216_y.jpg) ### Sun Hotel 10/10 Excellent "spotless" [](https://expedia.co.uk/Santa-Cruz-Hotels-Sun-Hotel.h12836211.Hotel-Information) ![Marriott Santa Cruz de la Sierra Hotel](https://images.trvl-media.com/lodging/22000000/21500000/21490300/21490226/a95726cf_y.jpg) ### Marriott Santa Cruz de la Sierra Hotel 10/10 Excellent "Muy bien exelente" [](https://expedia.co.uk/Santa-Cruz-Hotels-Marriott-Santa-Cruz-De-La-Sierra-Hotel.h21490226.Hotel-Information) ![HOTEL OSHO](https://images.trvl-media.com/lodging/76000000/75260000/75254900/75254801/286f65b1_y.jpg) ### HOTEL OSHO 10/10 Excellent "Hot tub worked well and room was very comfortable! 24 hr market across the street came in handy. The best hotel I've stayed at in Bolivia!" [](https://expedia.co.uk/Santa-Cruz-Hotels-HOTEL-OSHO.h75254801.Hotel-Information) ![Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel](https://images.trvl-media.com/lodging/1000000/20000/18800/18758/bb34bb1f_y.jpg) ### Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel 10/10 Excellent "Everything was absolutely amazing, from the second we arrived to the last day. The service, the room, the property. I always come back to this Hotel time after time. Thank you for all you do to make us feel at home while we’re there " [](https://expedia.co.uk/Santa-Cruz-Hotels-Los-Tajibos-Hotel-And-Convention-Center.h18758.Hotel-Information) ![Camino Real Hotel](https://images.trvl-media.com/lodging/1000000/450000/444500/444475/e96a8418_y.jpg) ### Camino Real Hotel 10/10 Excellent "Excellent hotel, I willl always used it in this location " [](https://expedia.co.uk/Santa-Cruz-Hotels-Camino-Real-Hotel.h444475.Hotel-Information) ![Chairú Eco Hotel](https://images.trvl-media.com/lodging/83000000/82390000/82389700/82389693/a88a9ace_y.jpg) ### Chairú Eco Hotel 10/10 Excellent "Clean and close to the malls and restaurants " [](https://expedia.co.uk/Santa-Cruz-Hotels-Chairu-Eco-Hotel.h82389693.Hotel-Information) ![Lido Hotel](https://images.trvl-media.com/lodging/99000000/98240000/98237600/98237549/da03536f_y.jpg) ### Lido Hotel 10/10 Excellent "The room was clean and comfortable; breakfast was a hot & cold buffet to meet most people’s requirements. It is located a short walk from the main square." [](https://expedia.co.uk/Santa-Cruz-Hotels-Hotel-Lido.h98237549.Hotel-Information) ## Find out more about Santa Cruz **Everything you need to know about** **Santa Cruz** **holiday rentals** Whether you’re excited for the perfect family holiday, a romantic getaway for two, or the ultimate city break, we’ve got the Santa Cruz holiday rental for you. At Expedia, you can take your pick from private holiday homes, [apartments](https://www.expedia.co.uk/aa/Apartments), cottages, [apart-hotels](https://www.expedia.co.uk/aa/ApartHotels), cabins, [villas](https://www.expedia.co.uk/aa/Villas)... The list goes on, and on… and on! There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Santa Cruz holiday rental for you by simply entering your desired dates. Then check your favourite filters to narrow down your search. **Santa Cruz holiday rentals: An excellent choice for every season** Whenever you want to travel, a warm welcome awaits you in Santa Cruz. If you’re looking for a little peace, consider booking during the quieter months, such as . For more hustle and bustle, you may prefer to visit in . Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Santa Cruz holiday rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a holiday rental with multiple bedrooms and shared living spaces to kick back in. The selection of Santa Cruz holiday rentals we have selected for you start as low as £28 per night. Entering your travel dates in the search wizard you might find even better deals! **How to find incredible deals on Santa Cruz rentals** At Expedia, we put the best Santa Cruz holiday rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. To find some top Santa Cruz rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Santa Cruz holiday. If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Santa Cruz. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence. ## Explore a world of travel with Expedia - Popular Santa Cruz Cities - [Santa Cruz Holiday Rentals ](https://expedia.co.uk/Santa-Cruz-Holiday-Rentals.d6053940.Travel-Guide-HolidayRentals) - [Samaipata Holiday Rentals ](https://expedia.co.uk/Samaipata-Holiday-Rentals.d6200976.Travel-Guide-HolidayRentals) - [Warnes Holiday Rentals ](https://expedia.co.uk/Warnes-Holiday-Rentals.d6352296.Travel-Guide-HolidayRentals)