Title: Holiday Rentals Santa Cruz from £29: Find Short-Term Rentals & Holiday Accommodations | Expedia.co.uk [Santa Cruz Hotels](https://expedia.co.uk/Destinations-In-Santa-Cruz.d6297178.Hotel-Destinations)[Santa Cruz Flights](https://expedia.co.uk/Destinations-In-Santa-Cruz.d6297178.Flight-Destinations)[Santa Cruz Car Hire](https://expedia.co.uk/Destinations-In-Santa-Cruz.d6297178.Car-Hire-Destinations)[Santa Cruz Holidays](https://expedia.co.uk/Santa-Cruz.d6297178.Holidays-City-Breaks) ![San Lorenzo Cathedral featuring heritage elements, heritage architecture and a church or cathedral](https://images.trvl-media.com/place/6098830/d6a325c3-d504-4e1a-ab2b-0e430beefd40.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6098830/d6a325c3-d504-4e1a-ab2b-0e430beefd40.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Santa Cruz Accommodation: Most Popular Cities to Stay ![Mountain view in Samaipata, Florida Province of the Santa Cruz Department, Bolivia](https://images.trvl-media.com/place/6200976/99855abd-1497-49bc-91a5-ef76c4e902cb.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Samaipata [](https://expedia.co.uk/Samaipata-Holiday-Rentals.d6200976.Travel-Guide-HolidayRentals) ![San Lorenzo Cathedral showing a garden](https://images.trvl-media.com/place/6098830/62a42b3d-1dbd-4a81-8566-cea655ebca33.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Santa Cruz [](https://expedia.co.uk/Santa-Cruz-Holiday-Rentals.d6053940.Travel-Guide-HolidayRentals) ![Portrait of a Tobas warrior during carnival called The Devil Dance (La Diablada), Oruro, Bolivia](https://images.trvl-media.com/place/6352296/feec42f5-cbd9-4576-97cc-129e51391796.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Warnes [](https://expedia.co.uk/Warnes-Holiday-Rentals.d6352296.Travel-Guide-HolidayRentals) ## Our top choices for Santa Cruz holiday rentals ![Standard Suite, 1 Queen Bed | Hypo-allergenic bedding, down duvets, desk, laptop workspace](https://images.trvl-media.com/lodging/91000000/90600000/90599400/90599395/e2b53d65.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Suite, 1 Queen Bed | Private kitchen | Mini-fridge, microwave, dishwasher, toaster](https://images.trvl-media.com/lodging/91000000/90600000/90599400/90599395/e1ac9300.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Suite, 1 Queen Bed | Private kitchen | Mini-fridge, microwave, dishwasher, toaster](https://images.trvl-media.com/lodging/91000000/90600000/90599400/90599395/6f15dda8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/91000000/90600000/90599400/90599395/3e13fa51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Aparthotel in Santa Cruz [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Equipetrol-Suites-Apart-Hotel.h90599395.Hotel-Information) 8.8/10 Excellent (13 reviews) "Perfect hotel" ![Turkey](https://a.travel-assets.com/egds/marks/flags/tr.svg) Yener £39 7 Apr - 8 Apr [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Equipetrol-Suites-Apart-Hotel.h90599395.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/121000000/120450000/120442100/120442096/w1125h1510x0y0-a0234ee9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Classic Apartment, City View | Desk, blackout curtains, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/121000000/120450000/120442100/120442096/c3714572.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Classic Apartment, City View | Desk, blackout curtains, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/121000000/120450000/120442100/120442096/00e02072.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic Area](https://images.trvl-media.com/lodging/121000000/120450000/120442100/120442096/w1125h1500x0y7-eed47d03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Santa Cruz [](https://www.expedia.co.uk/Santa-Cruz-Hotels-AMERICA-APARTMENTS.h120442096.Hotel-Information) 10/10 Exceptional (1 review) "Clean room, great staff " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Peter £41 10 Mar - 11 Mar [](https://www.expedia.co.uk/Santa-Cruz-Hotels-AMERICA-APARTMENTS.h120442096.Hotel-Information) ![Outdoor pool, open 9:00 AM to 8:00 PM, pool loungers](https://images.trvl-media.com/lodging/25000000/24410000/24404300/24404225/b86b5103.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast (USD 2.40 per person)](https://images.trvl-media.com/lodging/25000000/24410000/24404300/24404225/e3b6b11f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Panoramic Apartment, 1 King Bed with Sofa bed, Terrace | Premium bedding, down duvets, Tempur-Pedic beds, in-room safe](https://images.trvl-media.com/lodging/25000000/24410000/24404300/24404225/3e7101b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/25000000/24410000/24404300/24404225/b5037c5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Aparthotel in Santa Cruz [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Premium-Suites-Deluxe-Aparthotel-Equipetrol.h24404225.Hotel-Information) 9.0/10 Wonderful (86 reviews) "Good price, great hotel!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) James £29 10 Mar - 11 Mar [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Premium-Suites-Deluxe-Aparthotel-Equipetrol.h24404225.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/104000000/103790000/103788400/103788309/b3756d0a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, blackout curtains, free WiFi, bed sheets](https://images.trvl-media.com/lodging/104000000/103790000/103788400/103788309/aa4340a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, blackout curtains, free WiFi, bed sheets](https://images.trvl-media.com/lodging/104000000/103790000/103788400/103788309/130e8dcb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/104000000/103790000/103788400/103788309/894e0ecb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cabin in Samaipata [](https://www.expedia.co.uk/Samaipata-Hotels-Samaipata-Glaming.h103788309.Hotel-Information) £176 11 Mar - 12 Mar [](https://www.expedia.co.uk/Samaipata-Hotels-Samaipata-Glaming.h103788309.Hotel-Information) ![Bar (on property)](https://images.trvl-media.com/lodging/11000000/10960000/10950300/10950250/7e27a563.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Mini-fridge, microwave, electric kettle, cookware/dishes/utensils](https://images.trvl-media.com/lodging/11000000/10960000/10950300/10950250/6fc90c50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/11000000/10960000/10950300/10950250/47df2d8c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Room | Living area | 32-inch flat-screen TV with cable channels](https://images.trvl-media.com/lodging/11000000/10960000/10950300/10950250/ffaa8f14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Aparthotel in Santa Cruz [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Terranova-Suites.h10950250.Hotel-Information) 8.0/10 Very good (90 reviews) "Easy to access" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dorothy £35 23 Mar - 24 Mar [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Terranova-Suites.h10950250.Hotel-Information) ![1 bedroom, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/6000000/5930000/5928300/5928237/9a481119.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/6000000/5930000/5928300/5928237/3d263a1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business Apartment, Terrace (Plus) | Terrace/patio](https://images.trvl-media.com/lodging/6000000/5930000/5928300/5928237/e5844260.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business Apartment, 2 Bedrooms (Plus) | In-room dining](https://images.trvl-media.com/lodging/6000000/5930000/5928300/5928237/db59d5da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Santa Cruz [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Apart-Hotel-Premium-Suites-Santa-Cruz.h5928237.Hotel-Information) 8.6/10 Excellent (99 reviews) "Yes, staff were very friendly " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) veronica [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Apart-Hotel-Premium-Suites-Santa-Cruz.h5928237.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/11000000/10040000/10032000/10031984/83c0e879.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/11000000/10040000/10032000/10031984/912c7493.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/11000000/10040000/10032000/10031984/c0d4ffcf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor spa tub](https://images.trvl-media.com/lodging/11000000/10040000/10032000/10031984/809a343e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Aparthotel in Santa Cruz [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Apart-Hotel-Toborochi.h10031984.Hotel-Information) 8.8/10 Excellent (60 reviews) "Very comfortable and quiet place and very good location. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Luis [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Apart-Hotel-Toborochi.h10031984.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/120000000/119980000/119976800/119976771/w1290h2293x0y251-5b08e5b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/120000000/119980000/119976800/119976771/edb1b53e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hair dryer, towels, toilet paper](https://images.trvl-media.com/lodging/120000000/119980000/119976800/119976771/f6e53b9b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/120000000/119980000/119976800/119976771/21992b29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Santa Cruz de la Sierra [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Vrbo-Property.h119976771.Hotel-Information) 8.0/10 Very good (1 review) "Muy buen departamento, bien ubicado" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Elva £47 10 Mar - 11 Mar [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Vrbo-Property.h119976771.Hotel-Information) ![1 bedroom, free WiFi](https://images.trvl-media.com/lodging/101000000/100980000/100979600/100979521/9c6cc778.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/101000000/100980000/100979600/100979521/b5dde86c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, electric kettle, blender](https://images.trvl-media.com/lodging/101000000/100980000/100979600/100979521/27ac2eed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/101000000/100980000/100979600/100979521/ada57e01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Santa Cruz de la Sierra [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Travelers-Hideout.h100979521.Hotel-Information) 10/10 Exceptional (1 review) "The place was cozy, neat, and th host was very attentive and supportive. I recomend this place" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mauricio O. £60 10 Mar - 11 Mar [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Travelers-Hideout.h100979521.Hotel-Information) ![Pool](https://images.trvl-media.com/lodging/123000000/122870000/122865200/122865145/1b6db924.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/123000000/122870000/122865200/122865145/55cf49f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/123000000/122870000/122865200/122865145/d11c7efc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/123000000/122870000/122865200/122865145/85781538.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Santa Cruz de la Sierra [](https://www.expedia.co.uk/Santa-Cruz-Hotels-POX-24th-Floor-Green-Tower-Luxury-And-Panoramic-View.h122865145.Hotel-Information) £65 10 Mar - 11 Mar [](https://www.expedia.co.uk/Santa-Cruz-Hotels-POX-24th-Floor-Green-Tower-Luxury-And-Panoramic-View.h122865145.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/105000000/104270000/104261800/104261770/fdb44263.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/105000000/104270000/104261800/104261770/w1440h1583x0y0-5b3fde27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Spa](https://images.trvl-media.com/lodging/105000000/104270000/104261800/104261770/w1440h1049x0y0-23015e62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/105000000/104270000/104261800/104261770/w1440h1927x0y24-b8c75958.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Santa Cruz de la Sierra [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Dppto-Luminoso-Y-Lujoso-En-Equipe-Zona-Empresarial.h104261770.Hotel-Information) £51 10 Mar - 11 Mar [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Dppto-Luminoso-Y-Lujoso-En-Equipe-Zona-Empresarial.h104261770.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/101000000/100290000/100284400/100284354/6d55bdca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/101000000/100290000/100284400/100284354/43ed5064.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool](https://images.trvl-media.com/lodging/101000000/100290000/100284400/100284354/1c0d3586.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, stovetop, electric kettle](https://images.trvl-media.com/lodging/101000000/100290000/100284400/100284354/d7013903.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Condo in Santa Cruz de la Sierra [](https://www.expedia.co.uk/Santa-Cruz-Hotels-COMODO-MONOAMBIENTE-EN-EQUIPETROL-CON-PISCINA-EN-CONDOMINIO.h100284354.Hotel-Information) £53 10 Mar - 11 Mar [](https://www.expedia.co.uk/Santa-Cruz-Hotels-COMODO-MONOAMBIENTE-EN-EQUIPETROL-CON-PISCINA-EN-CONDOMINIO.h100284354.Hotel-Information) ![Pool](https://images.trvl-media.com/lodging/118000000/117690000/117687800/117687703/0ab047ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Games room](https://images.trvl-media.com/lodging/118000000/117690000/117687800/117687703/5ceba07c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/118000000/117690000/117687800/117687703/643fec6d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/118000000/117690000/117687800/117687703/bdb54fab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Santa Cruz de la Sierra [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Luxury-Apartment.h117687703.Hotel-Information) £37 10 Mar - 11 Mar [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Luxury-Apartment.h117687703.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/40000000/39200000/39191300/39191276/b0b12908.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Comfort Apartment | In-room safe, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/40000000/39200000/39191300/39191276/5afb2720.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Comfort Apartment | Living room | 42-inch Smart TV with cable channels, TV, Netflix](https://images.trvl-media.com/lodging/40000000/39200000/39191300/39191276/e3241ef3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Children’s activities](https://images.trvl-media.com/lodging/40000000/39200000/39191300/39191276/7ea6ea10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Santa Cruz [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Santos-Apartamentos.h39191276.Hotel-Information) £110 15 Mar - 16 Mar [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Santos-Apartamentos.h39191276.Hotel-Information) ![Dining](https://images.trvl-media.com/lodging/113000000/112830000/112829600/112829576/89a86d54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/113000000/112830000/112829600/112829576/08ad0327.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/113000000/112830000/112829600/112829576/5c4a14d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/113000000/112830000/112829600/112829576/3e497282.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Santa Cruz de la Sierra [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Cozy-2-Bedroom-Apartment-With-AC.h112829576.Hotel-Information) £40 13 Mar - 14 Mar [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Cozy-2-Bedroom-Apartment-With-AC.h112829576.Hotel-Information) ![Dining](https://images.trvl-media.com/lodging/91000000/90330000/90324500/90324441/w689h954x0y0-7d2c5be0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/91000000/90330000/90324500/90324441/bde12cb9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, WiFi](https://images.trvl-media.com/lodging/91000000/90330000/90324500/90324441/0169c880.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, oven, dishwasher, electric kettle](https://images.trvl-media.com/lodging/91000000/90330000/90324500/90324441/7272b045.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Home in Santa Cruz de la Sierra [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Furnished-Independent-House.h90324441.Hotel-Information) £41 10 Mar - 11 Mar [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Furnished-Independent-House.h90324441.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/114000000/113960000/113955300/113955297/9c745b9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/114000000/113960000/113955300/113955297/ee5e58e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/114000000/113960000/113955300/113955297/91978058.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/114000000/113960000/113955300/113955297/46d56e16.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Santa Cruz de la Sierra [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Lujo-Y-Confort-En-Zona-Exclusiva.h113955297.Hotel-Information) £44 10 Mar - 11 Mar [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Lujo-Y-Confort-En-Zona-Exclusiva.h113955297.Hotel-Information) ![Living area](https://images.trvl-media.com/lodging/109000000/108060000/108056200/108056147/0f570e73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, towels, toilet paper](https://images.trvl-media.com/lodging/109000000/108060000/108056200/108056147/09ebee18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/109000000/108060000/108056200/108056147/7409bf98.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/109000000/108060000/108056200/108056147/2254dc50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Santa Cruz de la Sierra [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Apartamento-Confortable-Para-2-Personas.h108056147.Hotel-Information) £34 13 Mar - 14 Mar [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Apartamento-Confortable-Para-2-Personas.h108056147.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/98000000/97250000/97247500/97247414/fbbf5c62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, coffee/tea maker, cookware/dishes/utensils](https://images.trvl-media.com/lodging/98000000/97250000/97247500/97247414/d44635cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/98000000/97250000/97247500/97247414/a66dc8d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/98000000/97250000/97247500/97247414/2b7e7464.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Santa Cruz de la Sierra [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Beautiful-Loft-In-A-Brand-New-Condo.h97247414.Hotel-Information) £48 21 Mar - 22 Mar [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Beautiful-Loft-In-A-Brand-New-Condo.h97247414.Hotel-Information) ![Pool](https://images.trvl-media.com/lodging/119000000/118520000/118517600/118517530/6663a26a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/119000000/118520000/118517600/118517530/ad376765.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/119000000/118520000/118517600/118517530/f8c2e918.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/119000000/118520000/118517600/118517530/w1257h960x23y0-1ca3484e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Santa Cruz de la Sierra [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Cozy-Studio-In-Enchanting-Santa-Cruz-De-La-Sierra-With-WiFi.h118517530.Hotel-Information) £38 10 Mar - 11 Mar [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Cozy-Studio-In-Enchanting-Santa-Cruz-De-La-Sierra-With-WiFi.h118517530.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-03-23&endDate=2026-03-24®ionId=6297178&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-uk-fr-de.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Holiday Sale Members save up to 40% on hotels and holiday homes. Plan this year’s big trip and save. [Book now](https://expedia.co.uk/cheap-deals?rfrr=VR_SPRING_PROMO_6297178) ## Find holiday rentals that suit your style Private holiday homes [](https://www.expedia.co.uk/Hotel-Search?destination=Santa+Cruz%2C+Bolivia®ionId=6297178&latLong=-17.783494%2C-63.182085&adults=2&startDate=2026-06-07&d1=2026-06-07&endDate=2026-06-10&d2=2026-06-10&lodging=VACATION_HOME) Apartments [](https://www.expedia.co.uk/Hotel-Search?destination=Santa+Cruz%2C+Bolivia®ionId=6297178&latLong=-17.783494%2C-63.182085&adults=2&startDate=2026-06-07&d1=2026-06-07&endDate=2026-06-10&d2=2026-06-10&lodging=APARTMENT) Aparthotels [](https://www.expedia.co.uk/Hotel-Search?destination=Santa+Cruz%2C+Bolivia®ionId=6297178&latLong=-17.783494%2C-63.182085&adults=2&startDate=2026-06-07&d1=2026-06-07&endDate=2026-06-10&d2=2026-06-10&lodging=APART_HOTEL) Condos [](https://www.expedia.co.uk/Hotel-Search?destination=Santa+Cruz%2C+Bolivia®ionId=6297178&latLong=-17.783494%2C-63.182085&adults=2&startDate=2026-06-07&d1=2026-06-07&endDate=2026-06-10&d2=2026-06-10&lodging=CONDO) Cabins [](https://www.expedia.co.uk/Hotel-Search?destination=Santa+Cruz%2C+Bolivia®ionId=6297178&latLong=-17.783494%2C-63.182085&adults=2&startDate=2026-06-07&d1=2026-06-07&endDate=2026-06-10&d2=2026-06-10&lodging=CABIN) Chalets [](https://www.expedia.co.uk/Hotel-Search?destination=Santa+Cruz%2C+Bolivia®ionId=6297178&latLong=-17.783494%2C-63.182085&adults=2&startDate=2026-06-07&d1=2026-06-07&endDate=2026-06-10&d2=2026-06-10&lodging=CHALET) Cottages [](https://www.expedia.co.uk/Hotel-Search?destination=Santa+Cruz%2C+Bolivia®ionId=6297178&latLong=-17.783494%2C-63.182085&adults=2&startDate=2026-06-07&d1=2026-06-07&endDate=2026-06-10&d2=2026-06-10&lodging=COTTAGE) Houseboats [](https://www.expedia.co.uk/Hotel-Search?destination=Santa+Cruz%2C+Bolivia®ionId=6297178&latLong=-17.783494%2C-63.182085&adults=2&startDate=2026-06-07&d1=2026-06-07&endDate=2026-06-10&d2=2026-06-10&lodging=HOUSE_BOAT) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Santa-Cruz.d6297178.Holiday-Rental-Destinations)[ Sign up, it's free ](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Santa-Cruz.d6297178.Holiday-Rental-Destinations) ## Top Santa Cruz Hotel Reviews ![Ibis Santa Cruz DE LA Sierra](https://images.trvl-media.com/lodging/88000000/87140000/87138700/87138613/03d4f9ed_y.jpg) ### Ibis Santa Cruz DE LA Sierra 10/10 Excellent "Good " [](https://expedia.co.uk/Santa-Cruz-Hotels-Ibis-Santa-Cruz-DE-LA-Sierra.h87138613.Hotel-Information) ![Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel](https://images.trvl-media.com/lodging/1000000/20000/18800/18758/ce43592e_y.jpg) ### Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel 10/10 Excellent "Yes" [](https://expedia.co.uk/Santa-Cruz-Hotels-Los-Tajibos-Hotel-And-Convention-Center.h18758.Hotel-Information) ![Hampton by Hilton Santa Cruz/Equipetrol, Bolivia](https://images.trvl-media.com/lodging/14000000/13180000/13179500/13179436/65fab765_y.jpg) ### Hampton by Hilton Santa Cruz/Equipetrol, Bolivia 6/10 Okay "The room was clean, breakfast was standard for South America and the staff were great. However, the bed was advertised as a queen and it was a double bed. The rolling desk chair on the tile floor is a serious accident waiting to happen. I enjoyed the views from the rooftop buffet. " [](https://expedia.co.uk/Santa-Cruz-Hotels-Hampton-By-Hilton-Santa-Cruz.h13179436.Hotel-Information) ![Novotel Santa Cruz De La Sierra](https://images.trvl-media.com/lodging/70000000/69570000/69566300/69566260/efe5b8af_y.jpg) ### Novotel Santa Cruz De La Sierra 10/10 Excellent "Quarto, restaurant, equipe" [](https://expedia.co.uk/Santa-Cruz-Hotels-Novotel-Santa-Cruz-De-La-Sierra.h69566260.Hotel-Information) ![Sun Hotel](https://images.trvl-media.com/lodging/13000000/12840000/12836300/12836211/c21617f6_y.jpg) ### Sun Hotel 8/10 Good "Yes was good " [](https://expedia.co.uk/Santa-Cruz-Hotels-Sun-Hotel.h12836211.Hotel-Information) ![Swissôtel Santa Cruz De La Sierra](https://images.trvl-media.com/lodging/61000000/60340000/60335700/60335614/6b27e04a_y.jpg) ### Swissôtel Santa Cruz De La Sierra 10/10 Excellent "Great room, spacious, quiet and the shower was great" [](https://expedia.co.uk/Santa-Cruz-Hotels-Swissotel-Santa-Cruz-De-La-Sierra.h60335614.Hotel-Information) ![Marriott Santa Cruz de la Sierra Hotel](https://images.trvl-media.com/lodging/22000000/21500000/21490300/21490226/02f3d22f_y.jpg) ### Marriott Santa Cruz de la Sierra Hotel 6/10 Okay "Mattress was hard, pillows flattened, no microwave and fridge was not cooling. Other than that, the personnel were 5 stars, friendly attentive and respectful. " [](https://expedia.co.uk/Santa-Cruz-Hotels-Marriott-Santa-Cruz-De-La-Sierra-Hotel.h21490226.Hotel-Information) ![Chairú Eco Hotel](https://images.trvl-media.com/lodging/83000000/82390000/82389700/82389693/a88a9ace_y.jpg) ### Chairú Eco Hotel 10/10 Excellent "I had room 29, a double bed with balcony. It was beautiful, modern, clean, and in a quiet area but only a couple blocks to restaurants. The breakfast is modest but satisfactory. To the hotel, I would suggest putting electric kettles in each room. I, as well as others, would use this to boil water and not have to rely on bottled water. Just a thought for an "eco" hotel." [](https://expedia.co.uk/Santa-Cruz-Hotels-Chairu-Eco-Hotel.h82389693.Hotel-Information) ![Prince Hotel](https://images.trvl-media.com/lodging/118000000/117980000/117976200/117976126/db53d748_y.jpg) ### Prince Hotel 10/10 Excellent "Nice place " [](https://expedia.co.uk/Santa-Cruz-Hotels-Prince-Hotel.h117976126.Hotel-Information) ## Find out more about Santa Cruz **Everything you need to know about** **Santa Cruz** **holiday rentals** Whether you’re excited for the perfect family holiday, a romantic getaway for two, or the ultimate city break, we’ve got the Santa Cruz holiday rental for you. At Expedia, you can take your pick from private holiday homes, [apartments](https://www.expedia.co.uk/aa/Apartments), cottages, [apart-hotels](https://www.expedia.co.uk/aa/ApartHotels), cabins, [villas](https://www.expedia.co.uk/aa/Villas)... The list goes on, and on… and on! There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Santa Cruz holiday rental for you by simply entering your desired dates. Then check your favourite filters to narrow down your search. **Santa Cruz holiday rentals: An excellent choice for every season** Whenever you want to travel, a warm welcome awaits you in Santa Cruz. If you’re looking for a little peace, consider booking during the quieter months, such as . For more hustle and bustle, you may prefer to visit in . Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Santa Cruz holiday rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a holiday rental with multiple bedrooms and shared living spaces to kick back in. The selection of Santa Cruz holiday rentals we have selected for you start as low as £29 per night. Entering your travel dates in the search wizard you might find even better deals! **How to find incredible deals on Santa Cruz rentals** At Expedia, we put the best Santa Cruz holiday rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. To find some top Santa Cruz rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Santa Cruz holiday. If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Santa Cruz. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence. ## Explore a world of travel with Expedia - Popular Santa Cruz Cities - [Santa Cruz Holiday Rentals ](https://expedia.co.uk/Santa-Cruz-Holiday-Rentals.d6053940.Travel-Guide-HolidayRentals) - [Samaipata Holiday Rentals ](https://expedia.co.uk/Samaipata-Holiday-Rentals.d6200976.Travel-Guide-HolidayRentals) - [Warnes Holiday Rentals ](https://expedia.co.uk/Warnes-Holiday-Rentals.d6352296.Travel-Guide-HolidayRentals) ### Expedia's Latest Trends Hotels - [Galápagos Accommodation](https://expedia.co.uk/Destinations-In-Galapagos.d1371.Hotel-Destinations) - [All-Inclusive Hotels in Rio de Janeiro State](https://expedia.co.uk/Destinations-In-Rio-De-Janeiro-State-All-Inclusive-Hotel.0-0-d6052641-tAllInclusiveHotel.Hotel-Filter-Destinations) Flights - [Cheap Flights to São Paulo State](https://expedia.co.uk/Destinations-In-Sao-Paulo-State.d6052648.Flight-Destinations) - [Cheap Flights to Florida](https://expedia.co.uk/Destinations-In-Florida.d6278083.Flight-Destinations) - [Cheap Flights to Tierra del Fuego Province](https://expedia.co.uk/Destinations-In-Tierra-Del-Fuego-Province.d6208785.Flight-Destinations) - [Cheap Flights to Galápagos](https://expedia.co.uk/Destinations-In-Galapagos.d1371.Flight-Destinations) - [Cheap Flights to Bahia State](https://expedia.co.uk/Destinations-In-Bahia-State.d6052623.Flight-Destinations) - [Flights to SRZ](https://expedia.co.uk/Cheap-Flights-To-Santa-Cruz.d6053940.Travel-Guide-Flights) - [Cheap Flights to Cusco Region](https://expedia.co.uk/Destinations-In-Cusco-Region.d6235224.Flight-Destinations) - [Cheap Flights to Rio de Janeiro State](https://expedia.co.uk/Destinations-In-Rio-De-Janeiro-State.d6052641.Flight-Destinations) Activities - [Things to do in Rio de Janeiro State](https://expedia.co.uk/Things-To-Do-In-Rio-De-Janeiro-State.d6052641.Travel-Guide-Activities) Packages - [Florida City Breaks](https://expedia.co.uk/Florida.d6278083.Holidays-City-Breaks) - [Bahia State City Breaks](https://expedia.co.uk/Bahia-State.d6052623.Holidays-City-Breaks) - [Santa Catarina City Breaks](https://expedia.co.uk/Santa-Catarina.d6052646.Holidays-City-Breaks) - [Alagoas City Breaks](https://expedia.co.uk/Alagoas.d6052620.Holidays-City-Breaks) - [Warnes City Breaks](https://expedia.co.uk/Warnes.d6352296.Holidays-City-Breaks) - [Galápagos City Breaks](https://expedia.co.uk/Galapagos.d1371.Holidays-City-Breaks) General - [Visit La Paz](https://expedia.co.uk/La-Paz.dx6297090) - [Visit Potosi](https://expedia.co.uk/Potosi.dx6297171) - [Visit Catamarca Province](https://expedia.co.uk/Catamarca-Province.dx6232516) - [Visit Santa Cruz](https://expedia.co.uk/Santa-Cruz.dx6053940) - [Visit La Pampa Province](https://expedia.co.uk/La-Pampa-Province.dx6232299) - [Visit Morona Santiago](https://expedia.co.uk/Morona-Santiago.dx6239604) - [Visit Jujuy Province](https://expedia.co.uk/Jujuy-Province.dx6232492) - [Visit Santa Fe Province](https://expedia.co.uk/Santa-Fe-Province.dx6232320) - [Visit Paraná](https://expedia.co.uk/Parana.dx6052638) - [Visit Mato Grosso do Sul](https://expedia.co.uk/Mato-Grosso-Do-Sul.dx6052631) - [Visit Magallanes y Antartica Chilena](https://expedia.co.uk/Magallanes-Y-Antartica-Chilena.dx6236290) - [Visit Santa Catarina](https://expedia.co.uk/Santa-Catarina.dx6052646) - [Visit Rio Grande do Sul](https://expedia.co.uk/Rio-Grande-Do-Sul.dx6052643)