Title: The 10 Best 5 Star Hotels in Santa Cruz - 2026 Updated Prices | Expedia.co.uk [Santa Cruz Travel Guide](https://expedia.co.uk/Santa-Cruz.dx6053940)[Hotels in Santa Cruz](https://expedia.co.uk/Santa-Cruz-Hotels.d6053940.Travel-Guide-Hotels)[Holiday Rentals in Santa Cruz](https://expedia.co.uk/Santa-Cruz-Holiday-Rentals.d6053940.Travel-Guide-HolidayRentals)[Flights to Santa Cruz](https://expedia.co.uk/Cheap-Flights-To-Santa-Cruz.d6053940.Travel-Guide-Flights)[Things to do in Santa Cruz](https://expedia.co.uk/Things-To-Do-In-Santa-Cruz.d6053940.Travel-Guide-Activities)[Santa Cruz Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Santa-Cruz.d6053940.Car-Hire-Guide)[Santa Cruz Holidays](https://expedia.co.uk/Santa-Cruz.d6053940.Holidays-City-Breaks) ![Santa Cruz](https://images.trvl-media.com/place/6053940/e11e6ae8-6b64-413c-ab96-4d4a810c4d57.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Compare and book 5 Star hotels in Santa Cruz, Santa Cruz - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Santa Cruz 5 Star Hotels Tonight [9 Jan - 10 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6053940&startDate=2026-01-09&endDate=2026-01-10&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [10 Jan - 11 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6053940&startDate=2026-01-10&endDate=2026-01-11&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [9 Jan - 11 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6053940&startDate=2026-01-09&endDate=2026-01-11&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [16 Jan - 18 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6053940&startDate=2026-01-16&endDate=2026-01-18&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Santa Cruz 5-star hotels ![Outdoor pool, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/22000000/21500000/21490300/21490226/02f3d22f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; international cuisine ](https://images.trvl-media.com/lodging/22000000/21500000/21490300/21490226/e8e161c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/22000000/21500000/21490300/21490226/00c20228.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/22000000/21500000/21490300/21490226/f930f88b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Marriott Santa Cruz de la Sierra Hotel [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Marriott-Santa-Cruz-De-La-Sierra-Hotel.h21490226.Hotel-Information) Santa Cruz 9.0/10 Wonderful (213) "Great hotel, food and location albeit a little expensive " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Reinaldo £83 16 Jan - 17 Jan [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Marriott-Santa-Cruz-De-La-Sierra-Hotel.h21490226.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/70000000/69570000/69566300/69566260/efe5b8af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/70000000/69570000/69566300/69566260/2f3b612d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/70000000/69570000/69566300/69566260/fb4d1503.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/70000000/69570000/69566300/69566260/864143db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Novotel Santa Cruz De La Sierra [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Novotel-Santa-Cruz-De-La-Sierra.h69566260.Hotel-Information) Santa Cruz 9.2/10 Wonderful (104) "Luxurious hotel,very chic and beautiful." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cristhian £93 3 Feb - 4 Feb [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Novotel-Santa-Cruz-De-La-Sierra.h69566260.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/17000000/16450000/16447300/16447274/c006f762.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/17000000/16450000/16447300/16447274/86b67014.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/17000000/16450000/16447300/16447274/b440a48c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/17000000/16450000/16447300/16447274/af0d61f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Radisson Hotel Santa Cruz [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Radisson-Hotel-Santa-Cruz.h16447274.Hotel-Information) Santa Cruz 8.8/10 Excellent (237) "Great experience! Great place to stay! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Anonymous traveller [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Radisson-Hotel-Santa-Cruz.h16447274.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Santa-Cruz-Hotels.s50-0-d6053940.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Santa-Cruz-Hotels.s50-0-d6053940.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Santa Cruz. ![Camino Real Hotel](https://images.trvl-media.com/lodging/1000000/450000/444500/444475/e96a8418_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Camino Real Hotel Av. San Martín y 4to. Anillo Santa Cruz £134 10 Jan - 11 Jan 8.8/10 Excellent! (410 reviews) [](https://expedia.co.uk/Santa-Cruz-Hotels-Camino-Real-Hotel.h444475.Hotel-Information) ![TRYP by Wyndham Santa Cruz](https://images.trvl-media.com/lodging/46000000/45620000/45617400/45617372/78f237b9_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### TRYP by Wyndham Santa Cruz Av. San Martin, Calle 9 Este Santa Cruz £74 15 Jan - 16 Jan 9.2/10 Wonderful! (149 reviews) [](https://expedia.co.uk/Santa-Cruz-Hotels-TRYP-By-Wyndham-Santa-Cruz.h45617372.Hotel-Information) ![Hampton by Hilton Santa Cruz/Equipetrol, Bolivia](https://images.trvl-media.com/lodging/14000000/13180000/13179500/13179436/65fab765_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hampton by Hilton Santa Cruz/Equipetrol, Bolivia San Martin Avenue Esq Street E - E Santa Cruz £55 1 Feb - 2 Feb 9.2/10 Wonderful! (258 reviews) [](https://expedia.co.uk/Santa-Cruz-Hotels-Hampton-By-Hilton-Santa-Cruz.h13179436.Hotel-Information) Still don't see what you're looking for? [See all properties in Santa Cruz.](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F01%2F2026&endDate=11%2F01%2F2026®ionId=6053940&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F01%2F2026&endDate=11%2F01%2F2026®ionId=6053940&star=50&star=50&amenities=POOL)[Spa](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F01%2F2026&endDate=11%2F01%2F2026®ionId=6053940&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F01%2F2026&endDate=11%2F01%2F2026®ionId=6053940&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F01%2F2026&endDate=11%2F01%2F2026®ionId=6053940&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F01%2F2026&endDate=11%2F01%2F2026®ionId=6053940&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Learn more about Santa Cruz Tropical energy pulses through Plaza 24 de Septiembre, where locals gather under palm trees and the Metropolitan Cathedral's twin towers stand watch. Biocentro Güembé offers rainforest trails with butterfly gardens, while the massive Ventura Mall provides air-conditioned shopping when afternoon temperatures climb. [See all hotels in Santa Cruz](https://www.expedia.co.uk/Hotel-Search?startDate=2026-01-23&endDate=2026-01-24&adults=2®ionId=6053940) ![San Lorenzo Cathedral showing a garden](https://images.trvl-media.com/place/6098830/62a42b3d-1dbd-4a81-8566-cea655ebca33.jpg?impolicy=fcrop&w=900&h=506&p=1&q=high) ## Top Santa Cruz Hotel Reviews ![Marriott Santa Cruz de la Sierra Hotel](https://images.trvl-media.com/lodging/22000000/21500000/21490300/21490226/a95726cf_y.jpg) ### Marriott Santa Cruz de la Sierra Hotel 10/10 Excellent "Muy bien exelente" [](https://expedia.co.uk/Santa-Cruz-Hotels-Marriott-Santa-Cruz-De-La-Sierra-Hotel.h21490226.Hotel-Information) ## Find out more about Santa Cruz ## Frequently asked questions ### What are the best 5-star hotels in Santa Cruz? ### How much does it cost to stay in a 5-star hotel in Santa Cruz? > - Search for the lowest price per night from £55 ### What makes a hotel 5 stars in Santa Cruz? ## Explore a world of travel with Expedia - Accommodation - Flights - 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[Flights from Cochabamba (CBB) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/cbb/srz/cochabamba-to-santa-cruz) - [Flights from Paris (CDG) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/cdg/srz/paris-to-santa-cruz) - [Flights from Central (CEM) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/cem/srz/central-to-santa-cruz) - [Flights from Cobija (CIJ) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/cij/srz/cobija-to-santa-cruz) - [Flights from Charlotte (CLT) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/clt/srz/charlotte-to-santa-cruz) - [Flights from Ciudad Del Carmen (CME) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/cme/srz/ciudad-del-carmen-to-santa-cruz) - [Flights from Copiapo (CPO) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/cpo/srz/copiapo-to-santa-cruz) - [Flights from Dhahran (DHA) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/dha/srz/dhahran-to-santa-cruz) - [Flights from The Dalles (DLS) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/dls/srz/the-dalles-to-santa-cruz) - [Flights from Derby (DRB) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/drb/srz/derby-to-santa-cruz) - [Flights from Dublin (DUB) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/dub/srz/dublin-to-santa-cruz) - [Flights from Dubai (DXB) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/dxb/srz/dubai-to-santa-cruz) - [Flights from Buenos Aires (EZE) to Santa Cruz (VVI) ](https://www.expedia.co.uk/lp/flights/eze/vvi/buenos-aires-to-santa-cruz) - [Flights from Flores (FRS) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/frs/srz/flores-to-santa-cruz) - [Flights from Gaya (GAY) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/gay/srz/gaya-to-santa-cruz) - [Flights from Rio de Janeiro (GIG) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/gig/srz/rio-de-janeiro-to-santa-cruz) - [Flights from Isla Baltra (GPS) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/gps/srz/isla-baltra-to-santa-cruz) - [Flights from São Paulo (GRU) to Santa Cruz (VVI) ](https://www.expedia.co.uk/lp/flights/gru/vvi/sao-paulo-to-santa-cruz) - 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[Flights from Orlando (MCO) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/mco/srz/orlando-to-santa-cruz) - [Flights from Managua (MGA) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/mga/srz/managua-to-santa-cruz) - [Flights from Nuremberg (NUE) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/nue/srz/nuremberg-to-santa-cruz) - [Flights from Oakland (ODM) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/odm/srz/oakland-to-santa-cruz) - [Flights from Orlando (ORL) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/orl/srz/orlando-to-santa-cruz) - [Flights from Panama City (PAC) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/pac/srz/panama-city-to-santa-cruz) - [Flights from Punta Islita (PBP) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/pbp/srz/punta-islita-to-santa-cruz) - [Flights from Potosi (POI) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/poi/srz/potosi-to-santa-cruz) - [Flights from Panama City (PTY) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/pty/srz/panama-city-to-santa-cruz) - [Flights from Puerto Vallarta (PVR) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/pvr/srz/puerto-vallarta-to-santa-cruz) - [Flights from Dallas (RBD) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/rbd/srz/dallas-to-santa-cruz) - [Flights from Resende (REZ) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/rez/srz/resende-to-santa-cruz) - [Flights from Riberalta (RIB) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/rib/srz/riberalta-to-santa-cruz) - [Flights from San Diego (SAN) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/san/srz/san-diego-to-santa-cruz) - [Flights from Santa Ana del Yacuma (SBL) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/sbl/srz/santa-ana-del-yacuma-to-santa-cruz) - [Flights from Stockton (SCK) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/sck/srz/stockton-to-santa-cruz) - [Flights from Santiago (SCL) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/scl/srz/santiago-to-santa-cruz) - [Flights from San Francisco (SFO) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/sfo/srz/san-francisco-to-santa-cruz) - [Flights from San Francisco (SFO) to Santa Cruz (VVI) ](https://www.expedia.co.uk/lp/flights/sfo/vvi/san-francisco-to-santa-cruz) - [Flights from Springfield (SGF) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/sgf/srz/springfield-to-santa-cruz) - [Flights from San Juan (SJU) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/sju/srz/san-juan-to-santa-cruz) - [Flights from Salt Lake City (SLC) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/slc/srz/salt-lake-city-to-santa-cruz) - [Flights from Santa Maria (SMX) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/smx/srz/santa-maria-to-santa-cruz) - [Flights from Alcantarí Intl. Airport (SRE) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/sre/srz/sucre-to-santa-cruz) - [Flights from Sydney (SYD) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/syd/srz/sydney-to-santa-cruz) - [Flights from Trinidad (TDD) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/tdd/srz/trinidad-to-santa-cruz) - [Flights from Tarija (TJA) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/tja/srz/tarija-to-santa-cruz) - [Flights from Tsushima (TSJ) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/tsj/srz/tsushima-to-santa-cruz) - [Flights from Lake Tahoe (TVL) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/tvl/srz/lake-tahoe-to-santa-cruz) - [Flights from Ulaangom (ULO) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/ulo/srz/ulaangom-to-santa-cruz) - [Flights from Upolu Point (UPP) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/upp/srz/upolu-point-to-santa-cruz) - [Flights from Uyuni (UYU) to Santa Cruz (VVI) ](https://www.expedia.co.uk/lp/flights/uyu/vvi/uyuni-to-santa-cruz) - [Flights from Veracruz (VER) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/ver/srz/veracruz-to-santa-cruz) - [Flights from Van Nuys (VNY) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/vny/srz/van-nuys-to-santa-cruz) - [Flights from Mayo (YMA) to Santa Cruz (SRZ) ](https://www.expedia.co.uk/lp/flights/yma/srz/mayo-to-santa-cruz) - [Visit Colinas del Urubo ](https://www.expedia.co.uk/Colinas-Del-Urubo.dx6349680) - [Ethno-Folkloric Museum ](https://www.expedia.co.uk/Ethno-Folkloric-Museum-Santa-Cruz.d6098834.Attraction)