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Check availability on Santa Cruz 4 Star Hotels

Top Santa Cruz 4 Star Hotels

Camino Real Hotel
Relax by the winding pool surrounded by lush greenery and palm trees.

Camino Real Hotel

4.5 star property
8.8 out of 10, Excellent, (393)
"Great Hotel, had a great time ."
The price is £104
12 Aug - 13 Aug
Camino Real Hotel
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
Enjoy a panoramic city view from the comfort of your dining area, featuring floor-to-ceiling windows and stylish seating.

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

4.5 star property
9.2 out of 10, Wonderful, (245)
"Location, surrounding, quietness, good service "
The price is £56
15 Aug - 16 Aug
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
TRYP by Wyndham Santa Cruz
Enjoy breathtaking city views from our rooftop pool, surrounded by a deck with seating.

TRYP by Wyndham Santa Cruz

4.0 star property
9.2 out of 10, Wonderful, (125)
"It should have a dinning room for meals not just breakfast "
The price is £81
19 Jul - 20 Jul
TRYP by Wyndham Santa Cruz
Hotel Maywa
Relax in a spacious room with a large bed, bedside table, and comfortable chair.

Hotel Maywa

4.0 star property
9.2 out of 10, Wonderful, (9)
"Es mi segunda vez hospedandome en el hotel, la atención excelente, desayuno muy rico y variado, la habitacion tiene cama muy comoda y una excelente limpieza"
The price is £34
4 Aug - 5 Aug
Hotel Maywa
Buganvillas Hotel Suites & Spa
Surrounded by lush greenery and palm trees, this resort offers a picturesque setting with a central swimming pool and multi-story buildings.

Buganvillas Hotel Suites & Spa

4.0 star property
7.4 out of 10, Good, (92)
"El Hotel es bonito, pero tienen su mobiliario bastante descuidado en la piscina y el servicio no es nada bueno. Tardan mucho para cosas simples y la piscina no está temperada como solía estar, han desmejorado mucho"
Buganvillas Hotel Suites & Spa
Swissôtel Santa Cruz De La Sierra
Relax in a serene spa room with a panoramic city view, featuring two treatment beds and a soothing atmosphere.

Swissôtel Santa Cruz De La Sierra

4.5 star property
9.2 out of 10, Wonderful, (77)
"Beautiful hotel"
The price is £60
2 Aug - 3 Aug
Swissôtel Santa Cruz De La Sierra
Royal Lodge Hotel
Front of property – evening/night

Royal Lodge Hotel

4.5 star property
6.4 out of 10, (29)
"Esta cerrado, ya no deberia dejar reservar, se nota q tiene tiempo fuera de servicio."
Royal Lodge Hotel
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Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Santa Cruz.
Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel

4to Anillo Entre Radial 23, At Calle Las Ramblas, Santa Cruz, Santa Cruz
The price is £89 per night from 8 Aug to 9 Aug
£89
8 Aug - 9 Aug
9/10 Wonderful! (191 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Santa Cruz

Santa Cruz awaits: its cafes, zoo, cathedral and more!

See all hotels in Santa Cruz
San Lorenzo Cathedral showing a garden

Top Santa Cruz Hotel Reviews

Hotel Maywa

Hotel Maywa

10/10 Excellent
"The hotel was conveniently located within walking distance to shoos, restaurants and attractions. The rooms were clean, spacious and comfortable. The hotel staff were friendly and helped our large group arrange transportation to and from the airport. "
Walter 1-night trip
Posted 2 days ago
Hotel Maywa

Frequently asked questions

What are the best 4-star hotels in Santa Cruz?
If you're seeking luxury comfort and loads of amenities during your Santa Cruz retreat, consider TRYP by Wyndham Santa Cruz. This 4-star hotel offers a spa tub and a terrace. Hampton by Hilton Santa Cruz/Equipetrol, Bolivia also gets stellar reviews from Expedia guests. Concierge services and a garden are among its conveniences.
How much does it cost to stay in a 4-star hotel in Santa Cruz?
Expedia can help you easily locate the perfect 4-star hotel for your holiday in Santa Cruz. Use our filter tool to tailor your search by things like price, conveniences and star rating and get access to terrific deals in a few clicks.

  • Search for the lowest price from £78

What's the difference between 5-star and 4-star hotels in Santa Cruz?
If you choose to spend your holiday at a 4-star hotel in Santa Cruz, you'll typically find plenty of conveniences to ensure you're comfortable, such as a restaurant, gym and pool. You can enjoy top-quality service and deluxe accommodation. Choose a 5-star hotel and you'll get a few extra perks — think concierge assistance, on-site spas and opulent turndown services. You're likely to get more amenities and premium services at a 5-star stay, but both are fabulous options for luxury travellers.