Santa Cruz Holidays
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to £750 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPackages with flights are ATOL protected
Your Santa Cruz Holiday
With a Santa Cruz holiday package, you can forget about planning hassles and simply focus on experiencing everything this thrilling destination has to offer. The best way to plan your trip to Santa Cruz is to begin with its most popular cities, which include Samaipata, Roboré and Camiri. Expedia is a one-stop shop when it comes to planning your Santa Cruz holiday. From flights and hotels, to activities and more, we're here to help you create a travel experience like no other.
Top destinations in Santa Cruz
Santa Cruz
Warnes
Where to stay in Santa Cruz
Find the best Santa Cruz areas for the activities you enjoy most.
Hamacas
When in Hamacas, you can plan a visit to Santa Cruz Zoo and Las Brisas Shopping Center, some noteworthy sights in the nearby area.
Santa Cruz Essential Information
Language | Spanish |
|---|---|
Currency | Bolivian bolivianos |
Local Welcome | ¡Hola! |
Local Goodbye | Adiós |
Closest Airport | Viru Viru Intl. Airport (VVI) |
Top Sights | Santa Cruz Zoo, Amboró National Park and Lomas de Arena Regional Park |
Top hotels in Santa Cruz
Ibis Santa Cruz DE LA Sierra
AVENIDA CRISTOBAL DE MENDOZA Santa Cruz
£32
12 Sept - 13 Sept
9.4/10 Exceptional! (137 reviews)
"La ubicación es muy buena y puedes caminar por la zona"
Reviewed on 31 Aug 2026
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Ave. San Martin, #455 Santa Cruz
£106
14 Sept - 15 Sept
9/10 Wonderful! (405 reviews)
"Breakfast is wonderful"
Reviewed on 1 Sept 2026
Marriott Santa Cruz de la Sierra Hotel
4to Anillo Entre Radial 23 Santa Cruz Santa Cruz
£78
2 Oct - 3 Oct
9/10 Wonderful! (247 reviews)
"Staff was super as well as how clean the room was."
Reviewed on 23 Aug 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
How much does a Santa Cruz travel package cost?
Handcraft your Santa Cruz package from just . Choose from any combination of hotels, flights and rental cars to craft the escape you've been dreaming of. Don't forget to add on some activities and experiences!
If I'm not able to travel, can I cancel my Santa Cruz travel package?
Yes, you can. We realise even the best-laid plans can go awry, so we're happy to help if you need to make changes to your Santa Cruz travel package. You may be able to cancel or change your itinerary at no cost if you've booked within 24 hours. Your hotel, airline or car rental company may charge you a fee if your booking was made more than 24 hours ago. Take a look at our Customer Service Portal for more information. Also, be sure to check your itinerary for the nitty-gritty on change fees.
How do I get a cheap travel package to Santa Cruz?
Bundle your flights and hotels with Expedia to save big on your next big adventure. With over 550 air carriers and 1,000,000 hotels worldwide, your Santa Cruz travel package can be customized exactly to suit your travel style. With all those extra dollars, why not include a few exciting tours and experiences? It's an easy way to unlock even more savings. Your dream getaway to Santa Cruz is much closer than you thought!
Does Expedia offer Book Now, Pay Later Santa Cruz holidays?
Yes, we do. Expedia has joined forces with online lender Klarna to help you conveniently pay for your holiday in instalments. Simply pick the payment plan that works for you during checkout and take away the stress of budgeting for your trip. Make sure you bundle your flights, hotel and car hire with Expedia to get the biggest bang for your buck. Consider these flexible payment options below:
- Pay monthly holidays: Escape on that dream holiday sooner with Klarna's convenient monthly instalment plans. If paying a little each month works for you, choose this option during the checkout process.
- Pay in instalments holidays: Into the idea of paying off your holiday in multiple transactions? Consider this Book Now, Pay Later option with Klarna.
- Low deposit holidays: Clicking the "book now" button is much easier with this payment option. Put down a small deposit on your booking and then start packing your suitcase.
What are the top hotels in Santa Cruz?
Camino Real Hotel and Sun Hotel know how to make their guests feel at home in Samaipata. If you also plan to stay in San Jose de Chiquitos, check out Camino Real Hotel and Sun Hotel. Both are popular with travellers.
How far in advance should I book my Santa Cruz holiday?
It's tricky picking the ideal time for airfares, but we usually say the earlier, the better. Most international journeys on Expedia become available to compare up to 12 months in advance. If you're booking last minute, fear not. Bargain prices occasionally appear within a few weeks of departure dates.
What does an Expedia Santa Cruz travel package include?
From flights and hotels to car rentals, Expedia can help you create a Santa Cruz package that's ideal for you. Holidaying for a while? Look into a hotel, rental car and flight bundle. If you're taking a quick break, a hotel and airfare deal could suit you better. Activities can also be added after you've booked. Our travel packages make it easy to plan and save.
What should I know before booking a Santa Cruz travel package?
A travel package can be more affordable than individually booking all you need for your trip. For example, combine your flights, hotels and rental cars and save a pretty penny. No matter your holiday goals, you're bound to find a package to suit your budget.
Can I choose my airline with a Santa Cruz Expedia travel package?
Yes, you sure can. We have more than 550 airline partners globally, so pick the carrier that suits your travel preferences.
Stay near popular Santa Cruz attractions
Plaza 24 de Septiembre
8.8/10 (164 reviews)
The heart of Santa Cruz lies in this public square, where locals relax and tourists sightsee in a welcoming, laid-back atmosphere.
San Lorenzo Cathedral
9.0/10 (84 reviews)
One of the most iconic landmarks in Santa Cruz is the city’s mighty cathedral, which houses a museum displaying important artwork.
Ventura Mall
9.0/10 (183 reviews)
During your visit to Santa Cruz, you can enjoy retail therapy at Ventura Mall. Make some time to visit the cathedral while you're in the area.
Guembe Biocenter
8.8/10 (60 reviews)
Explore the great outdoors at Guembe Biocenter, a lovely green space in Colinas del Urubo. While in the area, you can find time to visit its shops.
Santa Cruz Zoo
8.4/10 (53 reviews)
Why not visit the animals who call Santa Cruz Zoo home during your travels in Santa Cruz? While in the area, you can find time to visit its shops.
Cine Center
8.0/10 (53 reviews)
You can make plans for a show at Cine Center on your trip to Santa Cruz. While in the area, you can find time to visit its shops.
Ramon Tahuichi Aguilera Stadium
8.4/10 (18 reviews)
Catch an event at Ramon Tahuichi Aguilera Stadium during your trip to Santa Cruz. While in the area, you can find time to visit its shops.
What to do in Santa Cruz
Santa Cruz and Porongo: History, Markets, River, and Culture
£73
per adult
Santa Cruz: Wildlife Sanctuary and Preservation Park Tour
£62
per adult
Samaipata, Andes Adventure: El Codo De Los Andes Hike
£116
per adult
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.
