Santa Cruz Holidays

Book a Hotel + Flight or Car together to unlock savings

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    Packages with flights are ATOL protected

Your Santa Cruz Holiday

With a Santa Cruz holiday package, you can forget about planning hassles and simply focus on experiencing everything this thrilling destination has to offer. The best way to plan your trip to Santa Cruz is to begin with its most popular cities, which include Samaipata, Roboré and Camiri. Expedia is a one-stop shop when it comes to planning your Santa Cruz holiday. From flights and hotels, to activities and more, we're here to help you create a travel experience like no other.

Top destinations in Santa Cruz

A colonial-style building with a bell tower, palm trees, and a paved walkway.
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Santa Cruz

Santa Cruz
A person wearing a yellow and black costume with a headpiece.
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Warnes

Warnes

Where to stay in Santa Cruz

Find the best Santa Cruz areas for the activities you enjoy most.

Hamacas

When in Hamacas, you can plan a visit to Santa Cruz Zoo and Las Brisas Shopping Center, some noteworthy sights in the nearby area.

Santa Cruz Essential Information

Language
Spanish
Currency
Bolivian bolivianos
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Viru Viru Intl. Airport (VVI)
Top Sights
Santa Cruz Zoo, Amboró National Park and Lomas de Arena Regional Park

Top hotels in Santa Cruz

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455 Santa Cruz
The price is £97 per night from 19 Aug to 20 Aug
£97
19 Aug - 20 Aug
9/10 Wonderful! (389 reviews)
"Very nice hotel! Everthibg was perfect, clean and the breakfast was perfect"

Reviewed on 17 Jul 2026

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

3 out of 5
AVENIDA CRISTOBAL DE MENDOZA Santa Cruz
The price is £40 per night from 9 Aug to 10 Aug
£40
9 Aug - 10 Aug
9.4/10 Exceptional! (125 reviews)
"I was a solo traveler, the room was clean, I felt safe, there was a restaurant, and I even was able to walk to the zoo one day (30 min walk)! When I had to leave at 3 AM to catch a flight, the hotel helped arrange a taxi."

Reviewed on 16 Jul 2026

Ibis Santa Cruz DE LA Sierra
Camino Real Hotel

Camino Real Hotel

4.5 out of 5
Av. San Martín y 4to. Anillo Santa Cruz
The price is £121 per night from 3 Aug to 4 Aug
£121
3 Aug - 4 Aug
9/10 Wonderful! (433 reviews)
"Wonderful place to stay while visiting Santa Cruz Bolivia."

Reviewed on 7 Jul 2026

Camino Real Hotel
See all 322 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Frequently asked questions

How much does a Santa Cruz travel package cost?
Handcraft your Santa Cruz package from just . Choose from any combination of hotels, flights and rental cars to craft the escape you've been dreaming of. Don't forget to add on some activities and experiences!
If I'm not able to travel, can I cancel my Santa Cruz travel package?
Yes, you can. We realise even the best-laid plans can go awry, so we're happy to help if you need to make changes to your Santa Cruz travel package. You may be able to cancel or change your itinerary at no cost if you've booked within 24 hours. Your hotel, airline or car rental company may charge you a fee if your booking was made more than 24 hours ago. Take a look at our Customer Service Portal for more information. Also, be sure to check your itinerary for the nitty-gritty on change fees.
How do I get a cheap travel package to Santa Cruz?
Bundle your flights and hotels with Expedia to save big on your next big adventure. With over 550 air carriers and 1,000,000 hotels worldwide, your Santa Cruz travel package can be customized exactly to suit your travel style. With all those extra dollars, why not include a few exciting tours and experiences? It's an easy way to unlock even more savings. Your dream getaway to Santa Cruz is much closer than you thought!
Does Expedia offer Book Now, Pay Later Santa Cruz holidays?
Yes, we do. Expedia has joined forces with online lender Klarna to help you conveniently pay for your holiday in instalments. Simply pick the payment plan that works for you during checkout and take away the stress of budgeting for your trip. Make sure you bundle your flights, hotel and car hire with Expedia to get the biggest bang for your buck. Consider these flexible payment options below:

  • Pay monthly holidays: Escape on that dream holiday sooner with Klarna's convenient monthly instalment plans. If paying a little each month works for you, choose this option during the checkout process.
  • Pay in instalments holidays: Into the idea of paying off your holiday in multiple transactions? Consider this Book Now, Pay Later option with Klarna.
  • Low deposit holidays: Clicking the "book now" button is much easier with this payment option. Put down a small deposit on your booking and then start packing your suitcase.

What are the top hotels in Santa Cruz?
Camino Real Hotel and Sun Hotel know how to make their guests feel at home in Samaipata. If you also plan to stay in San Jose de Chiquitos, check out Camino Real Hotel and Sun Hotel. Both are popular with travellers.
How far in advance should I book my Santa Cruz holiday?
It's tricky picking the ideal time for airfares, but we usually say the earlier, the better. Most international journeys on Expedia become available to compare up to 12 months in advance. If you're booking last minute, fear not. Bargain prices occasionally appear within a few weeks of departure dates.
What does an Expedia Santa Cruz travel package include?
From flights and hotels to car rentals, Expedia can help you create a Santa Cruz package that's ideal for you. Holidaying for a while? Look into a hotel, rental car and flight bundle. If you're taking a quick break, a hotel and airfare deal could suit you better. Activities can also be added after you've booked. Our travel packages make it easy to plan and save.
What should I know before booking a Santa Cruz travel package?
A travel package can be more affordable than individually booking all you need for your trip. For example, combine your flights, hotels and rental cars and save a pretty penny. No matter your holiday goals, you're bound to find a package to suit your budget.
Can I choose my airline with a Santa Cruz Expedia travel package?
Yes, you sure can. We have more than 550 airline partners globally, so pick the carrier that suits your travel preferences.

Stay near popular Santa Cruz attractions

A historic building with arched windows and a clock. People are sitting and standing on the steps in front of the building.

Plaza 24 de Septiembre

8.8/10 (164 reviews)
The heart of Santa Cruz lies in this public square, where locals relax and tourists sightsee in a welcoming, laid-back atmosphere.
See properties

What to do in Santa Cruz

Private Tour of Santa Cruz: We'll visit the center, Porongo, markets, and the river

Private Tour of Santa Cruz: We visit the city center, Porongo, markets, and the river

£49
per adult
Private Tour of Santa Cruz: We visit the city center, Porongo, markets, and the river
Samaipata, Andes Adventure: El Codo De Los Andes Hike

Samaipata, Andes Adventure: El Codo De Los Andes Hike

£116
per adult
Samaipata, Andes Adventure: El Codo De Los Andes Hike
Vallegrande City

Vallegrande City Tour

£22
per adult
Vallegrande City Tour
See all activities in Santa Cruz

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.