Santa Cruz Holidays

Book a Hotel + Flight or Car together to unlock savings

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    Packages with flights are ATOL protected

Your Santa Cruz Holiday

With a Santa Cruz holiday package, you can forget about planning hassles and simply focus on experiencing everything this thrilling destination has to offer. The best way to plan your trip to Santa Cruz is to begin with its most popular cities, which include Samaipata, Roboré and Camiri. Expedia is a one-stop shop when it comes to planning your Santa Cruz holiday. From flights and hotels, to activities and more, we're here to help you create a travel experience like no other.

Top destinations in Santa Cruz

FlightsFlightsHotelsHotels

Santa Cruz

Santa Cruz
Portrait of a Tobas warrior during carnival called The Devil Dance (La Diablada), Oruro, Bolivia
FlightsFlightsHotelsHotels

Warnes

Warnes

Santa Cruz Essential Information

Language
Spanish
Currency
Bolivian bolivianos
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Viru Viru Intl. Airport (VVI)
Top Sights
Santa Cruz Zoo, Amboró National Park and Lomas de Arena Regional Park

Top hotels in Santa Cruz

Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

3 out of 5
AVENIDA CRISTOBAL DE MENDOZA Santa Cruz
The price is £41 per night from 25 Apr to 26 Apr
£41
25 Apr - 26 Apr
9.6/10 Exceptional! (105 reviews)
Muy limpio, ambiente agradable muy bueno para viaje de negocios. La comida es excelente. Es un must comprar el servicio de desayuno es un buffet muy variado, sabroso y hacen cambios diariamente en el menú. Lo único que sugiero mejoren es la señal del wifi es muy inestable. Pero por lo demás muy bueno ...

Reviewed on 3 Apr 2026

Ibis Santa Cruz DE LA Sierra
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455 Santa Cruz
The price is £114 per night from 21 May to 22 May
£114
21 May - 22 May
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Sun Hotel

Sun Hotel

3.5 out of 5
Av. Banzer Km 13 Santa Cruz Santa Cruz
The price is £72 per night from 24 Apr to 25 Apr
£72
24 Apr - 25 Apr
8.2/10 Very Good! (366 reviews)
No vip treatment! nothing special, booked a king room got a double, wc was running water all the time and the sink didn’t drain properly. Breakfast was lame. Staff was good and the bed was comfy, but that’s it.

Reviewed on 18 Apr 2026

Sun Hotel
See all 316 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Frequently asked questions

How much does a Santa Cruz travel package cost?
Handcraft your Santa Cruz package from just . Choose from any combination of hotels, flights and rental cars to craft the escape you've been dreaming of. Don't forget to add on some activities and experiences!
If I'm not able to travel, can I cancel my Santa Cruz travel package?
Yes, you can. We realise even the best-laid plans can go awry, so we're happy to help if you need to make changes to your Santa Cruz travel package. You may be able to cancel or change your itinerary at no cost if you've booked within 24 hours. Your hotel, airline or car rental company may charge you a fee if your booking was made more than 24 hours ago. Take a look at our Customer Service Portal for more information. Also, be sure to check your itinerary for the nitty-gritty on change fees.
How do I get a cheap travel package to Santa Cruz?
Bundle your flights and hotels with Expedia to save big on your next big adventure. With over 550 air carriers and 1,000,000 hotels worldwide, your Santa Cruz travel package can be customized exactly to suit your travel style. With all those extra dollars, why not include a few exciting tours and experiences? It's an easy way to unlock even more savings. Your dream getaway to Santa Cruz is much closer than you thought!
Does Expedia offer Book Now, Pay Later Santa Cruz holidays?
Yes, we do. Expedia has joined forces with online lender Klarna to help you conveniently pay for your holiday in instalments. Simply pick the payment plan that works for you during checkout and take away the stress of budgeting for your trip. Make sure you bundle your flights, hotel and car hire with Expedia to get the biggest bang for your buck. Consider these flexible payment options below:

  • Pay monthly holidays: Escape on that dream holiday sooner with Klarna's convenient monthly instalment plans. If paying a little each month works for you, choose this option during the checkout process.
  • Pay in instalments holidays: Into the idea of paying off your holiday in multiple transactions? Consider this Book Now, Pay Later option with Klarna.
  • Low deposit holidays: Clicking the "book now" button is much easier with this payment option. Put down a small deposit on your booking and then start packing your suitcase.

What are the top hotels in Santa Cruz?
Camino Real Hotel and Sun Hotel know how to make their guests feel at home in Samaipata. If you also plan to stay in San Jose de Chiquitos, check out Camino Real Hotel and Sun Hotel. Both are popular with travellers.
How far in advance should I book my Santa Cruz holiday?
It's tricky picking the ideal time for airfares, but we usually say the earlier, the better. Most international journeys on Expedia become available to compare up to 12 months in advance. If you're booking last minute, fear not. Bargain prices occasionally appear within a few weeks of departure dates.
What does an Expedia Santa Cruz travel package include?
From flights and hotels to car rentals, Expedia can help you create a Santa Cruz package that's ideal for you. Holidaying for a while? Look into a hotel, rental car and flight bundle. If you're taking a quick break, a hotel and airfare deal could suit you better. Activities can also be added after you've booked. Our travel packages make it easy to plan and save.
What should I know before booking a Santa Cruz travel package?
A travel package can be more affordable than individually booking all you need for your trip. For example, combine your flights, hotels and rental cars and save a pretty penny. No matter your holiday goals, you're bound to find a package to suit your budget.
Can I choose my airline with a Santa Cruz Expedia travel package?
Yes, you sure can. We have more than 550 airline partners globally, so pick the carrier that suits your travel preferences.

Popular places to visit

Ethno-folkloric Museum

You can spend an afternoon exploring the galleries in Ethno-folkloric Museum in Santa Cruz. While in the area, you can find time to visit its shops.

Ethno-folkloric Museum

What to do in Santa Cruz

Andes Adventure: El Codo De Los Andes Hike with Transport

Samaipata, Andes Adventure: El Codo De Los Andes Hike

£117
per adult
Samaipata, Andes Adventure: El Codo De Los Andes Hike
After the Footsteps of the Jaguar 3-Day Kaa Iya Expedition

After the Footsteps of the Jaguar 3-Day Kaa Iya Expedition

£1,069
per adult
After the Footsteps of the Jaguar 3-Day Kaa Iya Expedition
Santa Cruz: 2-day tour of the Che Guevara route in Bolivia

Santa Cruz: 2-Day Tour of the Che Guevara Route in Bolivia

£521
per adult
Santa Cruz: 2-Day Tour of the Che Guevara Route in Bolivia
See all activities in Santa Cruz

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.