Title: TOP Luxury Hotels in Santa Cruz for 2025 - Santa Cruz Upscale Hotels | Expedia.co.uk [Santa Cruz Travel Guide](https://expedia.co.uk/Santa-Cruz.dx6053940)[Hotels in Santa Cruz](https://expedia.co.uk/Santa-Cruz-Hotels.d6053940.Travel-Guide-Hotels)[Holiday Rentals in Santa Cruz](https://expedia.co.uk/Santa-Cruz-Holiday-Rentals.d6053940.Travel-Guide-HolidayRentals)[Flights to Santa Cruz](https://expedia.co.uk/Cheap-Flights-To-Santa-Cruz.d6053940.Travel-Guide-Flights)[Santa Cruz Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Santa-Cruz.d6053940.Car-Hire-Guide)[Santa Cruz Holidays](https://expedia.co.uk/Santa-Cruz.d6053940.Holidays-City-Breaks) ![Santa Cruz featuring a city](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/115000/115559-Santa-Cruz.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find luxury hotels in Santa Cruz ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Santa Cruz Luxury Hotels Tonight [11 Oct - 12 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6053940&startDate=2025-10-11&endDate=2025-10-12&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [12 Oct - 13 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6053940&startDate=2025-10-12&endDate=2025-10-13&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [17 Oct - 19 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6053940&startDate=2025-10-17&endDate=2025-10-19&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [24 Oct - 26 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6053940&startDate=2025-10-24&endDate=2025-10-26&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Santa Cruz Luxury Hotels ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/18800/18758/bb34bb1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Banquet hall](https://images.trvl-media.com/lodging/1000000/20000/18800/18758/9bf66d6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/1000000/20000/18800/18758/7d01dcfa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Banquet hall](https://images.trvl-media.com/lodging/1000000/20000/18800/18758/c96e3d06.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel Santa Cruz 9.0/10 Wonderful (333) "Hotel was excellent. Staff excellent, check in good and bar resturant really good. room was good and clean " £88 18 Oct - 19 Oct [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Los-Tajibos-Hotel-And-Convention-Center.h18758.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-10-25&endDate=2025-10-26®ionId=6053940&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true) ## Find out more about Santa Cruz ### Santa Cruzand its attractions for luxury travelers Santa Cruz, Bolivia, offers a blend of luxury and adventure that is perfect for discerning travellers. Begin your journey at the stunning Biocentro Güembé, a lavish tropical park where you can relax in a high-end spa or stroll through beautifully landscaped gardens filled with exotic wildlife. Next, explore the vibrant Mercado Los Pozos, where you can delight in an array of local crafts and flavours, perhaps picking up some unique Bolivian souvenirs. For a taste of culture, visit the impressive Museo de Arte Contemporáneo, showcasing contemporary works that reflect the country's rich heritage. Spend an afternoon at the exclusive Equipetrol neighbourhood, known for its upscale dining and boutique shops, providing a perfect backdrop for a leisurely lunch or an evening of fine dining. Finally, don't miss the chance to unwind at the Parque El Arenal, a serene oasis in the city where you can enjoy a leisurely stroll or a picnic with your family. When it comes to accommodation, luxury hotels in the Equipetrol area offer elegant rooms and exceptional service, ensuring you feel pampered during your stay. From fine dining options to personalised concierge services, these hotels create a perfect launchpad for your Santa Cruz adventures. ### Find the best luxury hotels and resorts in Santa Cruz For discerning travellers seeking a lavish getaway in Santa Cruz, these hotels offer unparalleled luxury and comfort, ensuring a memorable stay. [Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel](https://www.expedia.co.uk/Santa-Cruz-Hotels-Los-Tajibos-Hotel-And-Convention-Center.h18758.Hotel-Information) - **Why it's great for a luxury retreat:** Los Tajibos impresses luxury travellers with its refined ambiance and a solid guest review rating of 9.0. Highlights include a 24-hour restaurant, a rejuvenating spa with hydrotherapy treatments, and plush premium bedding, ensuring a restful retreat. Guests can unwind in the hot tub or enjoy the elegance of room service that operates around the clock. - **Other amenities:** Additional features include a terrace for evening relaxation, a fitness centre for those wishing to maintain their routine, and complimentary buffet breakfast. The hotel also offers exclusive spa treatments such as body wraps and scrubs, along with convenient airport shuttles, making it a haven for luxury and comfort. - **Nearby attractions:** Santa Cruz Zoo - 1.4 km, Patio Design LifeStyle Center - 1.4 km, Ventura Mall - 2.3 km [Marriott Santa Cruz de la Sierra Hotel](https://www.expedia.co.uk/Santa-Cruz-Hotels-Marriott-Santa-Cruz-De-La-Sierra-Hotel.h21490226.Hotel-Information) - **Why it's great for a luxury retreat:** Marriott Santa Cruz de la Sierra presents a luxurious retreat with an exceptional guest review rating of 9.0. Guests can revel in the comfort of executive rooms, complete with access to a private lounge, and experience the indulgence of in-room dining through 24-hour room service. The hotel also features onsite tennis facilities for those looking to stay active during their stay. - **Other amenities:** Beyond its luxury amenities, the hotel offers a beautiful rooftop garden terrace for relaxation and an outdoor pool with sun loungers. Guests can enjoy the convenience of onsite massage treatments and a full-service spa. With accessible fitness facilities and generous parking options, this hotel is designed to meet the needs of luxury travellers seeking both comfort and style. - **Nearby attractions:** Santa Cruz Zoo - 2.4 km, Patio Design LifeStyle Center - 1.9 km, Ventura Mall - 0.7 km [Camino Real Hotel](https://www.expedia.co.uk/Santa-Cruz-Hotels-Camino-Real-Hotel.h444475.Hotel-Information) - **Why it's great for a luxury retreat:** Camino Real Hotel stands out as a premier choice for luxury seekers, an impressive guest review rating of 8.8. Guests are treated to a wealth of high-end amenities, including a stunning outdoor pool with a swim-up bar, a tranquil spa offering massage treatments, and a restaurant with beautiful garden views. The 24-hour room service and concierge ensure that every need is catered to in style. - **Other amenities:** In addition to its luxurious offerings, the hotel features an art gallery on-site, perfect for those looking to indulge in culture during their stay. Guests can enjoy a poolside bar, a wellness centre with sauna and hydromassage options, and free buffet breakfast daily. With a shopping district nearby, guests can enjoy both relaxation and retail therapy while enjoying the spacious terrace for unwinding after a day of exploration. - **Nearby attractions:** Santa Cruz Zoo - 2 km, Patio Design LifeStyle Center - 2.2 km, Ventura Mall - 0.8 km [Sun Hotel](https://www.expedia.co.uk/Santa-Cruz-Hotels-Sun-Hotel.h12836211.Hotel-Information) - **Why it's great for a luxury retreat:** Sun Hotel offers a delightful blend of luxury and comfort, reflected in its guest review rating of 8.2. The hotel features a 24-hour room service option and designer toiletries in every room, providing guests with a touch of elegance. The inviting outdoor pool and hot tub create a perfect setting for relaxation after a day of exploring Santa Cruz. - **Other amenities:** Additional amenities include a terrace for enjoying the pleasant Bolivian climate, a buffet breakfast served daily, and various spa treatments such as reflexology and body treatments. Guests can also take advantage of the airport shuttle service, ensuring a seamless travel experience. The hotel’s arcade game room adds a playful touch to the luxury experience, ideal for unwinding in style. - **Nearby attractions:** Play Land Amusement Park - 2.6 km, Univalle - 8.8 km ## Top Santa Cruz Hotel Reviews ![Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel](//images.trvl-media.com/lodging/1000000/20000/18800/18758/bb34bb1f_y.jpg) ### Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel 10/10 Excellent "Hotel was excellent. Staff excellent, check in good and bar resturant really good. room was good and clean " [](https://expedia.co.uk/Santa-Cruz-Hotels-Los-Tajibos-Hotel-And-Convention-Center.h18758.Hotel-Information) ## Frequently asked questions ### Are you looking for a luxury hotel for your Santa Cruz holiday? > Fly into Santa Cruz (VVI-Viru Viru Intl.) Airport and then pamper yourself by staying at one of 7 Santa Cruz luxury hotels. Santa Cruz has some interesting things to see and do including Plaza 24 de Septiembre and Ramon Tahuichi Aguilera Stadium, so you might want to take in the local sights during your visit. ### What's the best high-end hotel in Santa Cruz? > [Marriott Santa Cruz de la Sierra Hotel](https://www.expedia.co.uk/Santa-Cruz-Hotels-Marriott-Santa-Cruz-De-La-Sierra-Hotel.h21490226.Hotel-Information) is a luxury hotel with a full-service spa and a rooftop terrace, and it's a popular choice for Expedia travellers looking for an elegant place to stay. [Hampton by Hilton Santa Cruz/Equipetrol, Bolivia](https://www.expedia.co.uk/Santa-Cruz-Hotels-Hampton-By-Hilton-Santa-Cruz.h13179436.Hotel-Information) and [Camino Real Hotel](https://www.expedia.co.uk/Santa-Cruz-Hotels-Camino-Real-Hotel.h444475.Hotel-Information) are two other upscale options for your trip. ### How many luxury hotels are there in Santa Cruz? > Lie in the lap of luxury during your getaway to Santa Cruz in one of Expedia's 7 luxury hotels. ### When can I expect good weather in Santa Cruz? > Planning for the weather is a good way to make your trip to Santa Cruz relaxing and enjoyable, especially when you're splurging. The hottest months are usually October and November, with an average temperature of 26°C, while the coldest months are June and July, with an average of 21°C. Average annual precipitation for Santa Cruz is 1208 mm. ### What's there to see and do in Santa Cruz? > Enjoy all that Santa Cruz has to offer when you visit Plaza 24 de Septiembre, Ramon Tahuichi Aguilera Stadium and Cine Center. If you have a little extra time during your trip, you might want to make a stop at Santa Cruz Zoo and Ventura Mall. ### How can I get around Santa Cruz? > It's easier to get around town comfortably when you know your options. 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[Flights from Stockton (SCK) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/sck/srz/stockton-to-santa-cruz) - [Flights from Santiago (SCL) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/scl/srz/santiago-to-santa-cruz) - [Flights from San Francisco (SFO) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/sfo/srz/san-francisco-to-santa-cruz) - [Flights from San Francisco (SFO) to Santa Cruz (VVI)](https://www.expedia.co.uk/lp/flights/sfo/vvi/san-francisco-to-santa-cruz) - [Flights from Springfield (SGF) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/sgf/srz/springfield-to-santa-cruz) - [Flights from San Juan (SJU) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/sju/srz/san-juan-to-santa-cruz) - [Flights from Salt Lake City (SLC) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/slc/srz/salt-lake-city-to-santa-cruz) - [Flights from Santa Maria (SMX) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/smx/srz/santa-maria-to-santa-cruz) - [Flights from Alcantarí Intl. Airport (SRE) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/sre/srz/sucre-to-santa-cruz) - [Flights from Sydney (SYD) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/syd/srz/sydney-to-santa-cruz) - [Flights from Trinidad (TDD) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/tdd/srz/trinidad-to-santa-cruz) - [Flights from Tarija (TJA) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/tja/srz/tarija-to-santa-cruz) - [Flights from Tsushima (TSJ) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/tsj/srz/tsushima-to-santa-cruz) - [Flights from Lake Tahoe (TVL) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/tvl/srz/lake-tahoe-to-santa-cruz) - [Flights from Ulaangom (ULO) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/ulo/srz/ulaangom-to-santa-cruz) - [Flights from Upolu Point (UPP) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/upp/srz/upolu-point-to-santa-cruz) - [Flights from Uyuni (UYU) to Santa Cruz (VVI)](https://www.expedia.co.uk/lp/flights/uyu/vvi/uyuni-to-santa-cruz) - [Flights from Veracruz (VER) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/ver/srz/veracruz-to-santa-cruz) - [Flights from Van Nuys (VNY) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/vny/srz/van-nuys-to-santa-cruz) - [Flights from Mayo (YMA) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/yma/srz/mayo-to-santa-cruz) - [Visit Colinas del Urubo](https://www.expedia.co.uk/Colinas-Del-Urubo.dx6349680) - [Ethno-Folkloric Museum](https://www.expedia.co.uk/Ethno-Folkloric-Museum-Santa-Cruz.d6098834.Attraction)