Southeast Missouri Pet-friendly Holidays

Book a Pet-friendly Hotel + Flight or Car together to unlock savings

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How to find a pet-friendly holiday in Southeast Missouri

How can I book the best pet-friendly holidays in Southeast Missouri?

As a pet parent, you want your best bud along for your Southeast Missouri holiday, right? So use our pet-friendly filter to find all the places that are purr-fect for cats, dogs or even well-trained rabbits. Think stacks of outside space, welcome treats and maybe something lovely that keeps the travel time to a minimum.

Can I book a cheap Southeast Missouri pet-friendly holiday?

pet-friendly package holidays start at , but prices and availability are subject to change, and additional terms may apply. To narrow down the best deals, sort by price and use the filters to find cheap places with tail-wag-worthy amenities.

How can I book holiday lets in Southeast Missouri that are pet friendly?

The space and seclusion of a holiday let is great for holidaying as a family or bigger group, and if your furry friends are with you, even better. Use both the private holiday home and pet-friendly filters to find all the options that tick both boxes.

How can I find pet-friendly holidays in Southeast Missouri with hot tubs?

Pet-friendly holidays aren’t just about the animals – you deserve to indulge yourself, too! Filter our Southeast Missouri properties using the hot-tub and pet-friendly holiday options and find somewhere you can relax while the pooches snooze.

Can I book a pet-friendly holiday in Southeast Missouri with a car?

For hassle-free pet-friendly travel, a car is a no-brainer. Book both your car hire and accommodation with Expedia and you’ll sniff out some great savings.

How can I book last-minute pet-friendly holidays in Southeast Missouri?

A spontaneous last-minute getaway to Southeast Missouri with your pet is what holiday dreams are made of. You might even dig up discounted rates on some hotels by booking close to the date.

Can I book a pet-friendly holiday in Southeast Missouri with free cancellation and/or flexible dates?

We offer several places to stay with free cancellation in Southeast Missouri, just use the fully refundable filter to find the ones available on your dates. Make sure you read the terms and conditions, too.

Why should I book Southeast Missouri pet-friendly travel with Expedia?

Thanks to our dedicated pet-friendly filter, it’s incredibly easy to find accommodation in Southeast Missouri that welcomes fur babies. Search, choose and book in just a few clicks. Purr-fect!

Top Pet-friendly Southeast Missouri Hotels

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO
  • 3 hours drive from Mark Twain National Forest
Stay at this motel in Poplar Bluff. Enjoy free Wi-Fi, free parking and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in their ...
8/10 Very good! (1,004 reviews)
"Terrific base accommodation. Clean, efficient. I use this place whenever I’m in the area. I’m"

Reviewed on 2 Oct 2026

Motel 6 Poplar Bluff, MO
Microtel Inn & Suites by Wyndham Sainte Genevieve

Microtel Inn & Suites by Wyndham Sainte Genevieve

21958 Hwy 32 Ste Genevieve MO
  • 4 hours drive from Mark Twain National Forest
Stay at this business-friendly hotel in Ste Genevieve. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean rooms ...
8.8/10 Excellent! (669 reviews)
"The design of this line is kind of "euro minimalist". Charming to me, and a nice offset to the old colonial "Habitant" vibe in town. Obviously well managed, but with limited amenities. Basically clean, but a few noticable oversights."

Reviewed on 18 Sept 2026

Microtel Inn & Suites by Wyndham Sainte Genevieve
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

1001 Veterans Blvd Festus MO
  • 3 hours drive from Mark Twain National Forest
Stay at this business-friendly hotel in Festus. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in their ...
7.8/10 Good! (1,001 reviews)
"Just used the hotel for an overnight stay but everything was clean and the staff was great. Great place to stay if you need a place."

Reviewed on 1 Oct 2026

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
See all 687 properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Things to do

Pythian Castle

Night Ghost Tour of Pythian Castle in Springfield Missouri

£15
per adult
96% of travellers recommend
Night Ghost Tour of Pythian Castle in Springfield Missouri
See all activities in Southeast Missouri

More holidays you might like

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.