Title: Eastern Panama Luxury Holidays 2025/2026 | Expedia.co.uk ![](https://images.trvl-media.com/place/6246376/42fe0cae-c805-47d5-a705-ee119c68d58c.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Eastern Panama Luxury Holidays ## Book a Luxury Hotel + Flight or Car together to unlock savings Photo by Nico Barner - ## Plan, book, travel with confidence - ### Better together Save up to £335 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Packages with flights are ATOL protected ## Top flight + Luxury hotel deals in Eastern Panama Price found within the past 48 hours. Click for updated prices. ![Decapolis Hotel Panama City](https://images.trvl-media.com/lodging/2000000/1090000/1082800/1082793/067e7d25_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Decapolis Hotel Panama City San Francisco £1,164 per person 25 Dec - 1 Jan found 11 hours ago Return direct flight included London (LHR) to Panama City (PTY) 17.2/10 Exceptional! (1,396 reviews) The room did not have towels when I arrived, I called to request them. Everything else was good. Reviewed on 3 Nov 2025 [](https://expedia.co.uk/go/package/search/FlightHotel/2025-12-25/2026-01-01/?FromAirport=LHR&Destination=PTY&NumRoom=1&NumAdult=2&NumChild=0&hotelId=1082793&paandie=true&HotelClass=40&dealMarker=e2n31Rw607s36pgPjs0NW2UA_2t-_pr_IiWCT7TA9McTxWkEH-ALMMnPvTPHeyz0) ![Megapolis Hotel Panamá](https://images.trvl-media.com/lodging/92000000/92000000/91995600/91995575/4aee4896_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Megapolis Hotel Panamá San Francisco £1,192 per person 25 Dec - 1 Jan found 11 hours ago Return direct flight included London (LHR) to Panama City (PTY) 16.8/10 Exceptional! (1,204 reviews) Megapolis it’s always a very nice option when you visit Panama either for leisure or business. Reviewed on 16 Nov 2025 [](https://expedia.co.uk/go/package/search/FlightHotel/2025-12-25/2026-01-01/?FromAirport=LHR&Destination=PTY&NumRoom=1&NumAdult=2&NumChild=0&hotelId=91995575&paandie=true&HotelClass=40&dealMarker=e2n31Rw607s36pgPjs0NW2UA_2t-_pr_IiWCT7TA9MevUvWavNCZo1hLKAZAk5ux) ![Casa Contemporanea by Wynwood House](https://images.trvl-media.com/lodging/100000000/99230000/99229300/99229225/64939a66_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Casa Contemporanea by Wynwood House Casco Viejo £1,795 per person 25 Dec - 1 Jan found 11 hours ago Return direct flight included London (LHR) to Panama City (PTY) 17.2/10 Exceptional! (19 reviews) Great experience, beautiful apartment. Minor maintenance issues that were addressed in a timely fashion. Would definitely recommend and stay there again! Reviewed on 28 Mar 2025 [](https://expedia.co.uk/go/package/search/FlightHotel/2025-12-25/2026-01-01/?FromAirport=LHR&Destination=PTY&NumRoom=1&NumAdult=2&NumChild=0&hotelId=99229225&paandie=true&HotelClass=40&dealMarker=QDycZ0z9SblsP5fsFfmmGFzb_6Zvmqb2BzrCUrH1aSBVOX5D_YdrqCo1OP5YMy1K) ![Bristol Panama, a Registry Collection Hotel](https://images.trvl-media.com/lodging/1000000/70000/69700/69638/1700edf5_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Bristol Panama, a Registry Collection Hotel Bella Vista £1,506 per person 25 Dec - 1 Jan found 11 hours ago Return direct flight included London (LHR) to Panama City (PTY) 18.4/10 Exceptional! (1,003 reviews) Super team. Danay always makes my stay wonderful as does the whole team. I go often. Reviewed on 16 Nov 2025 [](https://expedia.co.uk/go/package/search/FlightHotel/2025-12-25/2026-01-01/?FromAirport=LHR&Destination=PTY&NumRoom=1&NumAdult=2&NumChild=0&hotelId=69638&paandie=true&HotelClass=40&dealMarker=QDycZ0z9SblsP5fsFfmmGFzb_6Zvmqb2BzrCUrH1aSCYsOw2fgTx1FO0m_rD_uJ8) ![Hotel La Compañía Casco Antiguo](https://images.trvl-media.com/lodging/72000000/71140000/71136000/71135966/02cb9f51_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel La Compañía Casco Antiguo Casco Viejo Save 100% on your flight £2,734 per person 25 Dec - 1 Jan found 11 hours ago Return direct flight included London (LHR) to Panama City (PTY) 19.6/10 Exceptional! (245 reviews) Fabulous hotel in every way. Reviewed on 14 Nov 2025 [](https://expedia.co.uk/go/package/search/FlightHotel/2025-12-25/2026-01-01/?FromAirport=LHR&Destination=PTY&NumRoom=1&NumAdult=2&NumChild=0&hotelId=71135966&paandie=true&HotelClass=40&dealMarker=amRB0DpSX2roa1b4pu3bWYd1Smjk0-WhApu1fX5Q7U1zeHxxXskuwm93neQK4BL1) Don't see what you're looking for? See all available trips from London to Eastern Panama [View all trips](https://expedia.co.uk/go/package/search/FlightHotel/2025-12-18/2025-12-25/?FromAirport=LHR&Destination=PAC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## 5\* Luxury holidays in Eastern Panama Price found within the past 48 hours. Click for updated prices. ![Renaissance Panama City Hotel ](https://images.trvl-media.com/lodging/1000000/530000/527200/527169/d8dfdd09_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Renaissance Panama City Hotel Bella Vista £1,128 per person 25 Dec - 1 Jan found 11 hours ago Return direct flight included London (LHR) to Panama City (PTY) 18/10 Exceptional! (85 reviews) Very nice. Great staff. Reviewed on 12 Nov 2025 [](https://expedia.co.uk/go/package/search/FlightHotel/2025-12-25/2026-01-01/?FromAirport=LHR&Destination=PTY&NumRoom=1&NumAdult=2&NumChild=0&hotelId=527169&paandie=true&HotelClass=50&dealMarker=MRSdCRLx1sXP_6DkO-UTLxmS9ckjIxrc8pxExnFymz5AWxhZuDYVsDK4Iar99nKs) ![Bristol Panama, a Registry Collection Hotel](https://images.trvl-media.com/lodging/1000000/70000/69700/69638/1700edf5_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Bristol Panama, a Registry Collection Hotel Bella Vista £1,506 per person 25 Dec - 1 Jan found 11 hours ago Return direct flight included London (LHR) to Panama City (PTY) 18.4/10 Exceptional! (1,003 reviews) Super team. Danay always makes my stay wonderful as does the whole team. I go often. Reviewed on 16 Nov 2025 [](https://expedia.co.uk/go/package/search/FlightHotel/2025-12-25/2026-01-01/?FromAirport=LHR&Destination=PTY&NumRoom=1&NumAdult=2&NumChild=0&hotelId=69638&paandie=true&HotelClass=50&dealMarker=QDycZ0z9SblsP5fsFfmmGFzb_6Zvmqb2BzrCUrH1aSCYsOw2fgTx1FO0m_rD_uJ8) ![The Westin Playa Bonita Panama](https://images.trvl-media.com/lodging/5000000/4670000/4668700/4668643/6d441b5e_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Westin Playa Bonita Panama £1,982 per person 25 Dec - 1 Jan found 11 hours ago Return direct flight included London (LHR) to Panama City (PTY) 16/10 Exceptional! (1,000 reviews) Rooms were great! A/C felt AMAZING! Staff SUPER NICE AND FRIENDLY! FOOD AMAZING! There was literally nothing we ate that we did not love! We added the Premium all inclusive package when we arrived for a great price! We ate at all the restaurants, buffets and had top shelf liquor ! I would for sure stay here again! Reviewed on 11 Nov 2025 [](https://expedia.co.uk/go/package/search/FlightHotel/2025-12-25/2026-01-01/?FromAirport=LHR&Destination=PTY&NumRoom=1&NumAdult=2&NumChild=0&hotelId=4668643&paandie=true&HotelClass=50&dealMarker=HJVRWAM_ZqqyHiEDuFwx_fpu1sHDVjFC10qgEL15GDJUSHqKtEi8km2eLxUE3HB8) Don't see what you're looking for? See all available trips from London to Eastern Panama [View all trips](https://expedia.co.uk/go/package/search/FlightHotel/2025-12-18/2025-12-25/?FromAirport=LHR&Destination=PAC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## All you need to know about luxury holidays in Eastern Panama #### What can I expect from a luxury Eastern Panama holiday? Luxury on holiday is all about relaxing and feeling good. Whether you choose a sumptuous spa, Michelin-starred restaurant or super-king bed is your call. Use our amenities filters to find the things that tick all your boxes. #### How can I find all-inclusive luxury holidays in Eastern Panama? Tick the all-inclusive and 5-star filters to find the crème de la crème of Eastern Panama holidays. With everything included in the package price, you can drink and dine to your heart’s content, without worrying about that bill at the end. #### Can I book a cheap luxury holiday to Eastern Panama? A luxury holiday doesn’t have to break the bank. Travel out of peak season, choose a hotel or resort a little way out or go for a last-minute getaway and you’ll find some cracking deals. Sort by price to find luxury holidays to Eastern Panama starting at £1,128. Prices and availability are subject to change. Additional terms may apply. #### Are there luxury spa holidays in Eastern Panama? For sunset massages on the shoreline and view-filled saunas, use our spa filter to find your ideal Eastern Panama spa hotel. Book a whole weekend soaking away your stresses, or hop into the spa after the beach, some golf or a local advent-ahhhh. #### What should I look for when booking a luxury family holiday in Eastern Panama? Luxury isn’t just for adults. Those little touches designed for little people make a family holiday genuinely stress free … which is the greatest luxury of all. Look for spacious suites, pools toddlers can splash in, and breakfast buffets with waffles, pancakes and Nutella galore. #### Can I book luxury last-minute holidays to Eastern Panama? You can wangle a top-notch luxury holiday in Eastern Panama for a fraction of the normal price by booking last minute. Just enter your dates and see what’s available – if you’re flexible ... even better! #### Can I book a luxury holiday in Eastern Panama with free cancellation and/or flexible dates? If you’re splashing out on a luxury holiday, make sure your money is safe by booking with free cancellation. Just use the fully refundable filter and make sure you read all the terms and conditions. #### Why should I book my luxury travel to Eastern Panama with Expedia? Nobody does luxury quite like Expedia. With so many gorgeous properties in Eastern Panama to choose from, as well as access to first-class flight deals and hire cars with horsepower, there’s no better place to book. ## More holidays you might like ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Holidays [](https://expedia.co.uk/lp/theme-holidays/all-inclusive-holidays?rfrr=editorial.All_Inclusive%20Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Holidays [](https://expedia.co.uk/lp/theme-holidays/beach-holidays?rfrr=editorial.Beach_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Family Friendly Holidays [](https://expedia.co.uk/lp/theme-holidays/kid-friendly-holidays?rfrr=editorial.Family_Friendly%20Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Holidays [](https://expedia.co.uk/lp/theme-holidays/golf-holidays?rfrr=editorial.Golf_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Holidays [](https://expedia.co.uk/lp/theme-holidays/luxury-holidays?rfrr=editorial.Luxury_Holidays.click) ![gay friendly holiday packages](https://forever.travel-assets.com/flex/flexmanager/images/2023/06/15/LGBTQIA_Holiday_Package.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) LGBTQ+ Holidays [](https://expedia.co.uk/lp/theme-holidays/gay-friendly-holidays?rfrr=editorial.LGBTQ+_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Holidays [](https://expedia.co.uk/lp/theme-holidays/romantic-holidays?rfrr=editorial.Romantic_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Holidays [](https://expedia.co.uk/lp/theme-holidays/ski-holidays?rfrr=editorial.Ski_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/22/hero-image-pet-friendly_copy.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Pet Friendly Holidays [](https://expedia.co.uk/lp/theme-holidays/pet-friendly-holidays?rfrr=editorial.Pet_Friendly%20Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2023/05/10/mesog-34434-card-venice.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Where to go when [](https://expedia.co.uk/lp/b/where-to-go-when?rfrr=editorial.Where_to%20go%20when.click) ### Top Luxury Holiday Destinations > - 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Savings not available on all packages. Flight-inclusive packages are ATOL protected. ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app ![QR code to download the app](data:image/png;base64,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)