A calm sea with a small boat and a row of palm trees on the shore.

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Check prices for these dates

In two weeks
6 Nov - 8 Nov
In two months
18 Dec - 20 Dec
In three months
15 Jan - 17 Jan
In four months
12 Feb - 14 Feb

Our top choices for Eastern Panama holiday rentals

A tropical beach with clear turquoise waters, palm trees, and a small island with buildings.

1. san blas luxury tour

san blas luxury tour
2.0 star property
Nusatupo
The price is £91
includes taxes & fees
21 Nov - 22 Nov
san blas luxury tour
A tent with a view of a beach and palm trees, a red umbrella, and a wooden deck.

2. glampling sanblas luxury

glampling sanblas luxury
1.0 star property
Nargana
The price is £281
includes taxes & fees
22 Nov - 23 Nov
glampling sanblas luxury
A thatched-roof overwater bungalow with a wooden deck, clear blue water, and a distant mountain range.

3. San Blas Private Beach Cabin

San Blas Private Beach Cabin
2.5 star property
Narganá
The price is £191
includes taxes & fees
22 Nov - 23 Nov
San Blas Private Beach Cabin
A tropical beach with palm trees and clear turquoise waters.

4. San Blas Private Oceanfront Cabin

San Blas Private Oceanfront Cabin
2.5 star property
Narganá
The price is £287
includes taxes & fees
22 Nov - 23 Nov
San Blas Private Oceanfront Cabin
A beach with clear turquoise water, a wooden structure with a red roof, and a white sandy shore.

5. Pelicano Island

Pelicano Island
2.0 star property
Moraquedub
The price is £266
includes taxes & fees
22 Nov - 23 Nov
Pelicano Island
A beach with clear water and a distant island.

6. San Blas Tour Aridub

San Blas Tour Aridub
2.0 star property
Narganá
The price is £179
includes taxes & fees
21 Nov - 22 Nov
San Blas Tour Aridub
A coconut on a wooden table under a wooden structure by the beach with palm trees and the ocean in the background.

7. Sanblastourgy

Sanblastourgy
2.0 star property
Nargana
The price is £167
includes taxes & fees
23 Oct - 24 Oct
Sanblastourgy
A beach with palm trees, a thatched-roof hut, and a sandy shore.

8. Beachfront Cabin on the San Blas Islands: Aroma

Beachfront Cabin on the San Blas Islands: Aroma
Guna Yala
The price is £125
includes taxes & fees
26 Oct - 27 Oct
Beachfront Cabin on the San Blas Islands: Aroma
A wooden pier leading to a beach with clear turquoise water, surrounded by palm trees and a small building with a balcony.

9. Private Over-Water Cabins on San Blas Island

Private Over-Water Cabins on San Blas Island
2.5 star property
Narganá
The price is £246
includes taxes & fees
21 Nov - 22 Nov
Private Over-Water Cabins on San Blas Island
A hammock on a beach with palm trees and a clear view of the ocean.

10. Private Over-the-Water Cabin in San Blas including Meals

Private Over-the-Water Cabin in San Blas including Meals
2.5 star property
Mirladub
The price is £400
includes taxes & fees
24 Oct - 25 Oct
Private Over-the-Water Cabin in San Blas including Meals
A modern house with a swimming pool, surrounded by palm trees and a clear sky.

11. Casa frente al mar - turtle cay marina

Casa frente al mar - turtle cay marina
2.5 star property
Nombre de Dios
The price is £470
includes taxes & fees
15 Nov - 16 Nov
Casa frente al mar - turtle cay marina
A beach with palm trees and a clear view of the ocean.

12. All inclusive 4-bedroom Catamaran up to 8 people in San Blas Panama

All inclusive 4-bedroom Catamaran up to 8 people in San Blas Panama
Guna Yala Comarca
The price is £675
includes taxes & fees
26 Oct - 27 Oct
All inclusive 4-bedroom Catamaran up to 8 people in San Blas Panama
A tropical beach with palm trees and clear turquoise waters.

13. San Blas Private Over-the-Water Cabin

San Blas Private Over-the-Water Cabin
2.5 star property
Narganá
8.0 out of 10, Very good, (2 reviews)
"I liked the modern payment system that was used for booking the trip, the food was great, the location was as described. I disliked the communication with the reseller this booking goes through. They dropped the ball on communicating pickup time and itinerary confirmation, even when i tried calling and emailing them. I also disliked the value of what you get with this trip. Id expect better cleanliness and standards for this trip. I also disliked when the staff on the island said i needed to pay...
United States
Andrew
The price is £270
includes taxes & fees
23 Oct - 24 Oct
San Blas Private Over-the-Water Cabin
A covered outdoor dining area with a view of the beach and palm trees.

14. Caribbean getaway: beach cottage just on the sand

Caribbean getaway: beach cottage just on the sand
Palenque
9.0 out of 10, Wonderful, (4 reviews)
"the view is beautiful! We were taken care of well."
United States
Mirelys
The price is £240
includes taxes & fees
26 Oct - 27 Oct
Caribbean getaway: beach cottage just on the sand
A modern house with a covered patio, a lawn, and a view of the surrounding landscape.

15. Lovely Caribbean Apartment with AC + Wifi + BBQ + Beach + Kitchen + Parking

Lovely Caribbean Apartment with AC + Wifi + BBQ + Beach + Kitchen + Parking
Puerto Lindo
The price is £197
includes taxes & fees
23 Oct - 24 Oct
Lovely Caribbean Apartment with AC + Wifi + BBQ + Beach + Kitchen + Parking
A modern cabin with a sloped roof, surrounded by trees, and a gravel path leading to the entrance.

16. Tiny Cabin

Tiny Cabin
3.0 star property
Panamá
10.0 out of 10, Exceptional, (1 review)
The price is £110
includes taxes & fees
12 Nov - 13 Nov
Tiny Cabin
A modern living room with a dining area, a pool table, a TV, and a wall decorated with vinyl records.

17. Elegance and Comfort in Panama City's Old Town

Elegance and Comfort in Panama City's Old Town
Panamá
2.0 out of 10, (1 review)
"The address that’s depicted is not accurate to the map that’s shown and I tried multiple times to communicate with the host and no response"
United States
PAMELA
The price is £70
includes taxes & fees
22 Nov - 23 Nov
Elegance and Comfort in Panama City's Old Town
A covered outdoor seating area with two chairs and a table, surrounded by vegetation and a stone wall.

18. Cozy Cabin in the Misty Mountain

Cozy Cabin in the Misty Mountain
Panamá
The price is £89
includes taxes & fees
1 Nov - 2 Nov
Cozy Cabin in the Misty Mountain
A modern living room with a sofa, a dining table with placemats, and a view of the outdoors through a large window.

19. Cozy and Safe Environment Close to the Airport.

Cozy and Safe Environment Close to the Airport.
Panamá
The price is £64
includes taxes & fees
27 Oct - 28 Oct
Cozy and Safe Environment Close to the Airport.
A beach view with palm trees, a clear sky, and distant mountains.

20. Bala Bliss Charming 2-bedroom apartment with WiFi, AC in Maria Chiquita

Bala Bliss Charming 2-bedroom apartment with WiFi, AC in Maria Chiquita
Maria Chiquita
6.6 out of 10, (4 reviews)
"Well-appointed apartment, view of the ocean, big pool, fast Internet, attentive security. We had a great time here, thanks!"
United States
Will
The price is £124
includes taxes & fees
25 Oct - 26 Oct
Bala Bliss Charming 2-bedroom apartment with WiFi, AC in Maria Chiquita
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Eastern Panama Hotel Reviews

Caribbean Haven Of Nature 'Preci Beach'

Caribbean Haven Of Nature 'Preci Beach'

10/10 Excellent
"This is a great place to slow down and enjoy the sea and on-site amenities, including a pool, hot tub, sand volleyball court, and kid-friendly play spaces. This is very much a home that the owners make available to guests. Cone, the on-site custodian, is available and helpful. It is somewhat remote and while getting there is a bit of a challenge, once there, the serene and peaceful setting allows you to really unwind. At no time, was safety a concern for any of us. If you are looking for a pristine, sterile location this may not be for you, but if you want to feel welcomed into someone’s beach house in a magnificent setting, this place is excellent."
Norman B. 3-night trip
Posted 3 weeks ago
Caribbean Haven Of Nature 'Preci Beach'

Find out more about Eastern Panama

Everything you need to know about Eastern Panama holiday rentals

Whether you’re excited for the perfect family holiday, a romantic getaway for two, or the ultimate city break, we’ve got the Eastern Panama holiday rental for you. At Expedia, you can take your pick from private holiday homes, apartments, cottages, apart-hotels, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Eastern Panama holiday rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search. 

Eastern Panama holiday rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Eastern Panama. If you’re looking for a little peace, consider booking during the quieter months, such as  . For more hustle and bustle, you may prefer to visit in . 

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Eastern Panama holiday rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a holiday rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Eastern Panama holiday rentals we have selected for you start as low as £91 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on Eastern Panama rentals

At Expedia, we put the best Eastern Panama holiday rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. 

To find some top Eastern Panama rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Eastern Panama holiday.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Eastern Panama. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.