Eastern Panama Holidays from £658

Book a Hotel + Flight or Car together to unlock savings

Photo by Nico Barner

  • Plan, book, travel with confidence

  • Better together

    Save up to £750 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Packages with flights are ATOL protected

Your Eastern Panama Holiday

Leave all the planning to us with an Eastern Panama holiday package. With everything organised before you jet off, all you need to do is sit back, chill out and experience this destination's many wonders. Where to start your journey? In the most popular cities, of course. Isla Tigre and Palenque are two great places to kick off your itinerary during your trip to Eastern Panama. When it's time to stop daydreaming and start doing, Expedia will help turn your Eastern Panama holiday into reality.

Top Eastern Panama Flight + Hotel Deals

Price found within the past 48 hours. Click for updated prices.
San Francisco by Wynwood House

San Francisco by Wynwood House

3 out of 5
San Francisco
Price was £836, price is now £658 per person
£658
per person
11 Aug - 16 Aug
found 8 hours ago
Return flight included
Montego Bay (MBJ) to Panama City (PTY)
9.2/10 Wonderful! (56 reviews)
Clean and walkable location

Reviewed on 7 Dec 2025

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was £1,677, price is now £1,071 per person
£1,071
per person
25 Aug - 1 Sept
found 2 hours ago
Return direct flight included
London (LON) to Panama City (PTY)
8.4/10 Very Good! (1,553 reviews)
Rooms clean and spacious

Reviewed on 16 Jun 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Save 100% on your flight
Price was £1,156, price is now £762 per person
£762
per person
3 Aug - 7 Aug
found 14 hours ago
Return flight included
George Town (GCM) to Panama City (PTY)
9.2/10 Wonderful! (1,008 reviews)
Spacious and modern room with large bathroom and nice shower. Beautiful music during the day and evening. Excellent breakfast buffet and on-site dining. Pool and pool bar were lovely. Friendly staff. Highly recommend.

Reviewed on 14 Jun 2026

Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
San Francisco
Price was £1,362, price is now £1,056 per person
£1,056
per person
25 Aug - 1 Sept
found 2 hours ago
Return direct flight included
London (LON) to Panama City (PTY)
9/10 Wonderful! (1,036 reviews)
The staff and just the overall ambiance of the environment was top tier

Reviewed on 15 Jun 2026

Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City

5 out of 5
Casco Viejo
Price was £1,210, price is now £976 per person
£976
per person
3 Aug - 7 Aug
found 14 hours ago
Return flight included
George Town (GCM) to Panama City (PTY)
9.8/10 Exceptional! (664 reviews)
Hotel is in what they call old city (area looks colonial). There are many stores in the area for shopping. The hotel itself is nice. The staff was friendly. The pool was beautiful and I had a great time using the on site spa. The rooftop restaurant had good food and live entertainmen. The hotel was well kept.

Reviewed on 9 Jun 2026

Eastern Panama Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Tocumen Intl. Airport (PTY)

Top hotels in Eastern Panama

Ordovician Beach Resort

Ordovician Beach Resort

4.5 out of 5
Isla Grande Isla Grande Colon
The price is £350 per night from 22 Jun to 23 Jun
£350
22 Jun - 23 Jun
includes taxes & fees
10/10 Exceptional! (10 reviews)
"El hotel es una belleza, todo estaba extremadamente limpio, las habitaciones y áreas comunes súper cómodas. La atención de todo el personal es del más alto nivel y te hacen sentir como en casa. Las atracciones también son muy buenas y la comida excepcional."

Reviewed on 8 Jun 2026

Ordovician Beach Resort
Ranchos de Chalia

Ranchos de Chalia

3 out of 5
Portobelo via Puerto Lindo, Unit 3 Puerto Lindo Colón
The price is £103 per night from 2 Jul to 3 Jul
£103
2 Jul - 3 Jul
includes taxes & fees
9.8/10 Exceptional! (18 reviews)
"Here's a natural, conversational review in English: We had a wonderful stay here. The hotel is beautiful, with an amazing pool overlooking both the ocean and the rainforest. Everything was very clean, and the beds were extremely comfortable. The staff were incredibly friendly and welcoming. The owner ..."

Reviewed on 2 Jun 2026

Ranchos de Chalia
san blas luxury tour

san blas luxury tour

2 out of 5
guna yala Nusatupo Guna Yala
The price is £120 per night from 2 Jul to 3 Jul
£120
2 Jul - 3 Jul
includes taxes & fees
san blas luxury tour
See all 187 properties in Eastern Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Frequently asked questions

Can I cancel my flight booking to Eastern Panama due to COVID-19?
Our Customer Service Portal is where you can find useful information about cancelling or changing your flight due to COVID-19. Before booking your tickets, it's wise to scroll through the terms and conditions of your airfare too.
What's the best way to find cheap flights to Eastern Panama that have flexible change policies?
It's as easy as counting to three with Expedia. Firstly, enter your travel details and press "Search." Second step: Check the "No change fee" box under the "Flexible change policies" heading to the left of your screen. Step 3. Nab a cheap and flexible flight to Eastern Panama.
What are some of the general tips for travellers to Eastern Panama during the COVID-19 outbreak?
COVID-19 has resulted in significant changes to the way we travel. If you plan to jet off to Eastern Panama, these tips will help you navigate the "new normal:"
  • Before you lock in a flight, find out if any travel restrictions apply — in both your destination and origin. Keep informed with the latest updates by checking government and travel websites.
  • When you go through airport screening, keep your face mask on. You will be asked to lower it briefly to verify your identity. Passengers who refuse to wear a face mask may face civil penalties and may also be escorted from the building.
  • Rather than handing a TSA agent your boarding pass, position it directly on the reader yourself. Once that's done, hold it up for inspection.
  • TSA now allows passengers to take one container of hand sanitizer, up to 12 oz (350 ml) in size, in carry-on bags. This will need to be removed from your bag and presented for screening.
  • To minimize handling during screening, place items such as your phone, keys and wallet into your carry-on instead of the bins.
  • Transport all food items in a clear plastic bag and also place them in a screening bin. Keeping food separate from your carry-on means it's less likely a TSA employee will need to open and touch your bag for inspection.

Which airlines fly to Eastern Panama?
Copa Airlines is a well-known airline servicing Eastern Panama. Search for airfares to Tocumen Intl. Airport (PTY) and you'll have 3173 Copa Airlines flights every month to choose from.
How can I find cheap tickets to Eastern Panama?
You'll always find a fabulous deal with Expedia, but our "flexible dates" feature makes it that much easier. Enter your preferred travel date, then click on the flexible dates box above to see prices for nearby days. was the cheapest price for a flight to Eastern Panama in the last seven days.
How much is a flight to Eastern Panama?
There were lots of low-cost fares for the taking in the last seven days, with the cost of a round-trip flight to Eastern Panama varying between and . Many lucky travellers locked in one-way flights from () for only .
What are the most popular airports to fly into in Eastern Panama?
The main gateway to Eastern Panama, roughly 3507 flights land at Tocumen Intl. Airport (PTY) each month. Track down a top deal, book your seat and get ready to enjoy the best of this amazing region.
When is the cheapest time to fly to Eastern Panama?
Jetting off on a Tuesday, followed by a Monday, is generally the best way to land the cheapest fare. Steer clear of the weekend if you can, because Saturday is typically the most expensive day. Spend the dollars you saved having a good time in Eastern Panama instead!
How much is a plane ticket to Eastern Panama?
Prices varied from to over the last seven days. When you're ready to book, we'll be ready to help you pick up the best deal to Eastern Panama.
Which airlines with flights to Eastern Panama employ COVID-19 cleanliness policies?
In order to minimize contact between passengers and cabin crew during the COVID-19 outbreak, the majority of airlines have taken social distancing and other measures to the skies. Just a few of these are:
  • Copa Airlines - this airline is known for conducting passenger temperature checks and electrostatic cleaning.
  • United Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • American Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.