
Eastern Panama Holidays from £610
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to £750 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPackages with flights are ATOL protected
Your Eastern Panama Holiday
Leave all the planning to us with an Eastern Panama holiday package. With everything organised before you jet off, all you need to do is sit back, chill out and experience this destination's many wonders. Where to start your journey? In the most popular cities, of course. Isla Tigre and Palenque are two great places to kick off your itinerary during your trip to Eastern Panama. When it's time to stop daydreaming and start doing, Expedia will help turn your Eastern Panama holiday into reality.
Top Eastern Panama Flight + Hotel Deals



Decapolis Hotel Panama City
Reviewed on 5 Nov 2026

Hotel Riu Plaza Panama
Reviewed on 6 Nov 2026
Eastern Panama Essential Information
Language | Spanish |
|---|---|
Currency | Panamanian balboas |
Local Welcome | ¡Hola! |
Local Goodbye | Adiós |
Closest Airport | Tocumen Intl. Airport (PTY) |
Top hotels in Eastern Panama

Ordovician Beach Resort
"The best place in the world to have a relax and amazing vacation."
Reviewed on 5 Nov 2026

Private Ocean-Front Cabin with private bathroom on San Blas Island
"Staff was wonderful. Room was basic, as described. Basically camping on the beach with a comfortable bed. Fall asleep to ocean waves just feet from the door."
Reviewed on 15 Mar 2026

san blas luxury tour
Stay near popular Eastern Panama attractions
Frequently asked questions
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.











