Eastern Panama Holidays from £798

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    Packages with flights are ATOL protected

Your Eastern Panama Holiday

Leave all the planning to us with an Eastern Panama holiday package. With everything organised before you jet off, all you need to do is sit back, chill out and experience this destination's many wonders. Where to start your journey? In the most popular cities, of course. Isla Tigre and Palenque are two great places to kick off your itinerary during your trip to Eastern Panama. When it's time to stop daydreaming and start doing, Expedia will help turn your Eastern Panama holiday into reality.

Top Eastern Panama Flight + Hotel Deals

Price found within the past 48 hours. Click for updated prices.
MARINN Tropical Vibes Hotel

MARINN Tropical Vibes Hotel

3.5 out of 5
Amador
per person
26 Sept - 30 Sept
found 22 hours ago
Return direct flight included
London (LON) to Panama City (PTY)
8/10 Very Good! (111 reviews)
I liked that there were plenty activities and food options nearby. The staff were very friendly and helpful. Property and room was always clean. Just a wonderful overall experience.

Reviewed on 24 Jul 2025

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
per person
26 Sept - 30 Sept
found 22 hours ago
Return direct flight included
London (LON) to Panama City (PTY)
8.4/10 Very Good! (936 reviews)
The property was pretty good

Reviewed on 27 Jul 2025

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Bella Vista
per person
26 Sept - 30 Sept
found 22 hours ago
Return direct flight included
London (LON) to Panama City (PTY)
9/10 Wonderful! (4,078 reviews)
Beautiful stay, the room was great and the food was excellent. Definitely will stay there again

Reviewed on 30 Jul 2025

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
per person
26 Sept - 30 Sept
found 22 hours ago
Return direct flight included
London (LON) to Panama City (PTY)
9/10 Wonderful! (932 reviews)
Nuestra experiencia en el hotel fue excelente. Las instalaciones se mantienen impecablemente limpias y bien cuidadas, lo que hace que la estadía sea muy agradable. El personal es sumamente atento y gentil, siempre dispuesto a ayudar y hacer sentir a los huéspedes bienvenidos. Nos encantó la música en vivo que ofrecen, creando un ambiente relajado y acogedor. Además, la ubicación es perfecta: está muy cerca de los principales lugares turísticos, lo que facilita explorar la zona sin complicaciones. ¡Definitivamente volveríamos!

Reviewed on 25 Jul 2025

Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
San Francisco
per person
26 Sept - 30 Sept
found 22 hours ago
Return direct flight included
London (LON) to Panama City (PTY)
8.8/10 Excellent! (1,000 reviews)
amazing hotel great staff

Reviewed on 25 Jul 2025

Eastern Panama Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Tocumen Intl. Airport (PTY)

Top hotels in Eastern Panama

Ranchos de Chalia

Ranchos de Chalia

3 out of 5
Portobelo via Puerto Lindo, Unit 3, Puerto Lindo, Colón
The price is £115 per night from 14 Aug to 15 Aug
£115
14 Aug - 15 Aug
includes taxes & fees
9.6/10 Exceptional! (4 reviews)
"Such a beautiful place! Lovely view and very close to access to the beach. 5 min small boats ride. Relaxing environment mixing mountain feeling and beach view. Very cozy for family of 2 kids. The people in charge there are exceptional!"

Reviewed on 19 Apr 2025

Ranchos de Chalia
Ordovician Beach Resort

Ordovician Beach Resort

4.5 out of 5
Isla Grande, Isla Grande, Colon
10/10 Exceptional! (2 reviews)
"The Ordovician Hotel is a hidden gem on the peaceful west side of Isla Grande. From the moment we booked, the service was personal and seamless—thank you, Yohan! We were welcomed by name, greeted with a delicious tropical drink, and felt like cherished guests from start to finish. We stayed in the ..."

Reviewed on 25 Jul 2025

Get rates
Ordovician Beach Resort
Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island

2 out of 5
Diablo Island, Narganá, Guna Yala
Get rates
Private Ocean-Front Cabin with private bathroom on San Blas Island
See all 167 properties in Eastern Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Popular places to visit

Cayos Holandeses

Commune with nature and explore the great outdoors at Cayos Holandeses during your travels in San Blas Islands. Stroll along the seaside or experience the area's festivals.

Cayos Holandeses

Frequently asked questions

How much does an Eastern Panama travel package cost?
Perhaps less than you might think — from as low as £798, actually! By bundling hotels, flights and car rentals into a custom-built package, your Eastern Panama escape is only clicks away.
If I'm not able to travel, can I cancel my Eastern Panama travel package?
Because we understand life can be unpredictable, the answer is yes. To learn more, visit our Customer Service Portal. But generally speaking, if you've booked your Eastern Panama travel package in the last 24 hours, you may be able to change or cancel it with no penalties. Your airline, hotel or car rental company may impose a fee if your booking is older than that.
How do I get a cheap travel package to Eastern Panama?
Combine your bookings with Expedia to save big on your next exciting adventure. With more than 550 airlines and 1,000,000 properties around the globe, your Eastern Panama travel package can be tailored exactly to suit your travel style. With all those extra dollars, why not include some fun experiences and tours? It's an easy way to unlock even more savings. The holiday you've always dreamed of in Eastern Panama is much closer than you thought!
Does Expedia offer Book Now, Pay Later Eastern Panama holidays?
Expedia has partnered with online lender Klarna to make your next break easier on your bank balance. Paying in instalments means you can spread the costs of your next adventure, leaving you with more money to play with while you're away. Klarna has several payment plans to pick from, so you're sure to find something that works with your budget. Check out these flexible payment options:

  • Pay monthly holidays: Realise your holiday dreams sooner with Klarna's convenient monthly instalment plans. If paying bite-sized amounts each month works for you, choose this option at checkout.
  • Pay in instalments holidays: Like the idea of paying off your holiday in multiple transactions? Consider this Book Now, Pay Later option with Klarna.
  • Low deposit holidays: If paying a small percentage of your trip (rather than the full total upfront) makes it easier to click that "book now" button, opt for a low deposit holiday payment plan with Klarna.

How far in advance should I book my Eastern Panama holiday?
Your safest bet is to book early. Air carriers generally release flights up to 12 months in advance, and this is an excellent opportunity to land some of the cheapest prices. Boss just told you to use up some holiday time next week? That's fine too — Expedia are never short on fantastic bargains to whisk you away on the getaway of your dreams, at a price you can afford.
What does an Expedia Eastern Panama travel package include?
Much of that is up to you. You can pick from a variety of Eastern Panama packages, such as a flight, rental car and hotel. You can also book a hotel and a flight, or a flight with a rental car. Once you've made your booking, you can add the fun stuff like tours and activities. Whatever your dream Eastern Panama trip looks like, get ready to save!
What should I know before booking an Eastern Panama travel package?
Our prices are always low. However, you'll pick up even more savings if you book your flights, hotels and car rentals together. With an Expedia package, you'll always get transparent pricing and a huge range of choice.
Can I choose my airline with an Eastern Panama Expedia travel package?
With a travel package, you're in charge. Whether you're hoping to fly to Eastern Panama in business or coach, simply select from the available airline options. Expedia has access to more than 550 partner airlines throughout the world.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.