Eastern Panama Holidays from £1,177

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Your Eastern Panama Holiday

Leave all the planning to us with an Eastern Panama holiday package. With everything organised before you jet off, all you need to do is sit back, chill out and experience this destination's many wonders. Where to start your journey? In the most popular cities, of course. Isla Tigre and Palenque are two great places to kick off your itinerary during your trip to Eastern Panama. When it's time to stop daydreaming and start doing, Expedia will help turn your Eastern Panama holiday into reality.

Top Eastern Panama Flight + Hotel Deals

Price found within the past 48 hours. Click for updated prices.
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was £1,590, price is now £1,177 per person
£1,177
per person
4 Jun - 11 Jun
found 13 hours ago
Return direct flight included
London (LON) to Panama City (PTY)
8.4/10 Very Good! (1,524 reviews)
Good value for the dollar

Reviewed on 4 May 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was £1,937, price is now £1,337 per person
£1,337
per person
4 Jun - 11 Jun
found 13 hours ago
Return direct flight included
London (LON) to Panama City (PTY)
9.2/10 Wonderful! (1,005 reviews)
Excelente localización personal del hotel muy bueno. La crítica.: hotel no te tiene los útiles básicos como crema para la piel, gorro de baño. Cepillo dental etc. Hay q estar en la recepción para recordar y solicitarlo

Reviewed on 4 May 2026

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

5 out of 5
Juan Diaz
Price was £1,694, price is now £1,325 per person
£1,325
per person
4 Jun - 11 Jun
found 13 hours ago
Return direct flight included
London (LON) to Panama City (PTY)
9.6/10 Exceptional! (688 reviews)
This is the definition of a 5 start hotel. We went to celebrate my husbands birthday because he's an avid golfer. It was easy to book tee times and the service was impeccable. The course was wel maintained and even saw a crocodile. The hotel itself went above and beyond because our room wasn't ready at time of arrival.

Reviewed on 5 Apr 2026

Casa Mallet by Wynwood House

Casa Mallet by Wynwood House

4 out of 5
Casco Viejo
Price was £1,545, price is now £1,219 per person
£1,219
per person
4 Jun - 11 Jun
found 6 hours ago
Return direct flight included
London (LON) to Panama City (PTY)
9.8/10 Exceptional! (27 reviews)
In the middle of the old town, lovely rooftop. Beautiful apartment. Easy check in. WhatsApp line is available if anything was needed or if we had questions.

Reviewed on 12 Mar 2026

Wanders Panama by Boutique Apartments

Wanders Panama by Boutique Apartments

4 out of 5
San Francisco
Save 100% on your flight
Price was £3,542, price is now £2,819 per person
£2,819
per person
4 Jun - 11 Jun
found 6 hours ago
Return direct flight included
London (LON) to Panama City (PTY)
10/10 Exceptional! (3 reviews)
The apartment was great. It was very comfortable and spacious. The building is impressive and a great place from which to enjoy Panama City.

Reviewed on 29 Dec 2025

Eastern Panama Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Tocumen Intl. Airport (PTY)

Top hotels in Eastern Panama

Ciel y Miel

Ciel y Miel

3 out of 5
Caillle Principale Cacique Provincia de Colón
The price is £168 per night from 6 May to 7 May
£168
6 May - 7 May
includes taxes & fees
10/10 Exceptional! (10 reviews)
The views from this mountain-top boutique hotel are extraordinary.

Reviewed on 1 Feb 2026

Ciel y Miel
Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island

2 out of 5
Diablo Island Narganá Guna Yala
10/10 Exceptional! (1 review)
Staff was wonderful. Room was basic, as described. Basically camping on the beach with a comfortable bed. Fall asleep to ocean waves just feet from the door.

Reviewed on 15 Mar 2026

Get rates
Private Ocean-Front Cabin with private bathroom on San Blas Island
HOTEL ISLA GRANDE

HOTEL ISLA GRANDE

3 out of 5
Final de paseo La Punta Isla Grande, 01 Isla Grande Colón Province
The price is £89 per night from 6 May to 7 May
£89
6 May - 7 May
includes taxes & fees
HOTEL ISLA GRANDE
See all 178 properties in Eastern Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Frequently asked questions

Can I cancel my flight booking to Eastern Panama due to COVID-19?
Our Customer Service Portal is where you can find useful information about cancelling or changing your flight due to COVID-19. Before booking your tickets, it's wise to scroll through the terms and conditions of your airfare too.
What's the best way to find cheap flights to Eastern Panama that have flexible change policies?
It's as easy as counting to three with Expedia. Firstly, enter your travel details and press "Search." Second step: Check the "No change fee" box under the "Flexible change policies" heading to the left of your screen. Step 3. Nab a cheap and flexible flight to Eastern Panama.
What are some of the general tips for travellers to Eastern Panama during the COVID-19 outbreak?
COVID-19 has resulted in significant changes to the way we travel. If you plan to jet off to Eastern Panama, these tips will help you navigate the "new normal:"
  • Before you lock in a flight, find out if any travel restrictions apply — in both your destination and origin. Keep informed with the latest updates by checking government and travel websites.
  • When you go through airport screening, keep your face mask on. You will be asked to lower it briefly to verify your identity. Passengers who refuse to wear a face mask may face civil penalties and may also be escorted from the building.
  • Rather than handing a TSA agent your boarding pass, position it directly on the reader yourself. Once that's done, hold it up for inspection.
  • TSA now allows passengers to take one container of hand sanitizer, up to 12 oz (350 ml) in size, in carry-on bags. This will need to be removed from your bag and presented for screening.
  • To minimize handling during screening, place items such as your phone, keys and wallet into your carry-on instead of the bins.
  • Transport all food items in a clear plastic bag and also place them in a screening bin. Keeping food separate from your carry-on means it's less likely a TSA employee will need to open and touch your bag for inspection.

Which airlines fly to Eastern Panama?
Copa Airlines is a well-known airline servicing Eastern Panama. Search for airfares to Tocumen Intl. Airport (PTY) and you'll have 3173 Copa Airlines flights every month to choose from.
How can I find cheap tickets to Eastern Panama?
You'll always find a fabulous deal with Expedia, but our "flexible dates" feature makes it that much easier. Enter your preferred travel date, then click on the flexible dates box above to see prices for nearby days. was the cheapest price for a flight to Eastern Panama in the last seven days.
How much is a flight to Eastern Panama?
There were lots of low-cost fares for the taking in the last seven days, with the cost of a round-trip flight to Eastern Panama varying between and . Many lucky travellers locked in one-way flights from () for only .
What are the most popular airports to fly into in Eastern Panama?
The main gateway to Eastern Panama, roughly 3507 flights land at Tocumen Intl. Airport (PTY) each month. Track down a top deal, book your seat and get ready to enjoy the best of this amazing region.
When is the cheapest time to fly to Eastern Panama?
Jetting off on a Tuesday, followed by a Monday, is generally the best way to land the cheapest fare. Steer clear of the weekend if you can, because Saturday is typically the most expensive day. Spend the dollars you saved having a good time in Eastern Panama instead!
How much is a plane ticket to Eastern Panama?
Prices varied from to over the last seven days. When you're ready to book, we'll be ready to help you pick up the best deal to Eastern Panama.
Which airlines with flights to Eastern Panama employ COVID-19 cleanliness policies?
In order to minimize contact between passengers and cabin crew during the COVID-19 outbreak, the majority of airlines have taken social distancing and other measures to the skies. Just a few of these are:
  • Copa Airlines - this airline is known for conducting passenger temperature checks and electrostatic cleaning.
  • United Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • American Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.