Panama Luxury Holidays

Book a Luxury Hotel + Flight or Car together to unlock savings

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    Save up to £335 when you book a flight and hotel together*
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    Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
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    Rest easy

    Packages with flights are ATOL protected

Top flight + Luxury hotel deals in Panama

Price found within the past 48 hours. Click for updated prices.
Hotel Casa Panamá
Waldorf Astoria Panama
Hotel Riu Plaza Panama
Las Americas Golden Tower Panama
American Trade Hotel
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5* Luxury holidays in Panama

Price found within the past 48 hours. Click for updated prices.
Hotel Riu Plaza Panama
Waldorf Astoria Panama
The Westin Playa Bonita Panama
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See all available trips from Bogotá to Panama
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4 Night Luxury holidays in Panama

Price found within the past 48 hours. Click for updated prices.
Las Americas Golden Tower Panama
Waldorf Astoria Panama
Hotel Riu Plaza Panama
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See all available trips from Bogotá to Panama
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All you need to know about luxury holidays in Panama

What can I expect from a luxury Panama holiday?

Luxury on holiday is all about relaxing and feeling good. Whether you choose a sumptuous spa, Michelin-starred restaurant or super-king bed is your call. Use our amenities filters to find the things that tick all your boxes.

How can I find all-inclusive luxury holidays in Panama?

Tick the all-inclusive and 5-star filters to find the crème de la crème of Panama holidays. With everything included in the package price, you can drink and dine to your heart’s content, without worrying about that bill at the end.

Can I book a cheap luxury holiday to Panama?

A luxury holiday doesn’t have to break the bank. Travel out of peak season, choose a hotel or resort a little way out or go for a last-minute getaway and you’ll find some cracking deals. Sort by price to find luxury holidays to Panama starting at £308. Prices and availability are subject to change. Additional terms may apply.

Are there luxury spa holidays in Panama?

For sunset massages on the shoreline and view-filled saunas, use our spa filter to find your ideal Panama spa hotel. Book a whole weekend soaking away your stresses, or hop into the spa after the beach, some golf or a local advent-ahhhh.

What should I look for when booking a luxury family holiday in Panama?

Luxury isn’t just for adults. Those little touches designed for little people make a family holiday genuinely stress free … which is the greatest luxury of all. Look for spacious suites, pools toddlers can splash in, and breakfast buffets with waffles, pancakes and Nutella galore.

Can I book luxury last-minute holidays to Panama?

You can wangle a top-notch luxury holiday in Panama for a fraction of the normal price by booking last minute. Just enter your dates and see what’s available – if you’re flexible ... even better!

Can I book a luxury holiday in Panama with free cancellation and/or flexible dates?

If you’re splashing out on a luxury holiday, make sure your money is safe by booking with free cancellation. Just use the fully refundable filter and make sure you read all the terms and conditions.

Why should I book my luxury travel to Panama with Expedia?

Nobody does luxury quite like Expedia. With so many gorgeous properties in Panama to choose from, as well as access to first-class flight deals and hire cars with horsepower, there’s no better place to book.

Top Luxury Panama Hotels

JW Marriott Panama

JW Marriott Panama

5 out of 5
Calle Punta Colon, Punta Pacifica, Panama City, Panama
  • 7 min drive from Albrook Shopping Mall
The price is £167 per night from 1 Aug to 2 Aug
£167
1 Aug - 2 Aug
includes taxes & fees
Stay at this 5-star luxury hotel in Panama City. Enjoy free Wi-Fi, 4 outdoor pools and 3 restaurants. Our guests praise the helpful staff and the property condition ...
8.8/10 Excellent! (1,015 reviews)
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Reviewed on 15 Jul 2025

JW Marriott Panama
Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel

5 out of 5
Avenida Aquilino de La Guardia, Bella Vista, Panama City, Panama
  • 4 min drive from Albrook Shopping Mall
The price is £150 per night from 1 Aug to 2 Aug
£150
1 Aug - 2 Aug
includes taxes & fees
Stay at this luxury hotel in Panama City. Enjoy free Wi-Fi, free valet parking and a full-service spa. Our guests praise the helpful staff and the property condition ...
9.2/10 Wonderful! (1,002 reviews)
"Great hotel. Lovely staff."

Reviewed on 7 Jul 2025

Bristol Panama, a Registry Collection Hotel
Waldorf Astoria Panama

Waldorf Astoria Panama

5 out of 5
47th St. & Uruguay Street, Panama City, Panama
  • 4 min drive from Albrook Shopping Mall
The price is £169 per night from 16 Aug to 17 Aug
£169
16 Aug - 17 Aug
includes taxes & fees
Stay at this 5-star luxury hotel in Panama City. Enjoy free Wi-Fi, a full-service spa and 2 restaurants. Our guests praise the helpful staff in their reviews. ...
8.8/10 Excellent! (1,000 reviews)
"The customer service was top tier and the concierge, Lil always made the best record!"

Reviewed on 14 Jul 2025

Waldorf Astoria Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More holidays you might like

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.