Title: TOP Boutique Hotels in South San Francisco, CA for 2026 | Expedia.co.uk [Hotels in South San Francisco](https://expedia.co.uk/South-San-Francisco-Hotels.d6773.Travel-Guide-Hotels)[Holiday Rentals in South San Francisco](https://expedia.co.uk/South-San-Francisco-Holiday-Rentals.d6773.Travel-Guide-HolidayRentals)[Flights to South San Francisco](https://expedia.co.uk/Cheap-Flights-To-South-San-Francisco.d6773.Travel-Guide-Flights)[South San Francisco Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-South-San-Francisco.d6773.Car-Hire-Guide)[South San Francisco Holidays](https://expedia.co.uk/South-San-Francisco.d6773.Holidays-City-Breaks) ![#BVSBlue Aristodes Demetries, One Of Americas Best Known Sculptors Created This Steel Sculpture As A Symbol Of Cabot Cabot And Forbes Industrial Park. Situated 243 Feet Above Sea Level It Rises To A Be Seen From The Bay Bridge, The East Bay and SFO. Called The Wind Harp Locally. It emits eerie sounds when the wind 💨is at its strongest.](https://images.trvl-media.com/place/6773/149d3826-ba90-46a7-bd10-00098a5921a1.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Tonette Pineda✈⛵🚌🚉🚃🚅🚀 # Search Boutique Hotels in South San Francisco - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on South San Francisco Boutique Hotels Tonight [11 Dec - 12 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6773&startDate=2025-12-11&endDate=2025-12-12&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [12 Dec - 13 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6773&startDate=2025-12-12&endDate=2025-12-13&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [12 Dec - 14 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6773&startDate=2025-12-12&endDate=2025-12-14&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [19 Dec - 21 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6773&startDate=2025-12-19&endDate=2025-12-21&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for South San Francisco boutique hotels ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1180000/1175900/1175858/5bd0b8bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lounge](https://images.trvl-media.com/lodging/2000000/1180000/1175900/1175858/cb9fb20d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/2000000/1180000/1175900/1175858/7814d514.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/2000000/1180000/1175900/1175858/78023bc2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Berkeley City Club [](https://www.expedia.co.uk/Oakland-Hotels-Berkeley-City-Club.h1175858.Hotel-Information) Telegraph District 8.8/10 Excellent (696) "Wonderful, beautiful, old world hotel, right in the heart of bustling Berkeley. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Peter £146 includes taxes & fees 14 Dec - 15 Dec [](https://www.expedia.co.uk/Oakland-Hotels-Berkeley-City-Club.h1175858.Hotel-Information) ![Courtyard](https://images.trvl-media.com/lodging/10000000/9870000/9868900/9868852/173b8dfb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillow-top beds, in-room safe, desk](https://images.trvl-media.com/lodging/10000000/9870000/9868900/9868852/19abbe84.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/10000000/9870000/9868900/9868852/a3393d8c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/10000000/9870000/9868900/9868852/4817709a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Zephyr San Francisco [](https://www.expedia.co.uk/San-Francisco-Hotels-Hotel-Zephyr-San-Francisco.h9868852.Hotel-Information) Fisherman's Wharf 8.6/10 Excellent (2322) "Excellent location." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rena £151 includes taxes & fees 16 Dec - 17 Dec [](https://www.expedia.co.uk/San-Francisco-Hotels-Hotel-Zephyr-San-Francisco.h9868852.Hotel-Information) ![Dinner served](https://images.trvl-media.com/lodging/1000000/10000/5500/5425/b9c86224.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![55-inch LED TV with cable channels, TV, iPod dock](https://images.trvl-media.com/lodging/1000000/10000/5500/5425/a2ad4847.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down duvets, pillow-top beds, in-room safe](https://images.trvl-media.com/lodging/1000000/10000/5500/5425/6e765ef3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/10000/5500/5425/cb3eeb61.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Barnes San Francisco, Tapestry Collection by Hilton [](https://www.expedia.co.uk/San-Francisco-Hotels-Villa-Florence-San-Francisco-On-Union-Square.h5425.Hotel-Information) Union Square 8.2/10 Very good (764) "Great location, friendly staff." ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Lucy £107 includes taxes & fees 21 Dec - 22 Dec [](https://www.expedia.co.uk/San-Francisco-Hotels-Villa-Florence-San-Francisco-On-Union-Square.h5425.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/700000/693700/693658/69c56718.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/1000000/700000/693700/693658/e282d47e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/700000/693700/693658/1656ff5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/700000/693700/693658/100ffc4f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Clancy, Autograph Collection by Marriott [](https://www.expedia.co.uk/San-Francisco-Hotels-The-Clancy.h693658.Hotel-Information) Downtown San Francisco 9.2/10 Wonderful (1001) "cleanliness,good service, convenient location" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Harry £172 includes taxes & fees 21 Dec - 22 Dec [](https://www.expedia.co.uk/San-Francisco-Hotels-The-Clancy.h693658.Hotel-Information) ![Premium bedding, pillow-top beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/10000/1600/1511/dd6a8571.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/1600/1511/a0e2014a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch flat-screen TV with cable channels, TV](https://images.trvl-media.com/lodging/1000000/10000/1600/1511/1c71b5a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/1600/1511/badb47f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Inn At Union Square [](https://www.expedia.co.uk/San-Francisco-Hotels-Inn-At-Union-Square.h1511.Hotel-Information) Union Square 9.2/10 Wonderful (1004) "Friendly, cozy, unique and a great value. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brooke £110 includes taxes & fees 16 Dec - 17 Dec [](https://www.expedia.co.uk/San-Francisco-Hotels-Inn-At-Union-Square.h1511.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/20000/15800/15769/a6ba3784.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/1000000/20000/15800/15769/33ce2394.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/20000/15800/15769/105e4279.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fireplace](https://images.trvl-media.com/lodging/1000000/20000/15800/15769/b8c723b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Marker Union Square San Francisco [](https://www.expedia.co.uk/San-Francisco-Hotels-The-Marker-San-Francisco.h15769.Hotel-Information) Union Square 9.0/10 Wonderful (1100) "Beautiful hotel with very friendly staff!! Location is also very central, walkable to a lot of restaurants. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Akila £123 includes taxes & fees 16 Dec - 17 Dec [](https://www.expedia.co.uk/San-Francisco-Hotels-The-Marker-San-Francisco.h15769.Hotel-Information) ![City view](https://images.trvl-media.com/lodging/1000000/920000/915600/915510/e1f91bcd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillow-top beds, minibar, in-room safe](https://images.trvl-media.com/lodging/1000000/920000/915600/915510/2d47f36f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Water view](https://images.trvl-media.com/lodging/1000000/920000/915600/915510/7158d83b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/1000000/920000/915600/915510/568efffa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Argonaut Hotel [](https://www.expedia.co.uk/San-Francisco-Hotels-Argonaut-Hotel-A-Noble-House-Hotel.h915510.Hotel-Information) Fisherman's Wharf 9.4/10 Exceptional (1204) "Great location, excellent staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Walter £207 includes taxes & fees 18 Dec - 19 Dec [](https://www.expedia.co.uk/San-Francisco-Hotels-Argonaut-Hotel-A-Noble-House-Hotel.h915510.Hotel-Information) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/30000/23400/23383/4ff57257.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/30000/23400/23383/355c4c16.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/23400/23383/d5b628f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Bedroom (Campton) | Premium bedding, minibar, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/30000/23400/23383/0d62a8a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Taj Campton Place [](https://www.expedia.co.uk/San-Francisco-Hotels-Taj-Campton-Place.h23383.Hotel-Information) Union Square 9.2/10 Wonderful (1002) "Wonderful Staff and hospitality." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rachel £182 includes taxes & fees 14 Dec - 15 Dec [](https://www.expedia.co.uk/San-Francisco-Hotels-Taj-Campton-Place.h23383.Hotel-Information) ![Outdoor wedding area](https://images.trvl-media.com/lodging/1000000/60000/51000/50965/b4290f2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor wedding area](https://images.trvl-media.com/lodging/1000000/60000/51000/50965/805d73d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor wedding](https://images.trvl-media.com/lodging/1000000/60000/51000/50965/d66b940f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/60000/51000/50965/0c05be87.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### el PRADO [](https://www.expedia.co.uk/Palo-Alto-Hotels-El-PRADO.h50965.Hotel-Information) University South 9.4/10 Exceptional (608) "Great stay - big, well appointed rooms in an excellent location " ![Hong Kong SAR China](https://a.travel-assets.com/egds/marks/flags/hk.svg) David [](https://www.expedia.co.uk/Palo-Alto-Hotels-El-PRADO.h50965.Hotel-Information) ![Cocktail bar](https://images.trvl-media.com/lodging/1000000/10000/700/660/27f19182.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/700/660/1d0c1fa8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/700/660/7ebf7bbb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/700/660/87dba6c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Emblem San Francisco [](https://www.expedia.co.uk/San-Francisco-Hotels-Hotel-Emblem-San-Francisco.h660.Hotel-Information) Union Square 9.4/10 Exceptional (1000) "Nice room, helpful staff and great location. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Okan £146 includes taxes & fees 4 Jan - 5 Jan 2026 [](https://www.expedia.co.uk/San-Francisco-Hotels-Hotel-Emblem-San-Francisco.h660.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-12-26&endDate=2025-12-27®ionId=6773&adults=2&specialized_stays_group_explore=boutique_property&sort=RECOMMENDED&openPlayBack=true) ## Top South San Francisco Hotel Reviews ![The Marker Union Square San Francisco](https://images.trvl-media.com/lodging/1000000/20000/15800/15769/a6ba3784_y.jpg) ### The Marker Union Square San Francisco 10/10 Excellent "Check in young lady was absolutely fantastic. Will be coming back because of her. Room and overall hotel was very clean and beautiful architecture. " [](https://expedia.co.uk/San-Francisco-Hotels-The-Marker-San-Francisco.h15769.Hotel-Information) ![Fairmont San Francisco](https://images.trvl-media.com/lodging/1000000/20000/18200/18200/6f6889e4_y.jpg) ### Fairmont San Francisco 10/10 Excellent "Wonderful " [](https://expedia.co.uk/San-Francisco-Hotels-Fairmont-San-Francisco.h18200.Hotel-Information) ![Hotel Riu Plaza Fisherman's Wharf](https://images.trvl-media.com/lodging/1000000/30000/24700/24625/6fb55356_y.jpg) ### Hotel Riu Plaza Fisherman's Wharf 10/10 Excellent "Nice Property at an excellent location. Good restaurants around. Hotel staff is humble and helpful. Great Breakfast too. Super clean rooms" [](https://expedia.co.uk/San-Francisco-Hotels-Hotel-Riu-Plaza-Fishermans-Wharf.h24625.Hotel-Information) ![Chancellor Hotel on Union Square](https://images.trvl-media.com/lodging/1000000/30000/20600/20547/944f985c_y.jpg) ### Chancellor Hotel on Union Square 10/10 Excellent "Great hotel for the price i think beats every hotel around. I would definitely stay again everytime i need to be in SF" [](https://expedia.co.uk/San-Francisco-Hotels-Chancellor-Hotel-On-Union-Square.h20547.Hotel-Information) ![Travelodge by Wyndham San Francisco Airport North](https://images.trvl-media.com/lodging/1000000/20000/17000/16955/864c4988_y.jpg) ### Travelodge by Wyndham San Francisco Airport North 10/10 Excellent "Staff " [](https://expedia.co.uk/San-Francisco-Hotels-Travelodge-By-Wyndham-San-Francisco-Airport-North.h16955.Hotel-Information) ![Club Quarters Hotel in San Francisco](https://images.trvl-media.com/lodging/1000000/920000/913000/912982/5ee1ba27_y.jpg) ### Club Quarters Hotel in San Francisco 10/10 Excellent "Clean room. VERY comfortable mattress. Quiet" [](https://expedia.co.uk/San-Francisco-Hotels-Club-Quarters-Hotel-In-San-Francisco.h912982.Hotel-Information) ## Frequently asked questions ### What's there to see and do in South San Francisco? ### What kind of weather should I plan for when I travel to South San Francisco? ### What's the best way to get to my boutique hotel in South San Francisco? ## Explore a world of travel with Expedia - Accommodation - Flights - More ways to book - [Gay-Friendly Hotels in Avalon ](https://www.expedia.co.uk/Avalon-San-Francisco-Hotels-Gay-Friendly-Hotel.0-n553248635976479280-0-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - [Adults Only Resorts & in Bay Area ](https://www.expedia.co.uk/Bay-Area-Hotels-Adults-Only-Resorts.0-0-d6056043-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) - [Green Hotels in Bay Area ](https://www.expedia.co.uk/Bay-Area-Hotels-Green-Sustainable.0-0-d6056043-tGreenSustainable.Travel-Guide-Filter-Hotels) - [Hotels with a Bar in Bay Area ](https://www.expedia.co.uk/Bay-Area-Hotels-Hotel-With-A-Bar.0-0-d6056043-thotelwithabar.Travel-Guide-Filter-Hotels) - 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