An aerial view of San Francisco with the Golden Gate Bridge, hills, and the ocean.

Search Boutique Hotels in South San Francisco

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Save instantly and earn perks with One Key
    Learn about One Key

  • Be picky

    Search almost a million properties worldwide

Check availability on South San Francisco Boutique Hotels

Tonight
10 Oct - 11 Oct
Tomorrow
11 Oct - 12 Oct
Next weekend
16 Oct - 18 Oct
In two weeks
23 Oct - 25 Oct

Our top choices for South San Francisco boutique hotels

A hotel room with a bed, a nightstand with a lamp, a Gucci bag, a pizza, and a 'big little lies' shopping bag.
A modern lobby with a fireplace, orange seating, a coffee table, and a decorative wall piece.
A row of leather armchairs with checkered cushions in a lobby area.
A multi-story hotel with a classic architectural design, featuring a prominent corner location with a street view.

1. Hotel Abri - Union Square

Hotel Abri - Union Square
Union Square
United States
Matthew
£125
includes taxes & fees
24 Oct - 25 Oct
Hotel Abri - Union Square
An outdoor cafe with brick walls, outdoor seating, and a tree in the foreground.
A hotel room with a brick wall, a bed with a tray of food, a lamp, and a view of the city through a window.
A room with a large window overlooking a harbor, featuring a sailboat and a building with multiple stories.
A bar area with three black barstools, a wooden counter, and a shelf stocked with liquor bottles.

2. Argonaut Hotel

Argonaut Hotel
Fisherman's Wharf
United States
Richard
£240
includes taxes & fees
1 Nov - 2 Nov
Argonaut Hotel
A hotel courtyard with outdoor seating, a fire pit, and a vintage camper parked nearby.
A person reclining in a circular seating area with a plant and a colorful mural in the background.
A modern outdoor seating area with a fire pit, orange chairs, and a view of the cityscape.
A hotel room with a bed, a desk, a TV, and a view of the city.

3. Hotel Zephyr San Francisco

Hotel Zephyr San Francisco
Fisherman's Wharf
United States
Jon
£157
includes taxes & fees
9 Nov - 10 Nov
Hotel Zephyr San Francisco
A courtyard with a stone pathway, outdoor seating, and potted plants.
A spacious lounge area with leather chairs, a coffee table, and a bar in the background.
A modern living room with a leather sofa, a wooden coffee table with books, a bookshelf, and a large window.
A spacious lobby with wooden floors, modern furniture, and large windows allowing natural light.

4. Hotel Kabuki, part of JdV by Hyatt

Hotel Kabuki, part of JdV by Hyatt
Western Addition
United States
Filiberto
£230
includes taxes & fees
8 Nov - 9 Nov
Hotel Kabuki, part of JdV by Hyatt
A spacious lobby with a staircase, comfortable seating areas, and large windows offering views of the city.
An outdoor seating area with round tables and chairs, a fire feature, and string lights.
A modern building with a prominent entrance and a sign that reads "THE CLANCY".
A spacious lobby with a modern bar area, seating arrangements, and a geometric wall design.

5. The Clancy, Autograph Collection by Marriott

The Clancy, Autograph Collection by Marriott
Downtown San Francisco
Canada
Samantha
£189
includes taxes & fees
30 Oct - 31 Oct
The Clancy, Autograph Collection by Marriott
A modern living room with a large window overlooking a bridge, a flat-screen TV, a clock, and a brown leather sofa.
A cozy hotel lobby with a fireplace, two tables with teapots, and comfortable seating.
A room with large windows overlooking a bridge and a body of water.
A group of people dining at a restaurant with a table set for a meal, including a bottle of wine and various dishes.

6. Harbor Court Hotel

Harbor Court Hotel
Downtown San Francisco
Canada
Yoojin
£208
includes taxes & fees
31 Oct - 1 Nov
Harbor Court Hotel
A spacious lobby with a chandelier, a reception desk, a blue sofa, and a trash can.
A hotel reception area with a tea and sherry station, a coffee maker, and a trash bin.
A cityscape with various buildings, including a hotel with a visible sign.
A hotel room with a bed, a desk, a chair, a ceiling fan, and a wall-mounted lamp.

7. Kensington Park Hotel

Kensington Park Hotel
Union Square
United States
Megan
£126
includes taxes & fees
16 Oct - 17 Oct
Kensington Park Hotel
A modern bar area with a long wooden counter, multiple bar stools, and a variety of bottles and glasses.
A modern lounge area with a long table, multiple chairs, and a television screen displaying a fire.
A cozy reading nook with a stack of books, a teal sofa, and a floor lamp.
A bar area with a bartender, wooden shelves with bottles, and bar stools.

8. Hotel Emblem San Francisco

Hotel Emblem San Francisco
Union Square
United States
Keegan
£152
includes taxes & fees
31 Oct - 1 Nov
Hotel Emblem San Francisco
A grand lobby with high ceilings, chandeliers, and a fireplace.
A person with a suitcase at the entrance of a building with a blue wall and a decorative door.
A hallway with a Christmas tree and nutcracker statues.
A grand lobby with a checkered floor, a blue sofa, and a chandelier.

9. The Marker Union Square San Francisco

The Marker Union Square San Francisco
Union Square
United States
Scott
£138
includes taxes & fees
24 Oct - 25 Oct
The Marker Union Square San Francisco
A modern interior with a seating area featuring cushioned chairs and a table, large windows with a view of the street, and decorative lighting.
A hotel dining area with multiple tables and chairs, ceiling chandeliers, and a patterned floor.
A coastal view with a historic building on a hill, a marina with boats, and a lighthouse.
A modern hotel room with a bed, a TV, a sofa, a coffee table, and a ceiling fan.

10. The Barnes San Francisco, Tapestry Collection by Hilton

The Barnes San Francisco, Tapestry Collection by Hilton
Union Square
United States
Aurora
£153
includes taxes & fees
31 Oct - 1 Nov
The Barnes San Francisco, Tapestry Collection by Hilton
View all properties

Top South San Francisco Hotel Reviews

Hilton San Francisco Union Square

Hilton San Francisco Union Square

10/10 Excellent
"Loved staying here wished I booked more days !"
Evelyn 1-night trip
Posted 4 hours ago
Hilton San Francisco Union Square
Parc 55 San Francisco - A Hilton Hotel

Parc 55 San Francisco - A Hilton Hotel

10/10 Excellent
"The hotel staff took excellent care of us and ensured we had a wonderful stay."
Aron 2-night trip
Posted 7 hours ago
Parc 55 San Francisco - A Hilton Hotel
Handlery Union Square Hotel

Handlery Union Square Hotel

10/10 Excellent
"Great shower! Well thought out amenities. Would stay again."
Lawrence 1-night trip
Posted 9 hours ago
Handlery Union Square Hotel
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

10/10 Excellent
"Un hotel muy céntrico, cerca de muchos lugares que se puede ir caminando, zona tranquila y segura, el personal muy amable, súper atento, las habitaciones muy limpias, con camas y almohadas muy cómodas , el desayuno delicioso muy variado y completo. El transporte público pasa justo al frente y puedes tomar la ruta 28 , por 2.50 dólares te lleva al Golden Gate. Muy conveniente."
Maria 2-night trip
Posted 11 hours ago
Hotel Riu Plaza Fisherman's Wharf

Frequently asked questions

What's there to see and do in South San Francisco?
The shopping, restaurants and cafes are just some of the things to enjoy while you're in the area. While you're out and about in South San Francisco, popular attractions like San Francisco Bay, Chase Center and Oracle Park are worth a visit. You might also want to see spots like Pier 39, Santa Cruz Mountains and South San Francisco Hillside Sign during your trip.
What kind of weather should I plan for when I travel to South San Francisco?
Having a good idea of the weather in South San Francisco is important when planning your trip. The hottest months are usually September and August, with an average temperature of 17°C, while the coldest months are February and January, with an average of 11°C. Average annual precipitation for South San Francisco is 574 mm.
What's the best way to get to my boutique hotel in South San Francisco?
You have a few options for travelling to and around South San Francisco. The closest major airport is San Francisco International Airport (SFO), which is located 2.9 mi (4.6 km) from the heart of the city, but Oakland, CA (OAK-Oakland Intl.) may also be an option. Head to South San Francisco Metro Station for metro travel. If you want to explore the larger area, hop on a train at South San Francisco Station.

Explore a world of travel with Expedia