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Our top choices for Otay Mesa hotels

1. Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2. Quality Suites San Diego Otay Mesa
Quality Suites San Diego Otay Mesa
3. Rodeway Inn San Diego South San Ysidro Border
Rodeway Inn San Diego South San Ysidro Border
4. Best Western Americana Inn
Best Western Americana Inn
5. Valli Hi Motel
Valli Hi Motel
6. La Quinta Inn by Wyndham San Diego Chula Vista
La Quinta Inn by Wyndham San Diego Chula Vista
7. The Rambler Hotel
The Rambler Hotel
8. Ayres Hotel San Diego South - Chula Vista
Ayres Hotel San Diego South - Chula Vista
9. SpringHill Suites by Marriott Chula Vista Eastlake
SpringHill Suites by Marriott Chula Vista Eastlake
10. Comfort Inn Chula Vista San Diego South
Comfort Inn Chula Vista San Diego South
11. Howard Johnson by Wyndham National City/San Diego South
Howard Johnson by Wyndham National City/San Diego South
12. Loews Coronado Bay Resort
Loews Coronado Bay Resort
13. Best Western Plus Marina Gateway Hotel
Best Western Plus Marina Gateway Hotel
14. Best Western Chula Vista/Otay Valley Hotel
Best Western Chula Vista/Otay Valley Hotel
15. Hotel Palmeras Chula Vista
Hotel Palmeras Chula Vista
16. Sycuan Casino Resort
Sycuan Casino Resort
17. Hercor Hotel - Urban Boutique
Hercor Hotel - Urban Boutique
18. Holiday Inn Express San Diego South - Chula Vista by IHG
Holiday Inn Express San Diego South - Chula Vista by IHG
19. The Davis Downtown San Diego
The Davis Downtown San Diego
20. Crowne Plaza San Diego - Mission Valley by IHG
Crowne Plaza San Diego - Mission Valley by IHGCompare popular hotels in Otay Mesa
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
![]() Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG | 8.4 Very good 1,955 reviews | View | ||||||
![]() Quality Suites San Diego Otay Mesa | 7.2 Good 1,005 reviews | View | ||||||
![]() Ayres Hotel San Diego South - Chula Vista | 9.8 Exceptional 1,030 reviews | View | ||||||
![]() Best Western Americana Inn | 8.8 Excellent 1,430 reviews | View | ||||||
![]() SpringHill Suites by Marriott Chula Vista Eastlake | 9.6 Exceptional 823 reviews | View |
Where to stay in Otay Mesa

Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Pacific Beach
Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Gaslamp Quarter
San Diego’s historic heart has shed its seedy past to emerge as one of the city’s premier dining, shopping and entertainment hubs.

Mission Beach
If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Mission Bay
If you're spending some time in Mission Bay, Mission Bay and Ski Beach are top sights worth seeing.
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