Title: Cheap Car Hire in Otay Mesa, USA - Expedia.co.uk [Otay Mesa Travel Guide](https://expedia.co.uk/San-Diego-Otay-Mesa.dx6263723)[Hotels in Otay Mesa](https://expedia.co.uk/Otay-Mesa-San-Diego-Hotels.0-n6263723-0.Travel-Guide-Filter-Hotels)[Flights to San Diego](https://expedia.co.uk/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.co.uk/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Otay Mesa Holidays](https://expedia.co.uk/Otay-Mesa.d6263723.Holidays-City-Breaks) ![](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Car Rentals in Otay Mesa, USA ## Search and Compare from Car Companies in Otay Mesa ## Featured car rental suppliers Compare from agencies ![car supplier logos](https://forever.travel-assets.com/flex/flexmanager/images/2022/05/16/BEXUK-car-suppliers-logo-desktop.jpg) - ![protection illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__protection.svg) ### Change your mind Penalty-free cancellation on many/select car hire - ![trophy illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Treat yourself One Key members save 10% or more on over 1 million car hire [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![package illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__package.svg) ### Shop smart Compare car suppliers and package your flight, hotel, and car to save ## Top Rental Car Deals in Otay Mesa \* Price found within the past 6 days. Click for updated prices. Sat, 11 Apr - Sun, 12 Apr ### Economy Hyundai Venue or similar - 5 people - Unlimited mileage ![Avis](//mediaim.expedia.com/cars/logos/ZI.png) #### Pick-up location 2745 Otay Pacific Dr, Ste #6, Cross Border Xpress Cbx, San Diego, California 92154, USA 0.78 mi from Otay Mesa city centre ![Hyundai Venue](//mediaim.expedia.com/cars/41/8790b76e-3028-4f1e-b3ff-9c11cf788d03.jpg) #### £132 total found 21 hours ago [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=32.548230&olon=-116.974830&date1=11/04/2026&date2=12/04/2026&pprfrr=null&tprfrr=132.0&cvrfrr=ZI&ctrfrr=EC&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22economy%22]) Sat, 11 Apr - Sun, 12 Apr ### Compact Kia Soul or similar - 5 people - Unlimited mileage ![Avis](//mediaim.expedia.com/cars/logos/ZI.png) #### Pick-up location 2745 Otay Pacific Dr, Ste #6, Cross Border Xpress Cbx, San Diego, California 92154, USA 0.78 mi from Otay Mesa city centre ![Kia Soul](//mediaim.expedia.com/cars/41/e7c1fd21-3564-4890-a4ed-2f7ca59d757f.jpg) #### £135 total found 21 hours ago [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=32.548230&olon=-116.974830&date1=11/04/2026&date2=12/04/2026&pprfrr=null&tprfrr=135.4&cvrfrr=ZI&ctrfrr=CC&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22compact%22]) Sat, 11 Apr - Sun, 12 Apr ### Midsize Toyota Corolla or similar - 5 people - Unlimited mileage ![Avis](//mediaim.expedia.com/cars/logos/ZI.png) #### Pick-up location 2745 Otay Pacific Dr, Ste #6, Cross Border Xpress Cbx, San Diego, California 92154, USA 0.78 mi from Otay Mesa city centre ![Toyota Corolla](//mediaim.expedia.com/cars/41/724f6f6b-c451-44b5-b34e-8d67280e16eb.jpg) #### £134 total found 21 hours ago [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=32.548230&olon=-116.974830&date1=11/04/2026&date2=12/04/2026&pprfrr=null&tprfrr=134.5&cvrfrr=ZI&ctrfrr=IC&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22midsize%22]) Sat, 11 Apr - Sun, 12 Apr ### Full Size Toyota Camry or similar - 5 people - Unlimited mileage ![Avis](//mediaim.expedia.com/cars/logos/ZI.png) #### Pick-up location 2745 Otay Pacific Dr, Ste #6, Cross Border Xpress Cbx, San Diego, California 92154, USA 0.78 mi from Otay Mesa city centre ![Toyota Camry](//mediaim.expedia.com/cars/41/f8359e2f-1f3f-4c65-ac4c-bc85e53c01f5.jpg) #### £142 total found 21 hours ago [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=32.548230&olon=-116.974830&date1=11/04/2026&date2=12/04/2026&pprfrr=null&tprfrr=142.2&cvrfrr=ZI&ctrfrr=FC&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22fullsize%22]) Sat, 11 Apr - Sun, 12 Apr ### Standard Volkswagen Jetta or similar - 5 people - Unlimited mileage ![Avis](//mediaim.expedia.com/cars/logos/ZI.png) #### Pick-up location 2745 Otay Pacific Dr, Ste #6, Cross Border Xpress Cbx, San Diego, California 92154, USA 0.78 mi from Otay Mesa city centre ![Volkswagen Jetta](//mediaim.expedia.com/cars/41/518390a3-aa30-4ee4-9bb5-1243de3d0866.jpg) #### £142 total found 21 hours ago [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=32.548230&olon=-116.974830&date1=11/04/2026&date2=12/04/2026&pprfrr=null&tprfrr=142.2&cvrfrr=ZI&ctrfrr=SC&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22standard%22]) Sat, 11 Apr - Sun, 12 Apr ### Standard Elite SUV Ford Explorer or similar - 7 people - Unlimited mileage ![Avis](//mediaim.expedia.com/cars/logos/ZI.png) #### Pick-up location 2745 Otay Pacific Dr, Ste #6, Cross Border Xpress Cbx, San Diego, California 92154, USA 0.78 mi from Otay Mesa city centre ![Ford Explorer](//mediaim.expedia.com/cars/41/c92cbd55-45b2-4fbe-b152-5ae503cf5057.jpg) #### £178 total found 21 hours ago [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=32.548230&olon=-116.974830&date1=11/04/2026&date2=12/04/2026&pprfrr=null&tprfrr=178.18&cvrfrr=ZI&ctrfrr=RF&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22suv%22]) Wed, 15 Apr - Thu, 16 Apr ### Mini Van Chrysler Pacifica or similar - 7 people - Unlimited mileage ![Avis](//mediaim.expedia.com/cars/logos/ZI.png) #### Pick-up location 2745 Otay Pacific Dr, Ste #6, Cross Border Xpress Cbx, San Diego, California 92154, USA 0.78 mi from Otay Mesa city centre ![Chrysler Pacifica](//mediaim.expedia.com/cars/41/830d8f5e-8263-4790-b5a6-1a9c6632576b.jpg) #### £200 total found 3 days ago [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=32.548230&olon=-116.974830&date1=15/04/2026&date2=16/04/2026&pprfrr=null&tprfrr=199.85&cvrfrr=ZI&ctrfrr=MV&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22minivan%22]) ### Don't see what you're looking for? See all car hire in Otay Mesa [View all cars](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Otay%20Mesa,%20San%20Diego,%20California,%20United%20States%20of%20America&dpln=6263723&date1=16/04/2026&date2=18/04/2026&crfrr=defaultFlex&SearchType=Place) Lowest prices found within the past 21 hours. Prices and availability subject to change. Additional terms may apply. ## Car Hire Information | Popular car types: | [SUV](https://www.expedia.co.uk/lp/b/car-rental/suv?rfrr=car.table.SUV), [Full Size](https://www.expedia.co.uk/lp/b/car-rental/fullsize?rfrr=car.table.FullSize), [Economy](https://www.expedia.co.uk/lp/b/car-rental/economy?rfrr=car.table.Economy) | | -------------------------------- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | | Car suppliers available: | | | Our best deal of the day: | £132 | | Our second best deal of the day: | £134 | | Our third best deal of the day: | £135 | | From the airport to your hotel: | [Airport Transportation](https://www.expedia.co.uk/ground-transfers?rfrr=car.table.AirportTransportation) | ## Frequently asked questions ### How much is a rental car per day in Otay Mesa? ### What happens if I need to cancel my Otay Mesa car reservation? ### What types of cars can I rent in Otay Mesa? ### Where can I go on a road trip from Otay Mesa? > - Make tracks to Anaheim for a fantastic sightseeing adventure. Roughly 100 miles from Otay Mesa, it has lots of cool attractions, including Disneyland® Resort. > - Why not check out all that's on offer in Buena Park too? Popular attractions in this buzzing city include Knotts Berry Farm. Buena Park is around 110 miles from Otay Mesa. > - Make your way to Venice Beach for a day out in nature. Pack a picnic to enjoy or just recharge your batteries in the fresh air. From Otay Mesa, it's around 130 miles away. ### How do I find the best car hire deals in Otay Mesa with Expedia? ### How old do you have to be to rent a car in Otay Mesa? ### What do you need to hire a car in Otay Mesa? ### What is the cheapest car rental in Otay Mesa? ### Can I hire a car for a month or longer in Otay Mesa? ### Where can I find an Otay Mesa hire car if I am younger than 25? ### Can I drive in Otay Mesa with my current driver's license? > - Age restrictions: You must be at least 25 in many states in order to hire a car, although in some areas, 21 years and older is allowed. We recommend checking local regulations, as well as with the company you're hiring from before you travel to understand additional terms and conditions. > - Driving limitations: Don't forget to read the fine print before you drive off the lot so you can avoid any unnecessary charges. When hiring a car in the U.S, you typically can't cross country borders into Canada or Mexico, drive onto ferries or go off-roading with your car hire. Please read all the rules and regulations before you book! ### Why should I rent an Otay Mesa car with Expedia?