Title: The Best Hotels in Otay Mesa, San Diego - 2026 Updated Prices | Expedia.co.uk [Holiday Rentals in San Diego](https://expedia.co.uk/San-Diego-Holiday-Rentals.d3073.Travel-Guide-HolidayRentals)[Flights to San Diego](https://expedia.co.uk/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.co.uk/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Otay Mesa Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Otay-Mesa.d6263723.Car-Hire-Guide)[Otay Mesa Holidays](https://expedia.co.uk/Otay-Mesa.d6263723.Holidays-City-Breaks) ![Lodging Image](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [21 Feb - 22 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6263723&startDate=2026-02-21&endDate=2026-02-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [22 Feb - 23 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6263723&startDate=2026-02-22&endDate=2026-02-23&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [27 Feb - 1 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6263723&startDate=2026-02-27&endDate=2026-03-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [6 Mar - 8 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6263723&startDate=2026-03-06&endDate=2026-03-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Property class ## Our top choices for Otay Mesa hotels ![Free on-the-go breakfast ](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/bd6623c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/55248c07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Non Smoking | Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/70282182.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/586d04dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Suites San Diego Otay Mesa [](https://www.expedia.co.uk/San-Diego-Hotels-Quality-Suites-San-Diego-Otay-Mesa.h461837.Hotel-Information) Otay Mesa 7.0/10 Good (1,004 reviews) "Great staff.. location close to the airport!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Vivian £90 includes taxes & fees 1 Mar - 2 Mar [](https://www.expedia.co.uk/San-Diego-Hotels-Quality-Suites-San-Diego-Otay-Mesa.h461837.Hotel-Information) ![Free buffet breakfast ](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/3f975189.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/1779e3cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/a1b42446.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast ](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/242d8336.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG [](https://www.expedia.co.uk/San-Diego-Hotels-Holiday-Inn-Express-Hotel-Suites-San-Diego-Otay-Mesa.h1632358.Hotel-Information) Otay Mesa 8.0/10 Very good (1,653 reviews) "Clean, great breakfast, good service." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sara £109 includes taxes & fees 8 Mar - 9 Mar [](https://www.expedia.co.uk/San-Diego-Hotels-Holiday-Inn-Express-Hotel-Suites-San-Diego-Otay-Mesa.h1632358.Hotel-Information) ![3 outdoor pools, pool cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/22ecf276.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/3bb415c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![7 restaurants, breakfast served](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/250333ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![7 restaurants, breakfast served](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/08cac484.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sycuan Casino Resort [](https://www.expedia.co.uk/El-Cajon-Hotels-Sycuan-Casino-Resort.h33661441.Hotel-Information) 17.7 mi from Otay Mesa 9.2/10 Wonderful (1,759 reviews) "Very clean resort. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Petrina [](https://www.expedia.co.uk/El-Cajon-Hotels-Sycuan-Casino-Resort.h33661441.Hotel-Information) ![Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/2000000/1180000/1176000/1175963/9f03f218.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Smoking | Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/2000000/1180000/1176000/1175963/1e9b6911.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1180000/1176000/1175963/81f394e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1180000/1176000/1175963/325ce31e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham San Diego-East/El Cajon [](https://www.expedia.co.uk/El-Cajon-Hotels-Days-Inn-By-Wyndham-San-Diego-EastEl-Cajon.h1175963.Hotel-Information) 17 mi from Otay Mesa 7.6/10 Good (1,002 reviews) "Great service.room was clean and included breakfast " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Antonio £69 includes taxes & fees 1 Mar - 2 Mar [](https://www.expedia.co.uk/El-Cajon-Hotels-Days-Inn-By-Wyndham-San-Diego-EastEl-Cajon.h1175963.Hotel-Information) ![Breakfast and dinner served, American cuisine](https://images.trvl-media.com/lodging/19000000/18970000/18961900/18961850/5c7cc72f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down duvets, pillow-top beds, desk](https://images.trvl-media.com/lodging/19000000/18970000/18961900/18961850/27748452.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/19000000/18970000/18961900/18961850/782ee0d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/19000000/18970000/18961900/18961850/d6f6a325.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott San Diego El Cajon [](https://www.expedia.co.uk/El-Cajon-Hotels-Courtyard-By-Marriott-San-Diego-El-Cajon.h18961850.Hotel-Information) 16.4 mi from Otay Mesa 9.2/10 Wonderful (1,001 reviews) "Clean, quiet, beautiful " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Attia £130 includes taxes & fees 8 Mar - 9 Mar [](https://www.expedia.co.uk/El-Cajon-Hotels-Courtyard-By-Marriott-San-Diego-El-Cajon.h18961850.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/1000000/996200/996144/3bc75d28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 9:00 AM to 9:00 PM, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/1000000/1000000/996200/996144/c7c2145d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/1000000/996200/996144/83d682ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/1000000/996200/996144/fb684d7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 El Cajon, CA - San Diego [](https://www.expedia.co.uk/El-Cajon-Hotels-Motel-6-El-Cajon.h996144.Hotel-Information) 16.8 mi from Otay Mesa 7.4/10 Good (1,552 reviews) "We only stayed one night but it was comfortable and clean " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brandy £53 includes taxes & fees 26 Feb - 27 Feb [](https://www.expedia.co.uk/El-Cajon-Hotels-Motel-6-El-Cajon.h996144.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/20500/20454/aa7dcb3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/30000/20500/20454/35f12373.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/20500/20454/6141f13c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/30000/20500/20454/2639daee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus La Mesa San Diego [](https://www.expedia.co.uk/La-Mesa-Hotels-Best-Western-Plus-La-Mesa-San-Diego.h20454.Hotel-Information) 15.3 mi from Otay Mesa 8.4/10 Very good (1,005 reviews) "Room was clean, pleasant staff and great breakfast " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Wendy £87 includes taxes & fees 23 Feb - 24 Feb [](https://www.expedia.co.uk/La-Mesa-Hotels-Best-Western-Plus-La-Mesa-San-Diego.h20454.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/102000000/101350000/101340300/101340269/7991b564.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/102000000/101350000/101340300/101340269/c176e30b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/102000000/101350000/101340300/101340269/1fb9b89d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout curtains, free WiFi, bed sheets](https://images.trvl-media.com/lodging/102000000/101350000/101340300/101340269/e5917959.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### SpringHill Suites by Marriott Chula Vista Eastlake [](https://www.expedia.co.uk/Chula-Vista-Hotels-SpringHill-Suites-By-Marriott-Chula-Vista-Eastlake.h101340269.Hotel-Information) 6.5 mi from Otay Mesa 9.6/10 Exceptional (582 reviews) "Clean room and friendly staff " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael £147 includes taxes & fees 15 Mar - 16 Mar [](https://www.expedia.co.uk/Chula-Vista-Hotels-SpringHill-Suites-By-Marriott-Chula-Vista-Eastlake.h101340269.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/33000000/32400000/32393800/32393708/69474629.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/33000000/32400000/32393800/32393708/1f68deee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/33000000/32400000/32393800/32393708/3ced364d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/33000000/32400000/32393800/32393708/83212494.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ayres Hotel San Diego South - Chula Vista [](https://www.expedia.co.uk/Chula-Vista-Hotels-Ayres-Hotel-San-Diego-South-Chula-Vista.h32393708.Hotel-Information) 4.1 mi from Otay Mesa 9.8/10 Exceptional (1,118 reviews) "Great location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Irma £176 includes taxes & fees 1 Mar - 2 Mar [](https://www.expedia.co.uk/Chula-Vista-Hotels-Ayres-Hotel-San-Diego-South-Chula-Vista.h32393708.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/3000000/2820000/2811100/2811010/879bd035.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Spa](https://images.trvl-media.com/lodging/3000000/2820000/2811100/2811010/d5d4acc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Snack bar](https://images.trvl-media.com/lodging/3000000/2820000/2811100/2811010/8cf8ea27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Laptop workspace, blackout curtains, free WiFi, bed sheets](https://images.trvl-media.com/lodging/3000000/2820000/2811100/2811010/471e273e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Heritage Inn La Mesa [](https://www.expedia.co.uk/La-Mesa-Hotels-Heritage-Inn-La-Mesa.h2811010.Hotel-Information) 15.1 mi from Otay Mesa 7.0/10 Good (1,291 reviews) "Very friendly at front desk I wish it was a little cheaper and I would stay the whole trip here" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Haley £47 includes taxes & fees 24 Feb - 25 Feb [](https://www.expedia.co.uk/La-Mesa-Hotels-Heritage-Inn-La-Mesa.h2811010.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/1000000/470000/461200/461101/8da6f7c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/1000000/470000/461200/461101/f85548dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![King Suite | Premium bedding, pillow-top beds, iron/ironing board, cots/infant beds](https://images.trvl-media.com/lodging/1000000/470000/461200/461101/6b2cf932.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/470000/461200/461101/8acfb37a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lamplighter Inn & Suites at SDSU [](https://www.expedia.co.uk/San-Diego-Hotels-Lamplighter-Inn-Suites-At-SDSU.h461101.Hotel-Information) 15.2 mi from Otay Mesa 9.0/10 Wonderful (1,365 reviews) "Good accommodations for the price point." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Martin [](https://www.expedia.co.uk/San-Diego-Hotels-Lamplighter-Inn-Suites-At-SDSU.h461101.Hotel-Information) ![Free continental breakfast ](https://images.trvl-media.com/lodging/1000000/20000/12700/12645/bc7617fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/20000/12700/12645/ddddbc6a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/20000/12700/12645/6ad23cf3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/12700/12645/5a519562.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Chula Vista/Otay Valley Hotel [](https://www.expedia.co.uk/Chula-Vista-Hotels-Best-Western-Chula-VistaOtay-Valley-Hotel.h12645.Hotel-Information) 4.4 mi from Otay Mesa 7.8/10 Good (1,620 reviews) "Clean rooms and the breakfast was amazing " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Vanessa £84 includes taxes & fees 1 Mar - 2 Mar [](https://www.expedia.co.uk/Chula-Vista-Hotels-Best-Western-Chula-VistaOtay-Valley-Hotel.h12645.Hotel-Information) ![Free continental breakfast ](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/079ae4ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Double Beds, Non Smoking | Premium bedding, desk, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/4e7175aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/bfd1ccfe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/83180011.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn by Wyndham San Diego Chula Vista [](https://www.expedia.co.uk/Chula-Vista-Hotels-La-Quinta-Inn-By-Wyndham-San-Diego-Chula-Vista.h22810.Hotel-Information) 8 mi from Otay Mesa 8.6/10 Excellent (1,549 reviews) "The room was very clean and the staff was very nice." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rod £80 includes taxes & fees 15 Mar - 16 Mar [](https://www.expedia.co.uk/Chula-Vista-Hotels-La-Quinta-Inn-By-Wyndham-San-Diego-Chula-Vista.h22810.Hotel-Information) ![Outdoor pool, open 10:00 AM to 7:00 PM, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/1000000/20000/18900/18870/6211d6de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/18900/18870/36da2a73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, Multiple Beds, Non Smoking (Upgrade) | Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/20000/18900/18870/da630608.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/18900/18870/a48c362c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn Chula Vista San Diego South [](https://www.expedia.co.uk/Chula-Vista-Hotels-Comfort-Inn-Chula-Vista-San-Diego-South.h18870.Hotel-Information) 8.1 mi from Otay Mesa 8.2/10 Very good (1,353 reviews) "It’s very comfortable and wonderful place. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Carmen £86 includes taxes & fees 1 Mar - 2 Mar [](https://www.expedia.co.uk/Chula-Vista-Hotels-Comfort-Inn-Chula-Vista-San-Diego-South.h18870.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/35000000/34910000/34909900/34909853/7aa1b6a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout curtains, soundproofing, free WiFi](https://images.trvl-media.com/lodging/35000000/34910000/34909900/34909853/06274c72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Room, 2 Double Beds, Non Smoking | Desk, blackout curtains, soundproofing, free WiFi](https://images.trvl-media.com/lodging/35000000/34910000/34909900/34909853/9072a14b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/35000000/34910000/34909900/34909853/1a9b4d28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Valli Hi Motel [](https://www.expedia.co.uk/San-Ysidro-Hotels-Valli-Hi-Motel.h34909853.Hotel-Information) 4.9 mi from Otay Mesa 8.4/10 Very good (1,005 reviews) "Excelente " ![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg) Julio [](https://www.expedia.co.uk/San-Ysidro-Hotels-Valli-Hi-Motel.h34909853.Hotel-Information) ![Standard Single Room, 1 King Bed, Non Smoking | Desk, blackout curtains, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/60000/57300/57248/cf426036.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/60000/57300/57248/b510fde2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/60000/57300/57248/cebdbfb5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/60000/57300/57248/1f0a5a60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Palmeras Chula Vista [](https://www.expedia.co.uk/Chula-Vista-Hotels-Hotel-Palmeras-Chula-Vista.h57248.Hotel-Information) 8.9 mi from Otay Mesa 7.2/10 Good (2,157 reviews) "Good stay, quiet,place was easy to find." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Annie £54 includes taxes & fees 23 Feb - 24 Feb [](https://www.expedia.co.uk/Chula-Vista-Hotels-Hotel-Palmeras-Chula-Vista.h57248.Hotel-Information) ![Room, 2 Queen Beds, Non Smoking | Desk, blackout curtains, free WiFi, bed sheets](https://images.trvl-media.com/lodging/2000000/1290000/1284700/1284665/c2a638e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/2000000/1290000/1284700/1284665/78da4143.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/2000000/1290000/1284700/1284665/0244b166.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/bathtub, free toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/2000000/1290000/1284700/1284665/6e524de1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Milagro [](https://www.expedia.co.uk/Chula-Vista-Hotels-Highway-Inn-Chula-Vista.h1284665.Hotel-Information) 9.3 mi from Otay Mesa 7.8/10 Good (1,006 reviews) "Great frienly and welcoming staff. Clean and comfy." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Raquel £54 includes taxes & fees 1 Mar - 2 Mar [](https://www.expedia.co.uk/Chula-Vista-Hotels-Highway-Inn-Chula-Vista.h1284665.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/2000000/1670000/1664500/1664408/692b0ea0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Bedroom | Desk, blackout curtains, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/2000000/1670000/1664500/1664408/4884968c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/2000000/1670000/1664500/1664408/1730ccf5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout curtains, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/2000000/1670000/1664500/1664408/f688032a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express San Diego South - Chula Vista by IHG [](https://www.expedia.co.uk/Chula-Vista-Hotels-Holiday-Inn-Express-San-Diego-South-Chula-Vista.h1664408.Hotel-Information) 9 mi from Otay Mesa 9.4/10 Exceptional (1,031 reviews) "Clean, Spacious Room, Polite Staff, Nice Breakfast" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) ALFREDO £92 includes taxes & fees 15 Mar - 16 Mar [](https://www.expedia.co.uk/Chula-Vista-Hotels-Holiday-Inn-Express-San-Diego-South-Chula-Vista.h1664408.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1480000/1475800/1475800/57e60275.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/2000000/1480000/1475800/1475800/1c9bf72f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/2000000/1480000/1475800/1475800/fb95526d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/2000000/1480000/1475800/1475800/c9d13d5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hercor Hotel - Urban Boutique [](https://www.expedia.co.uk/Chula-Vista-Hotels-Hercor-Hotel-Urban-Boutique.h1475800.Hotel-Information) 8.5 mi from Otay Mesa 8.6/10 Excellent (1,380 reviews) "Excellent service and spotless place. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ruslan £81 includes taxes & fees 26 Feb - 27 Feb [](https://www.expedia.co.uk/Chula-Vista-Hotels-Hercor-Hotel-Urban-Boutique.h1475800.Hotel-Information) ![Gazebo](https://images.trvl-media.com/lodging/11000000/10050000/10049500/10049404/01a6e5a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/11000000/10050000/10049500/10049404/4de6e9f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/11000000/10050000/10049500/10049404/43c07429.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/11000000/10050000/10049500/10049404/525c92ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Berkshire Motor Hotel [](https://www.expedia.co.uk/San-Diego-Hotels-Berkshire-Motor-Hotel.h10049404.Hotel-Information) North Park, 16.6 mi from Otay Mesa 8.4/10 Very good (1,003 reviews) "Clean, very chill easy check in" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Susana £79 includes taxes & fees 23 Feb - 24 Feb [](https://www.expedia.co.uk/San-Diego-Hotels-Berkshire-Motor-Hotel.h10049404.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-03-08&endDate=2026-03-09®ionId=6263723&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Where to stay in Otay Mesa Find the best Otay Mesa areas for the activities you enjoy most. - Downtown San Diego - Mission Beach - Pacific Beach - Gaslamp Quarter - Ocean Beach ![Seaport Village featuring a church or cathedral](https://images.trvl-media.com/place/502533/365f2852-ae5f-4c96-a03a-d10b3391e979.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Waterfront Park which includes a river or creek and a fountain](https://images.trvl-media.com/place/6082871/59e6b6f0-e849-482c-83a3-e08618415371.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Petco Park featuring signage](https://images.trvl-media.com/place/6034816/44dd684e-a5ea-4f13-8a1c-1e6ddda338f7.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![SanDiego_DowntownSanDiego_800123_007](https://images.trvl-media.com/place/800123/3046af2b-73c3-4e5e-9d5e-84e5c8dff513.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![US Grant Hotel](https://images.trvl-media.com/place/800123/772b9d6a-cdc3-400e-b3ed-61d10adc7912.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.co.uk/Hotel-Search?pwaOverlay=map®ionId=800123) ![Downtown San Diego map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:yfwfEzeejUaMaj%40fa%40k%5CbLaPx%40qOkGcWu%40i%5B%60DgKrIcFdRgF%7CrAsAHjJvK%60IqKjOFzR%7EP%7CI%7BH%7CO%7CIfNma%40hn%40%7B%40fIe%5ChZma%40t%40o%40kSei%40E_FfEiEnLwEd%40&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=Cs9sAV_TcaQK48f0iT1-t86hPRE=) ### Downtown San Diego Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city. [See properties](https://www.expedia.co.uk/Hotel-Search?regionId=800123) ![Belmont Park featuring rides](https://images.trvl-media.com/place/6068527/d1fc07db-8dee-4063-b3e3-a30c399299a9.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Aerial of Mission Beach in San Diego, CA](https://images.trvl-media.com/place/553248635976496777/581ebb7c-51f6-4d01-87e7-0cd7469e242c.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![There’s a park across from the roller coaster where you can take this photo.](https://images.trvl-media.com/place/3073/084b4e9d-ace1-4dae-84ce-a01bda1c56c4.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) Photo by Jeff Bender ![Rollercoasters are such a fun time. Especially the old wooden ones! #missionbeach #patterns](https://images.trvl-media.com/place/3073/376d562f-6d30-4730-b244-74c2428eb6fc.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) Photo by aimlessbonvivant ![Mission Beach featuring tropical scenes, street scenes and a beach](https://images.trvl-media.com/place/506109/7668844c-8a76-415d-a747-d4762537804f.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.co.uk/Hotel-Search?pwaOverlay=map®ionId=553248635998112279) ![Mission Beach map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:ec%7DfE%7CgujU_Die%40%7BAYqk%40sBclAvBeNh%40wNtAcg%40%60H_DqUxGwAlD%7EF%60Dm%40v%40%40Bb%40tDIhRqFnGs%40nEBzOdBzF%40xI%7DAvNwH%60BMfBZt%40m%40EhIzJy%40hNJI%7DIrBvAjErA%7EJb%40%7CMcEjJsFzArBfF%7EcA&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=hFrZWtAC8u-2IGYk_Bcs7ztzP5Q=) ### Mission Beach If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing. [See properties](https://www.expedia.co.uk/Hotel-Search?regionId=553248635998112279) ![Pacific Beach Park showing surfing, swimming and rugged coastline](https://images.trvl-media.com/place/506113/202bc63e-797b-4bed-9119-ebaa960c37e3.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Pacific Beach Park featuring a sandy beach and a sunset](https://images.trvl-media.com/place/506113/e8c37164-6c94-4af7-851a-63228d77f477.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Pacific Beach Park featuring a beach and a sunset](https://images.trvl-media.com/place/506113/86074b31-270f-4e20-944e-cf9cb90fb612.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Pacific Beach Park featuring surfing, a sunset and general coastal views](https://images.trvl-media.com/place/506113/92705d2a-ce90-4cab-9138-2b2885705265.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Pacific Beach Park showing a sandy beach as well as a large group of people](https://images.trvl-media.com/place/506113/bb95ac54-636b-4ba7-9632-78fc40d6374d.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.co.uk/Hotel-Search?pwaOverlay=map®ionId=6185751) ![Pacific Beach map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:agfgEvyujUgHcNcG%60IiBwN%7BKtBkf%40inCoKyIyEoFcHy%40aKoT%60mBq_B%7Cl%40aZb%40xB%7DAlAuMdQsExHkAvMbB%7CVpV_F%7CGrk%40tPgDhDlTbMbDlZu%40%60V%7EDxQfMtAlJg%40xH_GxEkRnGkUrA%7DP%60IiFbTv%40lR%60J%7CNcKjBzCfUec%40%60L%7BUxIkP%60IuM%7CH&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=5FbBeekgWkepp0jnCE7WEy_Qh88=) ### Pacific Beach Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip. [See properties](https://www.expedia.co.uk/Hotel-Search?regionId=6185751) ![Gaslamp Quarter featuring signage](https://images.trvl-media.com/place/6130021/73065031-81bc-465c-b373-beee88d55810.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Gaslamp Quarter featuring signage](https://images.trvl-media.com/place/6130021/f0756e04-efb4-434c-95b5-12b91a89799e.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Gaslamp Quarter which includes a city and street scenes](https://images.trvl-media.com/place/6130021/4a742e8b-9292-4568-9b29-016c10b61eb3.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Gaslamp Quarter which includes a fountain, a city and night scenes](https://images.trvl-media.com/place/6130021/e4b226a5-e60c-4a12-b20e-07935b9e22c6.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Gaslamp Quarter featuring night scenes and a city](https://images.trvl-media.com/place/6130021/258c6781-44ad-46ff-b38f-d3216bdc8235.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.co.uk/Hotel-Search?pwaOverlay=map®ionId=6130021) ![Gaslamp Quarter map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:mmtfEh%7CbjUAwJqIDCm%5B%60x%40OmEpJ%7DPD%40zAiE%40A_B%7BEBFj%5B_HH&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=68cMX7ldk9-J6tcepLMBQKKwvpY=) ### Gaslamp Quarter San Diego’s historic heart has shed its seedy past to emerge as one of the city’s premier dining, shopping and entertainment hubs. [See properties](https://www.expedia.co.uk/Hotel-Search?regionId=6130021) ![Ocean Beach](https://images.trvl-media.com/place/177689/65873b7b-60c4-432c-b314-d6d38bf8b215.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Ocean Beach](https://images.trvl-media.com/place/177689/68237b41-acd9-4a21-9738-62b8e6af9f60.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Ocean Beach](https://images.trvl-media.com/place/177689/cc621791-5e43-465e-94ea-fbfd1b36839a.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Ocean Beach](https://images.trvl-media.com/place/177689/a7bb1c8c-521b-44cc-84f3-4b08835d7018.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Ocean Beach which includes a sandy beach and general coastal views](https://images.trvl-media.com/place/177689/94c11c71-8598-4eea-bb11-9d1f09d042f9.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.co.uk/Hotel-Search?pwaOverlay=map®ionId=177689) ![Ocean Beach map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:eq%7CfEneujUqO%7ByCl%5CdMdL%7B%40pnB%60%60BoUlb%40crB%60I&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=lCc_uj9JIfh1kP738Xl1bJJqo_A=) ### Ocean Beach Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Ocean Beach and Dog Beach. [See properties](https://www.expedia.co.uk/Hotel-Search?regionId=177689) ## Top Otay Mesa Hotel Reviews ![Bay Club Hotel & Marina](https://images.trvl-media.com/lodging/1000000/10000/2600/2514/8c022c3d_y.jpg) ### Bay Club Hotel & Marina 10/10 Excellent "Great room with a comfortable bed. Nice view on the second floor and the hotel is in a good location." [](https://expedia.co.uk/San-Diego-Hotels-Bay-Club-Hotel-Marina.h2514.Hotel-Information) ![Bahia Resort Hotel](https://images.trvl-media.com/lodging/1000000/20000/18300/18241/86eea647_y.jpg) ### Bahia Resort Hotel 10/10 Excellent "Friendly staff" [](https://expedia.co.uk/San-Diego-Hotels-Bahia-Resort-Hotel.h18241.Hotel-Information) ![The Dana on Mission Bay](https://images.trvl-media.com/lodging/1000000/50000/41000/40953/08585098_y.jpg) ### The Dana on Mission Bay 10/10 Excellent "It was a great place and loved it " [](https://expedia.co.uk/San-Diego-Hotels-The-Dana-On-Mission-Bay.h40953.Hotel-Information) ![San Diego Mission Bay Resort](https://images.trvl-media.com/lodging/1000000/30000/25600/25598/bbcdbd6d_y.jpg) ### San Diego Mission Bay Resort 10/10 Excellent "Yes room was clean, service was superb; we will stay here again for certain..!" [](https://expedia.co.uk/San-Diego-Hotels-San-Diego-Mission-Bay-Resort.h25598.Hotel-Information) ![Paradise Point Resort & Spa](https://images.trvl-media.com/lodging/1000000/10000/3800/3731/bc1e5add_y.jpg) ### Paradise Point Resort & Spa 10/10 Excellent "Beautiful " [](https://expedia.co.uk/San-Diego-Hotels-Paradise-Point-Resort-Spa.h3731.Hotel-Information) ![Hard Rock Hotel San Diego](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg) ### Hard Rock Hotel San Diego 10/10 Excellent "Staff was great! " [](https://expedia.co.uk/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) ![Days Inn by Wyndham San Diego Hotel Circle](https://images.trvl-media.com/lodging/1000000/20000/19300/19220/3334d773_y.jpg) ### Days Inn by Wyndham San Diego Hotel Circle 10/10 Excellent "Great stay, staff was friendly " [](https://expedia.co.uk/San-Diego-Hotels-Days-Inn-By-Wyndham-San-Diego-Hotel-Circle.h19220.Hotel-Information) ![Wyndham San Diego Bayside](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d_y.jpg) ### Wyndham San Diego Bayside 10/10 Excellent "Perfect location! Very clean and the staff were wonderful! The bay view was gorgeous. " [](https://expedia.co.uk/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![Best Western Seven Seas](https://images.trvl-media.com/lodging/1000000/10000/1800/1734/w3837h2556x3y3-8b148daf_y.jpg) ### Best Western Seven Seas 10/10 Excellent "Always a good experience " [](https://expedia.co.uk/San-Diego-Hotels-Best-Western-Seven-Seas.h1734.Hotel-Information) ## Frequently asked questions ### What are the best family hotels in Otay Mesa? > Another family-friendly option in Otay Mesa is [Quality Suites San Diego Otay Mesa](https://www.expedia.co.uk/San-Diego-Hotels-Quality-Suites-San-Diego-Otay-Mesa.h461837.Hotel-Information). Rated 7.2 by travellers, this hotel features a refreshing pool where kids can splash and play, making it a great place to unwind after a busy day. The hotel's connecting rooms and child-friendly window designs prioritize safety and comfort, ensuring that both parents and children feel at home. Additionally, the provision of free amenities for children adds extra value, making it easier for families to enjoy their stay without worrying about additional costs. ### What are the best spa hotels in Otay Mesa? ### What hotels in Otay Mesa offer free breakfast? > Another option in Otay Mesa is the [Quality Suites San Diego Otay Mesa](https://www.expedia.co.uk/San-Diego-Hotels-Quality-Suites-San-Diego-Otay-Mesa.h461837.Hotel-Information), which also offers a complimentary breakfast to start your day right. This hotel features an outdoor pool and hot tub, ideal for relaxation and family fun. The Quality Suites is particularly appealing for those requiring accessible parking and facilities, and with a review score of 7.2, it provides a comfortable experience for guests looking for extra conveniences. ### What are the best budget hotels in Otay Mesa? > Another great choice for budget-conscious travellers is the [Quality Suites San Diego Otay Mesa](https://www.expedia.co.uk/San-Diego-Hotels-Quality-Suites-San-Diego-Otay-Mesa.h461837.Hotel-Information), which has a review score of 7.2\. This hotel offers a range of amenities geared towards families, including a free breakfast and outdoor pool, which is sure to keep kids entertained. The rooms are designed with child-friendly window features, providing peace of mind for parents. Self-parking is complimentary as well, making it easy for families to explore the local area without worrying about extra fees. ### Can I cancel my hotel reservation on Expedia? ### How can I save on a Otay Mesa hotel booking with Expedia? ### How much is the nightly rate at a Otay Mesa hotel? ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - Other - More ways to book - [Hotels near Atlantis Laser Tag ](https://www.expedia.co.uk/Atlantis-Laser-Tag-Hotels.0-l553248621532638600-0.Travel-Guide-Filter-Hotels) - [Bonita Hotels ](https://www.expedia.co.uk/Bonita-Hotels.d177687.Travel-Guide-Hotels) - [Hotels near Brown Field Municipal ](https://www.expedia.co.uk/Brown-Field-Municipal-Airport-Hotels.0-aSDM-0.Travel-Guide-Filter-Hotels) - [Chula Vista Hotels ](https://www.expedia.co.uk/Chula-Vista-Hotels.d7442.Travel-Guide-Hotels) - [Dulzura Hotels ](https://www.expedia.co.uk/Dulzura-Hotels.d3000427615.Travel-Guide-Hotels) - [Emerald Hills Hotels ](https://www.expedia.co.uk/Emerald-Hills-San-Diego-Hotels.0-n797413919713509376-0.Travel-Guide-Filter-Hotels) - 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