Otay Mesa Holidays from £679

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The Sofia Hotel

The Sofia Hotel

3.5 out of 5
Downtown San Diego
Price was £1,099, price is now £679 per person
£679
per person
28 Oct - 4 Nov
found 22 hours ago
Return direct flight included
London (LHR) to San Diego (SAN)
8.4/10 Very Good! (1,536 reviews)
Overall it’s a cute hotel, this is our second time booking

Reviewed on 23 Aug 2025

Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter

4 out of 5
Downtown San Diego
Save 100% on your flight
Price was £1,450, price is now £908 per person
£908
per person
28 Oct - 4 Nov
found 22 hours ago
Return direct flight included
London (LHR) to San Diego (SAN)
9/10 Wonderful! (993 reviews)
Neighborhood was great!+++

Reviewed on 23 Aug 2025

El Cordova Hotel on Coronado Island

El Cordova Hotel on Coronado Island

3.5 out of 5
Historic Downtown Coronado
Save 100% on your flight
Price was £1,505, price is now £955 per person
£955
per person
28 Oct - 4 Nov
found 22 hours ago
Return direct flight included
London (LHR) to San Diego (SAN)
8.8/10 Excellent! (1,002 reviews)
This was a great place to stay with a wonderful location. Very vintage Hispanic team. Miguel’s restaurant which is basically inside the hotel is amazing. Right across from hotel del and right in orange ave. Rooms are a little dated

Reviewed on 21 Aug 2025

Hotel La Jolla, Curio Collection by Hilton

Hotel La Jolla, Curio Collection by Hilton

4 out of 5
La Jolla Shores
Save 100% on your flight
Price was £1,518, price is now £982 per person
£982
per person
28 Oct - 4 Nov
found 22 hours ago
Return direct flight included
London (LHR) to San Diego (SAN)
8.2/10 Very Good! (404 reviews)
We took a family vacation, La Jolla is a favorite. This property had beautiful views from the 9th floor, very convenient to walk to grab coffee or food, even to the beach if you’re not carrying too much stuff with you. Drinks and food were good from the restaurant! Housekeeping came by daily to tidy up. We loved it and will be back again.

Reviewed on 24 Aug 2025

InterContinental San Diego by IHG

InterContinental San Diego by IHG

4 out of 5
Downtown San Diego
Save 100% on your flight
Price was £1,745, price is now £1,136 per person
£1,136
per person
28 Oct - 4 Nov
found 22 hours ago
Return direct flight included
London (LHR) to San Diego (SAN)
9.2/10 Wonderful! (1,017 reviews)
No Fridge, easily get over charged for the mini bar. Never use the mini bar, but got charged after checked out without any notification.

Reviewed on 12 Aug 2025

Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
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Downtown San Diego

2 out of top 10 points of interest in this area
4.5/5(138 area reviews)

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Find hotels in Downtown San Diego

Top hotels in Otay Mesa

Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N, San Diego, CA
Fully refundableReserve now, pay when you stay
8/10 Very Good! (1,983 reviews)
"It’s a really good hotel off the beach."

Reviewed on 22 Aug 2025

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Handlery Hotel
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is £149 per night from 1 Sept to 2 Sept
£149
1 Sept - 2 Sept
includes taxes & fees
8.2/10 Very Good! (5,862 reviews)
"."

Reviewed on 21 Aug 2025

Wyndham San Diego Bayside
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is £95 per night from 1 Sept to 2 Sept
£95
1 Sept - 2 Sept
includes taxes & fees
7.8/10 Good! (1,123 reviews)
"Great location and easy to get to. Parking is horrible as the spaces are tiny but other than that, no complaints"

Reviewed on 22 Aug 2025

The DEXTRO Little Italy, BW Premier Collection
See all 4,639 properties in Otay Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

How much does an Otay Mesa travel package cost?
Discover the best of Otay Mesa from as low as £679. We offer a wonderful selection of hotels, flights and rental cars to suit every budget and style. You can score even more discounts when you add a few tours or activities to your travel package.
If I'm not able to travel, can I cancel my Otay Mesa travel package?
If your holiday plans in Otay Mesa have been upended, it's comforting to know that it is possible to cancel your booking. If you booked in the last 24 hours, you may be able to get a refund. If your booking was made more than 24 hours ago, your airline, hotel or car rental company may charge a fee. For more information, visit our Customer Service Portal.
How do I get a cheap travel package to Otay Mesa?
Book everything in the one place with our Otay Mesa travel packages. You'll discover bargains on flights, hotels, tours and more that'll keep your pocketbook happy and adventurous side satisfied. And, with more than 550 airlines and 1,000,000 properties across the globe to select from, you have countless opportunities to mix and match as you like.
Does Expedia offer Book Now, Pay Later Otay Mesa holidays?
Your bank balance shouldn't get in the way of taking a holiday, so Expedia has worked out a solution to help. Now that we've partnered with online lender Klarna, it's easier than ever to book your dream getaway without drying up your savings. Klarna offers flexible payment options at checkout that take the stress out of budgeting for your break. Check out these flexible payment options:

  • Pay monthly holidays: Klarna has manageable monthly payment plans that suit all types of budgets, so you can take that well-deserved holiday now.
  • Pay in instalments holidays: If you'd like to pay off your getaway across multiple transactions, holidays paid in instalments might be right for your Book Now, Pay Later holiday through Klarna.
  • Low deposit holidays: Pressing the "book now" button is easier with this payment option. Put down a small deposit on your booking and then start packing your bags.

Where should I stay in Otay Mesa?
Most who travel to Otay Mesa put both SeaWorld and San Diego Zoo on their to-do lists. Why not go for a hotel near these fantastic attractions?
What are the top hotels in Otay Mesa?
Book a stay at Manchester Grand Hyatt San Diego. It's one of this neighbourhood's most popular properties. Another top-rated option in Otay Mesa is Paradise Point Resort And Spa.
How far in advance should I book my Otay Mesa holiday?
Reserving your seat early with Expedia means one less thing to have to worry about. A number of air carriers display prices up to 12 months prior to departure dates. This is usually the cheapest time to book. If circumstances have left you booking late, low prices to Otay Mesa occasionally appear in the weeks leading up to departure.
What does an Expedia Otay Mesa travel package include?
You can select from any combination of flights, rental cars and hotels. Once you've made your booking, you can add the fun stuff like experiences and tours. Want to pick your fare class? That's also possible. The choice is yours when it comes to crafting your perfect Otay Mesa escape.
What should I know before booking an Otay Mesa travel package?
Design deals that fit your budget with an Expedia package. Flights, hotels, rental cars — we have them all. You'll save precious cash just for bundling your bookings. Whether you're embarking on a winter snow adventure or relaxing on a sunny beach, your dream getaway is only a few clicks away.
Can I choose my airline with an Otay Mesa Expedia travel package?
With a travel package, you're the boss. Whether you'd prefer to fly to Otay Mesa in business or coach, simply pick from the available airline options. Expedia has access to over 550 partner airlines across the world.

Popular places to visit

San Diego Zoo featuring zoo animals, landscape views and a pond

San Diego Zoo

4.5/5(47 reviews)

See nature up-close and personal at one of the country’s largest and most educational zoos.

San Diego Zoo
San Diego Convention Center

San Diego Convention Center

4/5(18 reviews)

During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's entertainment choices and acclaimed art galleries.

San Diego Convention Center
Mission Bay featuring a beach

Mission Bay

4.5/5(31 reviews)

Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.

Mission Bay

Things to do

Crossing Borders: Tijuana Day Trip from San Diego

Crossing Borders: Tijuana Day Trip from San Diego

£69
per adult
96% of travellers recommend
Crossing Borders: Tijuana Day Trip from San Diego
Kayak on the San Diego Bay

Kayak on the San Diego Bay

£15
per adult
Kayak on the San Diego Bay
Having a taste of Mexico

Intro to Mexico Walking Tour: Tijuana Day Trip from San Diego

£54
per adult
92% of travellers recommend
Intro to Mexico Walking Tour: Tijuana Day Trip from San Diego
See all activities in San Diego

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.