Otay Mesa Holidays

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to £750 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Packages with flights are ATOL protected
Price found within the past 48 hours. Click for updated prices.
  • Food and drink
    Jul 7 - Jul 17

    Porto Vista Hotel Downtown + Flight

    Downtown San Diego
    10 nights
    3.5 star property
    7.2/10 - Good (1,293 reviews)
    "This was my second time staying at the Porto Vista Hotel and once again, it was a great experience. The location can’t be beat - right in the heart of Little Italy downtown and just a short walk to the weekly farmers market, which is always a highlight for me when visiting San Diego. The staff were welcoming and helpful throughout my stay, especially the bartender at GlassDoor Restaurant & Bar, who was entertaining and an excellent mixologist. Another major plus is that the hotel is dog..."
    Reviewed May 21, 2026
    Return • Atlanta (ATL) - San Diego (SAN)
    ATL - SAN • 1 stop SAN - ATL • 1 stop
    Save 100% on your flight
    £1,754
    £1,233
    per traveller
    found 23 hours ago
    Porto Vista Hotel Downtown
  • Exterior
    Jul 7 - Jul 17

    The Sofia Hotel + Flight

    Downtown San Diego
    10 nights
    3.5 star property
    8.6/10 - Excellent (2,102 reviews)
    "Loved it"
    Reviewed May 23, 2026
    Return • Atlanta (ATL) - San Diego (SAN)
    ATL - SAN • 1 stop SAN - ATL • 1 stop
    £3,210
    £1,561
    per traveller
    found 23 hours ago
    The Sofia Hotel
  • Lobby
    Jul 7 - Jul 17

    Margaritaville Hotel San Diego Gaslamp Quarter + Flight

    Downtown San Diego
    10 nights
    4.0 star property
    9.0/10 - Wonderful (1,365 reviews)
    "Beautiful property! Helpful staff! Only thing that needed some work was the water pressure in the bathroom sink."
    Reviewed May 23, 2026
    Return • Atlanta (ATL) - San Diego (SAN)
    ATL - SAN • 1 stop SAN - ATL • 1 stop
    Save 100% on your flight
    £3,031
    £1,715
    per traveller
    found 23 hours ago
    Margaritaville Hotel San Diego Gaslamp Quarter
  • Standard Single Room, Oceanfront | View from room
    Jul 7 - Jul 17

    Ocean Park Inn + Flight

    Pacific Beach
    10 nights
    3.0 star property
    9.4/10 - Exceptional (1,007 reviews)
    "Great location, very clean"
    Reviewed May 24, 2026
    Return • Atlanta (ATL) - San Diego (SAN)
    ATL - SAN • 1 stop SAN - ATL • 1 stop
    Save 100% on your flight
    £3,466
    £2,149
    per traveller
    found 23 hours ago
    Ocean Park Inn
  • Interior
    Jul 7 - Jul 17

    Ancora by AvantStay + Flight

    Downtown San Diego
    10 nights
    4.0 star property
    10/10 - Exceptional (3 reviews)
    "Nice place to stay, water pressure in the shower was very weak. Overall nice time spent"
    Reviewed May 21, 2026
    Return • Atlanta (ATL) - San Diego (SAN)
    ATL - SAN • 1 stop SAN - ATL • 1 stop
    Save 100% on your flight
    £2,189
    £1,529
    per traveller
    found 23 hours ago
    Ancora by AvantStay

Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
Downtown San Diego

Downtown San Diego

4 out of top 10 points of interest in this area
4.5/5(138 area reviews)

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Find hotels in Downtown San Diego

Top hotels in Otay Mesa

The Sofia Hotel

The Sofia Hotel

3.5 out of 5
150 W Broadway San Diego CA
Fully refundableReserve now, pay when you stay
The price is £114 per night from 14 Jun to 15 Jun
£114
14 Jun - 15 Jun
includes taxes & fees
8.6/10 Excellent! (2,102 reviews)
"Loved it"

Reviewed on 23 May 2026

The Sofia Hotel
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
The price is £212 per night from 31 May to 1 Jun
£212
31 May - 1 Jun
includes taxes & fees
8.8/10 Excellent! (2,606 reviews)
"Very helpful. Excellent food, etc. My only complaint is that the towels all had a bad odor. That’s bath and pool towels."

Reviewed on 24 May 2026

Paradise Point Resort & Spa
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
Fully refundableReserve now, pay when you stay
The price is £257 per night from 12 Jun to 13 Jun
£257
12 Jun - 13 Jun
includes taxes & fees
9/10 Wonderful! (2,823 reviews)
"It of places to go walking distance to eat breakfast and dinner r"

Reviewed on 24 May 2026

Manchester Grand Hyatt San Diego
See all 4,903 properties in Otay Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Frequently asked questions

How much does an Otay Mesa travel package cost?
Discover the best of Otay Mesa from as low as . We offer a wonderful selection of hotels, flights and rental cars to suit every budget and style. You can score even more discounts when you add a few tours or activities to your travel package.
If I'm not able to travel, can I cancel my Otay Mesa travel package?
If your holiday plans in Otay Mesa have been upended, it's comforting to know that it is possible to cancel your booking. If you booked in the last 24 hours, you may be able to get a refund. If your booking was made more than 24 hours ago, your airline, hotel or car rental company may charge a fee. For more information, visit our Customer Service Portal.
How do I get a cheap travel package to Otay Mesa?
Book everything in the one place with our Otay Mesa travel packages. You'll discover bargains on flights, hotels, tours and more that'll keep your pocketbook happy and adventurous side satisfied. And, with more than 550 airlines and 1,000,000 properties across the globe to select from, you have countless opportunities to mix and match as you like.
Does Expedia offer Book Now, Pay Later Otay Mesa holidays?
Your bank balance shouldn't get in the way of taking a holiday, so Expedia has worked out a solution to help. Now that we've partnered with online lender Klarna, it's easier than ever to book your dream getaway without drying up your savings. Klarna offers flexible payment options at checkout that take the stress out of budgeting for your break. Check out these flexible payment options:

  • Pay monthly holidays: Klarna has manageable monthly payment plans that suit all types of budgets, so you can take that well-deserved holiday now.
  • Pay in instalments holidays: If you'd like to pay off your getaway across multiple transactions, holidays paid in instalments might be right for your Book Now, Pay Later holiday through Klarna.
  • Low deposit holidays: Pressing the "book now" button is easier with this payment option. Put down a small deposit on your booking and then start packing your bags.

Where should I stay in Otay Mesa?
Most who travel to Otay Mesa put both SeaWorld and San Diego Zoo on their to-do lists. Why not go for a hotel near these fantastic attractions?
What are the top hotels in Otay Mesa?
Book a stay at Manchester Grand Hyatt San Diego. It's one of this neighbourhood's most popular properties. Another top-rated option in Otay Mesa is Paradise Point Resort And Spa.
How far in advance should I book my Otay Mesa holiday?
Reserving your seat early with Expedia means one less thing to have to worry about. A number of air carriers display prices up to 12 months prior to departure dates. This is usually the cheapest time to book. If circumstances have left you booking late, low prices to Otay Mesa occasionally appear in the weeks leading up to departure.
What does an Expedia Otay Mesa travel package include?
You can select from any combination of flights, rental cars and hotels. Once you've made your booking, you can add the fun stuff like experiences and tours. Want to pick your fare class? That's also possible. The choice is yours when it comes to crafting your perfect Otay Mesa escape.
What should I know before booking an Otay Mesa travel package?
Design deals that fit your budget with an Expedia package. Flights, hotels, rental cars — we have them all. You'll save precious cash just for bundling your bookings. Whether you're embarking on a winter snow adventure or relaxing on a sunny beach, your dream getaway is only a few clicks away.
Can I choose my airline with an Otay Mesa Expedia travel package?
With a travel package, you're the boss. Whether you'd prefer to fly to Otay Mesa in business or coach, simply pick from the available airline options. Expedia has access to over 550 partner airlines across the world.

Popular places to visit

San Diego Zoo

San Diego Zoo

See nature up-close and personal at one of the country’s largest and most educational zoos.

San Diego Zoo
San Diego Convention Center

San Diego Convention Center

During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's fascinating museums and acclaimed art galleries.

San Diego Convention Center
Mission Bay

Mission Bay

Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.

Mission Bay

Things to do

Kayak on the San Diego Bay

Kayak on the San Diego Bay

£15
per adult
Kayak on the San Diego Bay
Crossing Borders: Tijuana Day Trip from San Diego

Crossing Borders: Tijuana Day Trip from San Diego

£68
per adult
92% of travellers recommend
Crossing Borders: Tijuana Day Trip from San Diego
From Tijuana: Valle de Guadalupe Shared Winery Tour

From Tijuana: Valle de Guadalupe Shared Winery Tour

£62
per adult
100% of travellers recommend
From Tijuana: Valle de Guadalupe Shared Winery Tour
See all activities in San Diego

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.