Otay Mesa Travel Guide
San Diego
Popular places to visit
San Diego Zoo
See nature up-close and personal at one of the country’s largest and most educational zoos.
San Diego Convention Center
During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's fascinating museums and acclaimed art galleries.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
USS Midway Museum
Experience the thrills and hardships of Navy life at this waterfront museum which has become a San Diego landmark.
Petco Park
Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.
Mission Beach
A favorite vacation spot for 100 years, this seaside village combines old-fashioned charm with modern amenities.
Things to do
Crossing Borders: Tijuana Day Trip from San Diego
From Tijuana: Valle de Guadalupe Shared Winery Tour
Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster
Crossing Borders: Tijuana Day Trip from San Diego
Stand up Paddle Board Lesson on The San Diego Bay
Top hotels in Otay Mesa
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
"Friendly staff"
Reviewed on 22 May 2026
The Sofia Hotel
"Loved it"
Reviewed on 23 May 2026
Paradise Point Resort & Spa
"Very helpful. Excellent food, etc. My only complaint is that the towels all had a bad odor. That’s bath and pool towels."
Reviewed on 24 May 2026
Manchester Grand Hyatt San Diego
"It of places to go walking distance to eat breakfast and dinner r"
Reviewed on 24 May 2026
Hard Rock Hotel San Diego
"first I bought 2 suites for my daughter's graduation. then on arrival they separated us to two different sides of hotel. one room with balcony faced all the air conditioning on top of joining building. disgusting view with loud units. The furniture has stains and wear. the sliding bath door was hanging ..."
Reviewed on 23 May 2026
The DEXTRO Little Italy, BW Premier Collection
"walking distance from the pier and lil italy restaurants-and parking gargage"
Reviewed on 24 May 2026
Other neighbourhoods around Otay Mesa
East Village
Travellers choose East Village for its great bars. Hop aboard the metro at City College Trolley Station or Park and Market Trolley Station and check out top sights like Petco Park.
Gaslamp Quarter
Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping.
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
North Park
North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area.
Little Italy
Visitors to Little Italy love its captivating waterfront views, and you can check out Maritime Museum of San Diego and San Diego Bay. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station.
Hillcrest
Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop.
