Title: Otay Mesa Travel Guide: Best of Otay Mesa, San Diego Travel 2026 | Expedia.co.uk [Hotels in Otay Mesa](https://expedia.co.uk/Otay-Mesa-San-Diego-Hotels.0-n6263723-0.Travel-Guide-Filter-Hotels)[Flights to San Diego](https://expedia.co.uk/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.co.uk/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Otay Mesa Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Otay-Mesa.d6263723.Car-Hire-Guide)[Otay Mesa Holidays](https://expedia.co.uk/Otay-Mesa.d6263723.Holidays-City-Breaks) # Otay Mesa Travel Guide ## San Diego ![Tijuana Neighborhood Seen Over Border Fence](https://images.trvl-media.com/place/6263723/a421f2e3-03d1-46f6-89f3-1009103bee11.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ## Visit Otay Mesa Things to do Hotels Where to stay [San Diego travel guide](https://expedia.co.uk/San-Diego.dx3073) --- ### Popular places to visit ![San Diego Zoo](https://images.trvl-media.com/place/502547/504b59eb-bcb1-4b86-9adb-3c97368fb431.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### San Diego Zoo See nature up-close and personal at one of the country’s largest and most educational zoos. [](https://expedia.co.uk/San-Diego-Zoo-San-Diego.d502547.Attraction) ![San Diego Convention Center](https://images.trvl-media.com/place/6125294/2fc00620-42cd-4ab5-9c91-9e9ac3371200.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### San Diego Convention Center During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's fascinating museums and acclaimed art galleries. [](https://expedia.co.uk/San-Diego-Convention-Center-Downtown-San-Diego.d6125294.Attraction) ![Mission Bay](https://images.trvl-media.com/place/6185904/de90e297-f912-4798-a530-b3d83f0907a3.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Mission Bay Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park. [](https://expedia.co.uk/Mission-Bay-San-Diego.d6185904.Attraction) ![Mission Beach](https://images.trvl-media.com/place/506109/7668844c-8a76-415d-a747-d4762537804f.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Mission Beach A favorite vacation spot for 100 years, this seaside village combines old-fashioned charm with modern amenities. [](https://expedia.co.uk/Mission-Beach-Central-Mission-Beach.d506109.Attraction) ![SeaWorld](https://images.trvl-media.com/place/3073/8f017bfb-436d-498f-a4c2-881869d60b1d.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### SeaWorld Animal interaction, entertaining rides and informative exhibits are all on offer at this family favorite destination. [](https://expedia.co.uk/SeaWorld-San-Diego.d502548.Attraction) ![Balboa Park](https://images.trvl-media.com/place/507458/5c140d77-7130-49d1-ab3d-705937c3610a.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Balboa Park Culture and nature converge in this diverse park located in the heart of the city. [](https://expedia.co.uk/Balboa-Park-San-Diego.d507458.Attraction) ### Things to do ![Kayak on the San Diego Bay ](https://mediaim.expedia.com/localexpert/2886775/5d70d5e6-3235-441a-b04c-fe30d2d13cd6.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Kayak on the San Diego Bay £15 per adult [](https://expedia.co.uk/things-to-do/kayak-on-the-san-diego-bay.a2886775.activity-details) ![Crossing Borders: Tijuana Day Trip from San Diego](https://mediaim.expedia.com/localexpert/48193768/b44264f9-db27-4b7e-bcd7-4af756e2b001.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Crossing Borders: Tijuana Day Trip from San Diego £70 per adult **90%** of travellers recommend [](https://expedia.co.uk/things-to-do/crossing-borders-tijuana-day-trip-from-san-diego.a48193768.activity-details) ![From Tijuana: Valle de Guadalupe Shared Winery Tour](https://mediaim.expedia.com/localexpert/48318065/7c11aa1b-54f4-48a9-89b8-61d2dfb76970.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### From Tijuana: Valle de Guadalupe Shared Winery Tour £61 per adult [](https://expedia.co.uk/things-to-do/from-tijuana-valle-de-guadalupe-shared-winery-tour.a48318065.activity-details) ![Crossing Borders: Tijuana Day Trip from San Diego](https://mediaim.expedia.com/localexpert/1385617/29d09da0-b871-4eb6-b122-9bf92b9782b7.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Crossing Borders: Tijuana Day Trip from San Diego £70 per adult **82%** of travellers recommend [](https://expedia.co.uk/things-to-do/crossing-borders-tijuana-day-trip-from-san-diego.a1385617.activity-details) ![ Stand up Paddle Board Lesson on The San Diego Bay ](https://mediaim.expedia.com/localexpert/1246891/0e157c0d-bd34-474b-a551-bd80f218d871.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Stand up Paddle Board Lesson on The San Diego Bay £19 per adult **100%** of travellers recommend [](https://expedia.co.uk/things-to-do/stand-up-paddle-board-lesson-on-the-san-diego-bay.a1246891.activity-details) ![San Diego Bay Sail Aboard a French Yacht: Beer and Wine Included ](https://mediaim.expedia.com/localexpert/50788154/00134805-7b12-4136-99e7-27b72339bb83.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### San Diego Bay Sail Aboard a French Yacht: Beer and Wine Included £179 per adult [](https://expedia.co.uk/things-to-do/san-diego-bay-sail-aboard-a-french-yacht-beer-and-wine-included.a50788154.activity-details) [See all activities in San Diego](https://expedia.co.uk/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities) --- ## Top hotels in Otay Mesa ![Paradise Point Resort & Spa](https://images.trvl-media.com/lodging/1000000/10000/3800/3731/d0f041ab_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Paradise Point Resort & Spa 1404 Vacation Rd San Diego CA £202 10 May - 11 May includes taxes & fees Stay at this beach resort in San Diego. Enjoy free Wi-Fi, 5 outdoor pools and a full-service spa. Our guests praise the pool and the helpful staff in their reviews. ... 8.8/10 Excellent! (2,524 reviews) Second time staying here and its a nice place. However, some maintenance is needed. Like faucets in showers just falling off when you turn them on. We were there with another family and their room had the exact same issue Reviewed on 8 Apr 2026 [](https://expedia.co.uk/Hotel-Search?startDate=10%2F05%2F2026&endDate=11%2F05%2F2026&selected=3731&PinnedHotelID=3731&HadPinnedHotel=true®ionId=6263723) ![Best Western Seven Seas](https://images.trvl-media.com/lodging/1000000/10000/1800/1734/w3837h2556x3y3-8b148daf_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Best Western Seven Seas 411 Hotel Circle South San Diego CA £70 20 Apr - 21 Apr includes taxes & fees Stay at this business-friendly hotel in San Diego. Enjoy free Wi-Fi, free parking and 2 hot tubs. Our guests praise the pool and the restaurant in their reviews. ... 8/10 Very Good! (3,368 reviews) Clean rooms, worth staying here. Reviewed on 8 Apr 2026 [](https://expedia.co.uk/Hotel-Search?startDate=20%2F04%2F2026&endDate=21%2F04%2F2026&selected=1734&PinnedHotelID=1734&HadPinnedHotel=true®ionId=6263723) ![Hard Rock Hotel San Diego](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/7e147d0f_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hard Rock Hotel San Diego 207 5th Ave San Diego CA £208 24 Apr - 25 Apr includes taxes & fees Stay at this hotel in San Diego. Enjoy free Wi-Fi, 2 restaurants and a nightclub. Our guests praise the helpful staff and the convenient parking in their reviews. ... 9/10 Wonderful! (3,516 reviews) Property was clean. Staff were friendly and helpful. Felt the Mary Jane's restaurant was a little overrated. Food wasn’t what I expected. Reviewed on 9 Apr 2026 [](https://expedia.co.uk/Hotel-Search?startDate=24%2F04%2F2026&endDate=25%2F04%2F2026&selected=1731557&PinnedHotelID=1731557&HadPinnedHotel=true®ionId=6263723) ![Handlery Hotel](https://images.trvl-media.com/lodging/1000000/10000/8400/8374/8cec183d_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Handlery Hotel 950 Hotel Cir N San Diego CA Fully refundableReserve now, pay when you stay £100 29 Apr - 30 Apr includes taxes & fees Stay at this business-friendly hotel in San Diego. Enjoy free Wi-Fi, 2 restaurants and 2 bars/lounges. Our guests praise the pool and the helpful staff in their ... 8.4/10 Very Good! (2,398 reviews) This is a nice enough place. We stayed here two times now and the rates are reasonable. The room was very clean. Paying for parking is ridiculously stupid in every awkward parking lot Reviewed on 8 Apr 2026 [](https://expedia.co.uk/Hotel-Search?startDate=29%2F04%2F2026&endDate=30%2F04%2F2026&selected=8374&PinnedHotelID=8374&HadPinnedHotel=true®ionId=6263723) ![The DEXTRO Little Italy, BW Premier Collection](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/6fe441dd_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### The DEXTRO Little Italy, BW Premier Collection 1617 1st Avenue San Diego CA £117 23 Apr - 24 Apr includes taxes & fees Stay at this business-friendly hotel in San Diego. Enjoy free Wi-Fi, breakfast (surcharge) and a 24-hour fitness centre. Our guests praise the helpful staff ... 8.8/10 Excellent! (1,336 reviews) I feel like the dextro is trying to be several things that it is emphatically not. it’s not a slick, hip modern stay. it’s not an elegant niche inn. it would be a better experience if the management acknowledged what it actually is, which is a casual but aging property with some limitations. our ... Reviewed on 9 Apr 2026 [](https://expedia.co.uk/Hotel-Search?startDate=23%2F04%2F2026&endDate=24%2F04%2F2026&selected=170338&PinnedHotelID=170338&HadPinnedHotel=true®ionId=6263723) ![Wyndham San Diego Bayside](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/a77f85c3_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Wyndham San Diego Bayside 1355 N Harbor Drive San Diego CA £158 3 May - 4 May includes taxes & fees Stay at this business-friendly hotel in San Diego. Enjoy free Wi-Fi, 3 restaurants and breakfast (surcharge). Our guests praise the pool and the restaurant in ... 8.4/10 Very Good! (6,122 reviews) Room was clean and comfortable. Parking Was Accessible and easy to use. Staff was very helpful upon arrival. TV Needs Netflix. Reviewed on 8 Apr 2026 [](https://expedia.co.uk/Hotel-Search?startDate=03%2F05%2F2026&endDate=04%2F05%2F2026&selected=11177&PinnedHotelID=11177&HadPinnedHotel=true®ionId=6263723) [See all 4,885 properties in Otay Mesa](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=10%2F04%2F2026&endDate=11%2F04%2F2026®ionId=6263723) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check Otay Mesa hotel availability [Tonight ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6263723&startDate=2026-04-09&endDate=2026-04-10)[9 Apr - 10 Apr](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6263723&startDate=2026-04-09&endDate=2026-04-10) [Tomorrow night ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6263723&startDate=2026-04-10&endDate=2026-04-11)[10 Apr - 11 Apr](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6263723&startDate=2026-04-10&endDate=2026-04-11) [This weekend ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6263723&startDate=10%2F04%2F2026&endDate=12%2F04%2F2026)[10 Apr - 12 Apr](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6263723&startDate=10%2F04%2F2026&endDate=12%2F04%2F2026) [Next weekend ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6263723&startDate=17%2F04%2F2026&endDate=19%2F04%2F2026)[17 Apr - 19 Apr](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6263723&startDate=17%2F04%2F2026&endDate=19%2F04%2F2026) --- ### Other neighbourhoods around Otay Mesa ![Gaslamp Quarter](https://images.trvl-media.com/place/6130021/5158ce24-3077-4ad7-bf7d-46fd554e646d.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Gaslamp Quarter Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping. [](https://expedia.co.uk/San-Diego-Gaslamp-Quarter.dx6130021) ![Downtown San Diego](https://images.trvl-media.com/place/800123/772b9d6a-cdc3-400e-b3ed-61d10adc7912.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Downtown San Diego 4.5/5(138 area reviews) Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city. [](https://expedia.co.uk/San-Diego-Downtown-San-Diego.dx800123) ![North Park sign at sunset, in San Diego, California](https://images.trvl-media.com/place/6346499/b86dcf12-1068-4f1b-98f0-547974936805.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### North Park North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area. [](https://expedia.co.uk/San-Diego-North-Park.dx6346499) ![Little Italy](https://images.trvl-media.com/place/6161280/027d3836-740c-44f0-bb0a-a8fb158f401a.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Little Italy Visitors to Little Italy love its captivating waterfront views, and you can check out Maritime Museum of San Diego and San Diego Bay. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station. [](https://expedia.co.uk/San-Diego-Little-Italy.dx6161280) ![Gossip Grill](https://images.trvl-media.com/place/6191797/60a250a8-62f2-4c0b-8601-b05dd917f234.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Hillcrest 5/5(1 area review) Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop. [](https://expedia.co.uk/San-Diego-Hillcrest.dx6191797) ![Mission San Diego de Alcala With Century Plant,San Diego, California, USA](https://images.trvl-media.com/place/800124/3acb7c99-e1a9-4421-ac6d-8b056ecd511f.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Mission Valley 4/5(36 area reviews) Known for its stunning beaches and popular shops, there's plenty to explore in Mission Valley. Check out top attractions like Mission Valley Mall and Fashion Valley Mall, and jump on the metro at Hazard Center Station or Mission Valley Center Station to see more of the city. [](https://expedia.co.uk/San-Diego-Mission-Valley.dx800124) --- --- - [Stays](?pwaLob=wizard-hotel-pwa-v2) - [Packages](?pwaLob=wizard-package-pwa) - [Flights](?pwaLob=wizard-flight-pwa) - [Things to do](?pwaLob=wizard-lx-pwa) - [Cruises](?pwaLob=wizard-cruise-pwa) - [Cars](?pwaLob=wizard-car-pwa) # Otay Mesa Travel Guide ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app