Otay Mesa Travel Guide

Name: Hard Rock Hotel San Diego
Price range: £182

San Diego

A city skyline with high-rise buildings and a bridge over a body of water.

An aerial view of a densely populated city with a mix of residential and commercial buildings, surrounded by greenery and a clear sky.

A hillside town with a winding road, a bridge in the distance, and a river in the foreground.

Visit Otay Mesa

Things to do

Hotels

San Diego travel guide

Stay near popular Otay Mesa attractions

Cross Border Xpress

Cross Border Xpress is just one of the places to see in San Diego, so why not enjoy the other things to explore during your travels? Visit the shops in this family-friendly area or simply enjoy its restaurants.

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Things to do

Crossing Borders: Tijuana Day Trip from San Diego

£68

per adult

94% of travellers recommend

Kayak on the San Diego Bay

£15

per adult

100% of travellers recommend

From Tijuana: Valle de Guadalupe Shared Winery Tour

£63

per adult

100% of travellers recommend

Stand up Paddle Board Lesson on The San Diego Bay

£18

per adult

100% of travellers recommend

Tijuana Urban Art Walk from San Diego

£59

per adult

From Tijuana: Valle de Guadalupe Private Winery Tour

£108

per adult

100% of travellers recommend

See all activities in San Diego

Top hotels in Otay Mesa

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2296 Niels Bohr Ct San Diego CA

£115

5 Oct - 6 Oct

includes taxes & fees

Stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in ...

Manchester Grand Hyatt San Diego

1 Market Pl San Diego CA

£211

8 Sept - 9 Sept

includes taxes & fees

Stay at this business-friendly hotel in San Diego. Enjoy 6 restaurants, 3 bars/lounges and breakfast (surcharge). Our guests praise the pool and the helpful ...

Wyndham San Diego Bayside

1355 N Harbor Drive San Diego CA

£157

7 Sept - 8 Sept

includes taxes & fees

Stay at this business-friendly hotel in San Diego. Enjoy free Wi-Fi, 3 restaurants and breakfast (surcharge). Our guests praise the pool and the restaurant in ...

8.4/10 Very good! (6,306 reviews)

"Loved the bay view"

Reviewed on 3 Sept 2026

Paradise Point Resort & Spa

1404 Vacation Rd San Diego CA

£216

7 Sept - 8 Sept

includes taxes & fees

Stay at this beach resort in San Diego. Enjoy free Wi-Fi, 5 outdoor pools and a full-service spa. Our guests praise the pool and the helpful staff in their reviews. ...

The Dana on Mission Bay

1710 W Mission Bay Dr San Diego CA

£158

29 Sept - 30 Sept

includes taxes & fees

Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina and 2 hot tubs. Our guests praise the pool and the restaurant in their reviews. Popular attractions ...

9/10 Wonderful! (4,454 reviews)

"Great stay with beautiful grounds. Amazing view from the room. Would recommend and will definitely stay there again!"

Reviewed on 3 Sept 2026

Hard Rock Hotel San Diego

207 5th Ave San Diego CA

£182

28 Sept - 29 Sept

includes taxes & fees

Stay at this hotel in San Diego. Enjoy free Wi-Fi, 2 restaurants and a nightclub. Our guests praise the helpful staff and the convenient parking in their reviews. ...

See all 5,024 properties in Otay Mesa

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most.

A plaza with a traditional building, benches, and a large tree.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

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A beach with surfers and swimmers during sunset.

Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.

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A roller coaster under construction with scaffolding and a ticket booth in the foreground.

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

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Gaslamp Quarter

Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Harlem of the West Sites – discover Gaslamp Quarter, a destination also famous for its shopping.

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