Otay Mesa Travel Guide

Name: Best Western Seven Seas
Price range: £73

San Diego

A city skyline with high-rise buildings and a bridge over a body of water.

An aerial view of a densely populated city with a mix of residential and commercial buildings, surrounded by greenery and a clear sky.

A hillside town with a winding road, a bridge in the distance, and a river in the foreground.

Visit Otay Mesa

Things to do

Hotels

San Diego travel guide

Stay near popular Otay Mesa attractions

Cross Border Xpress

Cross Border Xpress is just one of the places to see in San Diego, so why not enjoy the other things to explore during your travels? Visit the shops in this family-friendly area or simply enjoy its restaurants.

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Things to do

Kayak on the San Diego Bay

£15

per adult

100% of travellers recommend

From Tijuana: Valle de Guadalupe Private Winery Tour

£108

per adult

100% of travellers recommend

From Tijuana: Valle de Guadalupe Shared Winery Tour

£58

per adult

100% of travellers recommend

Taco Tuesday Hop to Tijuana from San Diego

£62

per adult

Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster

Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster

£90

per adult

Stand up Paddle Board Lesson on The San Diego Bay

£19

per adult

100% of travellers recommend

See all activities in San Diego

Top hotels in Otay Mesa

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2296 Niels Bohr Ct San Diego CA

£122

1 Nov - 2 Nov

includes taxes & fees

Stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in ...

Wyndham San Diego Bayside

1355 N Harbor Drive San Diego CA

£158

29 Oct - 30 Oct

includes taxes & fees

Stay at this business-friendly hotel in San Diego. Enjoy free Wi-Fi, 3 restaurants and breakfast (surcharge). Our guests praise the pool and the restaurant in ...

Hard Rock Hotel San Diego

207 5th Ave San Diego CA

Fully refundableReserve now, pay when you stay

£171

22 Nov - 23 Nov

includes taxes & fees

Stay at this hotel in San Diego. Enjoy free Wi-Fi, 2 restaurants and a nightclub. Our guests praise the helpful staff and the convenient parking in their reviews. ...

9/10 Wonderful! (4,567 reviews)

"The room was very clean and the cleaning staff was absolutely amazing. Cleanest room I've ever seen."

Reviewed on 27 Oct 2026

Handlery Hotel

950 Hotel Cir N San Diego CA

£92

16 Nov - 17 Nov

includes taxes & fees

Stay at this business-friendly hotel in San Diego. Enjoy free Wi-Fi, 2 restaurants and 2 bars/lounges. Our guests praise the pool and the helpful staff in their ...

8.4/10 Very good! (3,030 reviews)

"The door coming off the hinges Vending machine was out of water The door was so close to the toilet barely close it Carpet stained Very old"

Reviewed on 26 Oct 2026

Paradise Point Resort & Spa

1404 Vacation Rd San Diego CA

£231

15 Nov - 16 Nov

includes taxes & fees

Stay at this beach resort in San Diego. Enjoy free Wi-Fi, 5 outdoor pools and a full-service spa. Our guests praise the pool and the helpful staff in their reviews. ...

Best Western Seven Seas

411 Hotel Circle South San Diego CA

£73

29 Oct - 30 Oct

includes taxes & fees

Stay at this business-friendly hotel in San Diego. Enjoy free Wi-Fi, free parking and 2 hot tubs. Our guests praise the pool and the restaurant in their reviews. ...

See all 5,088 properties in Otay Mesa

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most.

A large stadium with the sign "Cobo Park" and palm trees around it.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

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A pier extending into the ocean with buildings at the end, under a partly cloudy sky.

Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.

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Gaslamp Quarter

Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Nova SD – discover Gaslamp Quarter, a destination also famous for its shopping.

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