Title: Santa Cruz Travel Guide: Best of Santa Cruz, Santa Cruz Travel 2025 | Expedia.co.uk [Hotels in Santa Cruz](https://expedia.co.uk/Santa-Cruz-Hotels.d6053940.Travel-Guide-Hotels)[Holiday Rentals in Santa Cruz](https://expedia.co.uk/Santa-Cruz-Holiday-Rentals.d6053940.Travel-Guide-HolidayRentals)[Flights to Santa Cruz](https://expedia.co.uk/Cheap-Flights-To-Santa-Cruz.d6053940.Travel-Guide-Flights)[Santa Cruz Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Santa-Cruz.d6053940.Car-Hire-Guide)[Santa Cruz Holidays](https://expedia.co.uk/Santa-Cruz.d6053940.Holidays-City-Breaks) # Santa Cruz Travel Guide ## Tourist Guide ![San Lorenzo Cathedral showing a garden](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/115000/115563-Santa-Cruz.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Santa Cruz featuring a city](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/115000/115559-Santa-Cruz.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![San Lorenzo Cathedral featuring heritage architecture and heritage elements](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/115000/115566-Santa-Cruz.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Santa Cruz showing a city](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/115000/115555-Santa-Cruz.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![San Lorenzo Cathedral](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/115000/115564-Santa-Cruz.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ## Visit Santa Cruz Where to stay Things to do Reviews #### Experience Bolivia as the locals see it in the country’s busiest city, where the museums, public squares and churches give you a glimpse into their everyday lives. Although Santa Cruz de la Sierra, more commonly known as Santa Cruz, is the most populous city in Bolivia, it is still relatively unknown by tourists. Sample an authentic Bolivian lifestyle in this busy city. Visit Santa Cruz’s churches and museums for an insight into the region’s history or simply soak up the atmosphere over a drink with the friendly locals. Explore a city that started out in a totally different location. Santa Cruz was founded in 1561, but had to move west after several decades of fending off attacks. Visit the historic heart of the city in [Plaza 24 de Septiembre](https://www.expedia.co.uk/Plaza-24-De-Septiembre-Santa-Cruz.d6098828.Attraction), which is more than 400 years old, to relax with the locals, who are known as “cruceños.” The most distinctive attraction in the city is [San Lorenzo Cathedral](https://www.expedia.co.uk/San-Lorenzo-Cathedral-Santa-Cruz.d6098830.Attraction), which is immediately recognizable for its red-brick frontage featuring two clock towers standing on either side of a pediment. The cathedral hosts the Museum of Sacred Art, with exhibits that display religious icons and Jesuit relics. Climb to the top of the clock tower for panoramic views of the city. Wander around the Parque Arenal, a green space in the middle of the city. The park has a boating lagoon and the Museo Etnofolklorico (Santa Cruz Ethnographic Museum). Other museums in the city include the Guarani Museum, which examines the culture of the indigenous Guarani people, and the National History Museum. Take children to the Zoological Gardens, where they can meet animals from around Bolivia. The zoo’s llamas and sloths are always popular with younger visitors. Fly into the busiest airport in Bolivia, Viru Viru International Airport. Flights arrive here from destinations in both Bolivia and cities in North and South America. Some operators even fly here from cities in Europe, such as Madrid. Santa Cruz de la Sierra is located in the lowlands of Bolivia in the east of the country, which means that rainfall is high during the summer months around January. Come during the high season, between May and October, for more dependable weather but higher prices. ### Where to stay in Santa Cruz ![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Hamacas When in Hamacas, you can plan a visit to Santa Cruz Zoo and Las Brisas Shopping Center, some noteworthy sights in the nearby area. [](https://expedia.co.uk/Santa-Cruz-Hamacas.dx553248635975875143) - Top hotels in Santa Cruz - Top Holiday Rentals in Santa Cruz ![Ibis Santa Cruz DE LA Sierra](https://images.trvl-media.com/lodging/88000000/87140000/87138700/87138613/640c92ef_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Ibis Santa Cruz DE LA Sierra AVENIDA CRISTOBAL DE MENDOZA, Santa Cruz £26 29 Sept - 30 Sept Stay at this 3-star business-friendly hotel in Santa Cruz. Enjoy free Wi-Fi, free parking and breakfast (surcharge). Our guests praise the helpful staff in their ... 9.6/10 Exceptional! (53 reviews) "The" Reviewed on 28 Jul 2025 [](https://expedia.co.uk/Hotel-Search?startDate=29%2F09%2F2025&endDate=30%2F09%2F2025&selected=87138613&PinnedHotelID=87138613&HadPinnedHotel=true®ionId=6053940) ![Marriott Santa Cruz de la Sierra Hotel](https://images.trvl-media.com/lodging/22000000/21500000/21490300/21490226/a95726cf_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Marriott Santa Cruz de la Sierra Hotel 4to Anillo Entre Radial 23, At Calle Las Ramblas, Santa Cruz, Santa Cruz £76 3 Oct - 4 Oct Stay at this 5-star luxury hotel in Santa Cruz. Enjoy free parking, a full-service spa and a rooftop terrace. Our guests praise the helpful staff and the property ... 9/10 Wonderful! (195 reviews) "Nice" Reviewed on 8 Sept 2025 [](https://expedia.co.uk/Hotel-Search?startDate=03%2F10%2F2025&endDate=04%2F10%2F2025&selected=21490226&PinnedHotelID=21490226&HadPinnedHotel=true®ionId=6053940) ![Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel](https://images.trvl-media.com/lodging/1000000/20000/18800/18758/bb34bb1f_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel Ave. San Martin, #455, Santa Cruz £96 12 Oct - 13 Oct Stay at this 3.5-star spa hotel in Santa Cruz. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff in their reviews. Popular ... 8.8/10 Excellent! (327 reviews) "Los Tajibos is perhaps the best place to stay in Santa Cruz." Reviewed on 4 Sept 2025 [](https://expedia.co.uk/Hotel-Search?startDate=12%2F10%2F2025&endDate=13%2F10%2F2025&selected=18758&PinnedHotelID=18758&HadPinnedHotel=true®ionId=6053940) [See all 282 properties in Santa Cruz](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=19%2F09%2F2025&endDate=20%2F09%2F2025®ionId=6053940) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![Apart Hotel Premium Suites Santa Cruz](https://images.trvl-media.com/lodging/6000000/5930000/5928300/5928237/e5844260_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Apart Hotel Premium Suites Santa Cruz Calle Las Begonias Nro 45, a 1 cuadra de la Av. San Martin, Santa Cruz Stay at this 3.5-star business-friendly aparthotel in Santa Cruz. Enjoy free Wi-Fi, free parking and room service. Popular attractions Patio Design LifeStyle ... 8.6/10 Excellent! (91 reviews) "Es buena locación , limpio , muy amables" Reviewed on 14 Sept 2025 [](https://expedia.co.uk/Santa-Cruz-Hotels-Apart-Hotel-Premium-Suites-Santa-Cruz.h5928237.Hotel-Information) ![Premium Suites Deluxe Aparthotel Equipetrol](https://images.trvl-media.com/lodging/25000000/24410000/24404300/24404225/12ef5e8d_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Premium Suites Deluxe Aparthotel Equipetrol Calle Las Azucenas No. 127, 1 block from San Martin Avenue, Santa Cruz, Santa Cruz Stay at this 3.5-star business-friendly aparthotel in Santa Cruz. Enjoy free Wi-Fi, free parking and breakfast (surcharge). Popular attractions Patio Design ... 9/10 Wonderful! (75 reviews) "Great folks with there. Clean rooms." Reviewed on 29 Aug 2025 [](https://expedia.co.uk/Santa-Cruz-Hotels-Premium-Suites-Deluxe-Aparthotel-Equipetrol.h24404225.Hotel-Information) ![Equipetrol Suites Apart Hotel](https://images.trvl-media.com/lodging/91000000/90600000/90599400/90599395/2b6207d2_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Equipetrol Suites Apart Hotel Equipetrol, Santa Cruz, Departamento de Santa Cruz Stay at this business-friendly aparthotel in Santa Cruz. Enjoy free breakfast, free Wi-Fi and a 24-hour front desk. Popular attractions Cine Center and Blacutt ... 8.6/10 Excellent! (8 reviews) Voltarei "Hotel cumpre o que promete, limpeza, localização e funcionários atentos e amáveis." Reviewed on 9 Aug 2025 [](https://expedia.co.uk/Santa-Cruz-Hotels-Equipetrol-Suites-Apart-Hotel.h90599395.Hotel-Information) [See all properties in Santa Cruz](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience®ionId=6053940&sort=VACATION_RENTAL) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check Santa Cruz hotel availability [](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6053940&startDate=2025-09-18&endDate=2025-09-19) [Tonight](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6053940&startDate=2025-09-18&endDate=2025-09-19) [](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6053940&startDate=2025-09-18&endDate=2025-09-19) [](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6053940&startDate=2025-09-18&endDate=2025-09-19)[18 Sept - 19 Sept](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6053940&startDate=2025-09-18&endDate=2025-09-19) [](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6053940&startDate=2025-09-19&endDate=2025-09-20) [Tomorrow night](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6053940&startDate=2025-09-19&endDate=2025-09-20) [](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6053940&startDate=2025-09-19&endDate=2025-09-20) [](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6053940&startDate=2025-09-19&endDate=2025-09-20)[19 Sept - 20 Sept](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6053940&startDate=2025-09-19&endDate=2025-09-20) [](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6053940&startDate=19%2F09%2F2025&endDate=21%2F09%2F2025) [This weekend](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6053940&startDate=19%2F09%2F2025&endDate=21%2F09%2F2025) [](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6053940&startDate=19%2F09%2F2025&endDate=21%2F09%2F2025) [](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6053940&startDate=19%2F09%2F2025&endDate=21%2F09%2F2025)[19 Sept - 21 Sept](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6053940&startDate=19%2F09%2F2025&endDate=21%2F09%2F2025) [](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6053940&startDate=26%2F09%2F2025&endDate=28%2F09%2F2025) [Next weekend](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6053940&startDate=26%2F09%2F2025&endDate=28%2F09%2F2025) [](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6053940&startDate=26%2F09%2F2025&endDate=28%2F09%2F2025) [](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6053940&startDate=26%2F09%2F2025&endDate=28%2F09%2F2025)[26 Sept - 28 Sept](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6053940&startDate=26%2F09%2F2025&endDate=28%2F09%2F2025) ### Popular places to visit ![Plaza 24 de Septiembre which includes heritage architecture and heritage elements as well as a large group of people](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/115000/115719-Plaza-24-De-Septiembre.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Plaza 24 de Septiembre The heart of Santa Cruz lies in this public square, where locals relax and tourists sightsee in a welcoming, laid-back atmosphere. [](https://expedia.co.uk/Plaza-24-De-Septiembre-Santa-Cruz.d6098828.Attraction) ![San Lorenzo Cathedral showing heritage elements, a church or cathedral and heritage architecture](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/115000/115709-San-Lorenzo-Cathedral.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### San Lorenzo Cathedral One of the most iconic landmarks in Santa Cruz is the city’s mighty cathedral, which houses a museum displaying important artwork. [](https://expedia.co.uk/San-Lorenzo-Cathedral-Santa-Cruz.d6098830.Attraction) #### Ventura Mall 4/5(1 review) During your visit to Santa Cruz, you can enjoy retail therapy at Ventura Mall. Make some time to visit the cathedral while you're in the area. [](https://expedia.co.uk/Ventura-Mall-Santa-Cruz.d553248634697753452.Attraction) #### Santa Cruz Zoo 4/5(1 review) Why not visit the animals who call Santa Cruz Zoo home during your travels in Santa Cruz? While in the area, you can find time to visit its shops. [](https://expedia.co.uk/Santa-Cruz-Zoo-Santa-Cruz.d6098836.Attraction) #### Guembe Biocenter 4/5(1 review) Explore the great outdoors at Guembe Biocenter, a lovely green space in Colinas del Urubo. While in the area, you can find time to visit its shops. [](https://expedia.co.uk/Guembe-Biocenter-Santa-Cruz.d553248621532465358.Attraction) #### Ramon Tahuichi Aguilera Stadium Catch an event at Ramon Tahuichi Aguilera Stadium during your trip to Santa Cruz. While in the area, you can find time to visit its shops. [](https://expedia.co.uk/Ramon-Tahuichi-Aguilera-Stadium-Santa-Cruz.d6098832.Attraction) ### Things to do ![Trekking through the area of ​​​​the last armed struggle of Che Guevara.](https://mediaim.expedia.com/localexpert/47088323/cdf71877-c1dc-46c6-8af1-3b0ab483f139.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### 3D/2N Getaway on the Che Guevara Route in Bolivia £370 per adult [](https://expedia.co.uk/things-to-do/3d2n-getaway-on-the-che-guevara-route-in-bolivia.a47088323.activity-details) [See all activities in Santa Cruz](https://expedia.co.uk/Things-To-Do-In-Santa-Cruz.d6053940.Travel-Guide-Activities) ## Reviews of Santa Cruz 3 Guest rating 5 - Excellent 0 4 - Good 0 3 - Okay 1 2 - Disappointing 0 1 - Terrible 0 ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - [5 Star Hotels in Colinas del Urubo](https://www.expedia.co.uk/5Star-Colinas-Del-Urubo-Hotels.s50-0-d6349680.Travel-Guide-Filter-Hotels) - [Colinas del Urubo Hotels](https://www.expedia.co.uk/Colinas-Del-Urubo-Hotels.d6349680.Travel-Guide-Hotels) - [Santa Cruz Hotels](https://www.expedia.co.uk/Destinations-In-Santa-Cruz.d6297178.Hotel-Destinations) - [Flights to El Trompillo](https://www.expedia.co.uk/Cheap-Flights-To-El-Trompillo.d6032083.Travel-Guide-Flights) - [Flights to Santa Cruz](https://www.expedia.co.uk/Destinations-In-Santa-Cruz.d6297178.Flight-Destinations) - [Flights from El Trompillo](https://www.expedia.co.uk/lp/airports/srz/flights-from-el-trompillo-airport) - [Flights from Wanigela (AGL) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/agl/srz/wanigela-to-santa-cruz) - [Flights from Antalaha (ANM) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/anm/srz/antalaha-to-santa-cruz) - [Flights from Artigas (ATI) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/ati/srz/artigas-to-santa-cruz) - [Flights from Altamira (ATM) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/atm/srz/altamira-to-santa-cruz) - [Flights from Alexandria (AXN) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/axn/srz/alexandria-to-santa-cruz) - 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[Flights from Ciudad Del Carmen (CME) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/cme/srz/ciudad-del-carmen-to-santa-cruz) - [Flights from Copiapo (CPO) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/cpo/srz/copiapo-to-santa-cruz) - [Flights from Dhahran (DHA) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/dha/srz/dhahran-to-santa-cruz) - [Flights from The Dalles (DLS) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/dls/srz/the-dalles-to-santa-cruz) - [Flights from Derby (DRB) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/drb/srz/derby-to-santa-cruz) - [Flights from Dublin (DUB) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/dub/srz/dublin-to-santa-cruz) - [Flights from Dubai (DXB) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/dxb/srz/dubai-to-santa-cruz) - [Flights from Flores (FRS) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/frs/srz/flores-to-santa-cruz) - [Flights from Gaya (GAY) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/gay/srz/gaya-to-santa-cruz) - [Flights from Rio de Janeiro (GIG) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/gig/srz/rio-de-janeiro-to-santa-cruz) - [Flights from Isla Baltra (GPS) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/gps/srz/isla-baltra-to-santa-cruz) - [Flights from São Paulo (GRU) to Santa Cruz (VVI)](https://www.expedia.co.uk/lp/flights/gru/vvi/sao-paulo-to-santa-cruz) - [Flights from Gatokae (GTA) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/gta/srz/gatokae-to-santa-cruz) - [Flights from Guayaquil (GYE) to Santa Cruz (VVI)](https://www.expedia.co.uk/lp/flights/gye/vvi/guayaquil-to-santa-cruz) - [Flights from Freetown (HGS) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/hgs/srz/freetown-to-santa-cruz) - [Flights from Frankfurt (HHN) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/hhn/srz/frankfurt-to-santa-cruz) - [Flights from Khajuraho (HJR) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/hjr/srz/khajuraho-to-santa-cruz) - [Flights from Takaka (KTF) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/ktf/srz/takaka-to-santa-cruz) - [Flights from Las Vegas (LAS) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/las/srz/las-vegas-to-santa-cruz) - [Flights from Los Angeles (LAX) to Santa Cruz (VVI)](https://www.expedia.co.uk/lp/flights/lax/vvi/los-angeles-to-santa-cruz) - [Flights from London (LHR) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/lhr/srz/london-to-santa-cruz) - [Flights from London (LHR) to Santa Cruz (VVI)](https://www.expedia.co.uk/lp/flights/lhr/vvi/london-to-santa-cruz) - [Flights from Lima (LIM) to Santa Cruz (VVI)](https://www.expedia.co.uk/lp/flights/lim/vvi/lima-to-santa-cruz) - [Flights from Ljubljana (LJU) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/lju/srz/ljubljana-to-santa-cruz) - [Flights from London (LON) to Santa Cruz (VVI)](https://www.expedia.co.uk/lp/flights/lon/vvi/london-to-santa-cruz) - [Flights from La Paz (LPB) to Santa Cruz (VVI)](https://www.expedia.co.uk/lp/flights/lpb/vvi/la-paz-to-santa-cruz) - [Flights from Madrid (MAD) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/mad/srz/madrid-to-santa-cruz) - [Flights from Madrid (MAD) to Santa Cruz (VVI)](https://www.expedia.co.uk/lp/flights/mad/vvi/madrid-to-santa-cruz) - [Flights from Manchester (MAN) to Santa Cruz (VVI)](https://www.expedia.co.uk/lp/flights/man/vvi/manchester-to-santa-cruz) - [Flights from Orlando (MCO) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/mco/srz/orlando-to-santa-cruz) - [Flights from Managua (MGA) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/mga/srz/managua-to-santa-cruz) - [Flights from Nuremberg (NUE) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/nue/srz/nuremberg-to-santa-cruz) - [Flights from Oakland (ODM) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/odm/srz/oakland-to-santa-cruz) - [Flights from Orlando (ORL) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/orl/srz/orlando-to-santa-cruz) - [Flights from Panama City (PAC) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/pac/srz/panama-city-to-santa-cruz) - [Flights from Punta Islita (PBP) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/pbp/srz/punta-islita-to-santa-cruz) - [Flights from Potosi (POI) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/poi/srz/potosi-to-santa-cruz) - [Flights from Panama City (PTY) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/pty/srz/panama-city-to-santa-cruz) - [Flights from Puerto Vallarta (PVR) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/pvr/srz/puerto-vallarta-to-santa-cruz) - [Flights from Dallas (RBD) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/rbd/srz/dallas-to-santa-cruz) - [Flights from Resende (REZ) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/rez/srz/resende-to-santa-cruz) - [Flights from Riberalta (RIB) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/rib/srz/riberalta-to-santa-cruz) - [Flights from San Diego (SAN) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/san/srz/san-diego-to-santa-cruz) - [Flights from Santa Ana del Yacuma (SBL) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/sbl/srz/santa-ana-del-yacuma-to-santa-cruz) - [Flights from Stockton (SCK) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/sck/srz/stockton-to-santa-cruz) - [Flights from Santiago (SCL) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/scl/srz/santiago-to-santa-cruz) - [Flights from San Francisco (SFO) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/sfo/srz/san-francisco-to-santa-cruz) - [Flights from San Francisco (SFO) to Santa Cruz (VVI)](https://www.expedia.co.uk/lp/flights/sfo/vvi/san-francisco-to-santa-cruz) - [Flights from Springfield (SGF) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/sgf/srz/springfield-to-santa-cruz) - [Flights from San Juan (SJU) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/sju/srz/san-juan-to-santa-cruz) - [Flights from Salt Lake City (SLC) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/slc/srz/salt-lake-city-to-santa-cruz) - [Flights from Santa Maria (SMX) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/smx/srz/santa-maria-to-santa-cruz) - [Flights from Alcantarí Intl. Airport (SRE) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/sre/srz/sucre-to-santa-cruz) - [Flights from Sydney (SYD) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/syd/srz/sydney-to-santa-cruz) - [Flights from Trinidad (TDD) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/tdd/srz/trinidad-to-santa-cruz) - [Flights from Tarija (TJA) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/tja/srz/tarija-to-santa-cruz) - [Flights from Tsushima (TSJ) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/tsj/srz/tsushima-to-santa-cruz) - [Flights from Lake Tahoe (TVL) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/tvl/srz/lake-tahoe-to-santa-cruz) - [Flights from Ulaangom (ULO) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/ulo/srz/ulaangom-to-santa-cruz) - [Flights from Upolu Point (UPP) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/upp/srz/upolu-point-to-santa-cruz) - [Flights from Uyuni (UYU) to Santa Cruz (VVI)](https://www.expedia.co.uk/lp/flights/uyu/vvi/uyuni-to-santa-cruz) - [Flights from Veracruz (VER) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/ver/srz/veracruz-to-santa-cruz) - [Flights from Van Nuys (VNY) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/vny/srz/van-nuys-to-santa-cruz) - [Flights from Mayo (YMA) to Santa Cruz (SRZ)](https://www.expedia.co.uk/lp/flights/yma/srz/mayo-to-santa-cruz) - [Visit Buena Vista](https://www.expedia.co.uk/Buena-Vista.dx3000445595) - [Visit Colinas del Urubo](https://www.expedia.co.uk/Colinas-Del-Urubo.dx6349680) - [Visit El Torno](https://www.expedia.co.uk/El-Torno.dx3000419675) - [Ethno-Folkloric Museum](https://www.expedia.co.uk/Ethno-Folkloric-Museum-Santa-Cruz.d6098834.Attraction) - [Visit La Belgica](https://www.expedia.co.uk/La-Belgica.dx6350205) - [Visit La Cruceña](https://www.expedia.co.uk/La-Crucena.dx553248635975857564) - [Visit La Guardia](https://www.expedia.co.uk/La-Guardia.dx6347124) - Cities near Santa Cruz - Places of interest [Colinas del Urubo](https://expedia.co.uk/Colinas-Del-Urubo.dx6349680) - [Ethno-folkloric Museum](https://expedia.co.uk/Ethno-Folkloric-Museum-Santa-Cruz.d6098834.Attraction) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. 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