Title: Otay Mesa West Travel Guide: Best of Otay Mesa West, San Diego Travel 2026 | Expedia.co.uk [Hotels in Otay Mesa West](https://expedia.co.uk/Otay-Mesa-West-San-Diego-Hotels.0-n553248625809641010-0.Travel-Guide-Filter-Hotels)[Flights to San Diego](https://expedia.co.uk/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.co.uk/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Otay Mesa West Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Otay-Mesa-West.d553248625809641010.Car-Hire-Guide)[Otay Mesa West Holidays](https://expedia.co.uk/Otay-Mesa-West.d553248625809641010.Holidays-City-Breaks) # Otay Mesa West Travel Guide ## San Diego ## Visit Otay Mesa West Things to do Hotels Where to stay [San Diego travel guide](https://expedia.co.uk/San-Diego.dx3073) --- ### Popular places to visit ![San Diego Zoo featuring zoo animals, landscape views and a pond](https://images.trvl-media.com/place/502547/504b59eb-bcb1-4b86-9adb-3c97368fb431.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### San Diego Zoo 4.5/5(47 reviews) See nature up-close and personal at one of the country’s largest and most educational zoos. [](https://expedia.co.uk/San-Diego-Zoo-San-Diego.d502547.Attraction) ![San Diego Convention Center](https://images.trvl-media.com/place/6125294/2fc00620-42cd-4ab5-9c91-9e9ac3371200.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### San Diego Convention Center 4/5(18 reviews) During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's fascinating museums and entertainment choices. [](https://expedia.co.uk/San-Diego-Convention-Center-Downtown-San-Diego.d6125294.Attraction) ![Bayside Skyride at Sea World, San Diego, CA](https://images.trvl-media.com/place/3073/8f017bfb-436d-498f-a4c2-881869d60b1d.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### SeaWorld 4/5(14 reviews) Animal interaction, entertaining rides and informative exhibits are all on offer at this family favorite destination. [](https://expedia.co.uk/SeaWorld-San-Diego.d502548.Attraction) ![Mission Bay featuring a beach](https://images.trvl-media.com/place/6185904/de90e297-f912-4798-a530-b3d83f0907a3.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Mission Bay 4.5/5(31 reviews) Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park. [](https://expedia.co.uk/Mission-Bay-San-Diego.d6185904.Attraction) ![Triton's Restaurant inside Disney Wonder. #lifeatexpedia ](https://images.trvl-media.com/place/3073/949a0f28-b95c-4e64-8ffd-e0ee735a9cf6.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Port of San Diego 4.5/5(34 reviews) Explore the waterfront in San Diego with a trip to Port of San Diego. Wander the seaside and beautiful beaches in the area. [](https://expedia.co.uk/Port-Of-San-Diego-San-Diego.d6131855.Attraction) ![Mission Beach featuring tropical scenes, street scenes and a beach](https://images.trvl-media.com/place/506109/7668844c-8a76-415d-a747-d4762537804f.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Mission Beach 4.5/5(61 reviews) A favorite vacation spot for 100 years, this seaside village combines old-fashioned charm with modern amenities. [](https://expedia.co.uk/Mission-Beach-Central-Mission-Beach.d506109.Attraction) ### Things to do ![LEGOLAND® California Resort](https://mediaim.expedia.com/localexpert/169428/4add278e-78ce-44aa-b7e4-703b2249aec9.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### LEGOLAND® California Resort £48 per adult **84%** of travellers recommend [](https://expedia.co.uk/things-to-do/legoland-california-resort.a169428.activity-details) ![San Diego Whale Watching Tour ](https://mediaim.expedia.com/localexpert/2836808/467b4391-ac11-41ae-8823-603a9c00d22e.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### San Diego Whale Watching & Dolphin Cruise £53 per adult **88%** of travellers recommend [](https://expedia.co.uk/things-to-do/san-diego-whale-watching-dolphin-cruise.a2836808.activity-details) ![San Diego: Luggage Storage in Marina](https://mediaim.expedia.com/localexpert/48212655/592cad7f-c489-4c0f-bd98-eadd3af5f4a9.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### San Diego: Luggage Storage in Marina £7 per adult **80%** of travellers recommend [](https://expedia.co.uk/things-to-do/san-diego-luggage-storage-in-marina.a48212655.activity-details) ![Kids folding the American Flag ](https://mediaim.expedia.com/localexpert/1384690/a7d69d90-e26a-41ab-9759-cdf944ee1831.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### San Diego Whale Watching Cruise £63 per adult **90%** of travellers recommend [](https://expedia.co.uk/things-to-do/san-diego-whale-watching-cruise.a1384690.activity-details) ![San Diego City Lights Night Tour](https://mediaim.expedia.com/localexpert/3907955/fcb14693-9145-4497-a52e-df7bfc5ecad7.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### San Diego City Lights Night Tour £33 per adult **96%** of travellers recommend [](https://expedia.co.uk/things-to-do/san-diego-city-lights-night-tour.a3907955.activity-details) ![San Diego Explorer Pass: Save up to 50 Percent - Includes USS Midway](https://mediaim.expedia.com/localexpert/3280085/d827a858-bc57-410e-91d0-e458588fc886.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### San Diego Explorer Pass: Save up to 50 Percent - Includes USS Midway £92 per adult **86%** of travellers recommend [](https://expedia.co.uk/things-to-do/san-diego-explorer-pass-save-up-to-50-percent-includes-uss-midway.a3280085.activity-details) [See all activities in San Diego](https://expedia.co.uk/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities) --- ## Top hotels in Otay Mesa West ![Bay Club Hotel & Marina](https://images.trvl-media.com/lodging/1000000/10000/2600/2514/8c022c3d_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Bay Club Hotel & Marina 2131 Shelter Island Dr San Diego CA Fully refundableReserve now, pay when you stay £107 24 Feb - 25 Feb includes taxes & fees Stay at this business-friendly hotel in San Diego. Enjoy free Wi-Fi, a marina and a health club. Our guests praise the breakfast and the restaurant in their ... 9/10 Wonderful! (3,311 reviews) Great location. Clean and quiet rooms. Decent gym. Reviewed on 22 Jan 2026 [](https://expedia.co.uk/Hotel-Search?startDate=24%2F02%2F2026&endDate=25%2F02%2F2026&selected=2514&PinnedHotelID=2514&HadPinnedHotel=true®ionId=553248625809641010) ![Manchester Grand Hyatt San Diego](https://images.trvl-media.com/lodging/1000000/20000/12100/12073/91e2517e_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Manchester Grand Hyatt San Diego 1 Market Pl San Diego CA £243 6 Feb - 7 Feb includes taxes & fees Stay at this business-friendly hotel in San Diego. Enjoy free Wi-Fi, 6 restaurants and 3 bars/lounges. Our guests praise the pool and the helpful staff in their ... 9/10 Wonderful! (2,913 reviews) Great Reviewed on 24 Jan 2026 [](https://expedia.co.uk/Hotel-Search?startDate=06%2F02%2F2026&endDate=07%2F02%2F2026&selected=12073&PinnedHotelID=12073&HadPinnedHotel=true®ionId=553248625809641010) ![Hard Rock Hotel San Diego](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hard Rock Hotel San Diego 207 5th Ave San Diego CA £181 28 Jan - 29 Jan includes taxes & fees Stay at this hotel in San Diego. Enjoy free Wi-Fi, 2 restaurants and a nightclub. Our guests praise the helpful staff and the convenient parking in their reviews. ... 8.8/10 Excellent! (3,253 reviews) Great location clean place and very friendly staff Reviewed on 20 Jan 2026 [](https://expedia.co.uk/Hotel-Search?startDate=28%2F01%2F2026&endDate=29%2F01%2F2026&selected=1731557&PinnedHotelID=1731557&HadPinnedHotel=true®ionId=553248625809641010) ![The Dana on Mission Bay](https://images.trvl-media.com/lodging/1000000/50000/41000/40953/08585098_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### The Dana on Mission Bay 1710 W Mission Bay Dr San Diego CA £151 22 Feb - 23 Feb includes taxes & fees Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina and 2 hot tubs. Our guests praise the pool and the restaurant in their reviews. Popular attractions ... 8.8/10 Excellent! (4,046 reviews) Excellent rooms and beautiful resort. Great staff and service. Reviewed on 27 Jan 2026 [](https://expedia.co.uk/Hotel-Search?startDate=22%2F02%2F2026&endDate=23%2F02%2F2026&selected=40953&PinnedHotelID=40953&HadPinnedHotel=true®ionId=553248625809641010) ![The DEXTRO Little Italy, BW Premier Collection](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/6fe441dd_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### The DEXTRO Little Italy, BW Premier Collection 1617 1st Avenue San Diego CA £81 28 Jan - 29 Jan includes taxes & fees Stay at this business-friendly hotel in San Diego. Enjoy free Wi-Fi, breakfast (surcharge) and a 24-hour fitness centre. Our guests praise the helpful staff ... 8.8/10 Excellent! (957 reviews) Staff was very friendly. Hotel was quite clean. Reviewed on 24 Jan 2026 [](https://expedia.co.uk/Hotel-Search?startDate=28%2F01%2F2026&endDate=29%2F01%2F2026&selected=170338&PinnedHotelID=170338&HadPinnedHotel=true®ionId=553248625809641010) ![Paradise Point Resort & Spa](https://images.trvl-media.com/lodging/1000000/10000/3800/3731/bc1e5add_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Paradise Point Resort & Spa 1404 Vacation Rd San Diego CA £160 22 Feb - 23 Feb includes taxes & fees Stay at this beach resort in San Diego. Enjoy free Wi-Fi, 5 outdoor pools and a full-service spa. Our guests praise the pool and the helpful staff in their reviews. ... 8.6/10 Excellent! (2,385 reviews) Resort was nice with lots of activities including 5 pools, beach and a marina. Rooms are alittle out dated but clean. Overall had a good time and would be back. Please note that parking is an extra $50 per day. Reviewed on 24 Jan 2026 [](https://expedia.co.uk/Hotel-Search?startDate=22%2F02%2F2026&endDate=23%2F02%2F2026&selected=3731&PinnedHotelID=3731&HadPinnedHotel=true®ionId=553248625809641010) [See all 6,908 properties in Otay Mesa West](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=28%2F01%2F2026&endDate=29%2F01%2F2026®ionId=553248625809641010) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check Otay Mesa West hotel availability [Tonight ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248625809641010&startDate=2026-01-27&endDate=2026-01-28)[27 Jan - 28 Jan](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248625809641010&startDate=2026-01-27&endDate=2026-01-28) [Tomorrow night ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248625809641010&startDate=2026-01-28&endDate=2026-01-29)[28 Jan - 29 Jan](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248625809641010&startDate=2026-01-28&endDate=2026-01-29) [This weekend ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248625809641010&startDate=30%2F01%2F2026&endDate=01%2F02%2F2026)[30 Jan - 1 Feb](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248625809641010&startDate=30%2F01%2F2026&endDate=01%2F02%2F2026) [Next weekend ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248625809641010&startDate=06%2F02%2F2026&endDate=08%2F02%2F2026)[6 Feb - 8 Feb](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248625809641010&startDate=06%2F02%2F2026&endDate=08%2F02%2F2026) --- ### Other neighbourhoods around Otay Mesa West ![Petco Park showing a statue or sculpture](https://images.trvl-media.com/place/6034816/3b5523cf-9fe3-4419-a57d-df61b6834ac5.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### East Village Travellers choose East Village for its great bars. Hop aboard the metro at City College Trolley Station or Park and Market Trolley Station and check out top sights like Petco Park. [](https://expedia.co.uk/San-Diego-East-Village.dx553248633849130034) ![Gaslamp Quarter featuring a bar, night scenes and street scenes](https://images.trvl-media.com/place/6130021/5158ce24-3077-4ad7-bf7d-46fd554e646d.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Gaslamp Quarter Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping. [](https://expedia.co.uk/San-Diego-Gaslamp-Quarter.dx6130021) ![US Grant Hotel](https://images.trvl-media.com/place/800123/772b9d6a-cdc3-400e-b3ed-61d10adc7912.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Downtown San Diego 4.5/5(138 area reviews) Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city. [](https://expedia.co.uk/San-Diego-Downtown-San-Diego.dx800123) ![Little Italy](https://images.trvl-media.com/place/6161280/027d3836-740c-44f0-bb0a-a8fb158f401a.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Little Italy Visitors to Little Italy love its captivating waterfront views, and you can check out Maritime Museum of San Diego and San Diego Bay. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station. [](https://expedia.co.uk/San-Diego-Little-Italy.dx6161280) ![SanDiego_NorthPark_6346499_001](https://images.trvl-media.com/place/6346499/6374335e-0d00-4eb7-8271-3d9bb2afaf80.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### North Park North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area. [](https://expedia.co.uk/San-Diego-North-Park.dx6346499) ![Gossip Grill](https://images.trvl-media.com/place/6191797/60a250a8-62f2-4c0b-8601-b05dd917f234.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Hillcrest 5/5(1 area review) Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop. [](https://expedia.co.uk/San-Diego-Hillcrest.dx6191797) --- --- - [Stays](?pwaLob=wizard-hotel-pwa-v2) - [Packages](?pwaLob=wizard-package-pwa) - [Flights](?pwaLob=wizard-flight-pwa) - [Things to do](?pwaLob=wizard-lx-pwa) - [Cruises](?pwaLob=wizard-cruise-pwa) - [Cars](?pwaLob=wizard-car-pwa) # Otay Mesa West Travel Guide ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - [Hotels near Brown Field Municipal ](https://www.expedia.co.uk/Brown-Field-Municipal-Airport-Hotels.0-aSDM-0.Travel-Guide-Filter-Hotels) - [Gay-Friendly Hotels in Imperial Beach ](https://www.expedia.co.uk/Imperial-Beach-Hotels-Gay-Friendly-Hotel.0-0-d177683-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Imperial Beach ](https://www.expedia.co.uk/Imperial-Beach-Hotels-Pet-Friendly-Hotel.0-0-d177683-tPetFriendlyHotel.Travel-Guide-Filter-Hotels) - [Imperial Beach Hotels ](https://www.expedia.co.uk/Imperial-Beach-Hotels.d177683.Travel-Guide-Hotels) - 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