Title: Otay Mesa West Travel Guide: Best of Otay Mesa West, San Diego Travel 2026 | Expedia.co.uk [Hotels in Otay Mesa West](https://expedia.co.uk/Otay-Mesa-West-San-Diego-Hotels.0-n553248625809641010-0.Travel-Guide-Filter-Hotels)[Flights to San Diego](https://expedia.co.uk/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.co.uk/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Otay Mesa West Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Otay-Mesa-West.d553248625809641010.Car-Hire-Guide)[Otay Mesa West Holidays](https://expedia.co.uk/Otay-Mesa-West.d553248625809641010.Holidays-City-Breaks) # Otay Mesa West Travel Guide ## San Diego ![Photo by Leonardo De Leon](https://mediaim.expedia.com/destination/2/c82ea711c1af69b78661e7f0e8d60f0e.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) [Photo by Leonardo De Leon](https://mediaim.expedia.com/destination/2/c82ea711c1af69b78661e7f0e8d60f0e.jpg) ![Photo by Leonardo De Leon](https://mediaim.expedia.com/destination/2/667dd0cd10e1be9cafd71fb4f6e59df6.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) [Photo by Leonardo De Leon](https://mediaim.expedia.com/destination/2/667dd0cd10e1be9cafd71fb4f6e59df6.jpg) ## Visit Otay Mesa West Things to do Hotels Where to stay [San Diego travel guide](https://expedia.co.uk/San-Diego.dx3073) --- ### Popular places to visit ![San Diego Zoo featuring zoo animals, landscape views and a pond](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/22000/22060-San-Diego-Zoo.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### San Diego Zoo 4.5/5(47 reviews) See nature up-close and personal at one of the country’s largest and most educational zoos. [](https://expedia.co.uk/San-Diego-Zoo-San-Diego.d502547.Attraction) ![San Diego Convention Center](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/481000/481325-San-Diego-Convention-Center.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### San Diego Convention Center 4/5(18 reviews) During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's acclaimed art galleries and entertainment choices. [](https://expedia.co.uk/San-Diego-Convention-Center-Downtown-San-Diego.d6125294.Attraction) ![Mission Bay featuring a beach](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/152000/152458-Mission-Bay.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Mission Bay 4.5/5(31 reviews) Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park. [](https://expedia.co.uk/Mission-Bay-San-Diego.d6185904.Attraction) ![Port of San Diego](https://mediaim.expedia.com/destination/2/beba4d719053c6c70c42b583c57b3f4a.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Port of San Diego 4.5/5(34 reviews) Explore the waterfront in San Diego with a trip to Port of San Diego. Wander the seaside and beautiful beaches in the area. [](https://expedia.co.uk/Port-Of-San-Diego-San-Diego.d6131855.Attraction) ![SeaWorld](https://mediaim.expedia.com/destination/2/c5bdde59527e71985c52f3ff9bde0d47.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### SeaWorld 4/5(14 reviews) Animal interaction, entertaining rides and informative exhibits are all on offer at this family favorite destination. [](https://expedia.co.uk/SeaWorld-San-Diego.d502548.Attraction) ![Petco Park](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/238000/238635-Petco-Park.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Petco Park 4.5/5(17 reviews) Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field. [](https://expedia.co.uk/Petco-Park-Downtown-San-Diego.d6034816.Attraction) ### Things to do ![LEGOLAND® California Resort](https://mediaim.expedia.com/localexpert/169428/4add278e-78ce-44aa-b7e4-703b2249aec9.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### LEGOLAND® California Resort £49 per adult **82%** of travellers recommend [](https://expedia.co.uk/things-to-do/legoland-california-resort.a169428.activity-details) ![San Diego City Lights Night Tour](https://mediaim.expedia.com/localexpert/3907955/fcb14693-9145-4497-a52e-df7bfc5ecad7.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### San Diego City Lights Night Tour £35 per adult **94%** of travellers recommend [](https://expedia.co.uk/things-to-do/san-diego-city-lights-night-tour.a3907955.activity-details) ![Kids folding the American Flag ](https://mediaim.expedia.com/localexpert/1384690/a7d69d90-e26a-41ab-9759-cdf944ee1831.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### San Diego Whale Watching Cruise £73 per adult **90%** of travellers recommend [](https://expedia.co.uk/things-to-do/san-diego-whale-watching-cruise.a1384690.activity-details) ![San Diego: Luggage Storage in Marina](https://mediaim.expedia.com/localexpert/48212655/592cad7f-c489-4c0f-bd98-eadd3af5f4a9.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### San Diego: Luggage Storage in Marina £6 per adult [](https://expedia.co.uk/things-to-do/san-diego-luggage-storage-in-marina.a48212655.activity-details) ![San Diego Premier Bottomless Mimosa Brunch Cruise](https://mediaim.expedia.com/localexpert/249262/6430755c-aaf5-4339-9000-11447afc253b.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### City Cruises San Diego: Premier Bottomless Mimosa Brunch Cruise £70 per adult **90%** of travellers recommend [](https://expedia.co.uk/things-to-do/city-cruises-san-diego-premier-bottomless-mimosa-brunch-cruise.a249262.activity-details) ![Kayak on the San Diego Bay ](https://mediaim.expedia.com/localexpert/2886775/5d70d5e6-3235-441a-b04c-fe30d2d13cd6.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Kayak on the San Diego Bay £15 per adult [](https://expedia.co.uk/things-to-do/kayak-on-the-san-diego-bay.a2886775.activity-details) [See all activities in San Diego](https://expedia.co.uk/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities) --- ## Top hotels in Otay Mesa West ![Bay Club Hotel & Marina](https://images.trvl-media.com/lodging/1000000/10000/2600/2514/8c022c3d_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Bay Club Hotel & Marina 2131 Shelter Island Dr San Diego CA £102 14 Dec - 15 Dec includes taxes & fees Stay at this business-friendly hotel in San Diego. Enjoy free Wi-Fi, a marina and a health club. Our guests praise the breakfast and the restaurant in their ... 9/10 Wonderful! (3,179 reviews) Great accommodations, friendly staff Reviewed on 11 Dec 2025 [](https://expedia.co.uk/Hotel-Search?startDate=14%2F12%2F2025&endDate=15%2F12%2F2025&selected=2514&PinnedHotelID=2514&HadPinnedHotel=true®ionId=553248625809641010) ![Legacy Resort Hotel & Spa](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/0bbd67f4_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Legacy Resort Hotel & Spa 875 Hotel Circle South San Diego CA £131 21 Dec - 22 Dec includes taxes & fees Stay at this spa hotel in San Diego. Enjoy free Wi-Fi, a full-service spa and breakfast (surcharge). Our guests praise the pool and the restaurant in their reviews. ... 9/10 Wonderful! (2,943 reviews) Great location and surrounding area. Parking was pretty straight forward, and fairly priced. The lobby area had a nice layout for the Christmas holiday. Check in was nice and easy and was asked if I had a preference in which floor to stay on. Room was well decorated, clean, and cozy. However, when ... Reviewed on 11 Dec 2025 [](https://expedia.co.uk/Hotel-Search?startDate=21%2F12%2F2025&endDate=22%2F12%2F2025&selected=41504735&PinnedHotelID=41504735&HadPinnedHotel=true®ionId=553248625809641010) ![The DEXTRO Little Italy, BW Premier Collection](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/6fe441dd_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### The DEXTRO Little Italy, BW Premier Collection 1617 1st Avenue San Diego CA £85 14 Dec - 15 Dec includes taxes & fees Stay at this business-friendly hotel in San Diego. Enjoy free Wi-Fi, breakfast (surcharge) and a 24-hour fitness centre. Our guests praise the helpful staff ... 8.8/10 Excellent! (728 reviews) Breakfast buffet was good. Room was clean. Friendly and helpful staff. San Diego was beautiful! Reviewed on 13 Dec 2025 [](https://expedia.co.uk/Hotel-Search?startDate=14%2F12%2F2025&endDate=15%2F12%2F2025&selected=170338&PinnedHotelID=170338&HadPinnedHotel=true®ionId=553248625809641010) ![Lafayette Hotel & Club](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/91a184a3_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Lafayette Hotel & Club 2223 El Cajon Blvd San Diego CA £194 6 Jan - 7 Jan 2026 includes taxes & fees Stay at this business-friendly hotel in San Diego. Enjoy free Wi-Fi, 2 restaurants and 3 bars/lounges. Our guests praise the helpful staff in their reviews. ... 9.2/10 Wonderful! (1,329 reviews) The hotel is big on charm and decor. It was in 1937 and the guest rooms haven’t been enlarged or highly modernized. What they did get is a big dash of kitsch. Clashing wall paper, canopied beds, retro appliances, and a huge room bar (you pay per drink). We took a second floor poolside room with a ... Reviewed on 11 Dec 2025 [](https://expedia.co.uk/Hotel-Search?startDate=06%2F01%2F2026&endDate=07%2F01%2F2026&selected=38077738&PinnedHotelID=38077738&HadPinnedHotel=true®ionId=553248625809641010) ![Hard Rock Hotel San Diego](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hard Rock Hotel San Diego 207 5th Ave San Diego CA £165 1 Jan - 2 Jan 2026 includes taxes & fees Stay at this hotel in San Diego. Enjoy free Wi-Fi, 2 restaurants and a nightclub. Our guests praise the helpful staff and the convenient parking in their reviews. ... 8.8/10 Excellent! (3,141 reviews) Breakfast was great Reviewed on 9 Dec 2025 [](https://expedia.co.uk/Hotel-Search?startDate=01%2F01%2F2026&endDate=02%2F01%2F2026&selected=1731557&PinnedHotelID=1731557&HadPinnedHotel=true®ionId=553248625809641010) ![Hampton Inn San Diego/Mission Valley](https://images.trvl-media.com/lodging/1000000/10000/4500/4415/036e1947_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hampton Inn San Diego/Mission Valley 2151 Hotel Circle South San Diego CA £82 5 Jan - 6 Jan 2026 includes taxes & fees Stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free Wi-Fi and a 24-hour fitness centre. Our guests praise the breakfast and the helpful ... 8.6/10 Excellent! (1,274 reviews) clean room Reviewed on 8 Dec 2025 [](https://expedia.co.uk/Hotel-Search?startDate=05%2F01%2F2026&endDate=06%2F01%2F2026&selected=4415&PinnedHotelID=4415&HadPinnedHotel=true®ionId=553248625809641010) [See all 6,882 properties in Otay Mesa West](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=14%2F12%2F2025&endDate=15%2F12%2F2025®ionId=553248625809641010) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check Otay Mesa West hotel availability [Tonight ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248625809641010&startDate=2025-12-13&endDate=2025-12-14)[13 Dec - 14 Dec](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248625809641010&startDate=2025-12-13&endDate=2025-12-14) [Tomorrow night ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248625809641010&startDate=2025-12-14&endDate=2025-12-15)[14 Dec - 15 Dec](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248625809641010&startDate=2025-12-14&endDate=2025-12-15) [Next weekend ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248625809641010&startDate=19%2F12%2F2025&endDate=21%2F12%2F2025)[19 Dec - 21 Dec](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248625809641010&startDate=19%2F12%2F2025&endDate=21%2F12%2F2025) --- ### Other neighbourhoods around Otay Mesa West ![Petco Park showing a statue or sculpture](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/238000/238636-Petco-Park.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### East Village Travellers choose East Village for its great bars. Hop aboard the metro at City College Trolley Station or Park and Market Trolley Station and check out top sights like Petco Park. [](https://expedia.co.uk/San-Diego-East-Village.dx553248633849130034) ![Gaslamp Quarter featuring a bar, night scenes and street scenes](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/22000/22037-San-Diego-Gaslamp-Quarter.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Gaslamp Quarter Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping. [](https://expedia.co.uk/San-Diego-Gaslamp-Quarter.dx6130021) ![Default Image](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/481000/481093-Downtown-San-Diego.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Downtown San Diego 4.5/5(138 area reviews) Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city. [](https://expedia.co.uk/San-Diego-Downtown-San-Diego.dx800123) ![Default Image](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/475000/475555-Southern-California.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Marina District Known for its fantastic nightlife and captivating waterfront views, there's plenty to explore in Marina District. Check out top attractions like Seaport Village and The Rady Shell at Jacobs Park, and jump on the metro at Seaport Village Station or Convention Center Station to see more of the city. [](https://expedia.co.uk/San-Diego-Marina-District.dx3000663388) ![Default Image](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/481000/481027-Little-Italy-San-Diego.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Little Italy Visitors to Little Italy love its captivating waterfront views, and you can check out Maritime Museum of San Diego and San Diego Bay. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station. [](https://expedia.co.uk/San-Diego-Little-Italy.dx6161280) ![Default Image](https://mediaim.expedia.com/destination/2/f9bc2a87fd24f0f17022207aa924680f.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### North Park North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area. [](https://expedia.co.uk/San-Diego-North-Park.dx6346499) --- --- - [Stays](?pwaLob=wizard-hotel-pwa-v2) - [Packages](?pwaLob=wizard-package-pwa) - [Flights](?pwaLob=wizard-flight-pwa) - [Things to do](?pwaLob=wizard-lx-pwa) - [Cruises](?pwaLob=wizard-cruise-pwa) - [Cars](?pwaLob=wizard-car-pwa) # Otay Mesa West Travel Guide ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - [Hotels near Brown Field Municipal ](https://www.expedia.co.uk/Brown-Field-Municipal-Airport-Hotels.0-aSDM-0.Travel-Guide-Filter-Hotels) - [Gay-Friendly Hotels in Imperial Beach ](https://www.expedia.co.uk/Imperial-Beach-Hotels-Gay-Friendly-Hotel.0-0-d177683-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Imperial Beach ](https://www.expedia.co.uk/Imperial-Beach-Hotels-Pet-Friendly-Hotel.0-0-d177683-tPetFriendlyHotel.Travel-Guide-Filter-Hotels) - [Imperial Beach Hotels ](https://www.expedia.co.uk/Imperial-Beach-Hotels.d177683.Travel-Guide-Hotels) - 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