Title: Cheap Car Hire in Otay Mesa West, USA - Expedia.co.uk [Otay Mesa West Travel Guide](https://expedia.co.uk/San-Diego-Otay-Mesa-West.dx553248625809641010)[Hotels in Otay Mesa West](https://expedia.co.uk/Otay-Mesa-West-San-Diego-Hotels.0-n553248625809641010-0.Travel-Guide-Filter-Hotels)[Flights to San Diego](https://expedia.co.uk/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.co.uk/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Otay Mesa West Holidays](https://expedia.co.uk/Otay-Mesa-West.d553248625809641010.Holidays-City-Breaks) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_car.jpeg?impolicy=fcrop&w=1200&h=300&q=medium) # Car Rentals in Otay Mesa West, USA ## Search and Compare from Car Companies in Otay Mesa West ## Featured car rental suppliers Compare from agencies ![car supplier logos](https://forever.travel-assets.com/flex/flexmanager/images/2022/05/16/BEXUK-car-suppliers-logo-desktop.jpg) - ![protection illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__protection.svg) ### Change your mind Penalty-free cancellation on many/select car hire - ![trophy illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Treat yourself One Key members save 10% or more on over 1 million car hire [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![package illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__package.svg) ### Shop smart Compare car suppliers and package your flight, hotel, and car to save ## Top Rental Car Deals in Otay Mesa West \* Price found within the past 6 days. Click for updated prices. Mon, 6 Apr - Tue, 7 Apr ### Economy Hyundai Venue or similar - 5 people - Unlimited mileage ![Avis](//mediaim.expedia.com/cars/logos/ZI.png) #### Pick-up location 2745 Otay Pacific Dr, Ste #6, Cross Border Xpress Cbx, San Diego, California 92154, USA 5.06 mi from Otay Mesa West city centre ![Hyundai Venue](//mediaim.expedia.com/cars/41/8790b76e-3028-4f1e-b3ff-9c11cf788d03.jpg) #### £132 total found 21 hours ago [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=32.548230&olon=-116.974830&date1=06/04/2026&date2=07/04/2026&pprfrr=null&tprfrr=132.0&cvrfrr=ZI&ctrfrr=EC&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22economy%22]) Mon, 6 Apr - Tue, 7 Apr ### Compact Kia Soul or similar - 5 people - Unlimited mileage ![Avis](//mediaim.expedia.com/cars/logos/ZI.png) #### Pick-up location 2745 Otay Pacific Dr, Ste #6, Cross Border Xpress Cbx, San Diego, California 92154, USA 5.06 mi from Otay Mesa West city centre ![Kia Soul](//mediaim.expedia.com/cars/41/e7c1fd21-3564-4890-a4ed-2f7ca59d757f.jpg) #### £135 total found 21 hours ago [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=32.548230&olon=-116.974830&date1=06/04/2026&date2=07/04/2026&pprfrr=null&tprfrr=135.4&cvrfrr=ZI&ctrfrr=CC&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22compact%22]) Mon, 6 Apr - Tue, 7 Apr ### Full Size Toyota Camry or similar - 5 people - Unlimited mileage ![Avis](//mediaim.expedia.com/cars/logos/ZI.png) #### Pick-up location 2745 Otay Pacific Dr, Ste #6, Cross Border Xpress Cbx, San Diego, California 92154, USA 5.06 mi from Otay Mesa West city centre ![Toyota Camry](//mediaim.expedia.com/cars/41/f8359e2f-1f3f-4c65-ac4c-bc85e53c01f5.jpg) #### £142 total found 21 hours ago [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=32.548230&olon=-116.974830&date1=06/04/2026&date2=07/04/2026&pprfrr=null&tprfrr=142.2&cvrfrr=ZI&ctrfrr=FC&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22fullsize%22]) Mon, 6 Apr - Tue, 7 Apr ### Standard Volkswagen Jetta or similar - 5 people - Unlimited mileage ![Avis](//mediaim.expedia.com/cars/logos/ZI.png) #### Pick-up location 2745 Otay Pacific Dr, Ste #6, Cross Border Xpress Cbx, San Diego, California 92154, USA 5.06 mi from Otay Mesa West city centre ![Volkswagen Jetta](//mediaim.expedia.com/cars/41/518390a3-aa30-4ee4-9bb5-1243de3d0866.jpg) #### £142 total found 21 hours ago [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=32.548230&olon=-116.974830&date1=06/04/2026&date2=07/04/2026&pprfrr=null&tprfrr=142.2&cvrfrr=ZI&ctrfrr=SC&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22standard%22]) Thu, 2 Apr - Fri, 3 Apr ### Midsize SUV Mazda CX-50 or similar - 5 people - Unlimited mileage ![Avis](//mediaim.expedia.com/cars/logos/ZI.png) #### Pick-up location 2745 Otay Pacific Dr, Ste #6, Cross Border Xpress Cbx, San Diego, California 92154, USA 5.06 mi from Otay Mesa West city centre ![Mazda CX-50](//mediaim.expedia.com/cars/41/1a0f38a4-52e7-4a61-b150-c14146efeab8.jpg) #### £152 total found 14 hours ago [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=32.548230&olon=-116.974830&date1=02/04/2026&date2=03/04/2026&pprfrr=null&tprfrr=152.4&cvrfrr=ZI&ctrfrr=IF&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22suv%22]) Mon, 6 Apr - Tue, 7 Apr ### Standard Elite SUV Ford Explorer or similar - 7 people - Unlimited mileage ![Avis](//mediaim.expedia.com/cars/logos/ZI.png) #### Pick-up location 2745 Otay Pacific Dr, Ste #6, Cross Border Xpress Cbx, San Diego, California 92154, USA 5.06 mi from Otay Mesa West city centre ![Ford Explorer](//mediaim.expedia.com/cars/41/c92cbd55-45b2-4fbe-b152-5ae503cf5057.jpg) #### £178 total found 21 hours ago [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=32.548230&olon=-116.974830&date1=06/04/2026&date2=07/04/2026&pprfrr=null&tprfrr=178.18&cvrfrr=ZI&ctrfrr=RF&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22suv%22]) ### Don't see what you're looking for? See all car hire in Otay Mesa West [View all cars](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Otay%20Mesa%20West,%20San%20Diego,%20California,%20United%20States%20of%20America&dpln=553248625809641010&date1=07/04/2026&date2=09/04/2026&crfrr=defaultFlex&SearchType=Place) Lowest prices found within the past 21 hours. Prices and availability subject to change. Additional terms may apply. ## Car Hire Information | Popular car types: | [SUV](https://www.expedia.co.uk/lp/b/car-rental/suv?rfrr=car.table.SUV), [Full Size](https://www.expedia.co.uk/lp/b/car-rental/fullsize?rfrr=car.table.FullSize), [Economy](https://www.expedia.co.uk/lp/b/car-rental/economy?rfrr=car.table.Economy) | | -------------------------------- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | | Car suppliers available: | | | Our best deal of the day: | £132 | | Our second best deal of the day: | £135 | | Our third best deal of the day: | £142 | | From the airport to your hotel: | [Airport Transportation](https://www.expedia.co.uk/ground-transfers?rfrr=car.table.AirportTransportation) | ## Frequently asked questions ### How much is a rental car per day in Otay Mesa West? ### What happens if I need to cancel my Otay Mesa West car reservation? ### What types of cars can I rent in Otay Mesa West? ### Where can I go on a road trip from Otay Mesa West? > - Make tracks to Anaheim for an excellent sightseeing adventure. Around 100 miles from Otay Mesa West, it has lots of inspiring attractions, including Disneyland® Resort. > - Why not enjoy the best of Los Angeles too? Popular sights in this vibrant city include Universal Studios Hollywood. Los Angeles is about 120 miles from Otay Mesa West. > - Venture into the outdoors and breathe in some fresh air at Venice Beach. You'll find it roughly 130 miles from Otay Mesa West. ### How do I find the best car hire deals in Otay Mesa West with Expedia? ### How old do you have to be to hire a car in Otay Mesa West? ### What do you need to hire a car in Otay Mesa West? ### What is the cheapest car hire in Otay Mesa West? ### Can I hire a car for a month or longer in Otay Mesa West? ### Where can I find an Otay Mesa West hire car if I am younger than 25? ### Can I drive in Otay Mesa West with my current driver's license? > - Age restrictions: You need to be 25 or older in many states to hire a car, although in some areas, 21 years and older is allowed. We recommend checking state and local regulations, and with the hire car company before your trip to understand additional terms and conditions. > - Driving limitations: Make sure you read the fine print before you leave the lot so you can avoid any unnecessary charges. When hiring a car in the United States, you typically can't cross country borders into Mexico or Canada, drive onto ferries or go off-roading with your hire car. Please read the details before you book! ### Why should I rent an Otay Mesa West car with Expedia?