Otay Mesa West Holidays from £1,255

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Your Otay Mesa West Holiday

Otay Mesa West is calling! Whatever type of getaway you're organising, you can see and experience the best of this neighbourhood with an Otay Mesa West holiday package. If you're all about sightseeing, no trip to Otay Mesa West is complete without stopping by nearby Kaiser Permanente Otay Mesa Medical Offices. Expedia is here to put your travel plans into action. Book your ultimate Otay Mesa West holiday now.

Price found within the past 48 hours. Click for updated prices.
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
Downtown San Diego
Price was £1,948, price is now £1,255 per person
£1,255
per person
21 Mar - 28 Mar
found 1 day ago
Return direct flight included
London (LHR) to San Diego (SAN)
8.4/10 Very Good! (1,627 reviews)
The hotel is located at a noisy intersection in a downtown area that is past its prime. The staff was indifferent. The room was small though it had been seen recent updating.

Reviewed on 11 Feb 2026

The Bristol Hotel San Diego

The Bristol Hotel San Diego

3.5 out of 5
Downtown San Diego
Price was £1,900, price is now £1,385 per person
£1,385
per person
21 Mar - 28 Mar
found 1 day ago
Return direct flight included
London (LHR) to San Diego (SAN)
8.6/10 Excellent! (1,428 reviews)
Great experience here I every aspect. Except the constant warning sound from the trams.

Reviewed on 5 Feb 2026

The Wayfarer San Diego

The Wayfarer San Diego

4 out of 5
Mission Beach
Price was £2,397, price is now £1,764 per person
£1,764
per person
21 Mar - 28 Mar
found 1 day ago
Return direct flight included
London (LHR) to San Diego (SAN)
9.4/10 Exceptional! (1,677 reviews)
The room was perfect. After a very long day of travel, our VRBO Host cancelled our reservation at the last moment. An agent found a comfy room at The Wayfarer. The night host, Blaze and security guard Rick went out of their way to make us feel welcome and took excellent care of us! Our daughter lives in San Diego,so we have often walked past the wall murals at your place...imagine after a tough day yesterday - waking up in a comfy bed, making a cup of coffee, and sitting on the balcony to look at the beautiful mural and ocean....I can not say enough for the kindness we received from your staff! We WILL definitely be back!

Reviewed on 12 Feb 2026

Shore House at The Del, LXR Hotels & Resorts

Shore House at The Del, LXR Hotels & Resorts

5 out of 5
Historic Downtown Coronado
Price was £3,408, price is now £2,531 per person
£2,531
per person
21 Mar - 28 Mar
found 1 day ago
Return direct flight included
London (LHR) to San Diego (SAN)
9.2/10 Wonderful! (109 reviews)
All was wonderful. Have to say that after making reservations two months in advance m, I was a bit disappointed in where we were placed. I should have said something when we check in but once I got over what I was expecting, the room location was okay but the room itself was over the top. We will go again but be a bit more vocal in our room placement. But this place comes with our strong recommendation to stay.

Reviewed on 12 Dec 2025

Where to stay in Otay Mesa West

Find the best Otay Mesa West areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa West
US Grant Hotel

Downtown San Diego

3 out of top 10 points of interest in this area
4.5/5(138 area reviews)

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Seaport Village and Petco Park are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Find hotels in Downtown San Diego

Top hotels in Otay Mesa West

Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
The price is £170 per night from 1 Mar to 2 Mar
£170
1 Mar - 2 Mar
includes taxes & fees
8.6/10 Excellent! (2,408 reviews)
Spotless

Reviewed on 11 Feb 2026

Paradise Point Resort & Spa
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
The price is £194 per night from 15 Feb to 16 Feb
£194
15 Feb - 16 Feb
includes taxes & fees
8.8/10 Excellent! (3,298 reviews)
Great stay

Reviewed on 12 Feb 2026

Hard Rock Hotel San Diego
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
Fully refundableReserve now, pay when you stay
The price is £99 per night from 22 Feb to 23 Feb
£99
22 Feb - 23 Feb
includes taxes & fees
8.8/10 Excellent! (1,041 reviews)
Clean room and available a few hours earlier than normal check in! Room was spacious and staff was great!

Reviewed on 11 Feb 2026

The DEXTRO Little Italy, BW Premier Collection
See all 6,851 properties in Otay Mesa West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

How much does an Otay Mesa West travel package cost?
Get set to book, because a trip to Otay Mesa West starts from an affordable £1,255. When you bundle your flights, hotels and more into a travel package, you'll score the best prices.
If I'm not able to travel, can I cancel my Otay Mesa West travel package?
Whether it's your hotel or flight, you can cancel or change it. Locked in your Otay Mesa West travel package in the last 24 hours? You may be able to make changes or cancellations at no cost. For older bookings, you may incur a charge from your hotel, airline or car rental company. For more details, take a look at our Customer Service Portal. We'll help you each step of the way.
How do I get a cheap travel package to Otay Mesa West?
Combining your hotel and flight with Expedia won't just save precious time — it'll save you cash too. An Otay Mesa West travel package makes it easy to organise your perfect trip. With more than 550 airlines throughout the world to select from, finding convenient flights that suit your busy schedule won't be hard. On top of that, we've got over 1,000,000 hotels globally to pick from. Talk about choice! Whatever your budget, Expedia can show you the world.
Does Expedia offer Book Now, Pay Later Otay Mesa West holidays?
Your bank balance shouldn't stop you from taking a holiday, so Expedia has devised a solution to help. Now that we've teamed up with online lender Klarna, it's easier than ever to book a dream getaway without hurting your hip pocket. Klarna offers flexible payment options during the checkout process that take the stress out of budgeting for your escape. Check out these flexible payment options:

  • Pay monthly holidays: If paying bite-sized amounts each month is something that would work for you, Klarna offers just that! Paying in easy monthly instalments will make that dream holiday possible.
  • Pay in instalments holidays: Into the idea of paying for your holiday in multiple transactions? Consider this Book Now, Pay Later option from Klarna.
  • Low deposit holidays: Clicking the "book now" button is much easier with this plan. Put down a small deposit on your booking and then start packing your suitcase.

Where should I stay in Otay Mesa West?
A visit to Otay Mesa West isn't complete without stopping by SeaWorld and San Diego Zoo. Look for somewhere to stay as close as possible for easy access to these fantastic tourist attractions.
What are the top hotels in Otay Mesa West?
Book a stay at Manchester Grand Hyatt San Diego. It's one of this neighbourhood's most in-demand properties. Another reputable option in Otay Mesa West is Paradise Point Resort And Spa.
How far in advance should I book my Otay Mesa West holiday?
While prices change frequently, we generally suggest booking your spot as early as possible. Many international fares can be compared on Expedia up to 12 months in advance. If you're booking last minute, you may still get lucky. Cheap tickets to Otay Mesa West sometimes occur just weeks before departure.
What does an Expedia Otay Mesa West travel package include?
Rental cars, flights and hotels — we have them well covered. With Expedia, you can create your Otay Mesa West travel package however you want. All you have to do is work out exactly what you need. Once you've made your booking, you can add on fun things like experiences and activities. The more you bundle, the greater the savings!
What should I know before booking an Otay Mesa West travel package?
A travel package can be easier on the hip pocket than individually booking everything you need for your escape. For example, combine your flights, hotels and rental cars and save a tidy sum. Whatever your holiday plans, you're sure to find a package that's perfect for you.
Can I choose my airline with an Otay Mesa West Expedia travel package?
Yes, and with over 550 airlines to pick from around the world, you've got lots of choice. Look through the available options and see which airline fits your needs and budget.

Popular places to visit

San Diego Zoo featuring zoo animals, landscape views and a pond

San Diego Zoo

4.5/5(47 reviews)

See nature up-close and personal at one of the country’s largest and most educational zoos.

San Diego Zoo
Mission Beach featuring tropical scenes, street scenes and a beach

Mission Beach

4.5/5(61 reviews)

A favorite vacation spot for 100 years, this seaside village combines old-fashioned charm with modern amenities.

Mission Beach
San Diego Convention Center

San Diego Convention Center

4/5(18 reviews)

During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's entertainment choices and fascinating museums.

San Diego Convention Center

Things to do

San Diego Premier Bottomless Mimosa Brunch Cruise

City Cruises San Diego: Premier Bottomless Mimosa Brunch Cruise

£83
per adult
90% of travellers recommend
City Cruises San Diego: Premier Bottomless Mimosa Brunch Cruise
LEGOLAND® California Resort

LEGOLAND® California Resort

£47
per adult
84% of travellers recommend
LEGOLAND® California Resort
San Diego: Museum of Illusions Entry Ticket

San Diego: Museum of Illusions Entry Ticket

£26
per adult
80% of travellers recommend
San Diego: Museum of Illusions Entry Ticket
See all activities in San Diego

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.