Otay Mesa West Holidays from £929

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Your Otay Mesa West Holiday

Otay Mesa West is calling! Whatever type of getaway you're organising, you can see and experience the best of this neighbourhood with an Otay Mesa West holiday package. If you're all about sightseeing, no trip to Otay Mesa West is complete without stopping by nearby Kaiser Permanente Otay Mesa Medical Offices. Expedia is here to put your travel plans into action. Book your ultimate Otay Mesa West holiday now.

Price found within the past 48 hours. Click for updated prices.
The Dextro Hotel, BW Premier Collection

The Dextro Hotel, BW Premier Collection

3 out of 5
Downtown San Diego
per person
16 Oct - 20 Oct
found 1 day ago
Return direct flight included
London (LON) to San Diego (SAN)
7.6/10 Good! (1,006 reviews)
Hotel was wonderful, beds were comfortable could use some new pillows. The staff were great very accommodating on whatever you needed.

Reviewed on 29 Jul 2025

The Sofia Hotel

The Sofia Hotel

3.5 out of 5
Downtown San Diego
Save 100% on your flight
per person
16 Oct - 20 Oct
found 1 day ago
Return direct flight included
London (LON) to San Diego (SAN)
8.4/10 Very Good! (1,488 reviews)
I reserved a room with 2 beds for my sister and I for a one night stay at Sophia hotel. When we arrived at 4PM our room was not ready and Ian gave me two waters and two chocolate candy bars and offered two rooms with one bed in place of the one room with two beds on the newly renovated floor right next to each other at no extra charge. It worked out perfectly as we had our own space.

Reviewed on 25 Jul 2025

Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter

4 out of 5
Downtown San Diego
Save 100% on your flight
per person
17 Sept - 24 Sept
found 24 hours ago
Return direct flight included
Manchester (MAN) to San Diego (SAN)
9/10 Wonderful! (936 reviews)
Property is great for walking. Great to go to Petco Park.

Reviewed on 23 Jul 2025

InterContinental San Diego by IHG

InterContinental San Diego by IHG

4 out of 5
Downtown San Diego
Save 100% on your flight
per person
17 Sept - 24 Sept
found 24 hours ago
Return direct flight included
Manchester (MAN) to San Diego (SAN)
9/10 Wonderful! (1,004 reviews)
We were greeted after a long flight where our luggage was lost on route by a very cheery and helpful front desk person Arianna. She made our whole stay very personable and made it more enjoyable. The hotel was clean and very mogern. Its also very well placed for downtown San Diego. Overall its a great place to stay for the San Diego experience

Reviewed on 29 Jul 2025

Sentral Gaslamp Quarter

Sentral Gaslamp Quarter

3 out of 5
Downtown San Diego
per person
16 Oct - 20 Oct
found 1 day ago
Return direct flight included
London (LON) to San Diego (SAN)
9.2/10 Wonderful! (166 reviews)
There should never a shortage of irons and boards especially if you upgrade to a Suite and l was told to use a steamer and if one becomes available they will send it and that never happened . All bottles of consumables should be full especially bath gel. Other than that my stay was pleasant.

Reviewed on 29 Jul 2025

Where to stay in Otay Mesa West

Find the best Otay Mesa West areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa West
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Downtown San Diego

2 out of top 10 points of interest in this area
4.5/5(138 area reviews)

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Find hotels in Downtown San Diego

Top hotels in Otay Mesa West

Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N, San Diego, CA
The price is £94 per night from 10 Aug to 11 Aug
£94
10 Aug - 11 Aug
includes taxes & fees
8/10 Very Good! (1,918 reviews)
Exceptional Staff / Front Desk Experience
"This hotel experience was exceptional because of the staff (thanks Pamela!) and care they took to ensure our stay was the best possible. I was there for Comic-Con and through the chaos we had a shuttle that ran every 15-20 minutes, a room with comfortable pillows and a view of the pool, reasonable ..."

Reviewed on 27 Jul 2025

Handlery Hotel
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is £146 per night from 30 Jul to 31 Jul
£146
30 Jul - 31 Jul
includes taxes & fees
8.2/10 Very Good! (5,794 reviews)
"Very nice property and friendly staff."

Reviewed on 27 Jul 2025

Wyndham San Diego Bayside
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is £196 per night from 29 Aug to 30 Aug
£196
29 Aug - 30 Aug
includes taxes & fees
9/10 Wonderful! (2,802 reviews)
"Outstanding"

Reviewed on 24 Jul 2025

Manchester Grand Hyatt San Diego
See all 6,564 properties in Otay Mesa West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
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Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Frequently asked questions

How much does an Otay Mesa West travel package cost?
Get set to book, because a trip to Otay Mesa West starts from an affordable £929. When you bundle your flights, hotels and more into a travel package, you'll score the best prices.
If I'm not able to travel, can I cancel my Otay Mesa West travel package?
Whether it's your hotel or flight, you can cancel or change it. Locked in your Otay Mesa West travel package in the last 24 hours? You may be able to make changes or cancellations at no cost. For older bookings, you may incur a charge from your hotel, airline or car rental company. For more details, take a look at our Customer Service Portal. We'll help you each step of the way.
How do I get a cheap travel package to Otay Mesa West?
Combining your hotel and flight with Expedia won't just save precious time — it'll save you cash too. An Otay Mesa West travel package makes it easy to organise your perfect trip. With more than 550 airlines throughout the world to select from, finding convenient flights that suit your busy schedule won't be hard. On top of that, we've got over 1,000,000 hotels globally to pick from. Talk about choice! Whatever your budget, Expedia can show you the world.
Does Expedia offer Book Now, Pay Later Otay Mesa West holidays?
Your bank balance shouldn't stop you from taking a holiday, so Expedia has devised a solution to help. Now that we've teamed up with online lender Klarna, it's easier than ever to book a dream getaway without hurting your hip pocket. Klarna offers flexible payment options during the checkout process that take the stress out of budgeting for your escape. Check out these flexible payment options:

  • Pay monthly holidays: If paying bite-sized amounts each month is something that would work for you, Klarna offers just that! Paying in easy monthly instalments will make that dream holiday possible.
  • Pay in instalments holidays: Into the idea of paying for your holiday in multiple transactions? Consider this Book Now, Pay Later option from Klarna.
  • Low deposit holidays: Clicking the "book now" button is much easier with this plan. Put down a small deposit on your booking and then start packing your suitcase.

Where should I stay in Otay Mesa West?
A visit to Otay Mesa West isn't complete without stopping by SeaWorld and San Diego Zoo. Look for somewhere to stay as close as possible for easy access to these fantastic tourist attractions.
What are the top hotels in Otay Mesa West?
Book a stay at Manchester Grand Hyatt San Diego. It's one of this neighbourhood's most in-demand properties. Another reputable option in Otay Mesa West is Paradise Point Resort And Spa.
How far in advance should I book my Otay Mesa West holiday?
While prices change frequently, we generally suggest booking your spot as early as possible. Many international fares can be compared on Expedia up to 12 months in advance. If you're booking last minute, you may still get lucky. Cheap tickets to Otay Mesa West sometimes occur just weeks before departure.
What does an Expedia Otay Mesa West travel package include?
Rental cars, flights and hotels — we have them well covered. With Expedia, you can create your Otay Mesa West travel package however you want. All you have to do is work out exactly what you need. Once you've made your booking, you can add on fun things like experiences and activities. The more you bundle, the greater the savings!
What should I know before booking an Otay Mesa West travel package?
A travel package can be easier on the hip pocket than individually booking everything you need for your escape. For example, combine your flights, hotels and rental cars and save a tidy sum. Whatever your holiday plans, you're sure to find a package that's perfect for you.
Can I choose my airline with an Otay Mesa West Expedia travel package?
Yes, and with over 550 airlines to pick from around the world, you've got lots of choice. Look through the available options and see which airline fits your needs and budget.

Popular places to visit

San Diego Zoo featuring zoo animals, landscape views and a pond

San Diego Zoo

See nature up-close and personal at one of the country’s largest and most educational zoos.

San Diego Zoo
San Diego Convention Center

San Diego Convention Center

During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's fascinating museums and entertainment choices.

San Diego Convention Center
Mission Bay featuring a beach

Mission Bay

Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.

Mission Bay

Things to do

LEGOLAND® California Resort

LEGOLAND® California Resort

£58
per adult
82% of travellers recommend
LEGOLAND® California Resort
San Diego City Lights Night Tour

San Diego City Lights Night Tour

£34
per adult
94% of travellers recommend
San Diego City Lights Night Tour
San Diego Explorer Pass: Save up to 50 Percent - Includes USS Midway

San Diego Explorer Pass: Save up to 50 Percent - Includes USS Midway

£91
per adult
86% of travellers recommend
San Diego Explorer Pass: Save up to 50 Percent - Includes USS Midway
See all activities in San Diego

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.