Title: Holiday Rentals Cape Girardeau County from £78: Find Short-Term Rentals & Holiday Accommodations | Expedia.co.uk [Cape Girardeau County Hotels](https://expedia.co.uk/Destinations-In-Cape-Girardeau-County.d553248635976430467.Hotel-Destinations)[Cape Girardeau County Car Hire](https://expedia.co.uk/Destinations-In-Cape-Girardeau-County.d553248635976430467.Car-Hire-Destinations)[Cape Girardeau County Holidays](https://expedia.co.uk/Cape-Girardeau-County.d553248635976430467.Holidays-City-Breaks) ![](https://mediaim.expedia.com/destination/2/5b27a574bbd8c4a139204e48a625a1c7.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Skyy # Search Holiday Rentals in Cape Girardeau County ![price find illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Top Holiday Rentals in Cape Girardeau County ![Terrace/patio](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/55527a20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, stovetop, dishwasher](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/ed5a3737.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/f4fbd89f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/c5155680.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Twisted Sassafras Treehouse Cape Girardeau 10/10 Exceptional (24) "My wife and I thoroughly enjoyed our stay here! A beautiful place built on a beautiful property; we enjoyed the hot tub under the stars and the morning coffee on the porch (and another hot tub ). Great place for some R&R, and excellent communication with the owner in advance. Wouldn’t hesitate to book again." £230 includes taxes & fees 6 Oct - 7 Oct [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-The-Twisted-Sassafras-Treehouse.h95879160.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/9ff1a808.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/927199d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/ad11073b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/143b0eab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Little Blue Cottage on Spanish Cape Girardeau 8.6/10 Excellent (43) "I would definitely stay here again!" £78 includes taxes & fees 28 Sept - 29 Sept [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Little-Blue-Cottage-On-Spanish.h45712431.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/29617056.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/a340bc3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/c59bcf0b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/ec557893.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Serenity South -- Gardens, River-Views, and Refreshing Space Cape Girardeau 10/10 Exceptional (140) "Beautiful house. Great stay. Would definitely stay again!" £186 includes taxes & fees 28 Sept - 29 Sept [](https://www.expedia.co.uk/Sikeston-Hotels-Serenity-South-Gardens.h38940154.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/72000000/71740000/71736900/71736900/17fd79b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/72000000/71740000/71736900/71736900/e90509fa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/72000000/71740000/71736900/71736900/941f57c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/72000000/71740000/71736900/71736900/89b52c31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO Cape Girardeau 9.6/10 Exceptional (40) "Nice place to stay! Clean, able to walk to everything!" £107 includes taxes & fees 1 Oct - 2 Oct [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Artistic-Indoor-Swing-2-Blocks-To-Downtown.h71736900.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/77000000/76550000/76544100/76544096/b002a425.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/77000000/76550000/76544100/76544096/1e923d10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/77000000/76550000/76544100/76544096/c93cba87.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/77000000/76550000/76544100/76544096/66471bcd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### “Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau Cape Girardeau 10/10 Exceptional (22) "Lovely home perfect for our weekend celebrating our daughter’s graduation. Chip was an excellent host, even found us champagne flutes! Beds were comfortable, house was clean and nicely decorated. " [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Remodeled-1920s-Dutch-Colonial-Revival-In-Downtown-Cape-Girardeau.h76544096.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/76000000/75900000/75891500/75891457/5f66921b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/76000000/75900000/75891500/75891457/e25fadd7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/76000000/75900000/75891500/75891457/0c802aa2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/76000000/75900000/75891500/75891457/0622af9a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Charming Secluded Getaway Cabin within minutes of amenities Cape girardeau 10/10 Exceptional (15) "Nice little Cabin in a beautiful area. Blair and her family were wonderful!" [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Charming-Getaway-Cabin.h75891457.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/bcbc8581.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor spa tub](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/7298889d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Games room](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/81932f13.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/1136aaf9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool Cape Girardeau 8.8/10 Excellent (34) "all was so nice and we enjoyed our stay. grandkids and us loved having pool table and card games and all the peace and quiet there. thank u again for contacting me and giving us address. we appreciated that very much. " £162 includes taxes & fees 1 Oct - 2 Oct [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Colorful-Oasis-5mins-To-DownTown-Lush-Yard-W-Summer-PoolVENUE-Now-Open.h71745619.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/89000000/88490000/88480900/88480885/312ce91f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, coffee/tea maker, toaster](https://images.trvl-media.com/lodging/89000000/88490000/88480900/88480885/d2829659.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/89000000/88490000/88480900/88480885/99214415.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/89000000/88490000/88480900/88480885/7fccdced.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Stones Throw from Giant City Park, Wineries, Hiking, Biking, Hunting and more. Makanda 9.8/10 Exceptional (62) "Nice place!" [](https://www.expedia.co.uk/Makanda-Hotels-Cabins-Stone-Creek-25-Miles-From-Giant-City-SP-Wineries.h88480885.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/d22aee4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/b0f0a7b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/6b2b149b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/4a0f272b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Rest, Relax and Renew. Our log cabin experience awaits your arrival. Anna 10/10 Exceptional (395) "Clean comfortable cabin in a beautiful relaxing setting. Would definitely stay again." £150 includes taxes & fees 1 Oct - 2 Oct [](https://www.expedia.co.uk/Anna-Hotels-Rest.h31189922.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/110000000/109740000/109730100/109730068/b6736ddb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/110000000/109740000/109730100/109730068/6f998875.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/110000000/109740000/109730100/109730068/235ba001.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, bed sheets](https://images.trvl-media.com/lodging/110000000/109740000/109730100/109730068/e29b8d77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Peaceful secluded cabin located near Horseshoe Lake Miller City 9.8/10 Exceptional (18) "Wasent long enough!" £151 includes taxes & fees 28 Sept - 29 Sept [](https://www.expedia.co.uk/Peaceful-Secluded-Cabin-Located-Near-Horseshoe-Lake.h109730068.Hotel-Information) ![Outdoor spa tub](https://images.trvl-media.com/lodging/76000000/75200000/75198900/75198808/ffcf524d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/76000000/75200000/75198900/75198808/3eee564d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, bed sheets](https://images.trvl-media.com/lodging/76000000/75200000/75198900/75198808/6f222913.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/76000000/75200000/75198900/75198808/562d6c01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### New cabin in the woods with private hot tub Cobden 10/10 Exceptional (127) "We absolutely love coming here. This was our 2nd stay and getting ready to book it for the fall again. " [](https://www.expedia.co.uk/Anna-Hotels-New-Cabin-In-The-Woods-With-Private-Hot-Tub.h75198808.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/75000000/74270000/74269700/74269659/47c539a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/75000000/74270000/74269700/74269659/37d61736.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/75000000/74270000/74269700/74269659/c9baf19c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/75000000/74270000/74269700/74269659/65af3734.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Brand new cabin in the woods with hot tub 1/2 mile from Starview Winery Cobden 10/10 Exceptional (143) "The cabin was perfect for our weekend getaway to celebrate my fiancés birthday. " [](https://www.expedia.co.uk/Anna-Hotels-Brand-New-Cabin-In-The-Woods-With-Hot-Tub-12-Mile-From-Starview-Winery.h74269659.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/93000000/92510000/92505900/92505836/23f9ec5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/93000000/92510000/92505900/92505836/5134f5f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, books](https://images.trvl-media.com/lodging/93000000/92510000/92505900/92505836/186ea39b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, books](https://images.trvl-media.com/lodging/93000000/92510000/92505900/92505836/198e5611.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Minutes from Giant City - SIU - Shawnee Winetrail - Cedar Lake - Shawnee Forest! Makanda 9.6/10 Exceptional (42) "This is our second time staying and it was lovely." £155 includes taxes & fees 2 Oct - 3 Oct [](https://www.expedia.co.uk/Makanda-Hotels-Minutes-From-Giant-City-SIU-Shawnee-Winetrail-Cedar-Lake-Shawnee-Forest.h92505836.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/89000000/88870000/88869200/88869111/db83638f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/89000000/88870000/88869200/88869111/853dbdda.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, coffee/tea maker, toaster](https://images.trvl-media.com/lodging/89000000/88870000/88869200/88869111/8845b0fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/89000000/88870000/88869200/88869111/48434221.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail! Makanda 9.8/10 Exceptional (56) "Great value and plenty of room, with a nice deck and BBQ. Cabin 2 had separate rooms and a very spacious living room. I would stay there again and it is my favorite for the region." £151 includes taxes & fees 27 Sept - 28 Sept [](https://www.expedia.co.uk/Makanda-Hotels-3-Minutes-To-Giant-City-6-Minutes-To-SIU-4-Minutes-To-Shawnee-Winetrail.h88869111.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/104000000/103090000/103080200/103080140/193ecf29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/104000000/103090000/103080200/103080140/36b0a800.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace](https://images.trvl-media.com/lodging/104000000/103090000/103080200/103080140/9b2c1789.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/104000000/103090000/103080200/103080140/e2d9442e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Beautiful location in the secluded woods Pomona 9.8/10 Exceptional (50) "Our trip was to attend my son's graduation from SIU. The cabin was in an accessible spot to Carbondale and was great for the 5 of us. We enjoyed our stay!" £137 includes taxes & fees 28 Sept - 29 Sept [](https://www.expedia.co.uk/Pomona-Hotels-Beautiful-Location-In-The-Secluded-Woods.h103080140.Hotel-Information) ![TV](https://images.trvl-media.com/lodging/70000000/69800000/69799800/69799724/826a8705.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/70000000/69800000/69799800/69799724/241f90a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/70000000/69800000/69799800/69799724/4c639f62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/70000000/69800000/69799800/69799724/a139cc5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### \* On the Wine Trail \* Hot Tub \* Wi-Fi \* Alto Pass 9.8/10 Exceptional (237) "We had an awesome stay. The host had stocked kitchen with coffee and snacks, checked in with us, and everything was just as described. Nice location on the wine trail." [](https://www.expedia.co.uk/Carbondale-Hotels-On-The-Wine-Trail-Hot-Tub-Wi-Fi.h69799724.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/89000000/88920000/88911700/88911673/89455c59.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/89000000/88920000/88911700/88911673/8c0be0a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/89000000/88920000/88911700/88911673/5c96f072.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/89000000/88920000/88911700/88911673/215ab86a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Winetrail Cabin - Giant City SP, SIU, Cedar Lake, & Shawnee Forest minutes away! Makanda 9.8/10 Exceptional (40) "A very simple cabin in a great spot for those heading to Cedar Lake, or other area lakes, hikes, or adventures. Though the cabin is a bit dated, and worn from years of travelers passing through, it functioned perfectly for me on my short stay. " [](https://www.expedia.co.uk/Makanda-Hotels-Winetrail-Cabin-Giant-City-SP.h88911673.Hotel-Information) ![Outdoor spa tub](https://images.trvl-media.com/lodging/103000000/102840000/102831500/102831406/722821ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/103000000/102840000/102831500/102831406/e5c9dbb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/103000000/102840000/102831500/102831406/028b7ca1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/103000000/102840000/102831500/102831406/a5107087.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hot Tub - Minutes from Winetrail, SIU, Giant City, Cedar Lake, Shawnee Forest! Makanda 10/10 Exceptional (53) "Had a great stay" [](https://www.expedia.co.uk/Makanda-Hotels-Hot-Tub-Minutes-From-Winetrail.h102831406.Hotel-Information) ![Outdoor spa tub](https://images.trvl-media.com/lodging/35000000/34340000/34332000/34331993/cb67aaf7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/35000000/34340000/34332000/34331993/3ef69aa9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/35000000/34340000/34332000/34331993/5387ea90.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/35000000/34340000/34332000/34331993/aa1de11c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cabin in Southern Illinois - Hot Tub - Romantic Getaway -Shawnee National Forest Jonesboro 10/10 Exceptional (258) "Had an amazing stay!" [](https://www.expedia.co.uk/Jonesboro-Hotels-Cabin-In-Southern-Illinois-Hot-Tub-Romantic-Getaway-Shawnee-National-Forest.h34331993.Hotel-Information) ![Outdoor spa tub](https://images.trvl-media.com/lodging/58000000/57130000/57120600/57120575/49a53649.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/58000000/57130000/57120600/57120575/9ff6baea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/58000000/57130000/57120600/57120575/9f159f90.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/58000000/57130000/57120600/57120575/90-e0ad0d28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Spacious 2 BR, 1 1/2 baths, hot tub, pool table, outside room, full kitchen Anna 9.8/10 Exceptional (159) "The place was lovely , it was a nice little private getaway " [](https://www.expedia.co.uk/Anna-Hotels-Spacious-2-BR.h57120575.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-10-10&endDate=2025-10-11®ionId=553248635976430467&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Cape-Girardeau-County.d553248635976430467.Holiday-Rental-Destinations)[Sign up, it's free](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Cape-Girardeau-County.d553248635976430467.Holiday-Rental-Destinations) ## Top Cape Girardeau County Hotel Reviews ![La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau](//images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/05fcda41_y.jpg) ### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau 10/10 Excellent "Friendly staff, very clean and pleasant environment." [](https://expedia.co.uk/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information) ![The Riverview](//images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046_y.jpg) ### The Riverview 10/10 Excellent "Staff friendly, room is clean and quiet " [](https://expedia.co.uk/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information) ![Fairfield Inn & Suites by Marriott Cape Girardeau](//images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/347bcd98_y.jpg) ### Fairfield Inn & Suites by Marriott Cape Girardeau 10/10 Excellent "Excellent hotel…" [](https://expedia.co.uk/Cape-Girardeau-Hotels-Fairfield-Inn-Suites-By-Marriott-Cape-Girardeau.h99972043.Hotel-Information) ![Drury Plaza Hotel Cape Girardeau Conference Center](//images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e_y.jpg) ### Drury Plaza Hotel Cape Girardeau Conference Center 10/10 Excellent "Very, Very nice. Always, first think I look at is landscaping. It foretells that attitude of the hotel. Drury of the Cape was nicely done, well maintained and fresh. Ok, good start. Start check in and Travelocity computer was not up to speed with Drury's. Desk person got manager, sorted it in just a few short minutes, with a smile the whole time, and up to my room. Room was immaculate, well appointed, nicely decorated, and just plain comfortable. Relaxed a few minutes in the comfortable chair and went down for complimentary dinner. No gigantic spread but, way more than I expected and very tasty. Eveything about my stay was over the top for the price I paid. Everyone working there seemed happy and smiling genuinely.Absolutely one of the nicest hotels I've ever stayed in. This company has the right idea on providing service while not trying to rob you at the same time. Thank You!" [](https://expedia.co.uk/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) ![Pear Tree Inn Cape Girardeau Near the Medical Center](//images.trvl-media.com/lodging/1000000/50000/40200/40113/7a520031_y.jpg) ### Pear Tree Inn Cape Girardeau Near the Medical Center 10/10 Excellent "Staff was friendly, room was clean, good location, good rate." [](https://expedia.co.uk/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-Near-The-Medical-Center.h40113.Hotel-Information) ![Drury Inn & Suites Jackson MO](//images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d_y.jpg) ### Drury Inn & Suites Jackson MO 10/10 Excellent "this place is awesome! evening snacks and drinks (a meal really!) and very nice breakfast comfortable bed and beautiful grounds-quite rural, but Dairy Queen across the road. easy and safe seeming parking " [](https://expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information) ![Pear Tree Inn Cape Girardeau West](//images.trvl-media.com/lodging/1000000/30000/21500/21410/3a7dec89_y.jpg) ### Pear Tree Inn Cape Girardeau West 10/10 Excellent "Very clean, sincerely friendly staff and very helpful. Pillows and bed comfy. Great location. " [](https://expedia.co.uk/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) ![Tru By Hilton Cape Girardeau](//images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/w3837h2560x3y0-1bbb6bc9_y.jpg) ### Tru By Hilton Cape Girardeau 10/10 Excellent "Brand new hotel and it’s not even shown on Google maps. Great condition and service!" [](https://expedia.co.uk/Cape-Girardeau-Hotels-Tru-By-Hilton-Cape-Girardeau.h111590879.Hotel-Information) ![Courtyard by Marriott Cape Girardeau Downtown](//images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/ae49c8da_y.jpg) ### Courtyard by Marriott Cape Girardeau Downtown 10/10 Excellent "My husband and I love this hotel. We stay here every single time we are in the area. While it’s a little pricier than a few other options it is definitely worth it for us. The hotel is beautiful and the staff is always very accommodating. Emily and the rest of the staff are so sweet and helpful. We will be back soon and can’t wait! " [](https://expedia.co.uk/Sikeston-Hotels-Courtyard-By-Marriott-Cape-Girardeau-Downtown.h24322039.Hotel-Information) ## Find out more about Cape Girardeau County **Everything you need to know about** **Cape Girardeau County** **holiday rentals** Whether you’re excited for the perfect family holiday, a romantic getaway for two, or the ultimate city break, we’ve got the Cape Girardeau County holiday rental for you. At Expedia, you can take your pick from private holiday homes, [apartments](https://www.expedia.co.uk/aa/Apartments), cottages, [apart-hotels](https://www.expedia.co.uk/aa/ApartHotels), cabins, [villas](https://www.expedia.co.uk/aa/Villas)... The list goes on, and on… and on! There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Cape Girardeau County holiday rental for you by simply entering your desired dates. Then check your favourite filters to narrow down your search.  **Cape Girardeau County holiday rentals: An excellent choice for every season** Whenever you want to travel, a warm welcome awaits you in Cape Girardeau County. If you’re looking for a little peace, consider booking during the quieter months, such as  . For more hustle and bustle, you may prefer to visit in .  Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Cape Girardeau County holiday rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a holiday rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Cape Girardeau County holiday rentals we have selected for you start as low as £78 per night. Entering your travel dates in the search wizard you might find even better deals! **How to find incredible deals on Cape Girardeau County rentals** At Expedia, we put the best Cape Girardeau County holiday rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.  To find some top Cape Girardeau County rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Cape Girardeau County holiday. If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Cape Girardeau County. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.