Santiago Metropolitan Region Luxury Holidays

Book a Luxury Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to £335 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Packages with flights are ATOL protected

The Annual Holiday Sale

Members save up to 40% on hotels and holiday homes. Plan this year’s big trip and save.

All you need to know about luxury holidays in Santiago Metropolitan Region

What can I expect from a luxury Santiago Metropolitan Region holiday?

Luxury on holiday is all about relaxing and feeling good. Whether you choose a sumptuous spa, Michelin-starred restaurant or super-king bed is your call. Use our amenities filters to find the things that tick all your boxes.

How can I find all-inclusive luxury holidays in Santiago Metropolitan Region?

Tick the all-inclusive and 5-star filters to find the crème de la crème of Santiago Metropolitan Region holidays. With everything included in the package price, you can drink and dine to your heart’s content, without worrying about that bill at the end.

Can I book a cheap luxury holiday to Santiago Metropolitan Region?

A luxury holiday doesn’t have to break the bank. Travel out of peak season, choose a hotel or resort a little way out or go for a last-minute getaway and you’ll find some cracking deals. Sort by price to find luxury holidays to Santiago Metropolitan Region starting at . Prices and availability are subject to change. Additional terms may apply.

Are there luxury spa holidays in Santiago Metropolitan Region?

For sunset massages on the shoreline and view-filled saunas, use our spa filter to find your ideal Santiago Metropolitan Region spa hotel. Book a whole weekend soaking away your stresses, or hop into the spa after the beach, some golf or a local advent-ahhhh.

What should I look for when booking a luxury family holiday in Santiago Metropolitan Region?

Luxury isn’t just for adults. Those little touches designed for little people make a family holiday genuinely stress free … which is the greatest luxury of all. Look for spacious suites, pools toddlers can splash in, and breakfast buffets with waffles, pancakes and Nutella galore.

Can I book luxury last-minute holidays to Santiago Metropolitan Region?

You can wangle a top-notch luxury holiday in Santiago Metropolitan Region for a fraction of the normal price by booking last minute. Just enter your dates and see what’s available – if you’re flexible ... even better!

Can I book a luxury holiday in Santiago Metropolitan Region with free cancellation and/or flexible dates?

If you’re splashing out on a luxury holiday, make sure your money is safe by booking with free cancellation. Just use the fully refundable filter and make sure you read all the terms and conditions.

Why should I book my luxury travel to Santiago Metropolitan Region with Expedia?

Nobody does luxury quite like Expedia. With so many gorgeous properties in Santiago Metropolitan Region to choose from, as well as access to first-class flight deals and hire cars with horsepower, there’s no better place to book.

Top Luxury Santiago Metropolitan Region Hotels

The Singular Santiago

The Singular Santiago

5 out of 5
Merced 294 Santiago Region Metropolitana
  • 4 min drive from Costanera Center
The price is £202 per night from 8 Apr to 9 Apr
£202
8 Apr - 9 Apr
Stay at this luxury hotel in Santiago. Enjoy free breakfast, free Wi-Fi and an outdoor pool. Our guests praise the bar and the helpful staff in their reviews. ...
9.6/10 Exceptional! (701 reviews)
Very nice hotel situated in a great part of Santiago

Reviewed on 12 Mar 2026

The Singular Santiago
Noi Vitacura

Noi Vitacura

5 out of 5
Av. Nueva Costanera 3736 Santiago Region Metropolitana
  • 23 min walk from Costanera Center
The price is £178 per night from 19 Mar to 20 Mar
£178
19 Mar - 20 Mar
Stay at this luxury hotel in Santiago. Enjoy free breakfast, free Wi-Fi and free parking. Popular attractions Parque Arauco Mall and Costanera Center are located ...
8.6/10 Excellent! (567 reviews)
Clean room, nice rooftop restaurant and very helpful, friendly staff! Thank you, Noi Staff! Ann from SF

Reviewed on 20 Feb 2026

Noi Vitacura
Renaissance Santiago Hotel by Marriott

Renaissance Santiago Hotel by Marriott

4.5 out of 5
Avenida Kennedy 4700 Santiago Region Metropolitana
  • 25 min walk from Costanera Center
The price is £127 per night from 3 Apr to 4 Apr
£127
3 Apr - 4 Apr
Stay at this luxury hotel in Santiago. Enjoy free Wi-Fi, a rooftop terrace and breakfast (surcharge). Our guests praise the helpful staff in their reviews. Popular ...
9/10 Wonderful! (384 reviews)
Excellent hotel, Junior Suite was spacious, clean and comfortable. Great location in Vitacura- very safe neighbourhood. A really really good breakfast (better than good - excellent), attentive staff and extensive selection of breakfast foods. The public spaces and bars are quirky (in a nice way) ...

Reviewed on 9 Feb 2026

Renaissance Santiago Hotel by Marriott
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More holidays you might like

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.