Luxury South America Holidays & Travel

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All you need to know about luxury holidays in South America

What can I expect from a luxury South America holiday?

Luxury on holiday is all about relaxing and feeling good. Whether you choose a sumptuous spa, Michelin-starred restaurant or super-king bed is your call. Use our amenities filters to find the things that tick all your boxes.

How can I find all-inclusive luxury holidays in South America?

Tick the all-inclusive and 5-star filters to find the crème de la crème of South America holidays. With everything included in the package price, you can drink and dine to your heart’s content, without worrying about that bill at the end.

Can I book a cheap luxury holiday to South America?

A luxury holiday doesn’t have to break the bank. Travel out of peak season, choose a hotel or resort a little way out or go for a last-minute getaway and you’ll find some cracking deals. Sort by price to find luxury holidays to South America starting at . Prices and availability are subject to change. Additional terms may apply.

Are there luxury spa holidays in South America?

For sunset massages on the shoreline and view-filled saunas, use our spa filter to find your ideal South America spa hotel. Book a whole weekend soaking away your stresses, or hop into the spa after the beach, some golf or a local advent-ahhhh.

What should I look for when booking a luxury family holiday in South America?

Luxury isn’t just for adults. Those little touches designed for little people make a family holiday genuinely stress free … which is the greatest luxury of all. Look for spacious suites, pools toddlers can splash in, and breakfast buffets with waffles, pancakes and Nutella galore.

Can I book luxury last-minute holidays to South America?

You can wangle a top-notch luxury holiday in South America for a fraction of the normal price by booking last minute. Just enter your dates and see what’s available – if you’re flexible ... even better!

Can I book a luxury holiday in South America with free cancellation and/or flexible dates?

If you’re splashing out on a luxury holiday, make sure your money is safe by booking with free cancellation. Just use the fully refundable filter and make sure you read all the terms and conditions.

Why should I book my luxury travel to South America with Expedia?

Nobody does luxury quite like Expedia. With so many gorgeous properties in South America to choose from, as well as access to first-class flight deals and hire cars with horsepower, there’s no better place to book.

Top Luxury South America Hotels

Hotel das Cataratas, A Belmond Hotel, Iguassu Falls

Hotel das Cataratas, A Belmond Hotel, Iguassu Falls

5 out of 5
Rodovia Br 469 Km 32 Foz do Iguaçu PR
The price is £634 per night from 23 Apr to 24 Apr
£634
23 Apr - 24 Apr
includes taxes & fees
Stay at this luxury hotel in Foz do Iguaçu. Enjoy free breakfast, free Wi-Fi and a full-service spa. Our guests praise the helpful staff and the property condition ...
9.8/10 Exceptional! (1,011 reviews)
Great breakfast buffet, Excellent room with a view of the falls, staff was helpful

Reviewed on 12 Apr 2026

Hotel das Cataratas, A Belmond Hotel, Iguassu Falls
Hotel Club Frances

Hotel Club Frances

4.5 out of 5
Rodríguez Peña 1832 Buenos Aires Capital Federal
The price is £143 per night from 29 Apr to 30 Apr
£143
29 Apr - 30 Apr
Stay at this luxury hotel in Buenos Aires. Enjoy free breakfast, free Wi-Fi and a full-service spa. Our guests praise the helpful staff in their reviews. Popular ...
9.4/10 Exceptional! (664 reviews)
Fun lobby, bar. Ok breakfast, good location. Decent value.

Reviewed on 28 Mar 2026

Hotel Club Frances
Palacio del Inka, A Luxury Collection Hotel by Marriott

Palacio del Inka, A Luxury Collection Hotel by Marriott

5 out of 5
Plazoleta Santo Domingo No 259 Cusco Cusco
The price is £307 per night from 27 Apr to 28 Apr
£307
27 Apr - 28 Apr
Stay at this luxury hotel in Cusco. Enjoy a full-service spa, room service and a fitness centre. Our guests praise the helpful staff in their reviews. Popular ...
9.6/10 Exceptional! (1,004 reviews)
The staff was very attentive to our needs. My wife received oxygen as soon as she arrive due to the altitude sickness. Providing a schedule for spa time outside of the office hours was handled well by the concierge. All in all, I highly recommend this hotel to family and friends!

Reviewed on 10 Apr 2026

Palacio del Inka, A Luxury Collection Hotel by Marriott
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.