Title: Luxury South America Holidays & Travel 2026/2027 | Expedia.co.uk ![](https://images.trvl-media.com/place/6140917/ba4ee8aa-2da1-4310-8a44-1015fb6e7a3d.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Luxury South America Holidays & Travel ## Book a Luxury Hotel + Flight or Car together to unlock savings - ## Plan, book, travel with confidence - ### Better together Save up to £335 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Packages with flights are ATOL protected ## Top flight + Luxury hotel deals in South America Price found within the past 48 hours. Click for updated prices. ![Charleston Santa Teresa Cartagena](https://images.trvl-media.com/lodging/1000000/890000/889900/889840/60f4ae0e_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Charleston Santa Teresa Cartagena Cartagena Walled City Save 100% on your flight £565 per person 31 Mar - 4 Apr found 1 day ago Additional charges may apply Return flight included Medellín (MDE) to Cartagena (CTG) 9.4/10 Exceptional! (765 reviews) The staff was great and the food at the restaurant was great. Reviewed on 24 Feb 2026 ![The Charlee Hotel](https://images.trvl-media.com/lodging/5000000/4130000/4129400/4129341/232f02be_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Charlee Hotel El Poblado £1,064 per person 30 Apr - 6 May found 1 day ago Additional charges may apply Return flight included London (LHR) to Medellín (MDE) 8.8/10 Excellent! (1,002 reviews) Amazing kind professional staff They made my stay very pleasant Perfect service ,very clean and great food Reviewed on 18 Feb 2026 ![Casa Pestagua Relais Châteaux](https://images.trvl-media.com/lodging/5000000/4110000/4107000/4106921/52f0058e_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Casa Pestagua Relais Châteaux Cartagena Walled City Save 100% on your flight £954 per person 31 Mar - 4 Apr found 1 day ago Additional charges may apply Return flight included Medellín (MDE) to Cartagena (CTG) 9.6/10 Exceptional! (271 reviews) Casa Pestagua is known for its elegant colonial architecture, beautifully maintained interiors, and intimate luxury atmosphere. The room was very spacious and clean. What truly makes a stay memorable, though, is the people, Eduardo, Leonard, Alvaro, Carlos, Juan, and the entire team delivered exceptional hospitality. Thoughtful, attentive staff can really elevate an already stunning property into an unforgettable experience. Cartagena itself, with its colorful streets and historic charm, is the perfect backdrop for a hotel like this. Casa Pestagua is a must-stay destination! Reviewed on 20 Feb 2026 ![Hotel Casa San Agustin](https://images.trvl-media.com/lodging/6000000/5620000/5610100/5610092/2b8555c9_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel Casa San Agustin Cartagena Walled City Save 100% on your flight £962 per person 31 Mar - 4 Apr found 1 day ago Additional charges may apply Return flight included Medellín (MDE) to Cartagena (CTG) 9.8/10 Exceptional! (450 reviews) This was a beautiful hotel with excellent service. A very luxurious stay. Reviewed on 17 Feb 2026 ![Aranwa Paracas Resort & Spa](https://images.trvl-media.com/lodging/9000000/8130000/8121600/8121560/c9c15357_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Aranwa Paracas Resort & Spa £1,011 per person 12 Apr - 17 Apr found 5 hours ago Return direct flight included London (LON) to Lima (LIM) 8.4/10 Very Good! (491 reviews) The staff was very nice, the rooms were clean(stayed in 3), the amenities were very good. The restaurant would be the only place i would say needs some attention, the food was not what i expexted and the juices in the breakfast buffet were watered down and not good. Reviewed on 24 Feb 2026 Don't see what you're looking for? See all available trips from Medellín to South America [View all trips](https://expedia.co.uk/go/package/search/FlightHotel/2026-03-28/2026-04-04/?FromAirport=MDE&Destination=null&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## 5\* Luxury holidays in South America Price found within the past 48 hours. Click for updated prices. ![Charleston Santa Teresa Cartagena](https://images.trvl-media.com/lodging/1000000/890000/889900/889840/60f4ae0e_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Charleston Santa Teresa Cartagena Cartagena Walled City Save 100% on your flight £565 per person 31 Mar - 4 Apr found 1 day ago Additional charges may apply Return flight included Medellín (MDE) to Cartagena (CTG) 9.4/10 Exceptional! (765 reviews) The staff was great and the food at the restaurant was great. Reviewed on 24 Feb 2026 ![The Charlee Hotel](https://images.trvl-media.com/lodging/5000000/4130000/4129400/4129341/232f02be_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Charlee Hotel El Poblado £1,064 per person 30 Apr - 6 May found 1 day ago Additional charges may apply Return flight included London (LHR) to Medellín (MDE) 8.8/10 Excellent! (1,002 reviews) Amazing kind professional staff They made my stay very pleasant Perfect service ,very clean and great food Reviewed on 18 Feb 2026 ![Miramar by Windsor Copacabana](https://images.trvl-media.com/lodging/1000000/10000/9100/9027/b01f6953_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Miramar by Windsor Copacabana Copacabana £1,280 per person 30 Apr - 6 May found 21 hours ago Return direct flight included London (LHR) to Rio de Janeiro (GIG) 9.6/10 Exceptional! (1,231 reviews) Yes, room was very clean and housekeeping came everyday to change out the sheets. Everyone was friendly and very helpful with questions regarding maneuvering through Rio Reviewed on 26 Feb 2026 Don't see what you're looking for? See all available trips from Medellín to South America [View all trips](https://expedia.co.uk/go/package/search/FlightHotel/2026-03-28/2026-04-04/?FromAirport=MDE&Destination=null&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## 3 Night Luxury holidays in South America Price found within the past 48 hours. Click for updated prices. ![Bastión Luxury Hotel](https://images.trvl-media.com/lodging/9000000/8270000/8268200/8268158/c291524c_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Bastión Luxury Hotel Cartagena Walled City £1,309 per person 6 May - 9 May found 20 hours ago Additional charges may apply Return flight included London (LHR) to Cartagena (CTG) 9.6/10 Exceptional! (1,001 reviews) Great staff, very clean and spacious room Reviewed on 27 Feb 2026 ![Ananda Hotel Boutique](https://images.trvl-media.com/lodging/3000000/2650000/2645700/2645670/2ed2aa61_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Ananda Hotel Boutique Cartagena Walled City £1,355 per person 6 May - 9 May found 20 hours ago Additional charges may apply Return flight included London (LHR) to Cartagena (CTG) 9.2/10 Wonderful! (422 reviews) Ananda Hotel Boutique was my favorite hotel that I stayed at while in Cartagena! We truly enjoyed our time there. We were treated like valued guests from the minute we checked in to the time we left. The hotel is beautiful with colonial architecture and lots of beautiful natural wood accents. The room was lovely with wooden beams on the ceiling. The beds were very comfortable, the sink and shower had plenty of hot water, the room was completley soundproof and our room was located right by the pool which was lovely. We enjoyed appetizers and lunch offered by the hotel restaurant. Please try the ceviche and crab empanadas. Also the welcome drink of traditional limonada (lime-ade) was the best I had the entire time in Cartagena. The first floor and rooftop pools were both lovely and refreshing. We will definitely stay at Ananda Hotel Boutique again! Reviewed on 27 Feb 2026 ![Charleston Santa Teresa Cartagena](https://images.trvl-media.com/lodging/1000000/890000/889900/889840/60f4ae0e_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Charleston Santa Teresa Cartagena Cartagena Walled City £1,448 per person 6 May - 9 May found 20 hours ago Additional charges may apply Return flight included London (LHR) to Cartagena (CTG) 9.4/10 Exceptional! (765 reviews) The staff was great and the food at the restaurant was great. Reviewed on 24 Feb 2026 Don't see what you're looking for? See all available trips from London to South America [View all trips](https://expedia.co.uk/go/package/search/FlightHotel/2026-03-28/2026-04-04/?FromAirport=LHR&Destination=null&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## 4 Night Luxury holidays in South America Price found within the past 48 hours. Click for updated prices. ![Charleston Santa Teresa Cartagena](https://images.trvl-media.com/lodging/1000000/890000/889900/889840/60f4ae0e_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Charleston Santa Teresa Cartagena Cartagena Walled City Save 100% on your flight £565 per person 31 Mar - 4 Apr found 1 day ago Additional charges may apply Return flight included Medellín (MDE) to Cartagena (CTG) 9.4/10 Exceptional! (765 reviews) The staff was great and the food at the restaurant was great. Reviewed on 24 Feb 2026 ![Casa Pestagua Relais Châteaux](https://images.trvl-media.com/lodging/5000000/4110000/4107000/4106921/52f0058e_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Casa Pestagua Relais Châteaux Cartagena Walled City Save 100% on your flight £954 per person 31 Mar - 4 Apr found 1 day ago Additional charges may apply Return flight included Medellín (MDE) to Cartagena (CTG) 9.6/10 Exceptional! (271 reviews) Casa Pestagua is known for its elegant colonial architecture, beautifully maintained interiors, and intimate luxury atmosphere. The room was very spacious and clean. What truly makes a stay memorable, though, is the people, Eduardo, Leonard, Alvaro, Carlos, Juan, and the entire team delivered exceptional hospitality. Thoughtful, attentive staff can really elevate an already stunning property into an unforgettable experience. Cartagena itself, with its colorful streets and historic charm, is the perfect backdrop for a hotel like this. Casa Pestagua is a must-stay destination! Reviewed on 20 Feb 2026 ![Hotel Casa San Agustin](https://images.trvl-media.com/lodging/6000000/5620000/5610100/5610092/2b8555c9_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel Casa San Agustin Cartagena Walled City Save 100% on your flight £962 per person 31 Mar - 4 Apr found 1 day ago Additional charges may apply Return flight included Medellín (MDE) to Cartagena (CTG) 9.8/10 Exceptional! (450 reviews) This was a beautiful hotel with excellent service. A very luxurious stay. Reviewed on 17 Feb 2026 Don't see what you're looking for? See all available trips from Medellín to South America [View all trips](https://expedia.co.uk/go/package/search/FlightHotel/2026-03-28/2026-04-04/?FromAirport=MDE&Destination=null&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-uk-fr-de.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Holiday Sale Members save up to 40% on hotels and holiday homes. Plan this year’s big trip and save. [Book now](https://expedia.co.uk/cheap-deals?rfrr=THVAD_SPRING_PROMO_6023117) ## All you need to know about luxury holidays in South America #### What can I expect from a luxury South America holiday? Luxury on holiday is all about relaxing and feeling good. Whether you choose a sumptuous spa, Michelin-starred restaurant or super-king bed is your call. Use our amenities filters to find the things that tick all your boxes. #### How can I find all-inclusive luxury holidays in South America? Tick the all-inclusive and 5-star filters to find the crème de la crème of South America holidays. With everything included in the package price, you can drink and dine to your heart’s content, without worrying about that bill at the end. #### Can I book a cheap luxury holiday to South America? A luxury holiday doesn’t have to break the bank. Travel out of peak season, choose a hotel or resort a little way out or go for a last-minute getaway and you’ll find some cracking deals. Sort by price to find luxury holidays to South America starting at £565\. Prices and availability are subject to change. Additional terms may apply. #### Are there luxury spa holidays in South America? For sunset massages on the shoreline and view-filled saunas, use our spa filter to find your ideal South America spa hotel. Book a whole weekend soaking away your stresses, or hop into the spa after the beach, some golf or a local advent-ahhhh. #### What should I look for when booking a luxury family holiday in South America? Luxury isn’t just for adults. Those little touches designed for little people make a family holiday genuinely stress free … which is the greatest luxury of all. Look for spacious suites, pools toddlers can splash in, and breakfast buffets with waffles, pancakes and Nutella galore. #### Can I book luxury last-minute holidays to South America? You can wangle a top-notch luxury holiday in South America for a fraction of the normal price by booking last minute. Just enter your dates and see what’s available – if you’re flexible ... even better! #### Can I book a luxury holiday in South America with free cancellation and/or flexible dates? If you’re splashing out on a luxury holiday, make sure your money is safe by booking with free cancellation. Just use the fully refundable filter and make sure you read all the terms and conditions. #### Why should I book my luxury travel to South America with Expedia? Nobody does luxury quite like Expedia. With so many gorgeous properties in South America to choose from, as well as access to first-class flight deals and hire cars with horsepower, there’s no better place to book. ## Top Luxury South America Hotels ![Hotel das Cataratas, A Belmond Hotel, Iguassu Falls](https://images.trvl-media.com/lodging/1000000/60000/53300/53288/7373d519_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hotel das Cataratas, A Belmond Hotel, Iguassu Falls Rodovia Br 469 Km 32 Foz do Iguaçu PR £684 14 Mar - 15 Mar includes taxes & fees Stay at this luxury hotel in Foz do Iguaçu. Enjoy free breakfast, free Wi-Fi and a full-service spa. Our guests praise the helpful staff and the property condition ... 9.8/10 Exceptional! (1,000 reviews) The entire hotel & view were stunning. Being able to walk to the falls after the park is closed felt like a gift, it was magical to walk up close to the falls with hardly anyone around. The staff were very attentive & everyone was so friendly. The buffets are a must! We loved the variety of food. ... Reviewed on 21 Feb 2026 [](https://expedia.co.uk/Foz-Do-Iguacu-Hotels-Hotel-Das-Cataratas.h53288.Hotel-Information) ![Hotel Club Frances](https://images.trvl-media.com/lodging/5000000/4920000/4914500/4914467/f4102dc9_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hotel Club Frances Rodríguez Peña 1832 Buenos Aires Capital Federal £162 1 Mar - 2 Mar Stay at this luxury hotel in Buenos Aires. Enjoy free breakfast, free Wi-Fi and a full-service spa. Our guests praise the helpful staff in their reviews. Popular ... 9.4/10 Exceptional! (653 reviews) A wonderful boutique hotel with a great history and excellent staff. Well located in an upscale part of BA. Highly recommend. Reviewed on 26 Feb 2026 [](https://expedia.co.uk/Buenos-Aires-Hotels-Hotel-Club-Frances.h4914467.Hotel-Information) ![Palacio del Inka, A Luxury Collection Hotel by Marriott](https://images.trvl-media.com/lodging/1000000/520000/519400/519319/bd303ee6_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Palacio del Inka, A Luxury Collection Hotel by Marriott Plazoleta Santo Domingo No 259 Cusco Cusco £245 15 Mar - 16 Mar Stay at this luxury hotel in Cusco. Enjoy a full-service spa, room service and a fitness centre. Our guests praise the helpful staff in their reviews. Popular ... 9.6/10 Exceptional! (989 reviews) Beautiful historic building in the heart of Cusco. Walking distance to major sites. Great breakfast buffet. Reviewed on 21 Feb 2026 [](https://expedia.co.uk/Cusco-Hotels-Palacio-Del-Inka.h519319.Hotel-Information) [See all 118,309 properties in South America](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Package®ionId=6023117) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## More holidays you might like ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Holidays [](https://expedia.co.uk/lp/theme-holidays/all-inclusive-holidays?rfrr=editorial.All_Inclusive%20Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Holidays [](https://expedia.co.uk/lp/theme-holidays/beach-holidays?rfrr=editorial.Beach_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Family Friendly Holidays [](https://expedia.co.uk/lp/theme-holidays/kid-friendly-holidays?rfrr=editorial.Family_Friendly%20Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Holidays [](https://expedia.co.uk/lp/theme-holidays/golf-holidays?rfrr=editorial.Golf_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Holidays [](https://expedia.co.uk/lp/theme-holidays/luxury-holidays?rfrr=editorial.Luxury_Holidays.click) ![gay friendly holiday packages](https://forever.travel-assets.com/flex/flexmanager/images/2023/06/15/LGBTQIA_Holiday_Package.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) LGBTQ+ Holidays [](https://expedia.co.uk/lp/theme-holidays/gay-friendly-holidays?rfrr=editorial.LGBTQ+_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Holidays [](https://expedia.co.uk/lp/theme-holidays/romantic-holidays?rfrr=editorial.Romantic_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Holidays [](https://expedia.co.uk/lp/theme-holidays/ski-holidays?rfrr=editorial.Ski_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/22/hero-image-pet-friendly_copy.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Pet Friendly Holidays [](https://expedia.co.uk/lp/theme-holidays/pet-friendly-holidays?rfrr=editorial.Pet_Friendly%20Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2023/05/10/mesog-34434-card-venice.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Where to go when [](https://expedia.co.uk/lp/b/where-to-go-when?rfrr=editorial.Where_to%20go%20when.click) ## More Holiday Ideas [South America Flights ](https://expedia.co.uk/Destinations-In-South-America.d6023117.Flight-Destinations)[ South America Hotels ](https://expedia.co.uk/Destinations-In-South-America.d6023117.Hotel-Destinations)[ South America Holiday Rentals ](https://expedia.co.uk/Destinations-In-South-America.d6023117.Holiday-Rental-Destinations)[ South America Car Hire ](https://expedia.co.uk/Destinations-In-South-America.d6023117.Car-Hire-Destinations)[ South America Holidays ](https://expedia.co.uk/South-America.d6023117.Holidays-City-Breaks) \* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected. ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app