Missouri Luxury Holidays

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    Packages with flights are ATOL protected

Top flight + Luxury hotel deals in Missouri

Price found within the past 48 hours. Click for updated prices.
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
River City Casino & Hotel
Four Seasons Hotel St Louis
Moonrise Hotel
 The Royal Sonesta Chase Park Plaza St. Louis
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5* Luxury holidays in Missouri

Price found within the past 48 hours. Click for updated prices.
Four Seasons Hotel St Louis
The Ritz-Carlton, St. Louis
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See all available trips from London to Missouri
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All you need to know about luxury holidays in Missouri

What can I expect from a luxury Missouri holiday?

Luxury on holiday is all about relaxing and feeling good. Whether you choose a sumptuous spa, Michelin-starred restaurant or super-king bed is your call. Use our amenities filters to find the things that tick all your boxes.

How can I find all-inclusive luxury holidays in Missouri?

Tick the all-inclusive and 5-star filters to find the crème de la crème of Missouri holidays. With everything included in the package price, you can drink and dine to your heart’s content, without worrying about that bill at the end.

Can I book a cheap luxury holiday to Missouri?

A luxury holiday doesn’t have to break the bank. Travel out of peak season, choose a hotel or resort a little way out or go for a last-minute getaway and you’ll find some cracking deals. Sort by price to find luxury holidays to Missouri starting at £714. Prices and availability are subject to change. Additional terms may apply.

Are there luxury spa holidays in Missouri?

For sunset massages on the shoreline and view-filled saunas, use our spa filter to find your ideal Missouri spa hotel. Book a whole weekend soaking away your stresses, or hop into the spa after the beach, some golf or a local advent-ahhhh.

What should I look for when booking a luxury family holiday in Missouri?

Luxury isn’t just for adults. Those little touches designed for little people make a family holiday genuinely stress free … which is the greatest luxury of all. Look for spacious suites, pools toddlers can splash in, and breakfast buffets with waffles, pancakes and Nutella galore.

Can I book luxury last-minute holidays to Missouri?

You can wangle a top-notch luxury holiday in Missouri for a fraction of the normal price by booking last minute. Just enter your dates and see what’s available – if you’re flexible ... even better!

Can I book a luxury holiday in Missouri with free cancellation and/or flexible dates?

If you’re splashing out on a luxury holiday, make sure your money is safe by booking with free cancellation. Just use the fully refundable filter and make sure you read all the terms and conditions.

Why should I book my luxury travel to Missouri with Expedia?

Nobody does luxury quite like Expedia. With so many gorgeous properties in Missouri to choose from, as well as access to first-class flight deals and hire cars with horsepower, there’s no better place to book.

Top Luxury Missouri Hotels

 The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis

4.5 out of 5
212 N Kingshighway, St. Louis, MO
  • 4 hours drive from GEHA Field at Arrowhead Stadium
The price is £195 per night from 31 Aug to 1 Sept
£195
31 Aug - 1 Sept
includes taxes & fees
Stay at this 4.5-star luxury hotel in St. Louis. Enjoy free Wi-Fi, an outdoor pool and 3 restaurants. Our guests praise the helpful staff and the clean rooms ...
8.8/10 Excellent! (1,001 reviews)
"."

Reviewed on 19 Aug 2025

The Royal Sonesta Chase Park Plaza St. Louis
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 out of 5
1 Ameristar Blvd, St. Charles, MO
  • 4 hours drive from GEHA Field at Arrowhead Stadium
The price is £158 per night from 25 Aug to 26 Aug
£158
25 Aug - 26 Aug
includes taxes & fees
Stay at this 4.5-star luxury hotel in St. Charles. Enjoy an outdoor pool, a full-service spa and 6 restaurants. Our guests praise the clean rooms and the property ...
8.2/10 Very Good! (1,001 reviews)
"Loved my stay here will be back"

Reviewed on 13 Aug 2025

Ameristar Casino Resort and Spa
The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis

5 out of 5
100 Carondelet Plaza, St. Louis, MO
  • 4 hours drive from GEHA Field at Arrowhead Stadium
The price is £447 per night from 21 Sept to 22 Sept
£447
21 Sept - 22 Sept
includes taxes & fees
Stay at this 5-star luxury hotel in St. Louis. Enjoy breakfast (surcharge), room service and a fitness centre. Our guests praise the helpful staff and the room ...
9.2/10 Wonderful! (544 reviews)
"Excellent"

Reviewed on 18 Jul 2025

The Ritz-Carlton, St. Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More holidays you might like

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.