
Missouri Luxury Holidays
Book a Luxury Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to £750 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPackages with flights are ATOL protected
Top flight + Luxury hotel deals in Missouri

Moonrise Hotel
Reviewed on 27 Apr 2026

Ameristar Casino Resort and Spa
Reviewed on 28 Apr 2026

Marriott St. Louis Airport
Reviewed on 21 Feb 2026


5* Luxury holidays in Missouri

4 Night Luxury holidays in Missouri

Moonrise Hotel
Reviewed on 27 Apr 2026

Ameristar Casino Resort and Spa
Reviewed on 28 Apr 2026

Marriott St. Louis Airport
Reviewed on 21 Feb 2026
All you need to know about luxury holidays in Missouri
What can I expect from a luxury Missouri holiday?
Luxury on holiday is all about relaxing and feeling good. Whether you choose a sumptuous spa, Michelin-starred restaurant or super-king bed is your call. Use our amenities filters to find the things that tick all your boxes.
How can I find all-inclusive luxury holidays in Missouri?
Tick the all-inclusive and 5-star filters to find the crème de la crème of Missouri holidays. With everything included in the package price, you can drink and dine to your heart’s content, without worrying about that bill at the end.
Can I book a cheap luxury holiday to Missouri?
A luxury holiday doesn’t have to break the bank. Travel out of peak season, choose a hotel or resort a little way out or go for a last-minute getaway and you’ll find some cracking deals. Sort by price to find luxury holidays to Missouri starting at £1,050. Prices and availability are subject to change. Additional terms may apply.
Are there luxury spa holidays in Missouri?
For sunset massages on the shoreline and view-filled saunas, use our spa filter to find your ideal Missouri spa hotel. Book a whole weekend soaking away your stresses, or hop into the spa after the beach, some golf or a local advent-ahhhh.
What should I look for when booking a luxury family holiday in Missouri?
Luxury isn’t just for adults. Those little touches designed for little people make a family holiday genuinely stress free … which is the greatest luxury of all. Look for spacious suites, pools toddlers can splash in, and breakfast buffets with waffles, pancakes and Nutella galore.
Can I book luxury last-minute holidays to Missouri?
You can wangle a top-notch luxury holiday in Missouri for a fraction of the normal price by booking last minute. Just enter your dates and see what’s available – if you’re flexible ... even better!
Can I book a luxury holiday in Missouri with free cancellation and/or flexible dates?
If you’re splashing out on a luxury holiday, make sure your money is safe by booking with free cancellation. Just use the fully refundable filter and make sure you read all the terms and conditions.
Why should I book my luxury travel to Missouri with Expedia?
Nobody does luxury quite like Expedia. With so many gorgeous properties in Missouri to choose from, as well as access to first-class flight deals and hire cars with horsepower, there’s no better place to book.
Top Luxury Missouri Hotels

The Royal Sonesta Chase Park Plaza St. Louis
This hotel was amazing. Highly recommend
Reviewed on 29 Apr 2026

Ameristar Casino Resort and Spa
They need a better Breakfast / Lunch area. Copper Wisk is to small and you have to stand in line to get waited on.
Reviewed on 28 Apr 2026

The Ritz-Carlton, St. Louis
When we arrived it was really loud hard to hear customer service as karaoke was going on.
Reviewed on 27 Apr 2026
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.










