£213 Cheap Flights from Santo Domingo (SDQ) to Panama City (PTY)

View £213 flight on Thu, 14 May 2026Opens in a new window

Flight 1

Popular airlines from Las Americas Intl. Airport (SDQ) to Tocumen Intl. Airport (PTY)

  • Be in the know

    Get alerts if flight prices drop or rise*

  • Book smarter

    Save up to 25% on select hotels after you book a flight*

  • Earn twice

    Earn your airline miles on top of our rewards
    Sign in

Cheap Flights from Santo Domingo (SDQ) to Panama City (PTY)

Prices were available within the past 7 days and start at £213 for one-way flights and £443 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

avianca
Fri, 15 May - Sun, 31 May
SDQ
Santo Domingo
PTY
Panama City
£443 Return, found 2 days ago
£443
Return
found 2 days ago
Select avianca flight, departing Fri, 15 May from Santo Domingo to Panama City, returning Sun, 31 May, priced at £443 found 2 days ago
avianca
Tue, 12 May - Tue, 19 May
SDQ
Santo Domingo
PTY
Panama City
£444 Return, found 6 hours ago
£444
Return
found 6 hours ago
Select avianca flight, departing Tue, 12 May from Santo Domingo to Panama City, returning Tue, 19 May, priced at £444 found 6 hours ago
avianca
Fri, 5 Jun - Wed, 10 Jun
SDQ
Santo Domingo
PTY
Panama City
£444 Return, found 4 days ago
£444
Return
found 4 days ago
Select avianca flight, departing Fri, 5 Jun from Santo Domingo to Panama City, returning Wed, 10 Jun, priced at £444 found 4 days ago
avianca
Fri, 15 May - Sun, 31 May
SDQ
Santo Domingo
PTY
Panama City
£457 Return, found 2 days ago
£457
Return
found 2 days ago
Select avianca flight, departing Fri, 15 May from Santo Domingo to Panama City, returning Sun, 31 May, priced at £457 found 2 days ago
avianca
Tue, 12 May - Tue, 19 May
SDQ
Santo Domingo
PTY
Panama City
£458 Return, found 6 hours ago
£458
Return
found 6 hours ago
Select avianca flight, departing Tue, 12 May from Santo Domingo to Panama City, returning Tue, 19 May, priced at £458 found 6 hours ago
avianca
Sun, 14 Jun - Sun, 21 Jun
SDQ
Santo Domingo
PTY
Panama City
£460 Return, found 14 hours ago
£460
Return
found 14 hours ago
Select avianca flight, departing Sun, 14 Jun from Santo Domingo to Panama City, returning Sun, 21 Jun, priced at £460 found 14 hours ago
avianca
Tue, 12 May - Sat, 16 May
SDQ
Santo Domingo
PTY
Panama City
£467 Return, found 4 days ago
£467
Return
found 4 days ago
Select avianca flight, departing Tue, 12 May from Santo Domingo to Panama City, returning Sat, 16 May, priced at £467 found 4 days ago
Copa
Fri, 15 May - Sat, 30 May
SDQ
Santo Domingo
PTY
Panama City
£495 Return, found 12 hours ago
£495
Return
found 12 hours ago
Select Copa flight, departing Fri, 15 May from Santo Domingo to Panama City, returning Sat, 30 May, priced at £495 found 12 hours ago
American Airlines
Wed, 2 Sept - Tue, 29 Sept
SDQ
Santo Domingo
PTY
Panama City
£669 Return, found 3 days ago
£669
Return
found 3 days ago
Select American Airlines flight, departing Wed, 2 Sept from Santo Domingo to Panama City, returning Tue, 29 Sept, priced at £669 found 3 days ago
Aeromexico
Tue, 12 May - Fri, 15 May
SDQ
Santo Domingo
PTY
Panama City
£983 Return, found 3 days ago
£983
Return
found 3 days ago
Select Aeromexico flight, departing Tue, 12 May from Santo Domingo to Panama City, returning Fri, 15 May, priced at £983 found 3 days ago

Frequently asked questions

What is the cheapest month to fly from Santo Domingo (SDQ-Las Americas Intl.) to Panama City (PTY-Tocumen Intl.)?
May is typically the cheapest month to fly from Santo Domingo (SDQ-Las Americas Intl.) to Panama City (PTY-Tocumen Intl.), with average return fares of approximately £685. This is about 15% lower than the average price throughout the year. May often sees lower prices as it falls outside of peak holiday seasons, making it a great time to find deals. Other cheap months to fly from Santo Domingo (SDQ-Las Americas Intl.) to Panama City (PTY-Tocumen Intl.) include June and July.
Which airlines fly direct from Santo Domingo (SDQ-Las Americas Intl.) to Panama City (PTY-Tocumen Intl.)?
Enter SDQ to PTY and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
How do I find cheap flights from Santo Domingo (SDQ-Las Americas Intl.) to Panama City (PTY-Tocumen Intl.)?
To find a cheap flight from Santo Domingo (SDQ-Las Americas Intl.) to Panama City (PTY-Tocumen Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best airline to fly with from Santo Domingo (SDQ-Las Americas Intl.) to Panama City (PTY-Tocumen Intl.)?
The best airline to fly with from Santo Domingo (SDQ-Las Americas Intl.) to Panama City (PTY-Tocumen Intl.) will differ from traveller to traveller. If you like to fly early, CM offers early morning flights. If price is the most important factor, CM typically offers the lowest fares. AV offers the most daily flights from Santo Domingo (SDQ-Las Americas Intl.) to Panama City (PTY-Tocumen Intl.), which is brilliant if flexibility is what you value most. The best carrier for this journey could also be the one you have a loyalty membership with, as flying with that airline or another airline within the same alliance could help you collect points or enjoy lounge access.
What is the best time to fly from Santo Domingo (SDQ-Las Americas Intl.) to Panama City (PTY-Tocumen Intl.)?
The best time to fly from Santo Domingo (SDQ-Las Americas Intl.) to Panama City (PTY-Tocumen Intl.) for a good deal is typically May or June. Based on booking data from the past year, you can expect to find return flights for around £685 during these months. While we don't have specific popularity data for this route, these months often offer a balance of good weather and fewer crowds, making them a pleasant time to travel.
How many flights per day from Santo Domingo (SDQ-Las Americas Intl.) to Panama City (PTY-Tocumen Intl.)?
When flying from Santo Domingo (SDQ-Las Americas Intl.) to Panama City (PTY-Tocumen Intl.), you'll find approximately 5 nonstop flights per day. For even more choice, look at flights that include layovers, as there are around 11 connecting flights per day. Some common connection points include El Dorado Intl. (BOG), Liberty Intl. (EWR), and Miami Intl. (MIA).
What is the earliest flight from Santo Domingo (SDQ-Las Americas Intl.) to Panama City (PTY-Tocumen Intl.)?
The earliest flight from Santo Domingo (SDQ-Las Americas Intl.) to Panama City (PTY-Tocumen Intl.) typically departs at approximately 5:00 AM local time, operated by American Airlines. This is a seasonal service active in April and May. An early departure like this can help maximise your time at your destination. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What day of the week has the most flights from Santo Domingo (SDQ-Las Americas Intl.) to Panama City (PTY-Tocumen Intl.)?
You'll typically find the most flights from Santo Domingo (SDQ-Las Americas Intl.) to Panama City (PTY-Tocumen Intl.) on a Thursday, with around 13 flights available. This gives you a good selection for your travel plans. Major airlines on this route include CM, AA, and UA. Flight schedules are consistent throughout the week, so you'll have plenty of options no matter when you choose to fly.
What are the most popular departure times for flights from Santo Domingo (SDQ-Las Americas Intl.) to Panama City (PTY-Tocumen Intl.)?
The most popular departure times for flights from Santo Domingo (SDQ-Las Americas Intl.) to Panama City (PTY-Tocumen Intl.) are in the early afternoon, from 12pm to 3pm. Approximately 31% of passengers prefer this time window. Many major carriers, including Copa, Avianca and American Airlines, offer flights during this window. This timing works well because you can have a relaxed morning before your flight and arrive in Panama City with plenty of time to settle in.
How long does it take to fly from Santo Domingo (SDQ-Las Americas Intl.) to Panama City (PTY-Tocumen Intl.)?
Flying nonstop from SDQ to PTY takes around 2 hours 30 minutes, with the route covering approximately 918 miles. Flights with a layover typically take 19 hours longer than direct options. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Santo Domingo (SDQ-Las Americas Intl.) to Panama City (PTY-Tocumen Intl.)?
Select the "Business class" and "First class" filters when looking for SDQ to PTY flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.
How do I earn miles on a Santo Domingo (SDQ-Las Americas Intl.) to Panama City (PTY-Tocumen Intl.) flight with Expedia?
It's easy to earn miles on a Santo Domingo (SDQ-Las Americas Intl.) to Panama City (PTY-Tocumen Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia. *Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Panama City from Las Americas Intl. (SDQ)?
When traveling from Las Americas Intl. (SDQ) to Panama City, you can fly into Tocumen Intl. (PTY) and Northwest Florida Beaches Intl. (ECP). Some flights may connect through major hubs like El Dorado Intl. (BOG), Liberty Intl. (EWR), John F. Kennedy Intl. (JFK) before reaching Panama City. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Santo Domingo (SDQ-Las Americas Intl.) to Panama City (PTY-Tocumen Intl.) at the last minute?
Typically, booking a last minute flight from Santo Domingo (SDQ-Las Americas Intl.) to Panama City (PTY-Tocumen Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Santo Domingo (SDQ-Las Americas Intl.) to Panama City (PTY-Tocumen Intl.) flight and hotel package?
Securing a Santo Domingo (SDQ-Las Americas Intl.) to Panama City (PTY-Tocumen Intl.) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Santo Domingo (SDQ-Las Americas Intl.) to Panama City (PTY-Tocumen Intl.)?
If you booked your Santo Domingo (SDQ-Las Americas Intl.) to Panama City (PTY-Tocumen Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Las Americas Intl.
Destination airport
Tocumen Intl.
Airlines serving
Aeromexico, American Airlines, Copa, avianca
Return price
£442
Distance
1468 km
Average flight time
1 hour 35 mins

Book with confidence

Compare flights from Santo Domingo to Panama City easily and book with confidence

For travelling on business or for pleasure, Expedia makes it easy to book your flights from Santo Domingo to Panama City. Operating between them flights per day, 20 airlines cover the route. And fly direct, getting you to Tocumen Intl. in just hours. If you have a preferred carrier, use our advanced search tool to find the right flight from Las Americas Intl. to Tocumen Intl..  

To make things even better, in the advanced search, you can also choose to fly economy, premium economy, business or first class, select your maximum number of stops, and pick your preferred departure and arrival time. You can also opt for refundable and direct flights. 

Grab a great deal on your flight from Las Americas Intl. (SDQ) to Tocumen Intl. (PTY)

The easiest way to view the best deals on flights from Santo Domingo to Panama City today is to enter your travel dates and hit search. From here, you can sort your results by price to see the cheapest flights first. Right now, return flights from Las Americas Intl. to Tocumen Intl. start at just £443 and range up to £983.  

To find an even better deal, try  

  • being flexible on your dates – midweek flights can be cheaper
  • looking for other airports near Santo Domingo and Panama City
  • booking your flight during May, the cheapest month on this route
  • varying your flight times – early morning and late at night are sometimes cheaper 

Why you should book your Santo Domingo to Panama City flight with Expedia!

We cater for all flight types, cabin classes and airlines. So whether you’re booking flights from Las Americas Intl. to Tocumen Intl. for a budget break or a business trip with a bit of pleasure thrown in, we make it easy to secure the seat that’s right for you.  

Thanks to our supersized inventory that offers great choice all in one place, you know you’ll get a great deal with Expedia. Especially if you bundle your flight together with your hotel, you will unlock amazing savings. For added peace of mind, you can choose flexible bookings or filter to find refundable options, so you won’t pay a fee to change your flight.  

Compare flights from Santo Domingo to Panama City easily and book with confidence

Explore a world of travel with Expedia

*Available to Expedia members.