£325 Cheap Flights from Santa Cruz (VVI) to Panama City (PTY)

View £325 flight on Fri, 29 May 2026Opens in a new window

Popular airlines from Santa Cruz (VVI-Viru Viru Intl.) to Tocumen Intl. Airport (PTY)

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Cheap Flights from Santa Cruz (VVI) to Panama City (PTY)

Prices were available within the past 7 days and start at £325 for one-way flights and £573 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

avianca
Thu, 14 May - Thu, 21 May
VVI
Santa Cruz
PTY
Panama City
£573 Return, found 5 days ago
£573
Return
found 5 days ago
Select avianca flight, departing Thu, 14 May from Santa Cruz to Panama City, returning Thu, 21 May, priced at £573 found 5 days ago
avianca
Thu, 14 May - Thu, 21 May
VVI
Santa Cruz
PTY
Panama City
£609 Return, found 5 days ago
£609
Return
found 5 days ago
Select avianca flight, departing Thu, 14 May from Santa Cruz to Panama City, returning Thu, 21 May, priced at £609 found 5 days ago
Copa
Wed, 20 May - Wed, 27 May
VVI
Santa Cruz
PTY
Panama City
£610 Return, found 5 days ago
£610
Return
found 5 days ago
Select Copa flight, departing Wed, 20 May from Santa Cruz to Panama City, returning Wed, 27 May, priced at £610 found 5 days ago
avianca
Thu, 14 May - Thu, 21 May
VVI
Santa Cruz
PTY
Panama City
£633 Return, found 5 days ago
£633
Return
found 5 days ago
Select avianca flight, departing Thu, 14 May from Santa Cruz to Panama City, returning Thu, 21 May, priced at £633 found 5 days ago
Copa
Fri, 15 May - Fri, 22 May
VVI
Santa Cruz
PTY
Panama City
£636 Return, found 5 days ago
£636
Return
found 5 days ago
Select Copa flight, departing Fri, 15 May from Santa Cruz to Panama City, returning Fri, 22 May, priced at £636 found 5 days ago
avianca
Thu, 14 May - Thu, 21 May
VVI
Santa Cruz
PTY
Panama City
£637 Return, found 5 days ago
£637
Return
found 5 days ago
Select avianca flight, departing Thu, 14 May from Santa Cruz to Panama City, returning Thu, 21 May, priced at £637 found 5 days ago
avianca
Sun, 12 Jul - Sat, 25 Jul
VVI
Santa Cruz
PTY
Panama City
£652 Return, found 5 hours ago
£652
Return
found 5 hours ago
Select avianca flight, departing Sun, 12 Jul from Santa Cruz to Panama City, returning Sat, 25 Jul, priced at £652 found 5 hours ago
avianca
Fri, 15 May - Fri, 22 May
VVI
Santa Cruz
PTY
Panama City
£666 Return, found 5 days ago
£666
Return
found 5 days ago
Select avianca flight, departing Fri, 15 May from Santa Cruz to Panama City, returning Fri, 22 May, priced at £666 found 5 days ago
Copa
Thu, 14 May - Thu, 21 May
VVI
Santa Cruz
PTY
Panama City
£670 Return, found 5 days ago
£670
Return
found 5 days ago
Select Copa flight, departing Thu, 14 May from Santa Cruz to Panama City, returning Thu, 21 May, priced at £670 found 5 days ago
avianca
Sun, 12 Jul - Sat, 25 Jul
VVI
Santa Cruz
PTY
Panama City
£671 Return, found 5 hours ago
£671
Return
found 5 hours ago
Select avianca flight, departing Sun, 12 Jul from Santa Cruz to Panama City, returning Sat, 25 Jul, priced at £671 found 5 hours ago

Alternative airports near Panama City

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Tocumen Intl. PTY. Cheapest option available. Average driving time to city centre is 16 minutes. Flights from £573
PTY
Tocumen Intl.
Cheapest
Average driving time to city centre16 min
Flights from £573

Frequently asked questions

Which airlines fly direct from Santa Cruz (VVI-Viru Viru Intl.) to Panama City (PTY-Tocumen Intl.)?
Enter VVI to PTY and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
How do I find cheap flights from Santa Cruz (VVI-Viru Viru Intl.) to Panama City (PTY-Tocumen Intl.)?
To find a cheap flight from Santa Cruz (VVI-Viru Viru Intl.) to Panama City (PTY-Tocumen Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best airline to fly with from Santa Cruz (VVI-Viru Viru Intl.) to Panama City (PTY-Tocumen Intl.)?
The best airline to fly with from Santa Cruz (VVI-Viru Viru Intl.) to Panama City (PTY-Tocumen Intl.) will differ from traveller to traveller. If you like to fly early, CM offers early morning flights. If price is the most important factor, CM typically offers the lowest fares. OB offers the most daily flights from Santa Cruz (VVI-Viru Viru Intl.) to Panama City (PTY-Tocumen Intl.), which is brilliant if flexibility is what you value most. The best carrier for this journey could also be the one you have a loyalty membership with, as flying with that airline or another airline within the same alliance could help you collect points or enjoy lounge access.
What is the best time to fly from Santa Cruz (VVI-Viru Viru Intl.) to Panama City (PTY-Tocumen Intl.)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
How many flights per day from Santa Cruz (VVI-Viru Viru Intl.) to Panama City (PTY-Tocumen Intl.)?
There are approximately 1 nonstop flight per day from Santa Cruz (VVI-Viru Viru Intl.) to Panama City (PTY-Tocumen Intl.). For even more choice, look at flights that include layovers, as there are around 2 connecting flights per day. Some common connection points include El Dorado Intl. (BOG), El Alto Intl. (LPB), and Miami Intl. (MIA).
What is the earliest flight from Santa Cruz (VVI-Viru Viru Intl.) to Panama City (PTY-Tocumen Intl.)?
The earliest flight from Santa Cruz (VVI-Viru Viru Intl.) to Panama City (PTY-Tocumen Intl.) typically departs at approximately 1:05 AM local time. This service is operated by Copa Airlines and is seasonal, active in May, June, July, August, September, October, November, and December. An early departure like this can help you maximise your time at your destination. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What day of the week has the most flights from Santa Cruz (VVI-Viru Viru Intl.) to Panama City (PTY-Tocumen Intl.)?
You'll typically find the most flights from Santa Cruz (VVI-Viru Viru Intl.) to Panama City (PTY-Tocumen Intl.) on a Monday, with around 3 flights available. This gives you a good selection for your travel plans. Major airlines on this route include CM and AV.
What are the most popular departure times for flights from Santa Cruz (VVI-Viru Viru Intl.) to Panama City (PTY-Tocumen Intl.)?
The most popular departure times for flights from Santa Cruz (VVI-Viru Viru Intl.) to Panama City (PTY-Tocumen Intl.) are in the early morning, from 3am to 6am. About 47% of passengers prefer this time. Avianca offers flights during this window. Many travelers prefer this time because it allows for an early arrival at your destination, giving you more time to settle in or start your day.
How long does it take to fly from Santa Cruz (VVI-Viru Viru Intl.) to Panama City (PTY-Tocumen Intl.)?
Flying nonstop from VVI to PTY takes around 4 hours 50 minutes, with the route covering approximately 2,153 miles. Flights with a layover typically take 17 hours 10 minutes longer than direct options. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Santa Cruz (VVI-Viru Viru Intl.) to Panama City (PTY-Tocumen Intl.)?
Select the "Business class" and "First class" filters when looking for VVI to PTY flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.
How do I earn miles on a Santa Cruz (VVI-Viru Viru Intl.) to Panama City (PTY-Tocumen Intl.) flight with Expedia?
It's easy to earn miles on a Santa Cruz (VVI-Viru Viru Intl.) to Panama City (PTY-Tocumen Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia. *Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Panama City from Viru Viru Intl. (VVI)?
If you're planning to travel to Panama City from Viru Viru Intl. (VVI), you can fly directly into Tocumen Intl. (PTY) Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Santa Cruz (VVI-Viru Viru Intl.) to Panama City (PTY-Tocumen Intl.) at the last minute?
Typically, booking a last minute flight from Santa Cruz (VVI-Viru Viru Intl.) to Panama City (PTY-Tocumen Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Santa Cruz (VVI-Viru Viru Intl.) to Panama City (PTY-Tocumen Intl.) flight and hotel package?
Securing a Santa Cruz (VVI-Viru Viru Intl.) to Panama City (PTY-Tocumen Intl.) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Santa Cruz (VVI-Viru Viru Intl.) to Panama City (PTY-Tocumen Intl.)?
If you booked your Santa Cruz (VVI-Viru Viru Intl.) to Panama City (PTY-Tocumen Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Viru Viru Intl.
Destination airport
Tocumen Intl.
Airlines serving
Copa, avianca
Return price
£573
Distance
3445 km
Average flight time
3 hours 52 mins

Book with confidence

Compare flights from Santa Cruz to Panama City easily and book with confidence

For travelling on business or for pleasure, Expedia makes it easy to book your flights from Santa Cruz to Panama City. Operating between them flights per day, 20 airlines cover the route. And fly direct, getting you to Tocumen Intl. in just hours. If you have a preferred carrier, use our advanced search tool to find the right flight from Viru Viru Intl. to Tocumen Intl..  

To make things even better, in the advanced search, you can also choose to fly economy, premium economy, business or first class, select your maximum number of stops, and pick your preferred departure and arrival time. You can also opt for refundable and direct flights. 

Grab a great deal on your flight from Viru Viru Intl. (VVI) to Tocumen Intl. (PTY)

The easiest way to view the best deals on flights from Santa Cruz to Panama City today is to enter your travel dates and hit search. From here, you can sort your results by price to see the cheapest flights first. Right now, return flights from Viru Viru Intl. to Tocumen Intl. start at just £573 and range up to £675.  

To find an even better deal, try  

  • being flexible on your dates – midweek flights can be cheaper
  • looking for other airports near Santa Cruz and Panama City
  • booking your flight during May, the cheapest month on this route
  • varying your flight times – early morning and late at night are sometimes cheaper 

Why you should book your Santa Cruz to Panama City flight with Expedia!

We cater for all flight types, cabin classes and airlines. So whether you’re booking flights from Viru Viru Intl. to Tocumen Intl. for a budget break or a business trip with a bit of pleasure thrown in, we make it easy to secure the seat that’s right for you.  

Thanks to our supersized inventory that offers great choice all in one place, you know you’ll get a great deal with Expedia. Especially if you bundle your flight together with your hotel, you will unlock amazing savings. For added peace of mind, you can choose flexible bookings or filter to find refundable options, so you won’t pay a fee to change your flight.  

Compare flights from Santa Cruz to Panama City easily and book with confidence

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*Available to Expedia members.