--- title: "£437 Cheap Flights from Santa Cruz to Panama City (VVI to PTY) - Expedia.co.uk" description: "Reserve one-way or return flights from Santa Cruz to Panama City with no change fee on selected flights. Earn your airline miles on top of our rewards! Get 2026 flight deals for now!" canonical: "https://www.expedia.co.uk/lp/flights/vvi/pty/santa-cruz-to-panama-city" language: en-GB market: GB currency: GBP prices_as_of: 2026-11-14T23:28:46Z --- # £437 Cheap Flights from Santa Cruz (VVI) to Panama City (PTY) ![A waterfront cityscape with historic buildings and a prominent tower.](https://images.trvl-media.com/place/5854288/59fb0aff-2480-4b30-a547-66acfc92b1e9.jpg?impolicy=fcrop&w=1200&h=500&q=medium) [View £437 flight on Wed, 2 Dec 2026](https://www.expedia.co.uk/Flights-Search?leg1=from:VVI,to:PTY,departure:02/12/2026TANYT&trip=oneway&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:437.00&airProductToken=AQpkCjAIwawBEgMxNjYYtUUgwTMokdmeAzD82p4DOFNAAFgBagVMSUdIVHIIU0VPQjFCUjkKMAjBrAESAjQwGMEzIO%5FEASjz4p4DMNzjngM4U0ABWAFqBUxJR0hUcghTRU9CMUJSORIKCAEQARgBKgJBVhgBIgQIARABKAIoAygEMAE) ## Popular airlines from Santa Cruz (VVI-Viru Viru Intl.) to Tocumen Intl. Airport (PTY) [Avianca](https://www.expedia.co.uk/Flights-Search?leg1=from:VVI,to:PTY,departure:28/11/2026TANYT&leg2=from:PTY,to:VVI,departure:05/12/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"AV"}}]) [Copa](https://www.expedia.co.uk/Flights-Search?leg1=from:VVI,to:PTY,departure:28/11/2026TANYT&leg2=from:PTY,to:VVI,departure:05/12/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"CM"}}]) ### Be in the know Get alerts if flight prices drop or rise\* ### Book smarter Save up to 25% on select hotels after you book a flight\* ### Earn twice Earn your airline miles on top of our rewards [Sign in](https://www.expedia.co.uk/login) ## Cheap Flights from Santa Cruz to Panama City (VVI-PTY) Prices were available within the past 7 days and start at £437 for one-way flights and £629 for return, for the period specified. Prices and availability are subject to change. Additional terms apply. All deals One way Return [Select Copa flight, departing Wed, 6 Jan from Santa Cruz to Panama City, returning Wed, 13 Jan, priced at £629 Found 3 hours ago](https://www.expedia.co.uk/Flights-Search?leg1=from:VVI,to:PTY,departure:06/01/2027TANYT&leg2=from:PTY,to:VVI,departure:13/01/2027TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:628.70&airProductToken=AQozCjEIw5oBEgMyMjAYtUUg78QBKNnmoQMw%5F-ihAzhMQABYAWoFQkFTSUNyCExMQTJNWTJTCjMKMQjDmgESAzEyNxjvxAEgtUUolLiiAzDGuqIDOExAAFgBagVCQVNJQ3IITExBMk1ZMlMSCggBEAEYASoCQ00YASIECAEQASgCKAMoBDAB) Wed, 6 Jan - Wed, 13 Jan · VVI · PTY · From £629 · Return [Select Copa flight, departing Wed, 6 Jan from Santa Cruz to Panama City, returning Wed, 13 Jan, priced at £645 Found 3 hours ago](https://www.expedia.co.uk/Flights-Search?leg1=from:VVI,to:PTY,departure:06/01/2027TANYT&leg2=from:PTY,to:VVI,departure:13/01/2027TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:644.42&airProductToken=AQozCjEIw5oBEgMxMjYYtUUg78QBKNrhoQMw%5FOOhAzhMQABYAWoFQkFTSUNyCExMQTJNWTJTCjMKMQjDmgESAzIyMRjvxAEgtUUoxbqiAzDwvKIDOExAAFgBagVCQVNJQ3IITExBMk1ZMlMSCggBEAEYASoCQ00YASIECAEQASgCKAMoBDAB) Wed, 6 Jan - Wed, 13 Jan · VVI · PTY · From £645 · Return [Select Copa flight, departing Wed, 6 Jan from Santa Cruz to Panama City, returning Wed, 13 Jan, priced at £648 Found 3 hours ago](https://www.expedia.co.uk/Flights-Search?leg1=from:VVI,to:PTY,departure:06/01/2027TANYT&leg2=from:PTY,to:VVI,departure:13/01/2027TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:647.56&airProductToken=AQozCjEIw5oBEgMyMjAYtUUg78QBKNnmoQMw%5F-ihAzhMQABYAWoFQkFTSUNyCExMQTJNWTJTCjMKMQjDmgESAzIyMRjvxAEgtUUoxbqiAzDwvKIDOExAAFgBagVCQVNJQ3IITExBMk1ZMlMSCggBEAEYASoCQ00YASIECAEQASgCKAMoBDAB) Wed, 6 Jan - Wed, 13 Jan · VVI · PTY · From £648 · Return [Select Avianca flight, departing Wed, 2 Dec from Santa Cruz to Panama City, returning Fri, 11 Dec, priced at £650 Found 3 hours ago](https://www.expedia.co.uk/Flights-Search?leg1=from:VVI,to:PTY,departure:02/12/2026TANYT&leg2=from:PTY,to:VVI,departure:11/12/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:649.60&airProductToken=AQpkCjAIwawBEgMxNjYYtUUgwTMokdmeAzD82p4DOFNAAFgBagVMSUdIVHIIU0VBQjFCUjkKMAjBrAESAjQwGMEzIO%5FEASjz4p4DMNzjngM4U0ABWAFqBUxJR0hUcghTRUFCMUJSOQpkCjAIwawBEgI0MRjvxAEgwTMoor6fAzCBv58DOFNAAFgBagVMSUdIVHIIU0VBQjFCUjkKMAjBrAESAzE2NxjBMyC1RSiWx58DMJDJnwM4U0ABWAFqBUxJR0hUcghTRUFCMUJSORIKCAEQARgBKgJBVhgBIgQIARABKAIoAygEMAE) Wed, 2 Dec - Fri, 11 Dec · VVI · PTY · From £650 · Return [Select Copa flight, departing Wed, 6 Jan from Santa Cruz to Panama City, returning Fri, 15 Jan, priced at £654 Found 3 hours ago](https://www.expedia.co.uk/Flights-Search?leg1=from:VVI,to:PTY,departure:06/01/2027TANYT&leg2=from:PTY,to:VVI,departure:15/01/2027TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:653.42&airProductToken=AQozCjEIw5oBEgMxMjYYtUUg78QBKNrhoQMw%5FOOhAzhMQABYAWoFQkFTSUNyCExMQTJNWTJTCjMKMQjDmgESAzEyNxjvxAEgtUUo1M6iAzCG0aIDOExAAFgBagVCQVNJQ3IITExBMk1ZMlMSCggBEAEYASoCQ00YASIECAEQASgCKAMoBDAB) Wed, 6 Jan - Fri, 15 Jan · VVI · PTY · From £654 · Return [Select Avianca flight, departing Wed, 2 Dec from Santa Cruz to Panama City, returning Fri, 11 Dec, priced at £671 Found 3 hours ago](https://www.expedia.co.uk/Flights-Search?leg1=from:VVI,to:PTY,departure:02/12/2026TANYT&leg2=from:PTY,to:VVI,departure:11/12/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:670.59&airProductToken=AQpkCjAIwawBEgMxNjYYtUUgwTMokdmeAzD82p4DOFNAAFgBagVMSUdIVHIIU0VBQjFCUjkKMAjBrAESAjU2GMEzIO%5FEASiR3p4DMP%5FengM4U0ABWAFqBUxJR0hUcghTRUFCMUJSOQpkCjAIwawBEgI1ORjvxAEgwTMo6cGfAzDNwp8DOFNAAFgBagVMSUdIVHIIU0VBQjFCUjkKMAjBrAESAzE2NxjBMyC1RSiWx58DMJDJnwM4U0ABWAFqBUxJR0hUcghTRUFCMUJSORIKCAEQARgBKgJBVhgBIgQIARABKAIoAygEMAE) Wed, 2 Dec - Fri, 11 Dec · VVI · PTY · From £671 · Return [Select Avianca flight, departing Wed, 2 Dec from Santa Cruz to Panama City, returning Fri, 11 Dec, priced at £673 Found 3 hours ago](https://www.expedia.co.uk/Flights-Search?leg1=from:VVI,to:PTY,departure:02/12/2026TANYT&leg2=from:PTY,to:VVI,departure:11/12/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:672.34&airProductToken=AQpkCjAIwawBEgMxNjYYtUUgwTMokdmeAzD82p4DOFNAAFgBagVMSUdIVHIIU0VBQjFCUjkKMAjBrAESAjU2GMEzIO%5FEASiR3p4DMP%5FengM4U0ABWAFqBUxJR0hUcghTRUFCMUJSOQpkCjAIwawBEgI0MRjvxAEgwTMoor6fAzCBv58DOFNAAFgBagVMSUdIVHIIU0VBQjFCUjkKMAjBrAESAzE2NxjBMyC1RSiWx58DMJDJnwM4U0ABWAFqBUxJR0hUcghTRUFCMUJSORIKCAEQARgBKgJBVhgBIgQIARABKAIoAygEMAE) Wed, 2 Dec - Fri, 11 Dec · VVI · PTY · From £673 · Return [Select Avianca flight, departing Wed, 2 Dec from Santa Cruz to Panama City, returning Fri, 11 Dec, priced at £676 Found 3 hours ago](https://www.expedia.co.uk/Flights-Search?leg1=from:VVI,to:PTY,departure:02/12/2026TANYT&leg2=from:PTY,to:VVI,departure:11/12/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:675.61&airProductToken=AQpkCjAIwawBEgMxNjYYtUUgwTMokdmeAzD82p4DOFNAAFgBagVMSUdIVHIIU0VBQjFCUjkKMAjBrAESAjYwGMEzIO%5FEASiO354DMPffngM4U0ABWAFqBUxJR0hUcghTRUFCMUJSOQpkCjAIwawBEgI0MRjvxAEgwTMoor6fAzCBv58DOFNAAFgBagVMSUdIVHIIU0VBQjFCUjkKMAjBrAESAzE2NxjBMyC1RSiWx58DMJDJnwM4U0ABWAFqBUxJR0hUcghTRUFCMUJSORIKCAEQARgBKgJBVhgBIgQIARABKAIoAygEMAE) Wed, 2 Dec - Fri, 11 Dec · VVI · PTY · From £676 · Return [Select Avianca flight, departing Wed, 2 Dec from Santa Cruz to Panama City, returning Thu, 10 Dec, priced at £694 Found 3 hours ago](https://www.expedia.co.uk/Flights-Search?leg1=from:VVI,to:PTY,departure:02/12/2026TANYT&leg2=from:PTY,to:VVI,departure:10/12/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:693.20&airProductToken=AQpkCjAIwawBEgMxNjYYtUUgwTMokdmeAzD82p4DOFNAAFgBagVMSUdIVHIIU0VBQjFCUjkKMAjBrAESAjYwGMEzIO%5FEASiO354DMPffngM4U0ABWAFqBUxJR0hUcghTRUFCMUJSOQpkCjAIwawBEgI2MRjvxAEgwTMotrmfAzCaup8DOFBAAFgBagVMSUdIVHIIUEVBQjFCUkIKMAjBrAESAzE2NxjBMyC1RSj2u58DMPC9nwM4UEABWAFqBUxJR0hUcghQRUFCMUJSQhIKCAEQARgBKgJBVhgBIgQIARABKAIoAygEMAE) Wed, 2 Dec - Thu, 10 Dec · VVI · PTY · From £694 · Return [Select Copa flight, departing Wed, 2 Dec from Santa Cruz to Panama City, returning Thu, 10 Dec, priced at £707 Found 3 hours ago](https://www.expedia.co.uk/Flights-Search?leg1=from:VVI,to:PTY,departure:02/12/2026TANYT&leg2=from:PTY,to:VVI,departure:10/12/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:706.94&airProductToken=AQozCjEIw5oBEgMyMjAYtUUg78QBKObcngMwl9-eAzhFQABYAWoFQkFTSUNyCEVMQTRNWTJTCjMKMQjDmgESAzEyNxjvxAEgtUUo1LmfAzCIvJ8DOEVAAFgBagVCQVNJQ3IIRUxBNE1ZMlMSCggBEAEYASoCQ00YASIECAEQASgCKAMoBDAB) Wed, 2 Dec - Thu, 10 Dec · VVI · PTY · From £707 · Return ## Alternative airports near Panama City Prices were available within the past 7 days. Prices and availability are subject to change. [Select flight to Marcos A. Gelabert Intl. PAC. Closest option available. Average driving time to city centre is 5 minutes.](https://www.expedia.co.uk/Flights-Search?leg1=from:VVI,to:PAC,departure:28/11/2026TANYT&trip=oneway&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&sortOrder=INCREASING&sortType=PRICE) 5 min · Search flights [Select flight to Panama Pacifico Intl. BLB. Average driving time to city centre is 15 minutes.](https://www.expedia.co.uk/Flights-Search?leg1=from:VVI,to:BLB,departure:28/11/2026TANYT&trip=oneway&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&sortOrder=INCREASING&sortType=PRICE) 15 min · Search flights [Select flight to Contadora Island OTD.](https://www.expedia.co.uk/Flights-Search?leg1=from:VVI,to:OTD,departure:28/11/2026TANYT&trip=oneway&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&sortOrder=INCREASING&sortType=PRICE) Search flights ## Find the cheapest month to fly from Santa Cruz (VVI) to Panama City (PTY) ### June is typically the cheapest month to fly From £466 - £1,058 per traveller. View flights in June Insights are based on prices from searches for economy trips of 10 days or less on our sites in the last 12 months. Insights are informative only and current prices may differ. ## Book with confidence ### Compare flights from Santa Cruz to Panama City easily and book with confidence For travelling on business or for pleasure, Expedia makes it easy to book your flights from Santa Cruz to Panama City. Operating between them 2 flights per day, 2 airlines cover the route. And Copa Airlines fly direct, getting you to Tocumen Intl. in just 4hours. If you have a preferred carrier, use our advanced search tool to find the right flight from Viru Viru Intl. to Tocumen Intl.. To make things even better, in the advanced search, you can also choose to fly economy, premium economy, business or first class, select your maximum number of stops, and pick your preferred departure and arrival time. You can also opt for refundable and direct flights. #### Grab a great deal on your flight from Viru Viru Intl. (VVI) to Tocumen Intl. (PTY) The easiest way to view the best deals on flights from Santa Cruz to Panama City today is to enter your travel dates and hit search. From here, you can sort your results by price to see the cheapest flights first. Right now, return flights from Viru Viru Intl. to Tocumen Intl. start at just £629 and range up to £707\. To find an even better deal, try - being flexible on your dates – midweek flights can be cheaper - looking for other airports near Santa Cruz and Panama City - booking your flight during January, the cheapest month on this route - varying your flight times – early morning and late at night are sometimes cheaper #### Why you should book your Santa Cruz to Panama City flight with Expedia! We cater for all flight types, cabin classes and airlines. So whether you’re booking flights from Viru Viru Intl. to Tocumen Intl. for a budget break or a business trip with a bit of pleasure thrown in, we make it easy to secure the seat that’s right for you. Thanks to our supersized inventory that offers great choice all in one place, you know you’ll get a great deal with Expedia. Especially if you bundle your flight together with your hotel, you will unlock amazing savings. For added peace of mind, you can choose flexible bookings or filter to find refundable options, so you won’t pay a fee to change your flight. ## Frequently Asked Questions ### How much does a flight from Santa Cruz (VVI-Viru Viru Intl.) to Panama City (PTY-Tocumen Intl.) cost? You can find one-way and return flights from VVI to PTY with Expedia. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see our cheapest fares first, and use the Price Tracking tool to receive alerts when VVI to PTY ticket fares go up or down. ### What is the cheapest month to fly from Santa Cruz (VVI-Viru Viru Intl.) to Panama City (PTY-Tocumen Intl.)? The cheapest months to fly from VVI to PTY are typically during off-peak season when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you are able to. Use the calendar view in your search to see which months have low fares on this route. ### Which airlines fly direct from Santa Cruz (VVI) to Panama City (PTY)? Enter VVI to PTY and your travel dates, then apply the 'Nonstop' filter to see only direct flights. ### How do I find cheap flights from Santa Cruz (VVI) to Panama City (PTY)? To find a cheap flight from Santa Cruz (VVI) to Panama City (PTY), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up [Price Tracking](https://www.expedia.co.uk/why/price-tracking) and receive alerts when fares go up or down. ### What is the best time to fly from Santa Cruz (VVI-Viru Viru Intl.) to Panama City (PTY-Tocumen Intl.)? The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience. ### What is the earliest flight from Santa Cruz (VVI) to Panama City (PTY)? Sort flights by "Departure (earliest)" on Expedia to find the earliest flight from Santa Cruz (VVI) to Panama City (PTY). To compare more early flights, use the "Early Morning" and "Morning" filters in your search. ### How long does it take to fly from Santa Cruz (VVI-Viru Viru Intl.) to Panama City (PTY-Tocumen Intl.)? Direct flights from VVI to PTY usually take about 5 hours, traveling roughly 3,465 kilometers. If you opt for a connecting flight, expect to add around 6 hours 20 minutes to your journey. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic. ### Can you fly business or first class from Santa Cruz (VVI) to Panama City (PTY)? Select the "Business class" and "First class" filters when looking for Santa Cruz (VVI) to Panama City (PTY) flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip. ### How do I earn miles on a Santa Cruz (VVI) to Panama City (PTY) flight with Expedia? It's easy to earn miles on a Santa Cruz (VVI) to Panama City (PTY) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of [One Key™](https://www.expedia.co.uk/welcome-one-key), you can also earn OneKeyCash™\* on top of your airline miles when you book with Expedia. \*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands. ### Is it cheaper to buy a plane ticket from Santa Cruz (VVI) to Panama City (PTY) at the last minute? Typically, booking a last minute flight from Santa Cruz (VVI) to Panama City (PTY) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare. ### Is it cheaper to book a Santa Cruz (VVI) to Panama City (PTY) flight and hotel package? Securing a Santa Cruz (VVI) to Panama City (PTY) [flight and hotel package](https://www.expedia.co.uk/tocumen.d6053184.holidays-city-breaks) is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars. ### Can I cancel or change the date of my flight from Santa Cruz (VVI) to Panama City (PTY)? If you booked your Santa Cruz (VVI) to Panama City (PTY) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in [your itinerary](https://www.expedia.co.uk/trips) or confirmation email. Or, head to our [Customer Service portal](https://www.expedia.co.uk/helpcenter/) if you'd like more information. ## Travel information | Origin airport | Santa Cruz | | ------------------- | --------------------- | | Destination airport | Tocumen Intl. Airport | | Distance | 2,153 miles away | | Airlines serving | Avianca, Copa | | Popular airline | Avianca | | Return price | £629 | | Average flight time | 4 hours 55 mins | ## Explore a world of travel with Expedia - [Lodging](?equalTargetTab=tab-0) - [Flights](?equalTargetTab=tab-1) - [Packages](?equalTargetTab=tab-2) - [Cars](?equalTargetTab=tab-3) - [Things to Do](?equalTargetTab=tab-4) - [Pleasant HOSTAL PANAMA](https://www.expedia.co.uk/24-De-Diciembre-Hotels-PLEASANT-HOSTAL-PANAMA.h113521121.Hotel-Information) - [Gay-Friendly Hotels in Cerro Azul](https://www.expedia.co.uk/Cerro-Azul-Hotels-Gay-Friendly-Hotel.0-0-d6053185-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - [Charming 3 Bedroom Apartment in San Miguelito](https://www.expedia.co.uk/San-Miguelito-Hotels-Charming-3-Bedroom-Apartment-In-San-Miguelito.h119491061.Hotel-Information) - [Express Inn Panama International Airport Hostel](https://www.expedia.co.uk/Tocumen-Hotels-Express-Inn-Panama-International-Airport-Hostel.h6461097.Hotel-Information) - [Tocumen Hotels](https://www.expedia.co.uk/Tocumen-Hotels.d6053184.Travel-Guide-Hotels) - [Hotels near Tocumen Intl.](https://www.expedia.co.uk/Tocumen-Intl-Airport-Hotels.0-aPTY-0.Travel-Guide-Filter-Hotels) - [Flights to Tocumen](https://www.expedia.co.uk/Cheap-Flights-To-Tocumen.d6053184.Travel-Guide-Flights) - [Ethiopian Airlines Addis Ababa (ADD) to Panama City (PTY) flights](https://www.expedia.co.uk/lp/flight-routes/ethiopian-airlines-from-bole-intl-to-tocumen-intl/et/add/pty) - [Klm London (LHR) to Panama City (PTY) flights](https://www.expedia.co.uk/lp/flight-routes/klm-from-heathrow-to-tocumen-intl/kl/lhr/pty) - [Flights from Auckland (AKL) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/akl/pty/auckland-to-panama-city) - [Flights from Amsterdam (AMS) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/ams/pty/amsterdam-to-panama-city) - [Flights from Atlanta (ATL) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/atl/pty/atlanta-to-panama-city) - [Flights from Barcelona (BCN) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/bcn/pty/barcelona-to-panama-city) - [Flights from Berlin (BER) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/ber/pty/berlin-to-panama-city) - [Flights from Bridgetown (BGI) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/bgi/pty/bridgetown-to-panama-city) - [Flights from Belfast (BHD) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/bhd/pty/belfast-to-panama-city) - [Flights from Birmingham (BHX) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/bhx/pty/birmingham-to-panama-city) - [Flights from Bangkok (BKK) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/bkk/pty/bangkok-to-panama-city) - [Flights from Balboa (BLB) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/blb/pty/balboa-to-panama-city) - [Flights from Bocas del Toro (BOC) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/boc/pty/bocas-del-toro-to-panama-city) - [Flights from Bogotá (BOG) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/bog/pty/bogota-to-panama-city) - [Flights from Mumbai (BOM) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/bom/pty/mumbai-to-panama-city) - [Flights from Bristol (BRS) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/brs/pty/bristol-to-panama-city) - [Flights from Paris (CDG) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/cdg/pty/paris-to-panama-city) - [Flights from Cali (CLO) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/clo/pty/cali-to-panama-city) - [Flights from Cartagena (CTG) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/ctg/pty/cartagena-to-panama-city) - [Flights from Cancun (CUN) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/cun/pty/cancun-to-panama-city) - [Flights from Cardiff (CWL) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/cwl/pty/cardiff-to-panama-city) - [Flights from David (DAV) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/dav/pty/david-to-panama-city) - [Flights from Dublin (DUB) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/dub/pty/dublin-to-panama-city) - [Flights from Durban (DUR) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/dur/pty/durban-to-panama-city) - [Flights from Edinburgh (EDI) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/edi/pty/edinburgh-to-panama-city) - [Flights from East Midlands (EMA) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/ema/pty/east-midlands-to-panama-city) - [Flights from Newark Liberty Intl. Airport (EWR) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/ewr/pty/newark-liberty-intl-airport-to-panama-city) - [Flights from Buenos Aires (EZE) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/eze/pty/buenos-aires-to-panama-city) - [Flights from Fort Lauderdale (FLL) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/fll/pty/fort-lauderdale-to-panama-city) - [Flights from Frankfurt (FRA) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/fra/pty/frankfurt-to-panama-city) - [Flights from George Town (GCM) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/gcm/pty/george-town-to-panama-city) - [Flights from Georgetown (GEO) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/geo/pty/georgetown-to-panama-city) - [Flights from Rio de Janeiro (GIG) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/gig/pty/rio-de-janeiro-to-panama-city) - [Flights from Glasgow (GLA) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/gla/pty/glasgow-to-panama-city) - [Flights from São Paulo (GRU) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/gru/pty/sao-paulo-to-panama-city) - [Flights from Guatemala City (GUA) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/gua/pty/guatemala-city-to-panama-city) - [Flights from Houston (IAH) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/iah/pty/houston-to-panama-city) - [Flights from Istanbul (IST) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/ist/pty/istanbul-to-panama-city) - [Flights from New York (JFK) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/jfk/pty/new-york-to-panama-city) - [Flights from Johannesburg (JNB) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/jnb/pty/johannesburg-to-panama-city) - [Flights from Kingston (KIN) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/kin/pty/kingston-to-panama-city) - [Flights from Kuala Lumpur (KUL) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/kul/pty/kuala-lumpur-to-panama-city) - [Flights from Los Angeles (LAX) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/lax/pty/los-angeles-to-panama-city) - [Flights from Leeds (LBA) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/lba/pty/leeds-to-panama-city) - [Flights from London (LCY) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/lcy/pty/london-to-panama-city) - [Flights from London (LGW) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/lgw/pty/london-to-panama-city) - [Flights from London (LHR) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/lhr/pty/london-to-panama-city) - [Flights from Lima (LIM) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/lim/pty/lima-to-panama-city) - [Flights from Liberia (LIR) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/lir/pty/liberia-to-panama-city) - [Flights from London (LON) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/lon/pty/london-to-panama-city) - [Flights from Liverpool (LPL) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/lpl/pty/liverpool-to-panama-city) - 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[Flights from Newcastle (NCL) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/ncl/pty/newcastle-to-panama-city) - [Flights from Norwich (NWI) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/nwi/pty/norwich-to-panama-city) - [Flights from Phoenix (PHX) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/phx/pty/phoenix-to-panama-city) - [Flights from Port of Spain (POS) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/pos/pty/port-of-spain-to-panama-city) - [Flights from Puerto Escondido (PXM) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/pxm/pty/puerto-escondido-to-panama-city) - [Flights from Santiago (SCL) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/scl/pty/santiago-to-panama-city) - [Flights from Santo Domingo (SDQ) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/sdq/pty/santo-domingo-to-panama-city) - [Flights from San José (SJO) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/sjo/pty/san-jose-to-panama-city) - [Flights from Santa Marta (SMR) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/smr/pty/santa-marta-to-panama-city) - [Flights from Southampton (SOU) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/sou/pty/southampton-to-panama-city) - [Flights from Tamarindo (TNO) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/tno/pty/tamarindo-to-panama-city) - [Flights from Quito (UIO) to Panama City (PTY)](https://www.expedia.co.uk/lp/flights/uio/pty/quito-to-panama-city) - [Visit Costa del Este](https://www.expedia.co.uk/Panama-City-Costa-Del-Este.dx3000663480) - [Visit Juan Diaz](https://www.expedia.co.uk/Panama-City-Juan-Diaz.dx553248623199113945) - [Rental cars Tocumen Intl. airport](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Tocumen-Intl.d5854288.Car-Hire-Guide) - [Things to do in Cerro Azul](https://www.expedia.co.uk/Things-To-Do-In-Cerro-Azul.d6053185.Travel-Guide-Activities) - [Things to do in Tocumen](https://www.expedia.co.uk/Things-To-Do-In-Tocumen.d6053184.Travel-Guide-Activities) \*Available to Expedia members. ## Other language versions ```yaml hreflang: x-default: https://www.expedia.com/lp/flights/vvi/pty/santa-cruz-to-panama-city es-ES: https://www.expedia.es/lp/vuelos/vvi/pty/santa-cruz-a-panama es: https://www.expedia.com/es/lp/vuelos/vvi/pty/santa-cruz-a-panama en-CA: https://www.expedia.ca/lp/flights/vvi/pty/santa-cruz-to-panama-city ar: https://www.expedia.sa/lp/flights/vvi/pty/santa-cruz-to-panama-city en-US: https://www.expedia.com/lp/flights/vvi/pty/santa-cruz-to-panama-city en-GB: https://www.expedia.co.uk/lp/flights/vvi/pty/santa-cruz-to-panama-city es-MX: https://www.expedia.mx/lp/vuelos/vvi/pty/santa-cruz-a-panama de-DE: https://www.expedia.de/lp/fluge/vvi/pty/santa-cruz-nach-panama-stadt ```