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£151 Cheap Flights from Medellín (MDE) to Panama City (PTY)

View £151 flight on Fri, 28 Aug 2026Opens in a new window

Popular airlines from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY)

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Cheap Flights from Medellín (MDE) to Panama City (PTY)

Prices were available within the past 7 days and start at £151 for one-way flights and £243 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

avianca
Fri, 14 Aug - Tue, 25 Aug
MDE
Medellín
PTY
Panama City
£243 Return, found 5 hours ago
£243
Return
found 5 hours ago
Select avianca flight, departing Fri, 14 Aug from Medellín to Panama City, returning Tue, 25 Aug, priced at £243 found 5 hours ago
avianca
Sat, 15 Aug - Mon, 17 Aug
MDE
Medellín
PTY
Panama City
£246 Return, found 5 hours ago
£246
Return
found 5 hours ago
Select avianca flight, departing Sat, 15 Aug from Medellín to Panama City, returning Mon, 17 Aug, priced at £246 found 5 hours ago
avianca
Fri, 14 Aug - Tue, 25 Aug
MDE
Medellín
PTY
Panama City
£254 Return, found 5 hours ago
£254
Return
found 5 hours ago
Select avianca flight, departing Fri, 14 Aug from Medellín to Panama City, returning Tue, 25 Aug, priced at £254 found 5 hours ago
avianca
Thu, 29 Oct - Mon, 2 Nov
MDE
Medellín
PTY
Panama City
£256 Return, found 5 days ago
£256
Return
found 5 days ago
Select avianca flight, departing Thu, 29 Oct from Medellín to Panama City, returning Mon, 2 Nov, priced at £256 found 5 days ago
Copa
Sat, 31 Oct - Mon, 2 Nov
MDE
Medellín
PTY
Panama City
£256 Return, found 5 hours ago
£256
Return
found 5 hours ago
Select Copa flight, departing Sat, 31 Oct from Medellín to Panama City, returning Mon, 2 Nov, priced at £256 found 5 hours ago
avianca
Wed, 26 Aug - Thu, 27 Aug
MDE
Medellín
PTY
Panama City
£257 Return, found 9 hours ago
£257
Return
found 9 hours ago
Select avianca flight, departing Wed, 26 Aug from Medellín to Panama City, returning Thu, 27 Aug, priced at £257 found 9 hours ago
avianca
Tue, 25 Aug - Fri, 28 Aug
MDE
Medellín
PTY
Panama City
£264 Return, found 1 day ago
£264
Return
found 1 day ago
Select avianca flight, departing Tue, 25 Aug from Medellín to Panama City, returning Fri, 28 Aug, priced at £264 found 1 day ago
avianca
Tue, 25 Aug - Fri, 28 Aug
MDE
Medellín
PTY
Panama City
£268 Return, found 1 day ago
£268
Return
found 1 day ago
Select avianca flight, departing Tue, 25 Aug from Medellín to Panama City, returning Fri, 28 Aug, priced at £268 found 1 day ago
avianca
Thu, 29 Oct - Mon, 2 Nov
MDE
Medellín
PTY
Panama City
£268 Return, found 5 days ago
£268
Return
found 5 days ago
Select avianca flight, departing Thu, 29 Oct from Medellín to Panama City, returning Mon, 2 Nov, priced at £268 found 5 days ago
avianca
Sat, 12 Dec - Fri, 1 Jan
MDE
Medellín
PTY
Panama City
£272 Return, found 9 hours ago
£272
Return
found 9 hours ago
Select avianca flight, departing Sat, 12 Dec from Medellín to Panama City, returning Fri, 1 Jan, priced at £272 found 9 hours ago

Find the cheapest month to fly from Medellín (MDE) to Panama City (PTY)

August is typically the cheapest month to fly

From £213 - £263 per traveller.

Frequently asked questions

How much does a flight from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.) cost?
You can find one-way and return flights from MAN to GDZ with Expedia. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see our cheapest fares first, and use the Price Tracking tool to receive alerts when MDE to PTY ticket fares go up or down.
What is the cheapest month to fly from Medellín (MDE) to Panama City (PTY)?
The cheapest months to fly from Medellín (MDE) to Panama City (PTY) are typically during off-peak season when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you are able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Medellín (MDE) to Panama City (PTY)?
Enter MDE to PTY and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
How do I find cheap flights from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.)?
To find a cheap flight from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best airline to fly with from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.)?
The best airline to fly with from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.) will differ from traveler to traveler. If you like to fly early, Copa offers early morning flights. If price is the most important factor, Copa typically offers the lowest fares. Avianca offers the most daily flights from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.), which is great if flexibility is what you value most. The best carrier for this journey could also be the one you have a loyalty membership with, as flying with that airline or another airline within the same alliance could help you collect points or enjoy lounge access.
What is the best time to fly from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.)?
The cheapest months to fly from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.) are typically May and November, with average return flights around £231. The most popular months for this route are February and April, meaning you'll find plenty of flight options during these times. While there isn't a single month that is both the cheapest and most popular, if you're looking for the best value, May and November offer more affordable fares. If having a wide selection of flights is your priority, February and April are excellent choices.
How many flights per day from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.)?
You'll find around 8 nonstop flights per day from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.). For even more choices, look at flights that include layovers, as there are approximately 25 connecting flights per day. Some common connection points include El Dorado Intl. (BOG), George Bush Intercontinental (IAH), and El Salvador Intl. (SAL).
What is the earliest flight from Medellín (MDE) to Panama City (PTY)?
Sort flights by "Departure (earliest)" on Expedia to find the earliest flight from Medellín (MDE) to Panama City (PTY). To compare more early flights, use the "Early Morning" and "Morning" filters in your search.
What day of the week has the most flights from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.)?
You'll generally find the most flights from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.) on a Friday, with around 34 flights available. This gives you a good selection of options for your travel plans. Major airlines on this route include Avianca, Copa, and C.A.I Second S.P.A. Flight schedules are quite consistent throughout the week, so you'll have plenty of choices no matter when you decide to fly.
What are the most popular departure times for flights from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.)?
The most popular departure times for flights from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.) are between 9am and 12pm. Many major carriers, including Avianca, Copa and C.A.I Second S.P.A, offer flights during this window. Many travellers prefer these times as they allow for a relaxed start to the day and an afternoon arrival, giving you time to settle in.
How long does it take to fly from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.)?
Direct flights from MDE to PTY usually take about 1 hour 30 minutes, traveling roughly 542 kilometers. If you opt for a connecting flight, expect to add around 13 hours 50 minutes to your journey. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.)?
You can fly business class between MDE and PTY. Airlines that offer business class service on this route include:
  • Avianca
  • Copa
  • Aeromexico
How do I earn miles on a Medellín (MDE) to Panama City (PTY) flight with Expedia?
It's easy to earn miles on a It'Medellín (MDE)Panama City (PTY) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
Is it cheaper to buy a plane ticket from Medellín (MDE) to Panama City (PTY) at the last minute?
Typically, booking a last minute flight from Medellín (MDE)Panama City (PTY) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Medellín (MDE) to Panama City (PTY) flight and hotel package?
Securing a Medellín (MDE)Panama City (PTY) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.)?
If you booked your Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
José María Córdova Intl.
Destination airport
Tocumen Intl.
Airlines serving
Copa, avianca
Return price
£242
Distance
539 km
Average flight time
1 hour 27 mins

Book with confidence

Compare flights from Medellín to Panama City easily and book with confidence

For travelling on business or for pleasure, Expedia makes it easy to book your flights from Medellín to Panama City. Operating between them flights per day, 20 airlines cover the route. And fly direct, getting you to Tocumen Intl. in just hours. If you have a preferred carrier, use our advanced search tool to find the right flight from José María Córdova Intl. to Tocumen Intl..  

To make things even better, in the advanced search, you can also choose to fly economy, premium economy, business or first class, select your maximum number of stops, and pick your preferred departure and arrival time. You can also opt for refundable and direct flights. 

Grab a great deal on your flight from José María Córdova Intl. (MDE) to Tocumen Intl. (PTY)

The easiest way to view the best deals on flights from Medellín to Panama City today is to enter your travel dates and hit search. From here, you can sort your results by price to see the cheapest flights first. Right now, return flights from José María Córdova Intl. to Tocumen Intl. start at just £243 and range up to £272.  

To find an even better deal, try  

  • being flexible on your dates – midweek flights can be cheaper
  • looking for other airports near Medellín and Panama City
  • booking your flight during August, the cheapest month on this route
  • varying your flight times – early morning and late at night are sometimes cheaper 

Why you should book your Medellín to Panama City flight with Expedia!

We cater for all flight types, cabin classes and airlines. So whether you’re booking flights from José María Córdova Intl. to Tocumen Intl. for a budget break or a business trip with a bit of pleasure thrown in, we make it easy to secure the seat that’s right for you.  

Thanks to our supersized inventory that offers great choice all in one place, you know you’ll get a great deal with Expedia. Especially if you bundle your flight together with your hotel, you will unlock amazing savings. For added peace of mind, you can choose flexible bookings or filter to find refundable options, so you won’t pay a fee to change your flight.  

Compare flights from Medellín to Panama City easily and book with confidence

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*Available to Expedia members.