£149 Cheap Flights from Medellín (MDE) to Panama City (PTY)

View £149 flight on Wed, 13 May 2026Opens in a new window

Flight 1

Popular airlines from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY)

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Cheap Flights from Medellín (MDE) to Panama City (PTY)

Prices were available within the past 7 days and start at £149 for one-way flights and £258 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Wed, 13 May - Wed, 20 May
MDE
Medellín
PTY
Panama City
£258 Return, found 1 day ago
£258
Return
found 1 day ago
Select Copa flight, departing Wed, 13 May from Medellín to Panama City, returning Wed, 20 May, priced at £258 found 1 day ago
Copa
Thu, 14 May - Sun, 17 May
MDE
Medellín
PTY
Panama City
£259 Return, found 6 days ago
£259
Return
found 6 days ago
Select Copa flight, departing Thu, 14 May from Medellín to Panama City, returning Sun, 17 May, priced at £259 found 6 days ago
Copa
Fri, 15 May - Mon, 18 May
MDE
Medellín
PTY
Panama City
£260 Return, found 9 hours ago
£260
Return
found 9 hours ago
Select Copa flight, departing Fri, 15 May from Medellín to Panama City, returning Mon, 18 May, priced at £260 found 9 hours ago
avianca
Fri, 15 May - Mon, 18 May
MDE
Medellín
PTY
Panama City
£264 Return, found 9 hours ago
£264
Return
found 9 hours ago
Select avianca flight, departing Fri, 15 May from Medellín to Panama City, returning Mon, 18 May, priced at £264 found 9 hours ago
avianca
Thu, 21 May - Thu, 28 May
MDE
Medellín
PTY
Panama City
£264 Return, found 5 days ago
£264
Return
found 5 days ago
Select avianca flight, departing Thu, 21 May from Medellín to Panama City, returning Thu, 28 May, priced at £264 found 5 days ago
Copa
Thu, 11 Jun - Thu, 18 Jun
MDE
Medellín
PTY
Panama City
£266 Return, found 4 days ago
£266
Return
found 4 days ago
Select Copa flight, departing Thu, 11 Jun from Medellín to Panama City, returning Thu, 18 Jun, priced at £266 found 4 days ago
Copa
Fri, 15 May - Mon, 18 May
MDE
Medellín
PTY
Panama City
£269 Return, found 9 hours ago
£269
Return
found 9 hours ago
Select Copa flight, departing Fri, 15 May from Medellín to Panama City, returning Mon, 18 May, priced at £269 found 9 hours ago
avianca
Thu, 21 May - Thu, 28 May
MDE
Medellín
PTY
Panama City
£271 Return, found 5 days ago
£271
Return
found 5 days ago
Select avianca flight, departing Thu, 21 May from Medellín to Panama City, returning Thu, 28 May, priced at £271 found 5 days ago
avianca
Thu, 4 Jun - Tue, 9 Jun
MDE
Medellín
PTY
Panama City
£271 Return, found 2 days ago
£271
Return
found 2 days ago
Select avianca flight, departing Thu, 4 Jun from Medellín to Panama City, returning Tue, 9 Jun, priced at £271 found 2 days ago
Copa
Wed, 13 May - Wed, 20 May
MDE
Medellín
PTY
Panama City
£273 Return, found 1 day ago
£273
Return
found 1 day ago
Select Copa flight, departing Wed, 13 May from Medellín to Panama City, returning Wed, 20 May, priced at £273 found 1 day ago

Frequently asked questions

How much does a flight from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.) cost?
One-way flights typically cost between £125 and £353 and return flights often range between £125 and £353. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Anaa (AAA) to Toronto, ON (YYZ-Pearson Intl.) ticket fares go up or down.
What is the cheapest month to fly from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.)?
May is typically the cheapest month to fly from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.), with average return fares of approximately £231. This is about 10% lower than the average price throughout the year. May often sees lower prices as it falls outside of major holiday periods, leading to reduced demand. Other cheap months to fly from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.) include April and November.
Which airlines fly direct from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.)?
Enter MDE to PTY and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
How do I find cheap flights from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.)?
To find a cheap flight from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best airline to fly with from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.)?
The best airline to fly with from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.) will differ from traveller to traveller. If you like to fly early, CM offers early morning flights. If price is the most important factor, CM typically offers the lowest fares. AV offers the most daily flights from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.), which is brilliant if flexibility is what you value most. The best carrier for this journey could also be the one you have a loyalty membership with, as flying with that airline or another airline within the same alliance could help you collect points or enjoy lounge access.
What is the best time to fly from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.)?
When looking for the best time to fly from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.), you'll find that May and November are typically the cheapest months, with average return flights around £231. However, the most popular months for this route are October and July, which means you'll have plenty of flight options during those times. While there isn't a single month that is both the cheapest and most popular, you can balance your priorities by considering May or November for better value, or October and July for more schedule flexibility, based on booking data from the past year.
How many flights per day from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.)?
There are approximately 8 nonstop flights per day from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.). For even more choice, look at flights that include layovers, as there are around 28 connecting flights per day. Some common connection points include El Dorado Intl. (BOG), George Bush Intercontinental (IAH), and El Salvador Intl. (SAL).
What is the earliest flight from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.)?
The earliest flight from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.) typically departs at approximately 12:00 AM local time, operated by Aeromexico. This is a seasonal service active in September. An early departure like this can help maximise your time at your destination. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What day of the week has the most flights from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.)?
You'll typically find the most flights from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.) on a Wednesday, with around 35 flights available. This gives you a good selection of options for your travel plans. Major airlines on this route include AV, CM, and VE. Flight schedules are consistent throughout the week, so you'll have plenty of options no matter when you choose to fly.
What are the most popular departure times for flights from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.)?
The most popular departure times for flights from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.) are in the early morning, between 6am and 9am. This accounts for around 21% of total traffic. Many major carriers, including Avianca, Copa and Conviasa, offer flights during this window. Many travelers prefer these times as they allow for an early start to their journey, getting you to your destination with plenty of time left in the day.
How long does it take to fly from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.)?
A nonstop flight from MDE to PTY typically takes around 1 hour 30 minutes, covering approximately 337 miles. Connecting flights on this route usually add 16 hours 50 minutes to your travel time. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.)?
Select the "Business class" and "First class" filters when looking for MDE to PTY flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.
How do I earn miles on a Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.) flight with Expedia?
It's easy to earn miles on a Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia. *Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Panama City from Jose Maria Cordova Intl. (MDE)?
When traveling from Jose Maria Cordova Intl. (MDE) to Panama City, you can fly into Northwest Florida Beaches Intl. (ECP) and Tocumen Intl. (PTY). Some flights may connect through major hubs like Miami Intl. (MIA), El Dorado Intl. (BOG), Jorge Chavez Intl. (LIM) before reaching Panama City. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.) at the last minute?
Typically, booking a last minute flight from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.) flight and hotel package?
Securing a Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.)?
If you booked your Medellín (MDE-José María Córdova Intl.) to Panama City (PTY-Tocumen Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
José María Córdova Intl.
Destination airport
Tocumen Intl.
Airlines serving
Copa, avianca
Return price
£256
Distance
539 km
Average flight time
1 hour 28 mins

Book with confidence

Compare flights from Medellín to Panama City easily and book with confidence

For travelling on business or for pleasure, Expedia makes it easy to book your flights from Medellín to Panama City. Operating between them flights per day, 20 airlines cover the route. And fly direct, getting you to Tocumen Intl. in just hours. If you have a preferred carrier, use our advanced search tool to find the right flight from José María Córdova Intl. to Tocumen Intl..  

To make things even better, in the advanced search, you can also choose to fly economy, premium economy, business or first class, select your maximum number of stops, and pick your preferred departure and arrival time. You can also opt for refundable and direct flights. 

Grab a great deal on your flight from José María Córdova Intl. (MDE) to Tocumen Intl. (PTY)

The easiest way to view the best deals on flights from Medellín to Panama City today is to enter your travel dates and hit search. From here, you can sort your results by price to see the cheapest flights first. Right now, return flights from José María Córdova Intl. to Tocumen Intl. start at just £258 and range up to £446.  

To find an even better deal, try  

  • being flexible on your dates – midweek flights can be cheaper
  • looking for other airports near Medellín and Panama City
  • booking your flight during May, the cheapest month on this route
  • varying your flight times – early morning and late at night are sometimes cheaper 

Why you should book your Medellín to Panama City flight with Expedia!

We cater for all flight types, cabin classes and airlines. So whether you’re booking flights from José María Córdova Intl. to Tocumen Intl. for a budget break or a business trip with a bit of pleasure thrown in, we make it easy to secure the seat that’s right for you.  

Thanks to our supersized inventory that offers great choice all in one place, you know you’ll get a great deal with Expedia. Especially if you bundle your flight together with your hotel, you will unlock amazing savings. For added peace of mind, you can choose flexible bookings or filter to find refundable options, so you won’t pay a fee to change your flight.  

Compare flights from Medellín to Panama City easily and book with confidence

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*Available to Expedia members.