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£137 Cheap Flights from Mexico City (MEX) to Panama City (PTY)

View £137 flight on Wed, 5 Aug 2026Opens in a new window

Popular airlines from Benito Juarez International Airport (MEX) to Tocumen Intl. Airport (PTY)

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Cheap Flights from Mexico City (MEX) to Panama City (PTY)

Prices were available within the past 7 days and start at £137 for one-way flights and £309 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Aeromexico
Sat, 15 Aug - Wed, 19 Aug
MEX
Mexico City
PTY
Panama City
£309 Return, found 2 days ago
£309
Return
found 2 days ago
Select Aeromexico flight, departing Sat, 15 Aug from Mexico City to Panama City, returning Wed, 19 Aug, priced at £309 found 2 days ago
Aeromexico
Thu, 13 Aug - Mon, 17 Aug
MEX
Mexico City
PTY
Panama City
£310 Return, found 1 day ago
£310
Return
found 1 day ago
Select Aeromexico flight, departing Thu, 13 Aug from Mexico City to Panama City, returning Mon, 17 Aug, priced at £310 found 1 day ago
Aeromexico
Tue, 25 Aug - Tue, 8 Sept
MEX
Mexico City
PTY
Panama City
£317 Return, found 6 days ago
£317
Return
found 6 days ago
Select Aeromexico flight, departing Tue, 25 Aug from Mexico City to Panama City, returning Tue, 8 Sept, priced at £317 found 6 days ago
Aeromexico
Wed, 4 Nov - Thu, 26 Nov
MEX
Mexico City
PTY
Panama City
£322 Return, found 6 days ago
£322
Return
found 6 days ago
Select Aeromexico flight, departing Wed, 4 Nov from Mexico City to Panama City, returning Thu, 26 Nov, priced at £322 found 6 days ago
Aeromexico
Tue, 25 Aug - Tue, 8 Sept
MEX
Mexico City
PTY
Panama City
£324 Return, found 6 days ago
£324
Return
found 6 days ago
Select Aeromexico flight, departing Tue, 25 Aug from Mexico City to Panama City, returning Tue, 8 Sept, priced at £324 found 6 days ago
Aeromexico
Thu, 29 Oct - Thu, 26 Nov
MEX
Mexico City
PTY
Panama City
£330 Return, found 6 days ago
£330
Return
found 6 days ago
Select Aeromexico flight, departing Thu, 29 Oct from Mexico City to Panama City, returning Thu, 26 Nov, priced at £330 found 6 days ago
avianca
Thu, 27 Aug - Mon, 31 Aug
MEX
Mexico City
PTY
Panama City
£331 Return, found 4 days ago
£331
Return
found 4 days ago
Select avianca flight, departing Thu, 27 Aug from Mexico City to Panama City, returning Mon, 31 Aug, priced at £331 found 4 days ago
Copa
Sat, 15 Aug - Wed, 19 Aug
MEX
Mexico City
PTY
Panama City
£347 Return, found 2 days ago
£347
Return
found 2 days ago
Select Copa flight, departing Sat, 15 Aug from Mexico City to Panama City, returning Wed, 19 Aug, priced at £347 found 2 days ago
United
Wed, 3 Feb - Tue, 2 Mar
MEX
Mexico City
PTY
Panama City
£850 Return, found 1 day ago
£850
Return
found 1 day ago
Select United flight, departing Wed, 3 Feb from Mexico City to Panama City, returning Tue, 2 Mar, priced at £850 found 1 day ago
American Airlines
Wed, 3 Feb - Tue, 2 Mar
MEX
Mexico City
PTY
Panama City
£869 Return, found 1 day ago
£869
Return
found 1 day ago
Select American Airlines flight, departing Wed, 3 Feb from Mexico City to Panama City, returning Tue, 2 Mar, priced at £869 found 1 day ago

Alternative airports near Panama City

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Tocumen Intl. PTY. Cheapest option available. Average driving time to city centre is 16 minutes. Flights from £537
PTY
Tocumen Intl.
Cheapest
Average driving time to city centre16 min
Flights from £537

Find the cheapest month to fly from Mexico City (MEX) to Panama City (PTY)

April is typically the cheapest month to fly

From £229 - £300 per traveller.

Frequently asked questions

How much does a flight from Mexico City (MEX) to Panama City (PTY) cost?
You can find one-way and return flights from Mexico City (MEX) to Panama City (PTY) with Expedia. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see our cheapest fares first, and use the Price Tracking tool to receive alerts when MEX to PTY ticket fares go up or down.
What is the cheapest month to fly from Mexico City (MEX) to Panama City (PTY)?
The cheapest months to fly from Mexico City (MEX) to Panama City (PTY) are typically during off-peak season when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you are able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Mexico City (MEX) to Panama City (PTY)?
Enter MEX to PTY and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Mexico City (MEX-Mexico City Intl.) to Panama City (PTY-Tocumen Intl.)?
Aeromexico is one of the cheapest airlines offering nonstop return flights from Mexico City (MEX-Mexico City Intl.) to Panama City (PTY-Tocumen Intl.), with tickets starting from around £269 for flights that can be booked for departure within the next year. Avianca offers one of the cheapest connecting return flights from Mexico City (MEX-Mexico City Intl.) to Panama City (PTY-Tocumen Intl.) with a layover in El Salvador Intl. (SAL), starting from around £270. These prices are per adult for economy/coach class. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.
How do I find cheap flights from Mexico City (MEX) to Panama City (PTY)?
To find a cheap flight from Mexico City (MEX) to Panama City (PTY), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Mexico City (MEX-Mexico City Intl.) to Panama City (PTY-Tocumen Intl.)?
The best time to fly from Mexico City (MEX) to Panama City (PTY) is typically February or January. These months offer the most affordable return flights, with average prices around £340. While these aren't the most popular months for travel, you can still find good flight options, especially if you book in advance. This information is Giving you a good idea of historical trends.
What is the earliest flight from Mexico City (MEX) to Panama City (PTY)?
Sort flights by "Departure (earliest)" on Expedia to find the earliest flight from Mexico City (MEX) to Panama City (PTY). To compare more early flights, use the "Early Morning" and "Morning" filters in your search.
How long does it take to fly from Mexico City (MEX-Mexico City Intl.) to Panama City (PTY-Tocumen Intl.)?
A nonstop flight from MEX to PTY typically takes around 3 hours 50 minutes, covering approximately 2,412 kilometers. Connecting flights on this route usually add 4 hours 10 minutes to your travel time. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Mexico City (MEX) to Panama City (PTY)?
Select the "Business class" and "First class" filters when looking for Mexico City (MEX) to Panama City (PTY) flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.
How do I earn miles on a Mexico City (MEX) to Panama City (PTY) flight with Expedia?
It's easy to earn miles on a Mexico City (MEX) to Panama City (PTY) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
Is it cheaper to buy a plane ticket from Mexico City (MEX) to Panama City (PTY) at the last minute?
Typically, booking a last minute flight from Mexico City (MEX) to Panama City (PTY) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Mexico City (MEX) to Panama City (PTY) flight and hotel package?
Securing a Mexico City (MEX) to Panama City (PTY) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Mexico City (MEX) to Panama City (PTY)?
If you booked your Mexico City (MEX) to Panama City (PTY) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Mexico City Intl.
Destination airport
Tocumen Intl.
Airlines serving
Aeromexico, Copa, avianca
Return price
£308
Distance
2397 km
Average flight time
4 hours 46 mins

Book with confidence

Compare flights from Mexico City to Panama City easily and book with confidence

For travelling on business or for pleasure, Expedia makes it easy to book your flights from Mexico City to Panama City. Operating between them flights per day, 20 airlines cover the route. And fly direct, getting you to Tocumen Intl. in just hours. If you have a preferred carrier, use our advanced search tool to find the right flight from Mexico City Intl. to Tocumen Intl..  

To make things even better, in the advanced search, you can also choose to fly economy, premium economy, business or first class, select your maximum number of stops, and pick your preferred departure and arrival time. You can also opt for refundable and direct flights. 

Grab a great deal on your flight from Mexico City Intl. (MEX) to Tocumen Intl. (PTY)

The easiest way to view the best deals on flights from Mexico City to Panama City today is to enter your travel dates and hit search. From here, you can sort your results by price to see the cheapest flights first. Right now, return flights from Mexico City Intl. to Tocumen Intl. start at just £309 and range up to £869.  

To find an even better deal, try  

  • being flexible on your dates – midweek flights can be cheaper
  • looking for other airports near Mexico City and Panama City
  • booking your flight during August, the cheapest month on this route
  • varying your flight times – early morning and late at night are sometimes cheaper 

Why you should book your Mexico City to Panama City flight with Expedia!

We cater for all flight types, cabin classes and airlines. So whether you’re booking flights from Mexico City Intl. to Tocumen Intl. for a budget break or a business trip with a bit of pleasure thrown in, we make it easy to secure the seat that’s right for you.  

Thanks to our supersized inventory that offers great choice all in one place, you know you’ll get a great deal with Expedia. Especially if you bundle your flight together with your hotel, you will unlock amazing savings. For added peace of mind, you can choose flexible bookings or filter to find refundable options, so you won’t pay a fee to change your flight.  

Compare flights from Mexico City to Panama City easily and book with confidence

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*Available to Expedia members.