Southwest Illinois adults only hotels from £54

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Top Adults only hotels in Southwest Illinois

The Principal Hotel
3.5 out of 5
310 S Main St, Columbia, IL
The price is £86 per night from 14 Aug to 15 Aug
£86
14 Aug - 15 Aug
includes taxes & fees
9.8/10 Exceptional! (115 reviews)
"wonderful place"

Reviewed on 6 Aug 2025

The Principal Hotel
Drury Plaza Hotel Mt. Vernon
3 out of 5
145 North 44th Street , Mount Vernon, IL
The price is £79 per night from 31 Aug to 1 Sept
£79
31 Aug - 1 Sept
includes taxes & fees
9.6/10 Exceptional! (1,412 reviews)
"Cannot think what would make it better; maybe a more refined dinner cuisine."

Reviewed on 9 Aug 2025

Drury Plaza Hotel Mt. Vernon
Drury Inn & Suites St. Louis Collinsville
3 out of 5
602 N Bluff Rd, Collinsville, IL
The price is £91 per night from 17 Aug to 18 Aug
£91
17 Aug - 18 Aug
includes taxes & fees
9.6/10 Exceptional! (1,005 reviews)
"Super comfy beds! Such nice staff as well!"

Reviewed on 10 Aug 2025

Drury Inn & Suites St. Louis Collinsville
Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
2.5 out of 5
120 MUDDY MONSTER ROAD, Murphysboro, IL
The price is £86 per night from 17 Aug to 18 Aug
£86
17 Aug - 18 Aug
includes taxes & fees
9.4/10 Exceptional! (460 reviews)
"This location is very clean and the staff is AWESOME! From the first smile at the front desk to continued communication, this place is one to come back to."

Reviewed on 10 Aug 2025

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
Holiday Inn Express & Suites Salem by IHG
2.5 out of 5
102 Holiday Lane, Salem, IL
The price is £94 per night from 1 Sept to 2 Sept
£94
1 Sept - 2 Sept
includes taxes & fees
9.4/10 Exceptional! (715 reviews)
Clean and comfortable with many breakfast options
"Check in was easy, the staff was friendly, the room and bathroom were clean, and the bed was comfortable. There was a lot of exterior space for walking my dog. Breakfast had a lot of choices, including two types of sausage. Why do hotel breakfast eggs have to be so consistently awful though?! Why ..."

Reviewed on 6 Aug 2025

Holiday Inn Express & Suites Salem by IHG
Drury Inn & Suites Marion
3 out of 5
2706 W DeYoung St, Marion, IL
The price is £58 per night from 31 Aug to 1 Sept
£58
31 Aug - 1 Sept
includes taxes & fees
9.2/10 Wonderful! (1,001 reviews)
"You can’t go wron"

Reviewed on 4 Aug 2025

Drury Inn & Suites Marion
SureStay Hotel by Best Western Whittington Rend Lake
2.5 out of 5
13277 Freeway Lane, Whittington, IL
The price is £67 per night from 31 Aug to 1 Sept
£67
31 Aug - 1 Sept
includes taxes & fees
8.8/10 Excellent! (841 reviews)
Clean and Comfortable
"Incredibly clean and comfortable stay! The staff were super friendly and I had one of the best night sleeps of my life haha"

Reviewed on 7 Aug 2025

SureStay Hotel by Best Western Whittington Rend Lake
Holiday Inn Express & Suites Vandalia by IHG
2.5 out of 5
21 Mattes Ave, Vandalia, IL
The price is £96 per night from 14 Aug to 15 Aug
£96
14 Aug - 15 Aug
includes taxes & fees
8.8/10 Excellent! (722 reviews)
"Great breakfast"

Reviewed on 2 Aug 2025

Holiday Inn Express & Suites Vandalia by IHG
Quality Inn & Suites Vandalia near I-70 and Hwy 51
2.5 out of 5
1920 Kennedy Boulevard, Vandalia, IL
The price is £54 per night from 7 Sept to 8 Sept
£54
7 Sept - 8 Sept
includes taxes & fees
8.2/10 Very Good! (1,002 reviews)
Pool is closed
"Overall a good stay. The only complaint we had was that the pool was closed and that was the whole point of us staying here."

Reviewed on 6 Aug 2025

Quality Inn & Suites Vandalia near I-70 and Hwy 51
Best Western Marion Hotel
2.5 out of 5
400 Comfort Dr, Marion, IL
The price is £61 per night from 17 Aug to 18 Aug
£61
17 Aug - 18 Aug
includes taxes & fees
8/10 Very Good! (1,001 reviews)
"Clean room - nice accessible shower - firm but comfortable bed - decent breakfast options."

Reviewed on 5 Aug 2025

Best Western Marion Hotel
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Frequently Asked Questions

How can I find the best adults only resorts in Southwest Illinois?

The best adults only resort for you is deeply personal. First off, decide what you want from your dream holiday, then use our filters to bring it to life. Find resorts with hot tubs, spas and incredible views, then check out the reviews to see how other guests enjoyed their stay.

How much does a Southwest Illinois adults-only hotel cost?

With Expedia, you can find adults only hotels from £54 to per night. Prices and availability are subject to change. Additional terms may apply.

How can I find an adults only all-inclusive holiday in Southwest Illinois?

It’s simple. Just select the all-inclusive filter to find the best resorts where you can eat, drink and holiday to your heart’s content.

What can I expect from Southwest Illinois 5-star all-inclusive adults only hotels?

Luxury comes as standard in the 5-star resorts of Southwest Illinois. Step into spotless surroundings, stellar service and all the amenities your heart desires, from spas and pools to casinos and cocktail bars.

Why should I book a Southwest Illinois adults only hotel with entertainment?

When you book an adult only hotel with entertainment, pack your bags to get dolled up for the very best of comedy, cabaret, music, magic and much more – all just steps from your room.

How can I find the best deals on adults only resorts in Southwest Illinois?

To find amazing deals in Southwest Illinois and for a quieter experience, book your holiday in . The more flexible you can be with your dates, the better your chances are of getting a fantastic wallet-friendly deal. You can always check out our latest cheap deals for a little inspiration.

Do adults only hotels in Southwest Illinois offer free cancellation?

Some adults only hotels here offer free cancellation. Some don’t. It’s always best to check before you book. You can filter by free cancellation and pay later options to find resorts with that extra flexibility you want.

Why should I book my adults only resort in Southwest Illinois with Expedia?

At Expedia, we put everything you need to book your dream trip in one place. With a vast selection of incredible adult only accommodation at your fingertips, all that’s left to do is set your sights on what’s right for you.