Title: TOP Southern Illinois Spa Hotels for 2025 - Spas in Southern Illinois, IL | Expedia.co.uk [Southern Illinois Travel Guide](https://expedia.co.uk/Southern-Illinois.dx6233859)[Hotels in Southern Illinois](https://expedia.co.uk/Southern-Illinois-Hotels.d6233859.Travel-Guide-Hotels)[Holiday Rentals in Southern Illinois](https://expedia.co.uk/Southern-Illinois-Holiday-Rentals.d6233859.Travel-Guide-HolidayRentals)[Flights to Southern Illinois](https://expedia.co.uk/Cheap-Flights-To-Southern-Illinois.d6233859.Travel-Guide-Flights)[Southern Illinois Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Southern-Illinois.d6233859.Car-Hire-Guide)[Southern Illinois Holidays](https://expedia.co.uk/Southern-Illinois.d6233859.Holidays-City-Breaks) ![Fort Massac State Park featuring a statue or sculpture, a park and a lake or waterhole](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/208000/208712-Southern-Illinois.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Spa Hotels in Southern Illinois, IL ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Southern Illinois Spa Hotels Tonight [11 Oct - 12 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6233859&startDate=2025-10-11&endDate=2025-10-12&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [12 Oct - 13 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6233859&startDate=2025-10-12&endDate=2025-10-13&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [17 Oct - 19 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6233859&startDate=2025-10-17&endDate=2025-10-19&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [24 Oct - 26 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6233859&startDate=2025-10-24&endDate=2025-10-26&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Southern Illinois Spa Hotels ![Sauna, hot tub, body treatments, hot stone massages](https://images.trvl-media.com/lodging/98000000/97070000/97064800/97064786/aecef3e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, seasonal outdoor pool](https://images.trvl-media.com/lodging/98000000/97070000/97064800/97064786/1aec7f72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/98000000/97070000/97064800/97064786/a0fca68c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sauna, hot tub, body treatments, hot stone massages](https://images.trvl-media.com/lodging/98000000/97070000/97064800/97064786/a53e0f55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Walker's Bluff Casino Resort Carterville 9.4/10 Exceptional (374) "Very nice room, nice scenery not an interstate running thru it" [](https://www.expedia.co.uk/Carterville-Hotels-Walkers-Bluff-Casino-Resort.h97064786.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/479dc559.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down duvets, pillow-top beds, in-room safe](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/eb2507f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free breakfast ](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/5fa70c20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG Cape Girardeau 9.4/10 Exceptional (1004) "It was right off the interstate with lots of restaurant options " £80 includes taxes & fees 26 Oct - 27 Oct [](https://www.expedia.co.uk/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information) ![Property entrance](https://images.trvl-media.com/lodging/12000000/11750000/11746100/11746044/01bd7541.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Room, 1 King Bed, Accessible (Covered Front Porch w Rocking Chairs ) | Balcony](https://images.trvl-media.com/lodging/12000000/11750000/11746100/11746044/d23e6f47.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily cooked-to-order breakfast (USD 17.76 per person)](https://images.trvl-media.com/lodging/12000000/11750000/11746100/11746044/57d753bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillow-top beds, individually decorated](https://images.trvl-media.com/lodging/12000000/11750000/11746100/11746044/66990eff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 1895 Washington Hotel Paducah 9.2/10 Wonderful (378) "An absolutely charming B&B with a great history." [](https://www.expedia.co.uk/Paducah-Hotels-1895-Washington-Hotel.h11746044.Hotel-Information) ![Hot tub, body treatments, hydrotherapy, aromatherapy, body scrubs](https://images.trvl-media.com/lodging/2000000/1880000/1873300/1873292/f78a36b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1880000/1873300/1873292/502ee41b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![6 restaurants, breakfast served](https://images.trvl-media.com/lodging/2000000/1880000/1873300/1873292/d825c5c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Casino](https://images.trvl-media.com/lodging/2000000/1880000/1873300/1873292/c42cf5fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ameristar Casino Resort and Spa St. Charles 8.4/10 Very good (1008) "What a fabulous hotel!!!! Will stay here again next time we're in the area!! " £168 includes taxes & fees 19 Oct - 20 Oct [](https://www.expedia.co.uk/St-Louis-Hotels-Ameristar-Casino-Resort-And-Spa.h1873292.Hotel-Information) ![Exclusive Room, 1 Queen Bed | Memory-foam beds, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/11000000/10240000/10239000/10238981/c47dc13f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Double Room | Bathroom | Shower, hydromassage showerhead, free toiletries, hair dryer](https://images.trvl-media.com/lodging/11000000/10240000/10239000/10238981/44563026.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/11000000/10240000/10239000/10238981/db3c9d42.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/11000000/10240000/10239000/10238981/a9cd898e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Arthur's Country Inn Arthur 8.4/10 Very good (130) "We loved this Inn it was a unique experience in comparison to modern hotels but definitely a nice change. " £88 includes taxes & fees 15 Oct - 16 Oct [](https://www.expedia.co.uk/Champaign-Hotels-Arthurs-Country-Inn.h10238981.Hotel-Information) ![Couples treatment room(s), hot tub, body treatments, aromatherapy](https://images.trvl-media.com/lodging/3000000/2860000/2851500/2851438/56a41562.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop bar](https://images.trvl-media.com/lodging/3000000/2860000/2851500/2851438/89e020ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop bar](https://images.trvl-media.com/lodging/3000000/2860000/2851500/2851438/5b370fff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Couples treatment room(s), hot tub, body treatments, aromatherapy](https://images.trvl-media.com/lodging/3000000/2860000/2851500/2851438/941b0ba8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Four Seasons Hotel St Louis Downtown St. Louis 9.4/10 Exceptional (1002) "Beautiful stay at the four seasons! " £372 includes taxes & fees 28 Oct - 29 Oct [](https://www.expedia.co.uk/St-Louis-Hotels-Four-Seasons-Hotel-St-Louis.h2851438.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/90000000/89170000/89164600/89164592/cd6b7758.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/90000000/89170000/89164600/89164592/fb7f173e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Billiards](https://images.trvl-media.com/lodging/90000000/89170000/89164600/89164592/d516d0f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/90000000/89170000/89164600/89164592/c45fd3f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 21C Museum Hotel St Louis Downtown West 9.0/10 Wonderful (1406) "Wonderful stay! " £138 includes taxes & fees 2 Nov - 3 Nov [](https://www.expedia.co.uk/St-Louis-Hotels-21C-Museum-Hotel-St-Louis.h89164592.Hotel-Information) ![Body treatments, aromatherapy, hot stone massages, deep-tissue massages](https://images.trvl-media.com/lodging/1000000/10000/6200/6132/b7162ce8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/6200/6132/a54897ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/6200/6132/9a597e77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/10000/6200/6132/w4000h2663x0y0-dfd3faff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Ritz-Carlton, St. Louis Clayton 9.2/10 Wonderful (550) "Service is exceptional!!!" £447 includes taxes & fees 26 Oct - 27 Oct [](https://www.expedia.co.uk/St-Louis-Hotels-The-Ritz-Carlton.h6132.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-10-25&endDate=2025-10-26®ionId=6233859&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Find out more about Southern Illinois ### Top Southern Illinois attractions for a relaxing vacation Southern Illinois is a paradise for travellers seeking a blend of relaxation and adventure, particularly for those who appreciate spa accommodations. Begin your journey in the stunning Shawnee National Forest, where you can unwind amidst the lush greenery, with opportunities for hiking, rock climbing, and horseback riding. After a day outdoors, indulge in rejuvenating treatments at nearby spa hotels that offer serene views of the forest. Take a leisurely stroll through the charming town of Carbondale, where you can explore local boutiques and cafes, then retreat to your hotel for a soothing massage or wellness programme. The renowned Giant City State Park provides a perfect backdrop for both relaxation and exploration, featuring unique sandstone cliffs and trails, along with picnic areas ideal for families. For a unique experience, consider a stay at a vineyard or winery in the region, where you can enjoy wine tasting and vineyard tours, followed by a tranquil evening soaking in the spa’s facilities. When you choose to stay in the heart of these experiences, you’ll find attentive service and top hotels that cater to high expectations, making your Southern Illinois getaway memorable. ## Top Southern Illinois Hotel Reviews ![Drury Inn & Suites St. Louis O'Fallon, IL](//images.trvl-media.com/lodging/2000000/1550000/1544100/1544028/d2bc121f_y.jpg) ### Drury Inn & Suites St. Louis O'Fallon, IL 10/10 Excellent "Fast check in. Was a solo female traveler and felt very safe here " [](https://expedia.co.uk/Collinsville-Hotels-Drury-Inn-Suites-St-Louis-OFallon.h1544028.Hotel-Information) ![Drury Inn & Suites St. Louis Fairview Heights](//images.trvl-media.com/lodging/1000000/50000/41900/41802/c56c0460_y.jpg) ### Drury Inn & Suites St. Louis Fairview Heights 10/10 Excellent "The staff is professional and courteous. The room is very clean. The property is well kept. Restaurants are within walking distant. It’s pet friendly." [](https://expedia.co.uk/Collinsville-Hotels-Drury-Inn-Suites-St-Louis-Fairview-Heights.h41802.Hotel-Information) ![Comfort Suites Mount Vernon](//images.trvl-media.com/lodging/2000000/1390000/1387400/1387309/b34f836a_y.jpg) ### Comfort Suites Mount Vernon 10/10 Excellent "Pool open to adults 24 hrs if quiet" [](https://expedia.co.uk/Mount-Vernon-Hotels-Comfort-Suites-Mount-Vernon.h1387309.Hotel-Information) ![Best Western Plus Pontoon Beach](//images.trvl-media.com/lodging/3000000/2700000/2695400/2695352/01153352_y.jpg) ### Best Western Plus Pontoon Beach 10/10 Excellent "Very friendly and clean . Very nice place to stay in the area we were !!! " [](https://expedia.co.uk/St-Louis-Hotels-Best-Western-Plus-Pontoon-Beach.h2695352.Hotel-Information) ![Drury Plaza Hotel Mt. Vernon](//images.trvl-media.com/lodging/1000000/50000/42100/42021/f9296f7b_y.jpg) ### Drury Plaza Hotel Mt. Vernon 10/10 Excellent "Check in staff was friendly and prompt. Room is clean and spacious." 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[Visit McLeansboro](https://www.expedia.co.uk/McLeansboro.dx3000346419) - [Visit Mount Vernon](https://www.expedia.co.uk/Mount-Vernon.dx2463) - [Pheasant Hollow Winery](https://www.expedia.co.uk/Pheasant-Hollow-Winery-Whittington.d6312899.Attraction) - [William Jennings Bryan Boyhood Home and Museum](https://www.expedia.co.uk/William-Jennings-Bryan-Boyhood-Home-And-Museum-Salem.d6187105.Attraction) - [Car hire Whittington](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Whittington.d56062.Car-Hire-Guide) - [People Carrier Car Hire in Flora](https://www.expedia.co.uk/Van-Car-Rentals-In-Flora.d178211-tVan.Car-Rental-Guide-Class) - [Dix Holiday Rentals](https://www.expedia.co.uk/Dix-Holiday-Rentals.d6023670.Travel-Guide-HolidayRentals) - [Enfield Holiday Rentals](https://www.expedia.co.uk/Enfield-Holiday-Rentals.d3000433975.Travel-Guide-HolidayRentals) - [Flora Holiday Rentals](https://www.expedia.co.uk/Flora-Holiday-Rentals.d178211.Travel-Guide-HolidayRentals) - [Nashville Holiday Rentals](https://www.expedia.co.uk/Nashville-Holiday-Rentals.d180762.Travel-Guide-HolidayRentals) - [Odin Holiday Rentals](https://www.expedia.co.uk/Odin-Holiday-Rentals.d3000346479.Travel-Guide-HolidayRentals) - [Sims Holiday Rentals](https://www.expedia.co.uk/Sims-Holiday-Rentals.d3000346582.Travel-Guide-HolidayRentals) - [Book Spa Hotels in Southern Illinois on Expedia.com](https://www.expedia.com/Southern-Illinois-Hotels-Spa-Hotel.0-0-d6233859-tSpaHotel.Travel-Guide-Filter-Hotels)