A forested valley with autumn foliage, a rocky cliff, and a sunset.

Find Spa Hotels in Southern Illinois, IL

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Save instantly and earn perks with One Key
    Learn about One Key
  • Be picky

    Search almost a million properties worldwide

Check availability on Southern Illinois Spa Hotels

Tonight
25 Aug - 26 Aug
Tomorrow
26 Aug - 27 Aug
This weekend
28 Aug - 30 Aug
Next weekend
4 Sept - 6 Sept

Our top choices for Southern Illinois hotels with a spa

1. Walker's Bluff Casino Resort

Walker's Bluff Casino Resort
Carterville
  • Luxurious spa retreat with hot stone massages, sauna, and seasonal pools awaits at this casino resort with attentive staff and fine dining.
£93
includes taxes & fees
2 Sept - 3 Sept
Walker's Bluff Casino Resort

2. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Cape Girardeau
  • Luxurious spa sanctuary awaits with full-service treatments and indoor pool in this centrally located hotel.
£84
includes taxes & fees
23 Sept - 24 Sept
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

3. 1895 Washington Hotel

1895 Washington Hotel
Paducah
  • Unwind in a Victorian sanctuary with relaxing reflexology and soothing hydrotherapy treatments for total rejuvenation.
£45
includes taxes & fees
31 Aug - 1 Sept
1895 Washington Hotel

4. Truitt Hotel

Truitt Hotel
Lafayette Square
£135
includes taxes & fees
31 Aug - 1 Sept
Truitt Hotel

5. Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
St. Charles
  • Riverside wellness oasis offers full-service spa with aromatherapy and hydrotherapy for a restorative retreat.
£149
includes taxes & fees
8 Sept - 9 Sept
Ameristar Casino Resort and Spa

6. 21C Museum Hotel St Louis

21C Museum Hotel St Louis
Downtown West
  • Discover spa services, a steam room, and an Olympic-sized indoor pool at this modern hotel, all designed for rejuvenating getaways.
£127
includes taxes & fees
20 Sept - 21 Sept
21C Museum Hotel St Louis

7. Arthur's Country Inn

Arthur's Country Inn
Arthur
£98
includes taxes & fees
30 Aug - 31 Aug
Arthur's Country Inn

8. Four Seasons Hotel St Louis

Four Seasons Hotel St Louis
Downtown St. Louis
  • Discover a tranquil haven with 12 treatment rooms, outdoor pool, and breathtaking views at this rejuvenating spa retreat.
£321
includes taxes & fees
27 Aug - 28 Aug
Four Seasons Hotel St Louis

9. The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis
Clayton
  • Revel in a rejuvenating spa retreat with aromatherapy treatments and hot stone massages at this luxury St. Louis hotel.
£470
includes taxes & fees
20 Sept - 21 Sept
The Ritz-Carlton, St. Louis
View all properties

Choose what matters most at spa hotels in Southern Illinois

Pool
Breakfast included
Hot tub
4 stars
5 stars

Find out more about Southern Illinois

Top Southern Illinois attractions for a relaxing vacation

Southern Illinois is a paradise for travellers seeking a blend of relaxation and adventure, particularly for those who appreciate spa accommodations. Begin your journey in the stunning Shawnee National Forest, where you can unwind amidst the lush greenery, with opportunities for hiking, rock climbing, and horseback riding. After a day outdoors, indulge in rejuvenating treatments at nearby spa hotels that offer serene views of the forest. Take a leisurely stroll through the charming town of Carbondale, where you can explore local boutiques and cafes, then retreat to your hotel for a soothing massage or wellness programme. The renowned Giant City State Park provides a perfect backdrop for both relaxation and exploration, featuring unique sandstone cliffs and trails, along with picnic areas ideal for families. For a unique experience, consider a stay at a vineyard or winery in the region, where you can enjoy wine tasting and vineyard tours, followed by a tranquil evening soaking in the spa’s facilities. When you choose to stay in the heart of these experiences, you’ll find attentive service and top hotels that cater to high expectations, making your Southern Illinois getaway memorable.

Top Southern Illinois Hotel Reviews

Drury Inn & Suites St. Louis O'Fallon, IL

Drury Inn & Suites St. Louis O'Fallon, IL

10/10 Excellent
"This hotel was fantastic! Very clean! Friendly and helpful staff! The breakfast was delicious and great variety! Definitely recommend this hotel and would stay again!"
Leilani 1-night trip
Posted 2 hours ago
Drury Inn & Suites St. Louis O'Fallon, IL
Country Inn & Suites by Radisson, Effingham, IL

Country Inn & Suites by Radisson, Effingham, IL

10/10 Excellent
"The breakfast didn't have anything I wanted, but the hotel was clean and quiet."
Roxanne 1-night trip
Posted 2 hours ago
Country Inn & Suites by Radisson, Effingham, IL
Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

10/10 Excellent
"It had been a long time since I stayed at a Drury Inn, I was very impressed and was cheaper than Comfort inn and Quality Inn and offered more. Like full breakfast and a Happy hour every evening. They have my choice..Thank you so much."
Barbara 2-night trip
Posted 9 hours ago
Drury Plaza Hotel Mt. Vernon
Comfort Suites Mount Vernon

Comfort Suites Mount Vernon

10/10 Excellent
"Room was very nice. Breakfast was very good."
Robert 1-night trip
Posted 1 day ago
Comfort Suites Mount Vernon
Quality Inn O'Fallon - St. Louis - Shiloh

Quality Inn O'Fallon - St. Louis - Shiloh

10/10 Excellent
"Great value- Clean room - Amazing staff- Surprisingly good breakfast - Plenty of surrounding food options"
Ollie 2-night trip
Posted 2 days ago
Quality Inn O'Fallon - St. Louis - Shiloh
Holiday Inn Express Metropolis by IHG

Holiday Inn Express Metropolis by IHG

10/10 Excellent
"Very friendly"
Valerie 2-night trip
Posted 5 days ago
Holiday Inn Express Metropolis by IHG

Explore a world of travel with Expedia