All Hotels by Best Western in Southern Illinois - 2026 Updated Prices

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Our top choices for Southern Illinois Best Western

A modern living room with a sofa, chairs, a coffee station, and a dining area.

A reception desk with a blue accent wall, a framed welcome sign, and a flat-screen TV above it.

A hotel room with a large bed, a bedside table, a lamp, and a wall-mounted light fixture.

A modern kitchen with a central island, bar stools, and pendant lighting.

1. Best Western St. Louis Fairview Heights

Fairview Heights

Darrel

£66

includes taxes & fees

31 Aug - 1 Sept

A hotel kitchen with wooden cabinets, a coffee station, and a dining area with tables and chairs.

A hotel room with two beds, a desk, and a window with a view.

A Best Western U.S. Inn with a modern design, featuring a covered entrance and a parking lot.

A reception area with a stone wall, a round mirror, a reception desk, and a computer setup.

2. Best Western U. S. Inn

Nashville

James

£96

includes taxes & fees

6 Sept - 7 Sept

A self-service breakfast area with a coffee machine, refrigerated display case, and various food items.

A hotel room with a bed, a television, a desk, a coffee machine, and a bathroom visible through an open door.

A Best Western hotel with a parking lot and a covered entrance.

A spacious lobby with a sofa, chairs, a coffee table, and a dining area with tables and chairs.

3. Best Western Marion Hotel

Marion

Lauren

£65

includes taxes & fees

30 Aug - 31 Aug

An indoor swimming pool with clear water, surrounded by lounge chairs and tables, and large windows offering views of the outside.

A hotel room with a bed, a desk, a chair, and a small table.

A lobby with a fireplace, blue armchairs, a brown sofa, and a patterned carpet.

A hotel room with a Samsung monitor displaying a hotel booking site, a smaller monitor, a keyboard, a mouse, and a printer.

4. Best Western Troy Hotel

Troy

£73

includes taxes & fees

31 Aug - 1 Sept

A hotel room with two beds, a desk, a chair, a TV, a lamp, and a painting on the wall.

An indoor swimming pool with clear blue water, a sunshade, and a seating area with chairs and a table.

A modern restaurant with a bar area, multiple tables and chairs, and a kitchen in the background.

A modern hotel lobby with leather sofas, a flat-screen TV, and framed artwork on the walls.

5. Best Western Saluki Inn

Carbondale

Bryan

£77

includes taxes & fees

13 Sept - 14 Sept

A hotel lobby with a dining area, kitchen, and seating.

A gym with treadmills, elliptical machines, and free weights.

A modern lobby with a reception desk, seating area, and a large flat-screen TV mounted on the wall.

An outdoor patio with a table and chairs, a white fence, and a building with large windows.

6. Best Western Heartland Inn

Mattoon

william

£73

includes taxes & fees

10 Sept - 11 Sept

A hotel room with a large bed, a desk, a chair, a TV, and a sofa.

A gym with treadmills, elliptical machines, and a stationary bike.

A modern hotel lobby with a brown sofa, a globe on a wooden stand, and a framed abstract painting on the wall.

A Best Western hotel with a large sign, a parking lot, and a FedEx package on the ground.

7. Best Western Flora Inn

Flora

Suzanne

£72

includes taxes & fees

31 Aug - 1 Sept

An indoor swimming pool with a clear view of the surrounding area, including a seating area with chairs and a view of the outdoors through large windows.

A Best Western hotel with a modern facade, a parking lot, and a clear sky.

A hotel room with a large bed, two bedside tables with lamps, a desk with a chair, a television, and a framed artwork on the wall.

A spacious dining area with a long wooden table, multiple chairs, and pendant lighting.

8. Best Western Delta Inn

Effingham

Chris

£74

includes taxes & fees

6 Sept - 7 Sept

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Top Southern Illinois Hotel Reviews

Quality Inn O'Fallon - St. Louis - Shiloh

10/10 Excellent

"Quick and easy service"

Holiday Inn Express & Suites Mount Vernon by IHG

8/10 Good

"Overall good."

Ramada by Wyndham Effingham

8/10 Good

"Room was clean. Could have used a little more lighting but that's just my preference. I had a single king room. The bed was firm but not uncomfortable. Breakfast was a pleasant surprise with eggs and sausage along with waffles, toast, yogurt, cereal, juice and coffee. Fruit would be a nice addition"

Drury Plaza Hotel Mt. Vernon

10/10 Excellent

"Bed was wonderful. They have a bar! The breakfast was tasty, many offerings. Definitely will stay again. Definitely making this hotel my road trip stay."

Motel 6 Caseyville, IL - Caseyville Il

10/10 Excellent

"Free pets nice staff close to interstate free waste bags for pets nice price kids free"

Comfort Suites Mount Vernon

10/10 Excellent

"The front desk lady was super good and friendly, she made us feel welcome."

Baymont by Wyndham Effingham

8/10 Good

"Room was clean but highway noise was a bit annoying. Staff was very pleasant and breakfast had a good variety of food."

Comfort Inn Edwardsville - St. Louis

10/10 Excellent

"Free parking, quiet and close to the freeway"

Quality Inn & Suites Metropolis I-24

10/10 Excellent

"Tv did not work but everything else was spot on."

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Search Hotels by Best Western in Southern Illinois from £65

Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for Southern Illinois Best Western

1. Best Western St. Louis Fairview Heights

2. Best Western U. S. Inn

3. Best Western Marion Hotel

4. Best Western Troy Hotel

5. Best Western Saluki Inn

6. Best Western Heartland Inn

7. Best Western Flora Inn

8. Best Western Delta Inn

Top Southern Illinois Hotel Reviews

Quality Inn O'Fallon - St. Louis - Shiloh

Holiday Inn Express & Suites Mount Vernon by IHG

Ramada by Wyndham Effingham

Drury Plaza Hotel Mt. Vernon

Motel 6 Caseyville, IL - Caseyville Il

Comfort Suites Mount Vernon

Baymont by Wyndham Effingham

Comfort Inn Edwardsville - St. Louis

Quality Inn & Suites Metropolis I-24

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