Title: TOP Family-Friendly Hotels in South San Diego, CA for 2025 - South San Diego Family Welcoming Hotels | Expedia.co.uk [South San Diego Travel Guide](https://expedia.co.uk/South-San-Diego.dx553248632063518562)[Hotels in South San Diego](https://expedia.co.uk/South-San-Diego-Hotels.d553248632063518562.Travel-Guide-Hotels)[Holiday Rentals in South San Diego](https://expedia.co.uk/South-San-Diego-Holiday-Rentals.d553248632063518562.Travel-Guide-HolidayRentals)[Flights to South San Diego](https://expedia.co.uk/Cheap-Flights-To-South-San-Diego.d553248632063518562.Travel-Guide-Flights)[Things to do in South San Diego](https://expedia.co.uk/Things-To-Do-In-South-San-Diego.d553248632063518562.Travel-Guide-Activities)[South San Diego Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-South-San-Diego.d553248632063518562.Car-Hire-Guide)[South San Diego Holidays](https://expedia.co.uk/South-San-Diego.d553248632063518562.Holidays-City-Breaks) ![](https://mediaim.expedia.com/destination/1/1577a5f9f9b33dbc18377fc367dd66b8.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Family-Friendly Hotels in South San Diego, CA ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on South San Diego Family-Friendly Hotels Tonight [13 Oct - 14 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=553248632063518562&startDate=2025-10-13&endDate=2025-10-14&adults=2&travelerType=FAMILY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [14 Oct - 15 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=553248632063518562&startDate=2025-10-14&endDate=2025-10-15&adults=2&travelerType=FAMILY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [17 Oct - 19 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=553248632063518562&startDate=2025-10-17&endDate=2025-10-19&adults=2&travelerType=FAMILY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [24 Oct - 26 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=553248632063518562&startDate=2025-10-24&endDate=2025-10-26&adults=2&travelerType=FAMILY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top South San Diego Family-Friendly Hotels ![Exterior](https://images.trvl-media.com/lodging/33000000/32400000/32393800/32393708/3c739431.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/33000000/32400000/32393800/32393708/ff230e8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/33000000/32400000/32393800/32393708/69474629.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/33000000/32400000/32393800/32393708/7d8dd276.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ayres Hotel San Diego South - Chula Vista Otay Ranch 9.8/10 Exceptional (1099) "The staff were friendly, clean rooms, and conveniently located to shops and places to eat " £113 includes taxes & fees 30 Oct - 31 Oct [](https://www.expedia.co.uk/Chula-Vista-Hotels-Ayres-Hotel-San-Diego-South-Chula-Vista.h32393708.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/bfd1ccfe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool loungers](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/2194e09f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/83180011.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free continental breakfast ](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/84883664.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn by Wyndham San Diego Chula Vista Chula Vista 8.6/10 Excellent (1434) "Clean room friendly staff easy parking " £88 includes taxes & fees 14 Oct - 15 Oct [](https://www.expedia.co.uk/Chula-Vista-Hotels-La-Quinta-Inn-By-Wyndham-San-Diego-Chula-Vista.h22810.Hotel-Information) ![View from room](https://images.trvl-media.com/lodging/1000000/20000/18300/18213/b70d99f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Balcony](https://images.trvl-media.com/lodging/1000000/20000/18300/18213/28c3172b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/20000/18300/18213/0df0eb3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, memory-foam beds, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/20000/18300/18213/e0c0af28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Rambler Chula Vista 9.0/10 Wonderful (1974) "Staff was amazing, room was clean and the area is both quiet and accessible to the rest of the city. Would absolutely stay again!" £86 includes taxes & fees 26 Oct - 27 Oct [](https://www.expedia.co.uk/Chula-Vista-Hotels-The-Rambler-Motel.h18213.Hotel-Information) ![Outdoor pool, open 10:00 AM to 9:30 PM, pool loungers](https://images.trvl-media.com/lodging/1000000/810000/806400/806327/04b5db82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/810000/806400/806327/18c3e6b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/810000/806400/806327/025fd645.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/810000/806400/806327/2ba90811.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Americana Inn San Ysidro 9.0/10 Wonderful (1154) "This is my go to place when traveling across the border and back. " £104 includes taxes & fees 19 Oct - 20 Oct [](https://www.expedia.co.uk/San-Ysidro-Hotels-Best-Western-Americana-Inn.h806327.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/18900/18870/36da2a73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/20000/18900/18870/434ca240.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/20000/18900/18870/2e7509ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/18900/18870/a48c362c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn Chula Vista San Diego South Chula Vista 8.2/10 Very good (1145) "Host was very professional and courteous! " £83 includes taxes & fees 19 Oct - 20 Oct [](https://www.expedia.co.uk/Chula-Vista-Hotels-Comfort-Inn-Chula-Vista-San-Diego-South.h18870.Hotel-Information) ![Deluxe Room, 1 King Bed | Premium bedding, down duvets, pillow-top beds, in-room safe](https://images.trvl-media.com/lodging/2000000/1480000/1475800/1475800/2602a017.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily continental breakfast (USD 13.49 per person)](https://images.trvl-media.com/lodging/2000000/1480000/1475800/1475800/1303c0cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/2000000/1480000/1475800/1475800/c9d13d5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/2000000/1480000/1475800/1475800/fb95526d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hercor Hotel - Urban Boutique Chula Vista 8.6/10 Excellent (1272) "Beautiful clean hotel great walkable to all restaurants and shops. " £78 includes taxes & fees 2 Nov - 3 Nov [](https://www.expedia.co.uk/Chula-Vista-Hotels-Hercor-Hotel-Urban-Boutique.h1475800.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/60000/57300/57235/79d129c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Vending machine](https://images.trvl-media.com/lodging/1000000/60000/57300/57235/19df6caa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Blackout curtains, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/60000/57300/57235/3345797f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/60000/57300/57235/59ede676.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 San Ysidro, CA - San Diego - Border San Ysidro 7.0/10 Good (1400) "Its clean, close to border of mexico, and restaurants too. " £54 includes taxes & fees 20 Oct - 21 Oct [](https://www.expedia.co.uk/San-Ysidro-Hotels-Motel-6-San-Ysidro.h57235.Hotel-Information) ![Coffee service](https://images.trvl-media.com/lodging/13000000/12500000/12496300/12496281/bc01198b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/13000000/12500000/12496300/12496281/add58e18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 Queen Bed, Accessible, Bathtub | Mini fridge](https://images.trvl-media.com/lodging/13000000/12500000/12496300/12496281/17786c6f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 Queen Bed, Accessible, Bathtub | Desk, blackout curtains, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/13000000/12500000/12496300/12496281/a3588783.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn San Diego South - Chula Vista Chula Vista 7.6/10 Good (1009) "Friendly staff and super clean rooms." £62 includes taxes & fees 19 Oct - 20 Oct [](https://www.expedia.co.uk/Chula-Vista-Hotels-SureStay-Plus-Hotel-By-Best-Western-Chula-Vista-West.h12496281.Hotel-Information) ![Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/673df2c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/16237f85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/55248c07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/c6a042c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Suites San Diego Otay Mesa Otay Mesa 7.2/10 Good (1004) "Clean, friendly staff and yummy breakfast :)" £84 includes taxes & fees 14 Oct - 15 Oct [](https://www.expedia.co.uk/San-Diego-Hotels-Quality-Suites-San-Diego-Otay-Mesa.h461837.Hotel-Information) ![Room, 1 King Bed, Non Smoking | Desk, iron/ironing board, free cots/infant beds, free WiFi](https://images.trvl-media.com/lodging/11000000/10560000/10554600/10554546/3113bfba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/11000000/10560000/10554600/10554546/269329b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bathroom sink](https://images.trvl-media.com/lodging/11000000/10560000/10554600/10554546/a3341925.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free cots/infant beds, free WiFi](https://images.trvl-media.com/lodging/11000000/10560000/10554600/10554546/56a72614.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham National City Chula Vista National City 7.0/10 Good (935) "Great stay, no issues" £59 includes taxes & fees 14 Oct - 15 Oct [](https://www.expedia.co.uk/National-City-Hotels-Super-8-By-Wyndham-National-City-Chula-Vista.h10554546.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-10-27&endDate=2025-10-28®ionId=553248632063518562&adults=2&travelerType=family_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top South San Diego Hotel Reviews ![The DEXTRO Little Italy, BW Premier Collection](//images.trvl-media.com/lodging/1000000/180000/170400/170338/84efd019_y.jpg) ### The DEXTRO Little Italy, BW Premier Collection 10/10 Excellent "Great Service " [](https://expedia.co.uk/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) ![Hotel del Coronado, Curio Collection by Hilton](//images.trvl-media.com/lodging/1000000/10000/7500/7496/20fe4d95_y.jpg) ### Hotel del Coronado, Curio Collection by Hilton 10/10 Excellent "Clean room, Staff Friendly" [](https://expedia.co.uk/Coronado-Hotels-Hotel-Del-Coronado.h7496.Hotel-Information) ![Best Western Plus Marina Gateway Hotel](//images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/f3777dfe_y.jpg) ### Best Western Plus Marina Gateway Hotel 10/10 Excellent "Clean room polite staff" [](https://expedia.co.uk/National-City-Hotels-Best-Western-Plus-Marina-Gateway-Hotel.h2816688.Hotel-Information) ![Handlery Hotel](//images.trvl-media.com/lodging/1000000/10000/8400/8374/ab6ccd55_y.jpg) ### Handlery Hotel 10/10 Excellent "The hotel is very clean, pool and spa are fantastic, the food at the hotel was excellent " [](https://expedia.co.uk/San-Diego-Hotels-Handlery-Hotel.h8374.Hotel-Information) ![Sheraton San Diego Resort](//images.trvl-media.com/lodging/1000000/20000/11200/11109/w4000h2662x0y0-91d299a1_y.jpg) ### Sheraton San Diego Resort 10/10 Excellent "Love it here. We try to stay here every time we’re in SD " [](https://expedia.co.uk/San-Diego-Hotels-Sheraton-San-Diego-Hotel-And-Marina.h11109.Hotel-Information) ![The Little Italy Hotel Downtown San Diego](//images.trvl-media.com/lodging/1000000/20000/13300/13205/0339a25b_y.jpg) ### The Little Italy Hotel Downtown San Diego 10/10 Excellent "Great location and hotel! Loved my stay " [](https://expedia.co.uk/San-Diego-Hotels-The-Little-Italy-Hotel-In-Downtown-San-Diego.h13205.Hotel-Information) ![Wyndham San Diego Bayside](//images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d_y.jpg) ### Wyndham San Diego Bayside 10/10 Excellent "Great that there is an airport shuttle. Very convenient to cruise terminal." [](https://expedia.co.uk/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![The Dana on Mission Bay](//images.trvl-media.com/lodging/1000000/50000/41000/40953/08585098_y.jpg) ### The Dana on Mission Bay 10/10 Excellent "Staff is awesome" [](https://expedia.co.uk/San-Diego-Hotels-The-Dana-On-Mission-Bay.h40953.Hotel-Information) ![Kings Inn San Diego](//images.trvl-media.com/lodging/1000000/20000/17000/16910/a5f26080_y.jpg) ### Kings Inn San Diego 10/10 Excellent "Front desk was eager to help with directions or anything you needed. 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[Gay-Friendly Hotels in Paradise Hills](https://www.expedia.co.uk/Paradise-Hills-San-Diego-Hotels-Gay-Friendly-Hotel.0-n553248635976007744-0-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - [Adults Only Resorts & in San Diego Coast](https://www.expedia.co.uk/San-Diego-Coast-Hotels-Adults-Only-Resorts.0-0-d553248633966884021-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) - [All-Inclusive Hotels in San Diego Coast](https://www.expedia.co.uk/San-Diego-Coast-Hotels-All-Inclusive-Hotel.0-0-d553248633966884021-tAllInclusiveHotel.Travel-Guide-Filter-Hotels) - [Beach Resorts & in San Diego Coast](https://www.expedia.co.uk/San-Diego-Coast-Hotels-Beach-Hotels.0-0-d553248633966884021-tBeachHotels.Travel-Guide-Filter-Hotels) - [Boutique Hotels in San Diego Coast](https://www.expedia.co.uk/San-Diego-Coast-Hotels-Boutique-Hotel.0-0-d553248633966884021-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - [Cheap Hotels in San Diego Coast](https://www.expedia.co.uk/San-Diego-Coast-Hotels-Budget-Hotels.0-0-d553248633966884021-tBudgetHotels.Travel-Guide-Filter-Hotels) - [Family-Friendly Hotels in San Diego Coast](https://www.expedia.co.uk/San-Diego-Coast-Hotels-Family-Friendly-Hotel.0-0-d553248633966884021-tFamilyFriendlyHotel.Travel-Guide-Filter-Hotels) - [Hotels Suites in San Diego Coast](https://www.expedia.co.uk/San-Diego-Coast-Hotels-Hotel-Suites.0-0-d553248633966884021-thotelsuites.Travel-Guide-Filter-Hotels) - [Hotels with a Bar in San Diego Coast](https://www.expedia.co.uk/San-Diego-Coast-Hotels-Hotel-With-A-Bar.0-0-d553248633966884021-thotelwithabar.Travel-Guide-Filter-Hotels) - [Hotels with a View in San Diego Coast](https://www.expedia.co.uk/San-Diego-Coast-Hotels-Hotel-With-A-View.0-0-d553248633966884021-thotelwithaview.Travel-Guide-Filter-Hotels) - [Hotels with Connecting Rooms in San Diego Coast](https://www.expedia.co.uk/San-Diego-Coast-Hotels-Hotel-With-Connecting-Rooms.0-0-d553248633966884021-thotelwithconnectingrooms.Travel-Guide-Filter-Hotels) - [Hotels with Early Check-in in San Diego Coast](https://www.expedia.co.uk/San-Diego-Coast-Hotels-Hotel-With-Early-Check-In.0-0-d553248633966884021-thotelwithearlycheckin.Travel-Guide-Filter-Hotels) - 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[Spa Hotels in South Bay](https://www.expedia.co.uk/South-Bay-Hotels-Spa-Hotels.0-0-d6056572-tSpaHotels.Travel-Guide-Filter-Hotels) - [Flights to Chula Vista](https://www.expedia.co.uk/Cheap-Flights-To-Chula-Vista.d7442.Travel-Guide-Flights) - [Flights to San Ysidro](https://www.expedia.co.uk/Cheap-Flights-To-San-Ysidro.d8380.Travel-Guide-Flights) - [Flights from San Ysidro](https://www.expedia.co.uk/lp/flights/8380/flights-from-san-ysidro) - [Visit Otay](https://www.expedia.co.uk/Chula-Vista-Otay.dx177685) - [Chula Vista Holidays](https://www.expedia.co.uk/Chula-Vista.d7442.Holidays-City-Breaks) - [Visit Chula Vista](https://www.expedia.co.uk/Chula-Vista.dx7442) - [Visit Ocean View Hills](https://www.expedia.co.uk/San-Diego-Ocean-View-Hills.dx553248635976008220) - [Visit Otay Mesa West](https://www.expedia.co.uk/San-Diego-Otay-Mesa-West.dx553248625809641010) - [Visit San Ysidro](https://www.expedia.co.uk/San-Ysidro.dx8380) - [Car hire Chula Vista](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Chula-Vista.d7442.Car-Hire-Guide) - [Car hire San Ysidro](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-San-Ysidro.d8380.Car-Hire-Guide) - [Chula Vista Holiday Rentals](https://www.expedia.co.uk/Chula-Vista-Holiday-Rentals.d7442.Travel-Guide-HolidayRentals) - [Things to do in Chula Vista](https://www.expedia.co.uk/Things-To-Do-In-Chula-Vista.d7442.Travel-Guide-Activities) - [Book Family-Friendly Hotels in South San Diego on Expedia.com](https://www.expedia.com/South-San-Diego-Hotels-Family-Hotel.0-0-d553248632063518562-tFamilyHotel.Travel-Guide-Filter-Hotels)