Title: TOP Luxury Hotels in South Carolina Midlands, SC for 2026 - South Carolina Midlands Upscale Hotels | Expedia.co.uk [South Carolina Midlands Travel Guide](https://expedia.co.uk/South-Carolina-Midlands.dx6057938)[Hotels in South Carolina Midlands](https://expedia.co.uk/South-Carolina-Midlands-Hotels.d6057938.Travel-Guide-Hotels)[Holiday Rentals in South Carolina Midlands](https://expedia.co.uk/South-Carolina-Midlands-Holiday-Rentals.d6057938.Travel-Guide-HolidayRentals)[Flights to South Carolina Midlands](https://expedia.co.uk/Cheap-Flights-To-South-Carolina-Midlands.d6057938.Travel-Guide-Flights)[Things to do in South Carolina Midlands](https://expedia.co.uk/Things-To-Do-In-South-Carolina-Midlands.d6057938.Travel-Guide-Activities)[South Carolina Midlands Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-South-Carolina-Midlands.d6057938.Car-Hire-Guide)[South Carolina Midlands Holidays](https://expedia.co.uk/South-Carolina-Midlands.d6057938.Holidays-City-Breaks) ![South Carolina State House](https://images.trvl-media.com/place/6082681/1934af6a-1aa9-4e01-8cd3-8eb8fe4af18f.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6082681/1934af6a-1aa9-4e01-8cd3-8eb8fe4af18f.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on South Carolina Midlands Luxury Hotels Tonight [17 Jan - 18 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6057938&startDate=2026-01-17&endDate=2026-01-18&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [18 Jan - 19 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6057938&startDate=2026-01-18&endDate=2026-01-19&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [23 Jan - 25 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6057938&startDate=2026-01-23&endDate=2026-01-25&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) In two weeks [30 Jan - 1 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6057938&startDate=2026-01-30&endDate=2026-02-01&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Our top choices for South Carolina Midlands luxury hotels ![View from property](https://images.trvl-media.com/lodging/1000000/800000/798500/798446/317b0952.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, seasonal outdoor pool, pool cabanas (surcharge)](https://images.trvl-media.com/lodging/1000000/800000/798500/798446/96f40d74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, seasonal outdoor pool, pool cabanas (surcharge)](https://images.trvl-media.com/lodging/1000000/800000/798500/798446/967f0f82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/800000/798500/798446/a2869f0c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Ballantyne, A Luxury Collection Hotel, Charlotte [](https://www.expedia.co.uk/Charlotte-Hotels-The-Ballantyne.h798446.Hotel-Information) Ballantyne 9.2/10 Wonderful (1,000 reviews) "Bed was super comfy Room service delicious " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Elizabeth £224 includes taxes & fees 25 Jan - 26 Jan [](https://www.expedia.co.uk/Charlotte-Hotels-The-Ballantyne.h798446.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/20100/20030/64598b80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/30000/20100/20030/f4cdc91c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/20100/20030/926d1d42.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lunch, dinner and brunch served](https://images.trvl-media.com/lodging/1000000/30000/20100/20030/f09c31e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Willcox [](https://www.expedia.co.uk/Aiken-Hotels-The-Willcox.h20030.Hotel-Information) Aiken 9.6/10 Exceptional (147 reviews) "Easy check in. Great room and our waiter at dinner Nicholas was awesome." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stephen £240 includes taxes & fees 19 Jan - 20 Jan [](https://www.expedia.co.uk/Aiken-Hotels-The-Willcox.h20030.Hotel-Information) ![Rooftop terrace](https://images.trvl-media.com/lodging/16000000/15720000/15719100/15719033/942f5474.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop terrace](https://images.trvl-media.com/lodging/16000000/15720000/15719100/15719033/5a87853c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Executive King Suite | Private kitchen | Full-sized fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/16000000/15720000/15719100/15719033/77592b59.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Regal mid-King Suite | In-room dining](https://images.trvl-media.com/lodging/16000000/15720000/15719100/15719033/6186e6dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Mantissa Hotel [](https://www.expedia.co.uk/Florence-Hotels-The-Mantissa-Hotel.h15719033.Hotel-Information) Hartsville 9.2/10 Wonderful (271 reviews) "Very nice spacious rooms friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Duane £125 includes taxes & fees 27 Jan - 28 Jan [](https://www.expedia.co.uk/Florence-Hotels-The-Mantissa-Hotel.h15719033.Hotel-Information) ![Breakfast area](https://images.trvl-media.com/lodging/18000000/17390000/17380300/17380261/bfdc100f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Smoking | Bathroom sink](https://images.trvl-media.com/lodging/18000000/17390000/17380300/17380261/13cfcb42.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/18000000/17390000/17380300/17380261/d4b79aee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/18000000/17390000/17380300/17380261/5f1ffd39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Travelodge by Wyndham Orangeburg [](https://www.expedia.co.uk/Orangeburg-Hotels-Travelodge-By-Wyndham-Orangeburg.h17380261.Hotel-Information) Orangeburg 8.2/10 Very good (1,002 reviews) "Enjoyed our stay " ![Australia](https://a.travel-assets.com/egds/marks/flags/au.svg) Marie £59 includes taxes & fees 19 Jan - 20 Jan [](https://www.expedia.co.uk/Orangeburg-Hotels-Travelodge-By-Wyndham-Orangeburg.h17380261.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/11000000/10940000/10931100/10931075/fed76e51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/11000000/10940000/10931100/10931075/df26a103.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/11000000/10940000/10931100/10931075/987d2802.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fireplace](https://images.trvl-media.com/lodging/11000000/10940000/10931100/10931075/05198f7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Carriage House Inn [](https://www.expedia.co.uk/Aiken-Hotels-Carriage-House-Inn.h10931075.Hotel-Information) Aiken 9.4/10 Exceptional (465 reviews) "Lots of charm, good location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Elizabeth £167 includes taxes & fees 20 Jan - 21 Jan [](https://www.expedia.co.uk/Aiken-Hotels-Carriage-House-Inn.h10931075.Hotel-Information) ![Exterior detail](https://images.trvl-media.com/lodging/1000000/160000/151400/151368/5424ac06.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Non Smoking | Premium bedding, pillow-top beds, in-room safe, individually furnished](https://images.trvl-media.com/lodging/1000000/160000/151400/151368/706048fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/1000000/160000/151400/151368/e887cc1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/160000/151400/151368/d5754d94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Microtel Inn & Suites by Wyndham Rock Hill/Charlotte Area [](https://www.expedia.co.uk/Rock-Hill-Hotels-Microtel-Inn-Suites-By-Wyndham-Rock-HillCharlotte-Area.h151368.Hotel-Information) Rock Hill 7.0/10 Good (1,001 reviews) "In the process of being renovated. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) James £48 includes taxes & fees 19 Jan - 20 Jan [](https://www.expedia.co.uk/Rock-Hill-Hotels-Microtel-Inn-Suites-By-Wyndham-Rock-HillCharlotte-Area.h151368.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/c321176c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillow-top beds, desk, iron/ironing board](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/f9325683.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/726f3d0d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/2b6111ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Inn on the Square, an Ascend Collection Hotel [](https://www.expedia.co.uk/Greenwood-Hotels-Inn-On-The-Square.h1212931.Hotel-Information) Uptown Greenwood 9.2/10 Wonderful (711 reviews) "It was a very clean and beautiful lace to stay. We were there for our honeymoon " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tracy £92 includes taxes & fees 8 Feb - 9 Feb [](https://www.expedia.co.uk/Greenwood-Hotels-Inn-On-The-Square.h1212931.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/2000000/1810000/1805100/1805074/60e6167a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1810000/1805100/1805074/34120105.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1810000/1805100/1805074/61b347da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1810000/1805100/1805074/24bdaf71.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sheraton Columbia Downtown Hotel [](https://www.expedia.co.uk/Columbia-Hotels-Sheraton-Columbia-Downtown-Hotel.h1805074.Hotel-Information) Downtown Columbia 8.4/10 Very good (1,002 reviews) "Clean rooms and hospitable staff!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) James £88 includes taxes & fees 23 Jan - 24 Jan [](https://www.expedia.co.uk/Columbia-Hotels-Sheraton-Columbia-Downtown-Hotel.h1805074.Hotel-Information) ![Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/43600/43558/a62a6b13.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/50000/43600/43558/1bf56910.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool, open 10 AM to 9:00 PM, pool loungers](https://images.trvl-media.com/lodging/1000000/50000/43600/43558/b9bd3e4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/50000/43600/43558/48ea85d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Greenwood [](https://www.expedia.co.uk/Greenwood-Hotels-Baymont-By-Wyndham-Greenwood.h43558.Hotel-Information) Greenwood 7.6/10 Good (773 reviews) "Was perfect for one stay, and located close to my Buinness meeting " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Raymond C £59 includes taxes & fees 23 Jan - 24 Jan [](https://www.expedia.co.uk/Greenwood-Hotels-Baymont-By-Wyndham-Greenwood.h43558.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/8136c59d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/4686cd8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/5b49de0c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/070e1043.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Red Roof Inn Santee [](https://www.expedia.co.uk/Orangeburg-Hotels-Red-Roof-Inn-Santee.h856695.Hotel-Information) Santee 6.6/10 (642 reviews) "A good option if traveling with pets. The hotel is clean and well maintained but dated. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Karen £58 includes taxes & fees 18 Jan - 19 Jan [](https://www.expedia.co.uk/Orangeburg-Hotels-Red-Roof-Inn-Santee.h856695.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-01-31&endDate=2026-02-01®ionId=6057938&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true) ## Find out more about South Carolina Midlands ### South Carolina Midlandsand its attractions for luxury travelers In the heart of South Carolina Midlands, luxury travellers can immerse themselves in a blend of history, culture, and natural beauty. Start your journey at the stunning Riverbanks Zoo & Garden, where you can stroll through beautifully landscaped gardens and encounter exotic animals in a serene environment – a perfect spot for families to enjoy an engaging day out. Next, explore the historic district of Columbia, with its charming architecture and vibrant arts scene, where upscale boutiques and art galleries await discovery. For a taste of Southern hospitality, indulge in a fine dining experience at The Capital Grille, renowned for its exceptional steaks and extensive wine list. Nature enthusiasts will appreciate a visit to Congaree National Park, where luxury hotels like The Inn at USC provide easy access to hiking trails and breathtaking views of ancient trees. Finally, don’t miss the South Carolina State Museum, which offers a wealth of exhibits ranging from art to science, all housed in a beautifully restored facility. Staying in the Midlands allows for a relaxing exploration of these attractions, with luxury hotels offering impeccable service and amenities, ensuring that your every need is catered to – from spa treatments to gourmet dining experiences. ## Top South Carolina Midlands Hotel Reviews ![Baymont by Wyndham Columbia Fort Jackson](https://images.trvl-media.com/lodging/1000000/580000/574500/574461/c68af965_y.jpg) ### Baymont by Wyndham Columbia Fort Jackson 10/10 Excellent "Friendly staff, clean and quiet " [](https://expedia.co.uk/Columbia-Hotels-Baymont-By-Wyndham-Columbia-Fort-Jackson.h574461.Hotel-Information) ![Holiday Inn Express & Suites Columbia-I-26 @ Harbison Blvd by IHG](https://images.trvl-media.com/lodging/1000000/690000/688700/688607/805d082b_y.jpg) ### Holiday Inn Express & Suites Columbia-I-26 @ Harbison Blvd by IHG 10/10 Excellent "Excellent " [](https://expedia.co.uk/Columbia-Hotels-Holiday-Inn-Express-Suites-Columbia-I-26-Harbison-Blvd.h688607.Hotel-Information) ![Sleep Inn Columbia](https://images.trvl-media.com/lodging/1000000/130000/127000/126908/de238acf_y.jpg) ### Sleep Inn Columbia 10/10 Excellent "Very friendly staff, clean room and comfortable bed. Very quiet location (not much going on in the area but right next to the highway). Not much choice for breakfast but at this price, one can't ask for too much." [](https://expedia.co.uk/Columbia-Hotels-Sleep-Inn-At-Bush-River-Road.h126908.Hotel-Information) ![Courtyard by Marriott Columbia Downtown at USC](https://images.trvl-media.com/lodging/1000000/10000/2300/2289/w3996h2667x0y0-8dd1e3e0_y.jpg) ### Courtyard by Marriott Columbia Downtown at USC 10/10 Excellent "We enjoyed our stay here during the most recent holiday. Check-in was smooth, the room and main areas were spotless. Overall great property!" [](https://expedia.co.uk/Columbia-Hotels-Courtyard-By-Marriott-Columbia-Downtown-At-USC.h2289.Hotel-Information) ![Graduate by Hilton Columbia SC](https://images.trvl-media.com/lodging/3000000/2520000/2515100/2515057/22f12a1f_y.jpg) ### Graduate by Hilton Columbia SC 10/10 Excellent "Loved our stay ." [](https://expedia.co.uk/Columbia-Hotels-Graduate-Columbia.h2515057.Hotel-Information) ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - Other - More ways to book - [5 Star Hotels in Columbia ](https://www.expedia.co.uk/5Star-Columbia-Hotels.s50-0-d764.Travel-Guide-Filter-Hotels) - [Spa Hotels in Blythewood ](https://www.expedia.co.uk/Blythewood-Hotels-Spa-Hotels.0-0-d180657-tSpaHotels.Travel-Guide-Filter-Hotels) - [Blythewood Hotels ](https://www.expedia.co.uk/Blythewood-Hotels.d180657.Travel-Guide-Hotels) - [Adults Only Resorts & in Columbia ](https://www.expedia.co.uk/Columbia-Hotels-Adults-Only-Resorts.0-0-d764-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Columbia ](https://www.expedia.co.uk/Columbia-Hotels-Budget-Hotels.0-0-d764-tBudgetHotels.Travel-Guide-Filter-Hotels) - [Gay-Friendly Hotels in Columbia ](https://www.expedia.co.uk/Columbia-Hotels-Gay-Friendly-Hotel.0-0-d764-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - 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