A monument with a statue on top, in front of a large building with columns.

Find luxury hotels in South Carolina Midlands, SC

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Save instantly and earn perks with One Key
  • Be picky

    Search almost a million properties worldwide

Check availability on South Carolina Midlands Luxury Hotels

This weekend
Next weekend

Our top choices for South Carolina Midlands luxury hotels

1. Holiday Inn Express & Suites Columbia-I-20 @ Clemson Rd by IHG

Holiday Inn Express & Suites Columbia-I-20 @ Clemson Rd by IHG
2.5 star property
Columbia
8.8 out of 10, Excellent, (964 reviews)
"Convenient location. Clean rooms and amenities"
United States
Joseph
The price is £89
includes taxes & fees
7 Dec - 8 Dec
Holiday Inn Express & Suites Columbia-I-20 @ Clemson Rd by IHG

2. Hampton Inn Columbia I-20-Clemson Road

Hampton Inn Columbia I-20-Clemson Road
2.5 star property
Columbia
8.8 out of 10, Excellent, (881 reviews)
"Clean room and great staff!"
United States
Charlotte
The price is £104
includes taxes & fees
2 Dec - 3 Dec
Hampton Inn Columbia I-20-Clemson Road

3. Holiday Inn Express Hotel & Suites Blythewood by IHG

Holiday Inn Express Hotel & Suites Blythewood by IHG
3.0 star property
Blythewood
8.6 out of 10, Excellent, (1,002 reviews)
"The stay was satisfactory."
United States
Ronnie
The price is £99
includes taxes & fees
6 Dec - 7 Dec
Holiday Inn Express Hotel & Suites Blythewood by IHG

4. Home2 Suites by Hilton Blythewood, SC

Home2 Suites by Hilton Blythewood, SC
3.0 star property
Blythewood
8.8 out of 10, Excellent, (371 reviews)
"Property was clean and staff was wonderful thank you!"
United States
John
The price is £109
includes taxes & fees
15 Nov - 16 Nov
Home2 Suites by Hilton Blythewood, SC

5. Hilton Garden Inn Columbia Northeast

Hilton Garden Inn Columbia Northeast
3.0 star property
Columbia
9.0 out of 10, Wonderful, (1,000 reviews)
"Staff was helpful in the rooms were very clean"
United States
LaNor
The price is £105
includes taxes & fees
23 Nov - 24 Nov
Hilton Garden Inn Columbia Northeast

6. Motel 6 Lugoff, SC

Motel 6 Lugoff, SC
2.0 star property
Lugoff
8.0 out of 10, Very good, (160 reviews)
"needed a place to stay for the night, super helpful staff and a very nice room"
United States
Dalton
The price is £57
includes taxes & fees
9 Nov - 10 Nov
Motel 6 Lugoff, SC

7. La Quinta Inn by Wyndham Columbia NE/Fort Jackson

La Quinta Inn by Wyndham Columbia NE/Fort Jackson
3.0 star property
Columbia
8.8 out of 10, Excellent, (2,179 reviews)
"Was a great stay!"
United States
maria
The price is £72
includes taxes & fees
15 Nov - 16 Nov
La Quinta Inn by Wyndham Columbia NE/Fort Jackson

8. TownePlace Suites by Marriott Columbia Southeast/Ft Jackson

TownePlace Suites by Marriott Columbia Southeast/Ft Jackson
3.0 star property
Columbia
8.8 out of 10, Excellent, (836 reviews)
"Very nice hotel. We had the suite for 3 people and it was very comfortable! The ladies at the front desk was the best at helping us pick food places and it was very close to the base for graduation!"
United States
Carolyn
The price is £77
includes taxes & fees
22 Nov - 23 Nov
TownePlace Suites by Marriott Columbia Southeast/Ft Jackson

9. Courtyard by Marriott Columbia Northeast/Fort Jackson Area

Courtyard by Marriott Columbia Northeast/Fort Jackson Area
3.0 star property
Columbia
8.8 out of 10, Excellent, (1,002 reviews)
"The stay here was a great experience. Facility was clean and modern. Staff were friendly and helpful. Hotel was easy to find."
United States
Brenda
The price is £93
includes taxes & fees
6 Dec - 7 Dec
Courtyard by Marriott Columbia Northeast/Fort Jackson Area

10. Residence Inn by Marriott Columbia Northeast/Fort Jackson Area

Residence Inn by Marriott Columbia Northeast/Fort Jackson Area
3.0 star property
Columbia
9.0 out of 10, Wonderful, (831 reviews)
"Excellent place to stay would recommend to anybody"
United States
Lauren
The price is £119
includes taxes & fees
16 Nov - 17 Nov
Residence Inn by Marriott Columbia Northeast/Fort Jackson Area

11. Hampton Inn Columbia I-26/Harbison Blvd.

Hampton Inn Columbia I-26/Harbison Blvd.
2.5 star property
St. Andrews
9.2 out of 10, Wonderful, (1,001 reviews)
"Will stay again."
United States
Robert
The price is £85
includes taxes & fees
6 Dec - 7 Dec
Hampton Inn Columbia I-26/Harbison Blvd.

12. Holiday Inn & Suites Columbia NE - Ft Jackson Area by IHG

Holiday Inn & Suites Columbia NE - Ft Jackson Area by IHG
3.0 star property
Columbia
8.2 out of 10, Very good, (1,001 reviews)
"Clean room and nice location."
United States
Karla
The price is £79
includes taxes & fees
15 Nov - 16 Nov
Holiday Inn & Suites Columbia NE - Ft Jackson Area by IHG

13. Holiday Inn Express Columbia NE - Fort Jackson by IHG

Holiday Inn Express Columbia NE - Fort Jackson by IHG
2.5 star property
Columbia
8.6 out of 10, Excellent, (1,002 reviews)
"Nice and convenient for a stay on our way home."
United States
Cynthia
The price is £91
includes taxes & fees
8 Nov - 9 Nov
Holiday Inn Express Columbia NE - Fort Jackson by IHG

14. La Quinta Inn by Wyndham Columbia SE / Fort Jackson

La Quinta Inn by Wyndham Columbia SE / Fort Jackson
3.0 star property
Columbia
8.4 out of 10, Very good, (1,027 reviews)
"Great stay."
United States
Sunta
The price is £72
includes taxes & fees
6 Dec - 7 Dec
La Quinta Inn by Wyndham Columbia SE / Fort Jackson

15. Travel Inn

Travel Inn
2.5 star property
Lugoff
7.8 out of 10, Good, (162 reviews)
"Enjoyed my stay"
United States
Adrian
The price is £53
includes taxes & fees
7 Nov - 8 Nov
Travel Inn

16. Tru By Hilton Columbia Downtown

Tru By Hilton Columbia Downtown
2.5 star property
Downtown Columbia
9.4 out of 10, Exceptional, (976 reviews)
"Great stay"
United States
Jennifer
The price is £81
includes taxes & fees
24 Nov - 25 Nov
Tru By Hilton Columbia Downtown

17. Tru By Hilton Columbia Greystone

Tru By Hilton Columbia Greystone
2.5 star property
Columbia
9.2 out of 10, Wonderful, (1,160 reviews)
"Very clean and friendly staff"
United States
Ken
The price is £83
includes taxes & fees
28 Nov - 29 Nov
Tru By Hilton Columbia Greystone

18. TownePlace Suites Columbia West/Lexington

TownePlace Suites Columbia West/Lexington
3.0 star property
West Columbia
9.2 out of 10, Wonderful, (512 reviews)
"We stay at this location often and enjoy proximity to convenient eating options, friendly staff and comfortable rooms. Free breakfast is a plus."
United States
Michael
The price is £92
includes taxes & fees
29 Nov - 30 Nov
TownePlace Suites Columbia West/Lexington

19. Courtyard by Marriott Columbia Cayce

Courtyard by Marriott Columbia Cayce
3.0 star property
Cayce
9.0 out of 10, Wonderful, (772 reviews)
"Nice hotel. Bar and restaurant in lobby was nice."
United States
Brett
The price is £83
includes taxes & fees
23 Nov - 24 Nov
Courtyard by Marriott Columbia Cayce

20. Residence Inn Columbia West/Lexington

Residence Inn Columbia West/Lexington
3.0 star property
West Columbia
9.2 out of 10, Wonderful, (432 reviews)
"The check in was a bit slow but the property was excellent. The room was great and the breakfast was excellent."
United States
Bruce E
The price is £91
includes taxes & fees
6 Dec - 7 Dec
Residence Inn Columbia West/Lexington
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about South Carolina Midlands

South Carolina Midlandsand its attractions for luxury travelers

In the heart of South Carolina Midlands, luxury travellers can immerse themselves in a blend of history, culture, and natural beauty. Start your journey at the stunning Riverbanks Zoo & Garden, where you can stroll through beautifully landscaped gardens and encounter exotic animals in a serene environment – a perfect spot for families to enjoy an engaging day out. Next, explore the historic district of Columbia, with its charming architecture and vibrant arts scene, where upscale boutiques and art galleries await discovery. For a taste of Southern hospitality, indulge in a fine dining experience at The Capital Grille, renowned for its exceptional steaks and extensive wine list. Nature enthusiasts will appreciate a visit to Congaree National Park, where luxury hotels like The Inn at USC provide easy access to hiking trails and breathtaking views of ancient trees. Finally, don’t miss the South Carolina State Museum, which offers a wealth of exhibits ranging from art to science, all housed in a beautifully restored facility. Staying in the Midlands allows for a relaxing exploration of these attractions, with luxury hotels offering impeccable service and amenities, ensuring that your every need is catered to – from spa treatments to gourmet dining experiences.

Top South Carolina Midlands Hotel Reviews

Explore a world of travel with Expedia