Title: TOP Luxury Hotels in South Carolina Midlands, SC for 2026 - South Carolina Midlands Upscale Hotels | Expedia.co.uk [South Carolina Midlands Travel Guide](https://expedia.co.uk/South-Carolina-Midlands.dx6057938)[Hotels in South Carolina Midlands](https://expedia.co.uk/South-Carolina-Midlands-Hotels.d6057938.Travel-Guide-Hotels)[Holiday Rentals in South Carolina Midlands](https://expedia.co.uk/South-Carolina-Midlands-Holiday-Rentals.d6057938.Travel-Guide-HolidayRentals)[Flights to South Carolina Midlands](https://expedia.co.uk/Cheap-Flights-To-South-Carolina-Midlands.d6057938.Travel-Guide-Flights)[Things to do in South Carolina Midlands](https://expedia.co.uk/Things-To-Do-In-South-Carolina-Midlands.d6057938.Travel-Guide-Activities)[South Carolina Midlands Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-South-Carolina-Midlands.d6057938.Car-Hire-Guide)[South Carolina Midlands Holidays](https://expedia.co.uk/South-Carolina-Midlands.d6057938.Holidays-City-Breaks) ![South Carolina State House](https://images.trvl-media.com/place/6082681/1934af6a-1aa9-4e01-8cd3-8eb8fe4af18f.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6082681/1934af6a-1aa9-4e01-8cd3-8eb8fe4af18f.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on South Carolina Midlands Luxury Hotels Tonight [3 Mar - 4 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6057938&startDate=2026-03-03&endDate=2026-03-04&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [4 Mar - 5 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6057938&startDate=2026-03-04&endDate=2026-03-05&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [6 Mar - 8 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6057938&startDate=2026-03-06&endDate=2026-03-08&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [13 Mar - 15 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6057938&startDate=2026-03-13&endDate=2026-03-15&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Our top choices for South Carolina Midlands luxury hotels ![View from property](https://images.trvl-media.com/lodging/1000000/800000/798500/798446/317b0952.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/800000/798500/798446/24906fad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/800000/798500/798446/a2869f0c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, seasonal outdoor pool, pool cabanas (surcharge)](https://images.trvl-media.com/lodging/1000000/800000/798500/798446/96f40d74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Ballantyne, A Luxury Collection Hotel, Charlotte [](https://www.expedia.co.uk/Charlotte-Hotels-The-Ballantyne.h798446.Hotel-Information) Ballantyne 9.2/10 Wonderful (1,002 reviews) "Great place " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) dominick £222 includes taxes & fees 22 Mar - 23 Mar [](https://www.expedia.co.uk/Charlotte-Hotels-The-Ballantyne.h798446.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/20100/20030/64598b80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/20100/20030/fdde6e01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/20100/20030/926d1d42.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lunch, dinner and brunch served](https://images.trvl-media.com/lodging/1000000/30000/20100/20030/f09c31e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Willcox [](https://www.expedia.co.uk/Aiken-Hotels-The-Willcox.h20030.Hotel-Information) Aiken 9.6/10 Exceptional (148 reviews) "Easy check in. Great room and our waiter at dinner Nicholas was awesome." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stephen £238 includes taxes & fees 5 Mar - 6 Mar [](https://www.expedia.co.uk/Aiken-Hotels-The-Willcox.h20030.Hotel-Information) ![Rooftop terrace](https://images.trvl-media.com/lodging/16000000/15720000/15719100/15719033/942f5474.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Regal mid-King Suite | In-room dining](https://images.trvl-media.com/lodging/16000000/15720000/15719100/15719033/6186e6dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop terrace](https://images.trvl-media.com/lodging/16000000/15720000/15719100/15719033/5a87853c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Regal mid-King Suite | Living area | Flat-screen TV](https://images.trvl-media.com/lodging/16000000/15720000/15719100/15719033/be52c8e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Mantissa Hotel [](https://www.expedia.co.uk/Florence-Hotels-The-Mantissa-Hotel.h15719033.Hotel-Information) Hartsville 9.2/10 Wonderful (275 reviews) "Very nice spacious rooms friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Duane £93 includes taxes & fees 14 Mar - 15 Mar [](https://www.expedia.co.uk/Florence-Hotels-The-Mantissa-Hotel.h15719033.Hotel-Information) ![Breakfast area](https://images.trvl-media.com/lodging/18000000/17390000/17380300/17380261/bfdc100f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/18000000/17390000/17380300/17380261/c4ff1065.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Smoking | Bathroom sink](https://images.trvl-media.com/lodging/18000000/17390000/17380300/17380261/13cfcb42.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/18000000/17390000/17380300/17380261/d4b79aee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Travelodge by Wyndham Orangeburg [](https://www.expedia.co.uk/Orangeburg-Hotels-Travelodge-By-Wyndham-Orangeburg.h17380261.Hotel-Information) Orangeburg 8.2/10 Very good (1,003 reviews) "The evening clerk is a joy, so friendly and helpful! Room clean and comfortable. Nice stay for passing through. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Debra £62 includes taxes & fees 4 Mar - 5 Mar [](https://www.expedia.co.uk/Orangeburg-Hotels-Travelodge-By-Wyndham-Orangeburg.h17380261.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/11000000/10940000/10931100/10931075/fed76e51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fireplace](https://images.trvl-media.com/lodging/11000000/10940000/10931100/10931075/05198f7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/11000000/10940000/10931100/10931075/987d2802.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily local cuisine breakfast ](https://images.trvl-media.com/lodging/11000000/10940000/10931100/10931075/80b5f3d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Carriage House Inn [](https://www.expedia.co.uk/Aiken-Hotels-Carriage-House-Inn.h10931075.Hotel-Information) Aiken 9.4/10 Exceptional (470 reviews) "Lots of charm, good location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Elizabeth £166 includes taxes & fees 12 Mar - 13 Mar [](https://www.expedia.co.uk/Aiken-Hotels-Carriage-House-Inn.h10931075.Hotel-Information) ![Exterior detail](https://images.trvl-media.com/lodging/1000000/160000/151400/151368/5424ac06.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Non Smoking | Premium bedding, pillow-top beds, in-room safe, individually furnished](https://images.trvl-media.com/lodging/1000000/160000/151400/151368/706048fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/1000000/160000/151400/151368/e887cc1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/160000/151400/151368/d5754d94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Microtel Inn & Suites by Wyndham Rock Hill/Charlotte Area [](https://www.expedia.co.uk/Rock-Hill-Hotels-Microtel-Inn-Suites-By-Wyndham-Rock-HillCharlotte-Area.h151368.Hotel-Information) Rock Hill 7.0/10 Good (1,003 reviews) "I enjoyed the amenities, the room was nice but 95% of the staff was friendly and helpful " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Elliot £50 includes taxes & fees 8 Mar - 9 Mar [](https://www.expedia.co.uk/Rock-Hill-Hotels-Microtel-Inn-Suites-By-Wyndham-Rock-HillCharlotte-Area.h151368.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/c321176c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/b23b9566.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/2b6111ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/726f3d0d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Inn on the Square, an Ascend Collection Hotel [](https://www.expedia.co.uk/Greenwood-Hotels-Inn-On-The-Square.h1212931.Hotel-Information) Uptown Greenwood 9.2/10 Wonderful (722 reviews) "The staff were all very pleasant. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) michelle £89 includes taxes & fees 29 Mar - 30 Mar [](https://www.expedia.co.uk/Greenwood-Hotels-Inn-On-The-Square.h1212931.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/2000000/1810000/1805100/1805074/60e6167a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1810000/1805100/1805074/5e830f88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1810000/1805100/1805074/24bdaf71.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1810000/1805100/1805074/61b347da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sheraton Columbia Downtown Hotel [](https://www.expedia.co.uk/Columbia-Hotels-Sheraton-Columbia-Downtown-Hotel.h1805074.Hotel-Information) Downtown Columbia 8.4/10 Very good (1,004 reviews) "Awesome hotel and great location. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Clayton £106 includes taxes & fees 15 Mar - 16 Mar [](https://www.expedia.co.uk/Columbia-Hotels-Sheraton-Columbia-Downtown-Hotel.h1805074.Hotel-Information) ![Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/43600/43558/a62a6b13.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/43600/43558/d2dce3b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool, open 10 AM to 9:00 PM, pool loungers](https://images.trvl-media.com/lodging/1000000/50000/43600/43558/b9bd3e4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/50000/43600/43558/48ea85d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Greenwood [](https://www.expedia.co.uk/Greenwood-Hotels-Baymont-By-Wyndham-Greenwood.h43558.Hotel-Information) Greenwood 7.6/10 Good (788 reviews) "The room was spotless and the staff was excellent. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Patricia £59 includes taxes & fees 12 Mar - 13 Mar [](https://www.expedia.co.uk/Greenwood-Hotels-Baymont-By-Wyndham-Greenwood.h43558.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/8136c59d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/070e1043.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/5b49de0c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/9e846421.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Red Roof Inn Santee [](https://www.expedia.co.uk/Orangeburg-Hotels-Red-Roof-Inn-Santee.h856695.Hotel-Information) Santee 6.6/10 (645 reviews) "A good option if traveling with pets. The hotel is clean and well maintained but dated. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Karen £48 includes taxes & fees 10 Mar - 11 Mar [](https://www.expedia.co.uk/Orangeburg-Hotels-Red-Roof-Inn-Santee.h856695.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-03-17&endDate=2026-03-18®ionId=6057938&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-uk-fr-de.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Holiday Sale Members save up to 40% on hotels and holiday homes. Plan this year’s big trip and save. [Book now](https://expedia.co.uk/cheap-deals?rfrr=AFFINITY_SPRING_PROMO_6057938) ## Find out more about South Carolina Midlands ### South Carolina Midlandsand its attractions for luxury travelers In the heart of South Carolina Midlands, luxury travellers can immerse themselves in a blend of history, culture, and natural beauty. Start your journey at the stunning Riverbanks Zoo & Garden, where you can stroll through beautifully landscaped gardens and encounter exotic animals in a serene environment – a perfect spot for families to enjoy an engaging day out. Next, explore the historic district of Columbia, with its charming architecture and vibrant arts scene, where upscale boutiques and art galleries await discovery. For a taste of Southern hospitality, indulge in a fine dining experience at The Capital Grille, renowned for its exceptional steaks and extensive wine list. Nature enthusiasts will appreciate a visit to Congaree National Park, where luxury hotels like The Inn at USC provide easy access to hiking trails and breathtaking views of ancient trees. Finally, don’t miss the South Carolina State Museum, which offers a wealth of exhibits ranging from art to science, all housed in a beautifully restored facility. Staying in the Midlands allows for a relaxing exploration of these attractions, with luxury hotels offering impeccable service and amenities, ensuring that your every need is catered to – from spa treatments to gourmet dining experiences. ## Top South Carolina Midlands Hotel Reviews ![Hyatt Place Columbia/Harbison](https://images.trvl-media.com/lodging/1000000/330000/327100/327027/68fe8568_y.jpg) ### Hyatt Place Columbia/Harbison 10/10 Excellent "I don't understand all those stars. My room was excellent." [](https://expedia.co.uk/Columbia-Hotels-Hyatt-Place-ColumbiaHarbison.h327027.Hotel-Information) ![Sleep Inn Columbia](https://images.trvl-media.com/lodging/1000000/130000/127000/126908/de238acf_y.jpg) ### Sleep Inn Columbia 10/10 Excellent "The room was clean, had everthing you could need plus somethings i brought myself, the staff was friendly and it was a great price. " [](https://expedia.co.uk/Columbia-Hotels-Sleep-Inn-At-Bush-River-Road.h126908.Hotel-Information) ![La Quinta Inn by Wyndham Columbia SE / Fort Jackson](https://images.trvl-media.com/lodging/1000000/10000/5100/5038/e9b1ea9e_y.jpg) ### La Quinta Inn by Wyndham Columbia SE / Fort Jackson 10/10 Excellent "Very clean and updated room." [](https://expedia.co.uk/Columbia-Hotels-La-Quinta-Inn-By-Wyndham-Columbia-SE-Fort-Jackson.h5038.Hotel-Information) ![Graduate by Hilton Columbia SC](https://images.trvl-media.com/lodging/3000000/2520000/2515100/2515057/22f12a1f_y.jpg) ### Graduate by Hilton Columbia SC 10/10 Excellent "The location , price, staff, and bar/food was second to none! Outstanding place, I highly recommend!" [](https://expedia.co.uk/Columbia-Hotels-Graduate-Columbia.h2515057.Hotel-Information) ![Holiday Inn Express & Suites Columbia-I-26 @ Harbison Blvd by IHG](https://images.trvl-media.com/lodging/1000000/690000/688700/688607/60336603_y.jpg) ### Holiday Inn Express & Suites Columbia-I-26 @ Harbison Blvd by IHG 10/10 Excellent "The room and the staff were great" [](https://expedia.co.uk/Columbia-Hotels-Holiday-Inn-Express-Suites-Columbia-I-26-Harbison-Blvd.h688607.Hotel-Information) ![Country Inn & Suites by Radisson, Columbia at Harbison, SC](https://images.trvl-media.com/lodging/4000000/3540000/3531500/3531475/dbe80ca4_y.jpg) ### Country Inn & Suites by Radisson, Columbia at Harbison, SC 10/10 Excellent "Nice room, absolutely amazing breakfast and friendly staff." 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[Dentsville Hotels ](https://www.expedia.co.uk/Dentsville-Hotels.d6345142.Travel-Guide-Hotels) - [Sports Hotels in South Carolina ](https://www.expedia.co.uk/Destinations-In-South-Carolina-Adventure-Sport-Hotel.0-0-d242-tAdventureSportHotel.Hotel-Filter-Destinations) - [All-Inclusive Hotels in South Carolina ](https://www.expedia.co.uk/Destinations-In-South-Carolina-All-Inclusive-Hotel.0-0-d242-tAllInclusiveHotel.Hotel-Filter-Destinations) - [Beach Resorts & in South Carolina ](https://www.expedia.co.uk/Destinations-In-South-Carolina-Beach-Hotels.0-0-d242-tBeachHotels.Hotel-Filter-Destinations) - [Boutique Hotels in South Carolina ](https://www.expedia.co.uk/Destinations-In-South-Carolina-Boutique-Hotel.0-0-d242-tBoutiqueHotel.Hotel-Filter-Destinations) - [Cheap Hotels in South Carolina ](https://www.expedia.co.uk/Destinations-In-South-Carolina-Budget-Hotels.0-0-d242-tBudgetHotels.Hotel-Filter-Destinations) - [Casino Hotels in South Carolina ](https://www.expedia.co.uk/Destinations-In-South-Carolina-Casino-Hotel.0-0-d242-tCasinoHotel.Hotel-Filter-Destinations) - 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