Search Business Hotels in South Carolina Midlands
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on South Carolina Midlands Business Hotels
Our top choices for South Carolina Midlands business-friendly hotels
9.8 out of 10, Exceptional, (671 reviews)
"Excellent place!"
Luis Ortiz
The price is £103
includes taxes & fees
24 Jul - 25 Jul
9.0 out of 10, Wonderful, (728 reviews)
"Very nice and clean, super friendly staff!"
Michelle
The price is £91
includes taxes & fees
12 Jul - 13 Jul
9.6 out of 10, Exceptional, (515 reviews)
"Stayed 3 nights really loved the breakfast, accommodations, and location."
Melissa
The price is £92
includes taxes & fees
7 Jul - 8 Jul
8.6 out of 10, Excellent, (385 reviews)
"everything was great, the place was nice and clean and perfect located."
Evelio
The price is £78
includes taxes & fees
29 Jul - 30 Jul
Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG
Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHGFlorence
8.6 out of 10, Excellent, (1,000 reviews)
"Very clean. Good breakfast buffet. Safe place to stay."
Jeffrey
The price is £120
includes taxes & fees
19 Jul - 20 Jul
9.6 out of 10, Exceptional, (272 reviews)
"Nice and clean spot!"
April
The price is £106
includes taxes & fees
3 Aug - 4 Aug
9.2 out of 10, Wonderful, (1,011 reviews)
"Great stay"
Monique
The price is £86
includes taxes & fees
24 Jul - 25 Jul
9.4 out of 10, Exceptional, (646 reviews)
"My wife and I have stayed at this location several times and it is always well kept and the service is always exceptional.
Thank you"
Richard and Deborah
The price is £102
includes taxes & fees
31 Jul - 1 Aug
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top South Carolina Midlands Hotel Reviews
Sleep Inn Columbia
10/10 Excellent
Frequently asked questions
Explore a world of travel with Expedia
- Cayce Hotels
- Baymont by Wyndham Columbia Northwest
- Charming Spacious 4
- Graduate by Hilton Columbia SC
- Hampton Inn Columbia
- Holiday Inn Columbia
- Holiday Inn & Suites Columbia NE
- Holiday Inn Express Columbia NE
- Hotels with Early Check-in in Columbia
- Hyatt Place Columbia/Harbison
- Lakeside Oasis
- Luxury Hotels in Columbia
- Mainstay Suites Columbia Harbison
- The cozy little heaven of Columbia
- The Rose Door Retreat w/ Huge King Bedroom Suite
- The Tiki Suite
- Wingate by Wyndham Columbia/Fort Jackson
- Columbia Hotels
- Adults Only Resorts & in South Carolina
- Sports Hotels in South Carolina
- All-Inclusive Hotels in South Carolina
- Beach Resorts & in South Carolina
- Cheap Hotels in South Carolina
- Family-Friendly Hotels in South Carolina
- Green Hotels in South Carolina
- Luxury Hotels in South Carolina
- Marina Hotels in South Carolina
- Mountain Hotels in South Carolina
- South Carolina Hotels
- Downtown Columbia Hotels
- Motel 6 Lugoff
- Rustic Waterfront Cabin Lake Wateree
- Hotels with Indoor Pools in Santee
- Farmstay in South Carolina
- Cabin Rentals in South Carolina
- Capsule Hotels in South Carolina
- Caravan Parks in South Carolina
- Chalets in South Carolina
- Studio 6 West Columbia
- Flights to Columbia
- Flights to South Carolina Midlands
- Flights to West Columbia
- Flights to South Carolina
- Flights from Columbia Metropolitan
- Flights from South Carolina
- Flights from Elgin
- Flights from Columbia
- Flights from Atlanta (ATL) to Columbia (CAE)
- Flights from Belfast (BFS) to Columbia (CAE)
- Flights from Birmingham (BHM) to Columbia (CAE)
- Flights from Birmingham (BHX) to Columbia (CAE)
- Flights from Bournemouth (BOH) to Columbia (CAE)
- Flights from Boston (BOS) to Columbia (CAE)
- Flights from Bristol (BRS) to Columbia (CAE)
- Flights from Baltimore (BWI) to Columbia (CAE)
- Flights from Charleston (CHS) to Columbia (CAE)
- Flights from Charlotte (CLT) to Columbia (CAE)
- Flights from Washington (DCA) to Columbia (CAE)
- Flights from Dublin (DUB) to Columbia (CAE)
- Flights from Edinburgh (EDI) to Columbia (CAE)
- Flights from Tortola (EIS) to Columbia (CAE)
- Flights from Glasgow (GLA) to Columbia (CAE)
- Flights from New York (JFK) to Columbia (CAE)
- Flights from Las Vegas (LAS) to Columbia (CAE)
- Flights from Los Angeles (LAX) to Columbia (CAE)
- Flights from London (LGW) to Columbia (CAE)
- Flights from London (LHR) to Columbia (CAE)
- Flights from London (LON) to Columbia (CAE)
- Flights from Manchester (MAN) to Columbia (CAE)
- Flights from Orlando (MCO) to Columbia (CAE)
- Flights from Mexico City (MEX) to Columbia (CAE)
- Flights from Miami (MIA) to Columbia (CAE)
- Flights from Newcastle (NCL) to Columbia (CAE)
- Flights from Newquay (NQY) to Columbia (CAE)
- Flights from Norwich (NWI) to Columbia (CAE)
- Flights from Chicago (ORD) to Columbia (CAE)
- Flights from Philadelphia (PHL) to Columbia (CAE)
- Flights from Seattle (SEA) to Columbia (CAE)
- Flights from San Francisco (SFO) to Columbia (CAE)
- Flights from Toronto (YYZ) to Columbia (CAE)