Title: TOP Business Hotels in South Carolina Midlands, SC for 2026 | Expedia.co.uk [South Carolina Midlands Travel Guide](https://expedia.co.uk/South-Carolina-Midlands.dx6057938)[Hotels in South Carolina Midlands](https://expedia.co.uk/South-Carolina-Midlands-Hotels.d6057938.Travel-Guide-Hotels)[Holiday Rentals in South Carolina Midlands](https://expedia.co.uk/South-Carolina-Midlands-Holiday-Rentals.d6057938.Travel-Guide-HolidayRentals)[Flights to South Carolina Midlands](https://expedia.co.uk/Cheap-Flights-To-South-Carolina-Midlands.d6057938.Travel-Guide-Flights)[Things to do in South Carolina Midlands](https://expedia.co.uk/Things-To-Do-In-South-Carolina-Midlands.d6057938.Travel-Guide-Activities)[South Carolina Midlands Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-South-Carolina-Midlands.d6057938.Car-Hire-Guide)[South Carolina Midlands Holidays](https://expedia.co.uk/South-Carolina-Midlands.d6057938.Holidays-City-Breaks) ![South Carolina State House](https://images.trvl-media.com/place/6082681/1934af6a-1aa9-4e01-8cd3-8eb8fe4af18f.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6082681/1934af6a-1aa9-4e01-8cd3-8eb8fe4af18f.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on South Carolina Midlands Business Hotels Tonight [2 Feb - 3 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6057938&startDate=2026-02-02&endDate=2026-02-03&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [3 Feb - 4 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6057938&startDate=2026-02-03&endDate=2026-02-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [6 Feb - 8 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6057938&startDate=2026-02-06&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [13 Feb - 15 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6057938&startDate=2026-02-13&endDate=2026-02-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for South Carolina Midlands business-friendly hotels ![Lobby](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/e4f3361f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/00586c85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/96d5feb4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/0b9239a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Park Inn by Radisson Florence, SC [](https://www.expedia.co.uk/Florence-Hotels-Park-Inn-By-Radisson-Florence.h47086732.Hotel-Information) Florence 9.0/10 Wonderful (2,248 reviews) "Room was clean, staff friendly, and the includes breakfast was great " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Samantha £69 includes taxes & fees 8 Feb - 9 Feb [](https://www.expedia.co.uk/Florence-Hotels-Park-Inn-By-Radisson-Florence.h47086732.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/64840011.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/fad493a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Non Smoking | Pillow-top beds, desk, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/a63ff680.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/fefdad76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Florence Center Area [](https://www.expedia.co.uk/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) Florence 9.2/10 Wonderful (1,211 reviews) "The staff was friendly and the room was clean. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Camila £80 includes taxes & fees 1 Mar - 2 Mar [](https://www.expedia.co.uk/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1170000/1160800/1160796/7d6c02d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1170000/1160800/1160796/bcb0f0ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/2000000/1170000/1160800/1160796/87830651.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Accessible, Non Smoking | Premium bedding, down duvets, individually furnished, desk](https://images.trvl-media.com/lodging/2000000/1170000/1160800/1160796/12c9570f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country Inn & Suites by Radisson, Columbia Airport, SC [](https://www.expedia.co.uk/Columbia-Hotels-Country-Inn-Suites-By-Radisson.h1160796.Hotel-Information) Cayce 8.4/10 Very good (1,001 reviews) "Breakfast was great " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mayah £75 includes taxes & fees 22 Feb - 23 Feb [](https://www.expedia.co.uk/Columbia-Hotels-Country-Inn-Suites-By-Radisson.h1160796.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/970000/970000/969975/9fdaeb31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/970000/970000/969975/9f09eded.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/970000/970000/969975/689a1cfa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast ](https://images.trvl-media.com/lodging/1000000/970000/970000/969975/83cb7582.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG [](https://www.expedia.co.uk/Florence-Hotels-Holiday-Inn-Express-Hotel-Suites-Florence-I-95-At-Hwy-327.h969975.Hotel-Information) Florence 8.6/10 Excellent (1,001 reviews) "Friendly staff, quick check in, nice lobby" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jennifer £97 includes taxes & fees 8 Feb - 9 Feb [](https://www.expedia.co.uk/Florence-Hotels-Holiday-Inn-Express-Hotel-Suites-Florence-I-95-At-Hwy-327.h969975.Hotel-Information) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/1000000/30000/22000/21992/2f1f8cba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic Area](https://images.trvl-media.com/lodging/1000000/30000/22000/21992/5f4afc1a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/22000/21992/1aef51e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![LCD TV](https://images.trvl-media.com/lodging/1000000/30000/22000/21992/bea66887.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Rock Hill [](https://www.expedia.co.uk/Rock-Hill-Hotels-Hampton-Inn-Rock-Hill.h21992.Hotel-Information) Rock Hill 9.2/10 Wonderful (1,002 reviews) "We have stayed here several times and it never disappoints! Room is clean, staff very friendly, and they provide a great breakfast!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Erma £69 includes taxes & fees 8 Feb - 9 Feb [](https://www.expedia.co.uk/Rock-Hill-Hotels-Hampton-Inn-Rock-Hill.h21992.Hotel-Information) ![Room, 2 Queen Beds, Non Smoking | Desk, blackout curtains, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/1987eeb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/320acff9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/756b4cd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/25ebdfeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Santee [](https://www.expedia.co.uk/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information) Santee 8.0/10 Very good (1,425 reviews) "Always a great stay. Clean room, friendly staff " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Angela £61 includes taxes & fees 3 Feb - 4 Feb [](https://www.expedia.co.uk/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/c8bc9166.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Serves lunch and dinner](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/e2ea309a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property – evening/night](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/c29c3321.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout curtains, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/0e00b7af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Place Florence Downtown [](https://www.expedia.co.uk/Florence-Hotels-Hyatt-Place-Florence-Downtown.h32772870.Hotel-Information) Florence 9.0/10 Wonderful (1,002 reviews) "Great location and well maintained property. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Karen £82 includes taxes & fees 9 Feb - 10 Feb [](https://www.expedia.co.uk/Florence-Hotels-Hyatt-Place-Florence-Downtown.h32772870.Hotel-Information) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/99c8fb35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/eb4d1288.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/f2adc30e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/c5155ebb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru by Hilton Orangeburg [](https://www.expedia.co.uk/Orangeburg-Hotels-Tru-By-Hilton-Orangeburg.h34323336.Hotel-Information) Orangeburg 9.2/10 Wonderful (1,005 reviews) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Thomas £92 includes taxes & fees 16 Feb - 17 Feb [](https://www.expedia.co.uk/Orangeburg-Hotels-Tru-By-Hilton-Orangeburg.h34323336.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/50000000/49040000/49035900/49035821/bed9bec2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, bed sheets](https://images.trvl-media.com/lodging/50000000/49040000/49035900/49035821/421910eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/50000000/49040000/49035900/49035821/a4b552f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/50000000/49040000/49035900/49035821/4e5c59d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Lexington Columbia [](https://www.expedia.co.uk/Columbia-Hotels-Hampton-Inn-Suites-Lexington.h49035821.Hotel-Information) Lexington 9.8/10 Exceptional (613 reviews) "Wonderful facility but most excellent staff!!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Darin £96 includes taxes & fees 8 Feb - 9 Feb [](https://www.expedia.co.uk/Columbia-Hotels-Hampton-Inn-Suites-Lexington.h49035821.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/27000000/26600000/26598800/26598714/26a37b6d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast ](https://images.trvl-media.com/lodging/27000000/26600000/26598800/26598714/aa45ff7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 2 Queen Beds, Non Smoking | Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/27000000/26600000/26598800/26598714/cfa61c33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/27000000/26600000/26598800/26598714/7d3e14d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Rock Hill [](https://www.expedia.co.uk/Rock-Hill-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Rock-Hill.h26598714.Hotel-Information) Rock Hill 9.0/10 Wonderful (1,094 reviews) "Would stay here again, good location. Clean, good room with comfortable bed. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) laura £68 includes taxes & fees 9 Feb - 10 Feb [](https://www.expedia.co.uk/Rock-Hill-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Rock-Hill.h26598714.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-02-16&endDate=2026-02-17®ionId=6057938&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top South Carolina Midlands Hotel Reviews ![Sleep Inn Columbia](https://images.trvl-media.com/lodging/1000000/130000/127000/126908/de238acf_y.jpg) ### Sleep Inn Columbia 10/10 Excellent "Super clean, new carpet, excellent staff." [](https://expedia.co.uk/Columbia-Hotels-Sleep-Inn-At-Bush-River-Road.h126908.Hotel-Information) ![Courtyard by Marriott Columbia Downtown at USC](https://images.trvl-media.com/lodging/1000000/10000/2300/2289/w3996h2667x0y0-8dd1e3e0_y.jpg) ### Courtyard by Marriott Columbia Downtown at USC 10/10 Excellent "The toom was spotless! The entire staff was awesome! The location was great! The amenities were amazing! We loved everything about this hitel." [](https://expedia.co.uk/Columbia-Hotels-Courtyard-By-Marriott-Columbia-Downtown-At-USC.h2289.Hotel-Information) ![Graduate by Hilton Columbia SC](https://images.trvl-media.com/lodging/3000000/2520000/2515100/2515057/22f12a1f_y.jpg) ### Graduate by Hilton Columbia SC 10/10 Excellent "Courteous staff. Convient location. " [](https://expedia.co.uk/Columbia-Hotels-Graduate-Columbia.h2515057.Hotel-Information) ![Holiday Inn Express & Suites Columbia-I-26 @ Harbison Blvd by IHG](https://images.trvl-media.com/lodging/1000000/690000/688700/688607/805d082b_y.jpg) ### Holiday Inn Express & Suites Columbia-I-26 @ Harbison Blvd by IHG 10/10 Excellent "Yes" [](https://expedia.co.uk/Columbia-Hotels-Holiday-Inn-Express-Suites-Columbia-I-26-Harbison-Blvd.h688607.Hotel-Information) ![Baymont by Wyndham Columbia Fort Jackson](https://images.trvl-media.com/lodging/1000000/580000/574500/574461/c68af965_y.jpg) ### Baymont by Wyndham Columbia Fort Jackson 10/10 Excellent "Rooms were nice and the checking was fast and easy. " [](https://expedia.co.uk/Columbia-Hotels-Baymont-By-Wyndham-Columbia-Fort-Jackson.h574461.Hotel-Information) ![Hyatt Place Columbia/Downtown/The Vista](https://images.trvl-media.com/lodging/9000000/8700000/8690600/8690567/c2bace01_y.jpg) ### Hyatt Place Columbia/Downtown/The Vista 10/10 Excellent "The staff was very friendly. Loved the bar and food. Great location for Gamecocks basketball games " [](https://expedia.co.uk/Columbia-Hotels-Hyatt-Place-ColumbiaDowntownThe-Vista.h8690567.Hotel-Information) ## Frequently asked questions ### How much do business hotels in South Carolina Midlands cost? ### How many business hotels are there in South Carolina Midlands? ### Why book your business hotel in South Carolina Midlands with Expedia? ### How can I find cheap business hotels in South Carolina Midlands? ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - Other - More ways to book - [5 Star Hotels in Columbia ](https://www.expedia.co.uk/5Star-Columbia-Hotels.s50-0-d764.Travel-Guide-Filter-Hotels) - [Spa Hotels in Blythewood ](https://www.expedia.co.uk/Blythewood-Hotels-Spa-Hotels.0-0-d180657-tSpaHotels.Travel-Guide-Filter-Hotels) - [Blythewood Hotels ](https://www.expedia.co.uk/Blythewood-Hotels.d180657.Travel-Guide-Hotels) - [Adults Only Resorts & in Columbia ](https://www.expedia.co.uk/Columbia-Hotels-Adults-Only-Resorts.0-0-d764-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) - 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