Santa Cruz Holidays
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Your Santa Cruz Holiday
With one of our holiday packages to Santa Cruz, you'll find countless opportunities for adventure and relaxation. There's so much to experience, including its beaches and lively atmosphere. If taking in sights is part of the programme during your trip to Santa Cruz, check out major attractions like Plaza 24 de Septiembre, Guembe Biocenter and Ventura Mall. Whoever you're heading away with and whatever the size of your budget, your dream Santa Cruz holiday is just clicks away with Expedia.
Where to stay in Santa Cruz
Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most. Learn more about Santa Cruz
Equipetrol
When in Equipetrol, you can plan a visit to Santa Cruz Zoo and Ventura Mall, some noteworthy sights in the nearby area.
Centro Histórico
3 out of top 10 points of interest in this area
If you're spending some time in Centro Histórico, Plaza 24 de Septiembre and La Recova Artisan Walk are top sights worth seeing.
Hamacas
When in Hamacas, you can plan a visit to Las Brisas Shopping Center and Santa Cruz Zoo, some noteworthy sights in the nearby area.
Urubó
While there might not be top attractions in Urubó, you can explore the larger area and discover places like Guembe Biocenter and Ventura Mall.
Zona Sur (South Zone)
Though Zona Sur (South Zone) may not have many top sights, you can venture to the surrounding area to see attractions like Cine Center and Blacutt Square.
Santa Cruz Essential Information
Language | Spanish |
|---|---|
Currency | Bolivian bolivianos |
Local Welcome | ¡Hola! |
Local Goodbye | Adiós |
Closest Airport | Viru Viru Intl. Airport (VVI) |
Max Temp Winter | 27ºC |
Max Temp Summer | 32ºC |
Top Sights | Santa Cruz Zoo, San Lorenzo Cathedral and Sacred Art Museum |
Top hotels in Santa Cruz
Ibis Santa Cruz DE LA Sierra
AVENIDA CRISTOBAL DE MENDOZA Santa Cruz
£34
2 Oct - 3 Oct
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Ave. San Martin, #455 Santa Cruz
£107
2 Oct - 3 Oct
9/10 Wonderful! (411 reviews)
"The room was ample and clean. The restaurant has very helpful staff."
Reviewed on 16 Sept 2026
Marriott Santa Cruz de la Sierra Hotel
4to Anillo Entre Radial 23 Santa Cruz Santa Cruz
£79
2 Oct - 3 Oct
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular Santa Cruz attractions
Plaza 24 de Septiembre
8.8/10 (164 reviews)
Plaza 24 de Septiembre buzzes with local culture beneath swaying palms and colonial architecture. Climb the Cathedral's bell tower for spectacular city views while sampling authentic Bolivian coffee from vendors.
San Lorenzo Cathedral
9.0/10 (84 reviews)
This grand neoclassical cathedral dominates Santa Cruz's skyline with its towering spires and ornate façade. Climb the bell tower at sunset for breathtaking panoramic views of the city.
Ventura Mall
9.0/10 (183 reviews)
Ventura Mall, Santa Cruz's premier shopping destination, features international brands and local boutiques. Enjoy the cinema complex, food court, and entertainment options in this contemporary Bolivian retail hub.
Guembe Biocenter
8.8/10 (60 reviews)
This vibrant ecological sanctuary showcases hundreds of butterfly species in a lush, tropical environment. Explore walking trails, enjoy boat rides, and learn about biodiversity in this serene natural retreat.
Santa Cruz Zoo
8.4/10 (53 reviews)
The Santa Cruz Municipal Zoo showcases Bolivia's native wildlife in naturalistic habitats, featuring jaguars, tapirs, and free-ranging sloths. Morning visits offer the best chance to see active animals.
Las Brisas Shopping Center
8.4/10 (40 reviews)
This modern complex offers 80+ stores, a nine-screen cinema, and a unique outdoor restaurant promenade. Explore the gastronomic boulevard for dining experiences beyond the standard food court options.
Ramon Tahuichi Aguilera Stadium
8.4/10 (18 reviews)
This multi-purpose stadium hosts Bolivia's most passionate football rivalries and tournaments. Experience the electric atmosphere of a local derby while enjoying modernised facilities and vibrant Santa Cruz culture.
Cine Center
8.0/10 (53 reviews)
This premier entertainment complex offers state-of-the-art cinema experiences with immersive 4D E-Motion formats. Enjoy the latest films, then explore the shopping centre and diverse dining options in the food court.
What to do in Santa Cruz
Santa Cruz and Porongo: History, Markets, River, and Culture
£73
per adult
Samaipata Fort Tour: Ancient Ruins in 1 Full Day
£231
per adult
4D/3N Expedition: Che Guevara Route - Disconnect from the World
£586
per adult
Frequently asked questions
Why should I book my Santa Cruz holiday with Expedia?
With great-value airfares, car hire and accommodation choices all in the same place, Expedia makes planning your Santa Cruz adventure hassle-free. Plus, we can help you bundle your bookings into a package holiday so you can get even more savings. Select from amazing stays, add flights and/or a hire car (and maybe even some exciting activities!) and score incredible prices. Had a change of plans? Expedia offers a flexible cancellation policy for many reservations. To learn more, head over to our Customer Service Portal link.
When is the best time of year to holiday in Santa Cruz?
Santa Cruz is at its busiest in March, August and September. If you want a more laid-back getaway, go there in January, May and December. To get an idea of the type of weather to expect, the daytime average temperature in June, the coolest month in Santa Cruz, is 19ºC. The warmest month here is October, when temperatures are around 26ºC.
What is the top hotel for my holiday in Santa Cruz?
Offering many of home's creature comforts, Camino Real Hotel will make the ideal base for your Santa Cruz getaway.
How do I get a cheap holiday to Santa Cruz?
Creating your own Santa Cruz holiday with Expedia is a great way to save. We have more than 400 airlines and 321,000 hotel options throughout the world. With such a huge range to select from, you'll have no trouble putting together your ideal holiday. Learn more about how you can save money on your holiday when you bundle your flight and hotel bookings with Expedia.
What should I do on my Santa Cruz holiday?
Make sure your holiday in Santa Cruz is an unforgettable one by visiting its most popular attractions. Plaza 24 de Septiembre, Ventura Mall, Guembe Biocenter and Santa Cruz Zoo are just some of the things we recommend seeing while you're in the city.
What is the best area to stay in when on holiday in Santa Cruz?
There's so much to do in Santa Cruz, so stay near its top attractions and maximise your time sightseeing. Plaza 24 de Septiembre is one place to put on your itinerary.
Do I need a visa for my Santa Cruz holiday?
Visa requirements for Santa Cruz vary depending on your nationality and the reason for your visit. It's wise to check official government websites to determine if you need a visa for your trip. They'll give you the most up-to-date information, including details about application procedures or supporting documentation that may be necessary. Enquire about your visa requirements well in advance to ensure a hassle-free travel experience. Finally, make sure your passport is valid for a further six months from your return date.
What should I wear on my Santa Cruz holiday?
First, think about the types of things you'll be doing during your trip to Santa Cruz and travel with pieces that you can easily mix and match. For fashion inspiration or even information on dress codes, look up a few style blogs or relevant social media accounts. Pack your bags with confidence by checking the weather conditions in Santa Cruz. October brings the warmest temperatures, with daytime averages of 26ºC, while June days average 19ºC, making it the coolest time of year.
What does an Expedia Santa Cruz holiday include?
Expedia has everything you need to organise your Santa Cruz trip, but what your package looks like is up to you. Choose from a combination of hotels, flights and hire cars. Searching for some tours or activities to keep you busy? Once you've made your booking, you can add them too. No matter your budget or style, there's a holiday package to meet your needs. Expedia features all types of properties, with the most popular in Santa Cruz including apartments and hotels. With Expedia, you can expect the freedom and flexibility to tailor-make your holiday your way.
Does Expedia offer Book Now, Pay Later Santa Cruz holidays?
Expedia has joined forces with online lender Klarna to make your next break a little easier on the wallet. Paying in instalments means you can spread the costs of your dream holiday, leaving you with more cash to splash while you're travelling. Klarna has several payment plans to pick from, so you're sure to find one that works with your budget. Browse these flexible payment options:
- Pay monthly holidays: Klarna offers the ability to pay in multiple transactions that fit all budgets, so you can have that well-deserved holiday now.
- No-deposit holidays: When you want to jump on an awesome deal but don't have the full amount yet, Klarna's no-deposit holiday plan will allow you to Book Now, Pay Later to secure your getaway.
Can I choose my airline with a Santa Cruz Expedia holiday?
Yes — that's one of the best things about an Expedia holiday package. You get to decide. We have more than 400 airline partners across the globe, so you have lots of choice when creating your Santa Cruz getaway.
Explore a world of travel with Expedia
- Santa Cruz Hotels
- Barcelo Hotels in Santa Cruz
- Casino Hotels in Santa Cruz
- Gay-Friendly Hotels in Santa Cruz
- Hotel Arenal
- Hotel BY Armonia SCZ
- Hotel LP Equipetrol
- Hotel Puerta del Rey
- Hotels with Airport Transfers in Santa Cruz
- Ibis Santa Cruz DE LA Sierra
- Alfonsina Hotel Boutique by Inboccaluppo
- Los Tajibos
- Modern Studio Apartment in Equipetrol – Fully Equipped with Top Amenities
- Nomad Hostel
- Royal Lodge Hotel
- Swissôtel Santa Cruz De La Sierra
- Terranova Suites
- Urban Suites Apart Hotel
- Wedding Hotels in Santa Cruz
- Santa Cruz Hotels
- Hotels near Viru Viru Intl.
- Flights to El Trompillo
- Flights to Santa Cruz
- Flights to Viru Viru Intl.
- Flights to Santa Cruz
- Flights from El Trompillo
- Air Europa Madrid (MAD) to Santa Cruz (VVI) flights
- Boliviana De Aviacion Madrid (MAD) to Santa Cruz (VVI) flights
- Latam Airlines Group Milan (MXP) to Santa Cruz (VVI) flights
- Flights from Abuja (ABV) to Santa Cruz (VVI)
- Flights from Asuncion (ASU) to Santa Cruz (VVI)
- Flights from Barcelona (BCN) to Santa Cruz (VVI)
- Flights from Hartford (BDL) to Santa Cruz (SRZ)
- Flights from Belfast (BHD) to Santa Cruz (SRZ)
- Flights from Birmingham (BHX) to Santa Cruz (VVI)
- Flights from Bangkok (BKK) to Santa Cruz (VVI)
- Flights from Bogotá (BOG) to Santa Cruz (VVI)
- Flights from Bournemouth (BOH) to Santa Cruz (SRZ)
- Flights from Boston (BOS) to Santa Cruz (SRZ)
- Flights from Guangzhou (CAN) to Santa Cruz (SRZ)
- Flights from Cochabamba (CBB) to Santa Cruz (VVI)
- Flights from Campo Grande (CGR) to Santa Cruz (VVI)
- Flights from Calama (CJC) to Santa Cruz (VVI)
- Flights from Charlotte (CLT) to Santa Cruz (SRZ)
- Flights from Copiapo (CPO) to Santa Cruz (SRZ)
- Flights from Cartagena (CTG) to Santa Cruz (VVI)
- Flights from Cusco (CUZ) to Santa Cruz (VVI)
- Flights from Dhaka (DAC) to Santa Cruz (VVI)
- Flights from Dhahran (DHA) to Santa Cruz (SRZ)
- Flights from Dublin (DUB) to Santa Cruz (VVI)
- Flights from Entebbe (EBB) to Santa Cruz (VVI)
- Flights from Edinburgh (EDI) to Santa Cruz (VVI)
- Flights from Newark Liberty Intl. Airport (EWR) to Santa Cruz (VVI)
- Flights from Buenos Aires (EZE) to Santa Cruz (VVI)
- Flights from Fort Wayne (FWA) to Santa Cruz (VVI)
- Flights from Gaya (GAY) to Santa Cruz (SRZ)
- Flights from Rio de Janeiro (GIG) to Santa Cruz (SRZ)
- Flights from São Paulo (GRU) to Santa Cruz (VVI)
- Flights from Guayaquil (GYE) to Santa Cruz (VVI)
- Flights from Houston (IAH) to Santa Cruz (VVI)
- Flights from Iguassu Falls (IGU) to Santa Cruz (VVI)
- Flights from New York (JFK) to Santa Cruz (VVI)
- Flights from Las Vegas (LAS) to Santa Cruz (SRZ)
- Flights from Los Angeles (LAX) to Santa Cruz (VVI)
- Flights from London (LCY) to Santa Cruz (VVI)
- Flights from London (LGW) to Santa Cruz (VVI)
- Flights from London (LHR) to Santa Cruz (SRZ)
- Flights from London (LHR) to Santa Cruz (VVI)
- Flights from Lima (LIM) to Santa Cruz (VVI)
- Flights from London (LON) to Santa Cruz (VVI)
- Flights from La Paz (LPB) to Santa Cruz (VVI)
- Flights from Madrid (MAD) to Santa Cruz (SRZ)
- Flights from Madrid (MAD) to Santa Cruz (VVI)
- Flights from Manchester (MAN) to Santa Cruz (VVI)
- Flights from Orlando (MCO) to Santa Cruz (VVI)
- Flights from Medford (MFR) to Santa Cruz (VVI)
- Flights from Managua (MGA) to Santa Cruz (VVI)
- Flights from Miami (MIA) to Santa Cruz (VVI)
- Flights from Milan (MXP) to Santa Cruz (VVI)
- Flights from Nairobi (NBO) to Santa Cruz (VVI)
- Flights from Orlando (ORL) to Santa Cruz (SRZ)
- Flights from Portland (PDX) to Santa Cruz (VVI)
- Flights from Potosi (POI) to Santa Cruz (VVI)
- Flights from Riberalta (RIB) to Santa Cruz (SRZ)
- Flights from Rio de Janeiro (RIO) to Santa Cruz (VVI)
- Flights from Santa Ana del Yacuma (SBL) to Santa Cruz (SRZ)
- Flights from Santiago (SCL) to Santa Cruz (SRZ)
- Flights from Santiago (SCL) to Santa Cruz (VVI)
- Flights from San Francisco (SFO) to Santa Cruz (SRZ)
- Flights from San Francisco (SFO) to Santa Cruz (VVI)
- Flights from San Jose (SJC) to Santa Cruz (VVI)
- Flights from Santa Cruz de la Palma (SPC) to Santa Cruz (VVI)
- Flights from Tarija (TJA) to Santa Cruz (SRZ)
- Flights from Tarija (TJA) to Santa Cruz (VVI)
- Flights from Quito (UIO) to Santa Cruz (VVI)
- Flights from Uyuni (UYU) to Santa Cruz (VVI)
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.
